메뉴 건너뛰기




Volumn 314, Issue 5, 2018, Pages H928-H939

Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure

Author keywords

Exosomal microRNAs; Myocardial infarction; Nuclear factor erythroid 2 related factor 2 dysregulation; Oxidative stress

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 27A; MICRORNA 28 3P; MICRORNA 34A; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; NFE2L2 PROTEIN, RAT;

EID: 85046899809     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00602.2017     Document Type: Article
Times cited : (130)

References (53)
  • 1
    • 84961377007 scopus 로고    scopus 로고
    • Novel perspectives in redox biology and pathophysiology of failing myocytes: Modulation of the intramyocardial redox milieu for therapeutic interventions – a review article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology
    • Arcaro A, Pirozzi F, Angelini A, Chimenti C, Crotti L, Giordano C, Mancardi D, Torella D, Tocchetti CG. Novel perspectives in redox biology and pathophysiology of failing myocytes: modulation of the intramyocardial redox milieu for therapeutic interventions – a review article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology. Oxid Med Cell Longev 2016: 6353469, 2016. doi:10.1155/2016/6353469.
    • (2016) Oxid Med Cell Longev , vol.2016
    • Arcaro, A.1    Pirozzi, F.2    Angelini, A.3    Chimenti, C.4    Crotti, L.5    Giordano, C.6    Mancardi, D.7    Torella, D.8    Tocchetti, C.G.9
  • 4
    • 84866929338 scopus 로고    scopus 로고
    • Redox signaling in cardiac physiology and pathology
    • Burgoyne JR, Mongue-Din H, Eaton P, Shah AM. Redox signaling in cardiac physiology and pathology. Circ Res 111: 1091–1106, 2012. doi:10.1161/CIRCRESAHA.111.255216.
    • (2012) Circ Res , vol.111 , pp. 1091-1106
    • Burgoyne, J.R.1    Mongue-Din, H.2    Eaton, P.3    Shah, A.M.4
  • 6
    • 0030451213 scopus 로고    scopus 로고
    • NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • Chan K, Lu R, Chang JC, Kan YW. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci USA 93: 13943–13948, 1996. doi:10.1073/pnas.93.24.13943.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 8
    • 84866634824 scopus 로고    scopus 로고
    • Cardiac natriuretic peptides: Contributors to cardiac cachexia or possible anti-obesity agents or both?
    • Costello-Boerrigter LC. Cardiac natriuretic peptides: contributors to cardiac cachexia or possible anti-obesity agents or both? Diabetes 61: 2403–2404, 2012. doi:10.2337/db12-0763.
    • (2012) Diabetes , vol.61 , pp. 2403-2404
    • Costello-Boerrigter, L.C.1
  • 9
    • 84930924311 scopus 로고    scopus 로고
    • Extracellular vesicle microRNA transfer in cardiovascular disease
    • Das S, Halushka MK. Extracellular vesicle microRNA transfer in cardiovascular disease. Cardiovasc Pathol 24: 199–206, 2015. doi:10.1016/j.carpath.2015.04.007.
    • (2015) Cardiovasc Pathol , vol.24 , pp. 199-206
    • Das, S.1    Halushka, M.K.2
  • 11
    • 84937977362 scopus 로고    scopus 로고
    • Exosomes and exosomal miRNAs in cardiovascular protection and repair
    • Emanueli C, Shearn AI, Angelini GD, Sahoo S. Exosomes and exosomal miRNAs in cardiovascular protection and repair. Vascul Pharmacol 71: 24–30, 2015. doi:10.1016/j.vph.2015.02.008.
    • (2015) Vascul Pharmacol , vol.71 , pp. 24-30
    • Emanueli, C.1    Shearn, A.I.2    Angelini, G.D.3    Sahoo, S.4
  • 12
    • 54749089704 scopus 로고    scopus 로고
    • Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: Potential mechanism for sympathetic overactivity in heart failure
    • Gao L, Wang WZ, Wang W, Zucker IH. Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failure. Hypertension 52: 708–714, 2008. doi:10.1161/HYPERTENSIONAHA.108.116228.
