Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity

Cell Reports

Volumn 20, Issue 11, 2017, Pages 2666-2677

  Reznik, Ed ^a,b   Christodoulou, Dimitris ^c,d   Goldford, Joshua E ^e   Briars, Emma ^e   Sauer, Uwe ^c   Segrè, Daniel ^b,e,f   Noor, Elad ^c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Boston University   (United States)

^c ETH ZURICH   (Switzerland)

^d PhD Program in Molecular Life Sciences Zurich   (Switzerland)

^e BOSTON UNIVERSITY   (United States)

^f Boston University   (United States)

Author keywords

elasticity; enzyme kinetics; metabolism; regulatory network; small molecule regulation; trade offs

Indexed keywords

ARTICLE; BINDING AFFINITY; CARBON METABOLISM; ENZYME ACTIVITY; ENZYME REGULATION; ESCHERICHIA COLI; GENE STRUCTURE; HOMEOSTASIS; METABOLOMICS; MOLECULAR EVOLUTION; NONHUMAN; ORGANISMAL INTERACTION; PHYLOGENY; PRIORITY JOURNAL; REGULATORY MECHANISM; SMALL MOLECULE REGULATORY NETWORK; THERMODYNAMICS; BACTERIAL GENOME; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; METABOLOME;

CARBON;

CARBON; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENE REGULATORY NETWORKS; GENOME, BACTERIAL; METABOLOME; THERMODYNAMICS; TRANSCRIPTION, GENETIC;

EID: 85029349659     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.08.066     Document Type: Article

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