Reserve Flux Capacity in the Pentose Phosphate Pathway Enables Escherichia coli's Rapid Response to Oxidative Stress

Cell Systems

Volumn 6, Issue 5, 2018, Pages 569-578.e7

  Christodoulou, Dimitris ^a,b   Link, Hannes ^a,c   Fuhrer, Tobias ^a   Kochanowski, Karl ^a,d   Gerosa, Luca ^a,e   Sauer, Uwe ^a  

^a ETH ZURICH   (Switzerland)

^b PhD Program in Molecular Life Sciences Zurich   (Switzerland)

^c MAX PLANCK INSTITUTE FOR TERRESTRIAL MICROBIOLOGY   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

allosteric regulation; central metabolism; kinetic modeling; metabolomics; oxidative stress

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROGEN PEROXIDE; PENTOSE PHOSPHATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ESCHERICHIA COLI PROTEIN; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BACTERIAL METABOLISM; BINDING AFFINITY; CONTROLLED STUDY; ESCHERICHIA COLI; GLYCOLYSIS; GROWTH RATE; IN VITRO STUDY; KINETIC PARAMETERS; KINETICS; METABOLOME; NEGATIVE FEEDBACK; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; STEADY STATE; GENETICS; METABOLIC FLUX ANALYSIS; METABOLISM; PENTOSE PHOSPHATE CYCLE; PHYSIOLOGY; PROCEDURES;

ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLUCOSEPHOSPHATE DEHYDROGENASE; GLYCOLYSIS; HYDROGEN PEROXIDE; METABOLIC FLUX ANALYSIS; METABOLIC NETWORKS AND PATHWAYS; NADP; OXIDATIVE STRESS; PENTOSE PHOSPHATE PATHWAY; REACTIVE OXYGEN SPECIES;

EID: 85046760957     PISSN: 24054712     EISSN: 24054720     Source Type: Journal    
DOI: 10.1016/j.cels.2018.04.009     Document Type: Article

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