    • (2008) Hypertension , vol.52 , pp. 708-714
    • Gao, L.1    Wang, W.Z.2    Wang, W.3    Zucker, I.H.4
  • 13
    • 85019884852 scopus 로고    scopus 로고
    • SelectiveNrf2 gene deletion in the rostral ventrolateral medulla evokes hypertension and sympathoexcitation in mice
    • Gao L, Zimmerman MC, Biswal S, Zucker IH. SelectiveNrf2 gene deletion in the rostral ventrolateral medulla evokes hypertension and sympathoexcitation in mice. Hypertension 69: 1198–1206, 2017. doi:10.1161/HYPERTENSIONAHA.117.09123.
    • (2017) Hypertension , vol.69 , pp. 1198-1206
    • Gao, L.1    Zimmerman, M.C.2    Biswal, S.3    Zucker, I.H.4
  • 14
    • 34249035782 scopus 로고    scopus 로고
    • Cardiac hypertrophy: Mechanisms and therapeutic opportunities
    • Gupta S, Das B, Sen S. Cardiac hypertrophy: mechanisms and therapeutic opportunities. Antioxid Redox Signal 9: 623–652, 2007. doi:10.1089/ars.2007.1474.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 623-652
    • Gupta, S.1    Das, B.2    Sen, S.3
  • 15
    • 33750475625 scopus 로고    scopus 로고
    • Free radicals, mitochondria, and oxidized lipids: The emerging role in signal transduction in vascular cells
    • Gutierrez J, Ballinger SW, Darley-Usmar VM, Landar A. Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ Res 99: 924–932, 2006. doi:10.1161/01.RES.0000248212.86638.e9.
    • (2006) Circ Res , vol.99 , pp. 924-932
    • Gutierrez, J.1    Ballinger, S.W.2    Darley-Usmar, V.M.3    Landar, A.4
  • 16
    • 33748323383 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy by intracellular signalling pathways
    • Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7: 589–600, 2006. doi:10.1038/nrm1983.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 589-600
    • Heineke, J.1    Molkentin, J.D.2
  • 18
    • 3242661655 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo
    • Hu CM, Chen YH, Chiang MT, Chau LY. Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo. Circulation 110: 309–316, 2004. doi:10.1161/01.CIR.0000135475.35758.23.
    • (2004) Circulation , vol.110 , pp. 309-316
    • Hu, C.M.1    Chen, Y.H.2    Chiang, M.T.3    Chau, L.Y.4
  • 19
    • 70349843323 scopus 로고    scopus 로고
    • Nrf2:INrf2 (Keap1) signaling in oxidative stress
    • Kaspar JW, Niture SK, Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med 47: 1304–1309, 2009. doi:10.1016/j.freeradbiomed.2009.07.035.
    • (2009) Free Radic Biol Med , vol.47 , pp. 1304-1309
    • Kaspar, J.W.1    Niture, S.K.2    Jaiswal, A.K.3
  • 20
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24: 7130–7139, 2004. doi:10.1128/MCB.24.16.7130-7139.2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 21
    • 33744477355 scopus 로고    scopus 로고
    • Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts
    • Kraft DC, Deocaris CC, Wadhwa R, Rattan SI. Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts. Ann N Y Acad Sci 1067: 420–424, 2006. doi:10.1196/annals.1354.060.
    • (2006) Ann N Y Acad Sci , vol.1067 , pp. 420-424
    • Kraft, D.C.1    Deocaris, C.C.2    Wadhwa, R.3    Rattan, S.I.4
  • 22
    • 0036240610 scopus 로고    scopus 로고
    • Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter
    • Kwak MK, Itoh K, Yamamoto M, Kensler TW. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol 22: 2883–2892, 2002. doi:10.1128/MCB.22.9.2883-2892.2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 2883-2892
    • Kwak, M.K.1    Itoh, K.2    Yamamoto, M.3    Kensler, T.W.4
  • 23
    • 79952742806 scopus 로고    scopus 로고
    • Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
    • Li N, Muthusamy S, Liang R, Sarojini H, Wang E. Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1. Mech Ageing Dev 132: 75–85, 2011. doi:10.1016/j.mad.2010.12.004.
    • (2011) Mech Ageing Dev , vol.132 , pp. 75-85
    • Li, N.1    Muthusamy, S.2    Liang, R.3    Sarojini, H.4    Wang, E.5
  • 25
    • 0035672065 scopus 로고    scopus 로고
    • Heart failure, redox alterations, and endothelial dysfunction
    • López Farré A, Casado S. Heart failure, redox alterations, and endothelial dysfunction. Hypertension 38: 1400–1405, 2001. doi:10.1161/hy1201.099612.
    • (2001) Hypertension , vol.38 , pp. 1400-1405
    • López Farré, A.1    Casado, S.2
  • 26
    • 37349041037 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction
    • Lu Z, Xu X, Hu X, Zhu G, Zhang P, van Deel ED, French JP, Fassett JT, Oury TD, Bache RJ, Chen Y. Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension 51: 19–25, 2008. doi:10.1161/HYPERTENSIONAHA.107.098186.
    • (2008) Hypertension , vol.51 , pp. 19-25
    • Lu, Z.1    Xu, X.2    Hu, X.3    Zhu, G.4    Zhang, P.5    Van Deel, E.D.6    French, J.P.7    Fassett, J.T.8    Oury, T.D.9    Bache, R.J.10    Chen, Y.11
  • 27
    • 79952455513 scopus 로고    scopus 로고
    • Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome
    • Luo ZF, Qi W, Feng B, Mu J, Zeng W, Guo YH, Pang Q, Ye ZL, Liu L, Yuan FH. Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome. Life Sci 88: 512–520, 2011. doi:10.1016/j.lfs.2010.12.023.
    • (2011) Life Sci , vol.88 , pp. 512-520
    • Luo, Z.F.1    Qi, W.2    Feng, B.3    Mu, J.4    Zeng, W.5    Guo, Y.H.6    Pang, Q.7    Ye, Z.L.8    Liu, L.9    Yuan, F.H.10
  • 30
    • 0142036803 scopus 로고    scopus 로고
    • Modulation of L-type calcium channel expression during retinoic acidinduced differentiation of H9C2 cardiac cells
    • Ménard C, Pupier S, Mornet D, Kitzmann M, Nargeot J, Lory P. Modulation of L-type calcium channel expression during retinoic acidinduced differentiation of H9C2 cardiac cells. J Biol Chem 274: 29063–29070, 1999. doi:10.1074/jbc.274.41.29063.
    • (1999) J Biol Chem , vol.274 , pp. 29063-29070
    • Ménard, C.1    Pupier, S.2    Mornet, D.3    Kitzmann, M.4    Nargeot, J.5    Lory, P.6
  • 31
    • 84870859466 scopus 로고    scopus 로고
    • Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SHSY5Y cells
    • Narasimhan M, Patel D, Vedpathak D, Rathinam M, Henderson G, Mahimainathan L. Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SHSY5Y cells. PLoS One 7: e51111, 2012. doi:10.1371/journal.pone.0051111.
    • (2012) Plos One , vol.7
    • Narasimhan, M.1    Patel, D.2    Vedpathak, D.3    Rathinam, M.4    Henderson, G.5    Mahimainathan, L.6
  • 32
    • 84901781833 scopus 로고    scopus 로고
    • Hydrogen peroxide responsive miR153 targets Nrf2/ ARE cytoprotection in paraquat induced dopaminergic neurotoxicity
    • Narasimhan M, Riar AK, Rathinam ML, Vedpathak D, Henderson G, Mahimainathan L. Hydrogen peroxide responsive miR153 targets Nrf2/ ARE cytoprotection in paraquat induced dopaminergic neurotoxicity. Toxicol Lett 228: 179–191, 2014. doi:10.1016/j.toxlet.2014.05.020.
    • (2014) Toxicol Lett , vol.228 , pp. 179-191
    • Narasimhan, M.1    Riar, A.K.2    Rathinam, M.L.3    Vedpathak, D.4    Henderson, G.5    Mahimainathan, L.6
  • 36
    • 79960549767 scopus 로고    scopus 로고
    • TNF mediates the sustained activation of Nrf2 in human monocytes
    • Rushworth SA, Shah S, MacEwan DJ. TNF mediates the sustained activation of Nrf2 in human monocytes. J Immunol 187: 702–707, 2011. doi:10.4049/jimmunol.1004117.
    • (2011) J Immunol , vol.187 , pp. 702-707
    • Rushworth, S.A.1    Shah, S.2    Macewan, D.J.3
  • 37
    • 78549277802 scopus 로고    scopus 로고
    • MicroRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
    • Sangokoya C, Telen MJ, Chi JT. microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. Blood 116: 4338–4348, 2010. doi:10.1182/blood-2009-04-214817.
    • (2010) Blood , vol.116 , pp. 4338-4348
    • Sangokoya, C.1    Telen, M.J.2    Chi, J.T.3
  • 38
    • 31444447800 scopus 로고    scopus 로고
    • Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers
    • Satoh T, Okamoto SI, Cui J, Watanabe Y, Furuta K, Suzuki M, Tohyama K, Lipton SA. Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. Proc Natl Acad Sci USA 103: 768–773, 2006. doi:10.1073/pnas.0505723102.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 768-773
    • Satoh, T.1    Okamoto, S.I.2    Cui, J.3    Watanabe, Y.4    Furuta, K.5    Suzuki, M.6    Tohyama, K.7    Lipton, S.A.8
  • 39
    • 34547185623 scopus 로고    scopus 로고
    • Oxidative stress and redox signalling in cardiac hypertrophy and heart failure
    • Seddon M, Looi YH, Shah AM. Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart 93: 903–907, 2007. doi:10.1136/hrt.2005.068270.
    • (2007) Heart , vol.93 , pp. 903-907
    • Seddon, M.1    Looi, Y.H.2    Shah, A.M.3
  • 40
    • 0034995893 scopus 로고    scopus 로고
    • Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts
    • Siwik DA, Pagano PJ, Colucci WS. Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am J Physiol Cell Physiol 280: C53–C60, 2001. doi:10.1152/ajpcell.2001.280.1.C53.
    • (2001) Am J Physiol Cell Physiol , vol.280 , pp. C53-C60
    • Siwik, D.A.1    Pagano, P.J.2    Colucci, W.S.3
  • 41
    • 0033597951 scopus 로고    scopus 로고
    • Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro
    • Siwik DA, Tzortzis JD, Pimental DR, Chang DL, Pagano PJ, Singh K, Sawyer DB, Colucci WS. Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro. Circ Res 85: 147–153, 1999. doi:10.1161/01.RES.85.2.147.
    • (1999) Circ Res , vol.85 , pp. 147-153
    • Siwik, D.A.1    Tzortzis, J.D.2    Pimental, D.R.3    Chang, D.L.4    Pagano, P.J.5    Singh, K.6    Sawyer, D.B.7    Colucci, W.S.8
  • 42
    • 33846418746 scopus 로고    scopus 로고
    • Role of oxidative stress in cardiac hypertrophy and remodeling
    • Takimoto E, Kass DA. Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension 49: 241–248, 2007. doi:10.1161/01.HYP.0000254415.31362.a7.
    • (2007) Hypertension , vol.49 , pp. 241-248
    • Takimoto, E.1    Kass, D.A.2
  • 45
    • 33750915424 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress, DNA damage, and heart failure
    • Tsutsui H, Ide T, Kinugawa S. Mitochondrial oxidative stress, DNA damage, and heart failure. Antioxid Redox Signal 8: 1737–1744, 2006. doi:10.1089/ars.2006.8.1737.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1737-1744
    • Tsutsui, H.1    Ide, T.2    Kinugawa, S.3
  • 46
    • 34047113312 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with heart failure in general practices and hospitals
    • JCARE-GENERAL Investigators
    • Tsutsui H, Tsuchihashi-Makaya M, Kinugawa S, Goto D, Takeshita A; JCARE-GENERAL Investigators. Characteristics and outcomes of patients with heart failure in general practices and hospitals. Circ J 71: 449–454, 2007. doi:10.1253/circj.71.449.
    • (2007) Circ J , vol.71 , pp. 449-454
    • Tsutsui, H.1    Tsuchihashi-Makaya, M.2    Kinugawa, S.3    Goto, D.4    Takeshita, A.5
  • 47
    • 80052381608 scopus 로고    scopus 로고
    • Characterization of extracellular circulating microRNA
    • Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res 39: 7223–7233, 2011. doi:10.1093/nar/gkr254.
    • (2011) Nucleic Acids Res , vol.39 , pp. 7223-7233
    • Turchinovich, A.1    Weiz, L.2    Langheinz, A.3    Burwinkel, B.4
  • 48
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9: 654–659, 2007. doi:10.1038/ncb1596.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 49
    • 84908110467 scopus 로고    scopus 로고
    • Vascular dysfunction in ocular blood flow regulation: Impact of reactive oxygen species in an experimental setup
    • Wagenfeld L, Weiss S, Klemm M, Richard G, Zeitz O. Vascular dysfunction in ocular blood flow regulation: impact of reactive oxygen species in an experimental setup. Invest Ophthalmol Vis Sci 55: 5531–5536, 2014. doi:10.1167/iovs.14-14032.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 5531-5536
    • Wagenfeld, L.1    Weiss, S.2    Klemm, M.3    Richard, G.4    Zeitz, O.5
  • 50
    • 59649117586 scopus 로고    scopus 로고
    • Examining the influence of microRNAs on translation efficiency and on mRNA deadenylation and decay
    • Wu L, Belasco JG. Examining the influence of microRNAs on translation efficiency and on mRNA deadenylation and decay. Methods Enzymol 449: 373–393, 2008. doi:10.1016/S0076-6879(08)02418-X.
    • (2008) Methods Enzymol , vol.449 , pp. 373-393
    • Wu, L.1    Belasco, J.G.2
  • 51
    • 80052570740 scopus 로고    scopus 로고
    • MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
    • Yang M, Yao Y, Eades G, Zhang Y, Zhou Q. MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism. Breast Cancer Res Treat 129: 983–991, 2011. doi:10.1007/s10549-011-1604-1.
    • (2011) Breast Cancer Res Treat , vol.129 , pp. 983-991
    • Yang, M.1    Yao, Y.2    Eades, G.3    Zhang, Y.4    Zhou, Q.5
  • 52
    • 84904667280 scopus 로고    scopus 로고
    • The role of Nrf2-mediated pathway in cardiac remodeling and heart failure
    • Zhou S, Sun W, Zhang Z, Zheng Y. The role of Nrf2-mediated pathway in cardiac remodeling and heart failure. Oxid Med Cell Longev 2014: 260429, 2014. doi:10.1155/2014/260429.
    • (2014) Oxid Med Cell Longev , vol.2014
    • Zhou, S.1    Sun, W.2    Zhang, Z.3    Zheng, Y.4
  • 53
    • 51449117002 scopus 로고    scopus 로고
    • Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress
    • Zhu H, Jia Z, Misra BR, Zhang L, Cao Z, Yamamoto M, Trush MA, Misra HP, Li Y. Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress. Cardiovasc Toxicol 8: 71–85, 2008. doi:10.1007/s12012-008-9016-0.
    • (2008) Cardiovasc Toxicol , vol.8 , pp. 71-85
    • Zhu, H.1    Jia, Z.2    Misra, B.R.3    Zhang, L.4    Cao, Z.5    Yamamoto, M.6    Trush, M.A.7    Misra, H.P.8    Li, Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.