-
2
-
-
85038809639
-
Is It Possible to Develop a “Universal” Influenza Virus Vaccine? Immunogenetic Considerations Underlying B-Cell Biology in the Development of a Pan-Subtype Influenza A Vaccine Targeting the Hemagglutinin Stem
-
Andrews, S.F.; Graham, B.S.; Mascola, J.R.; McDermott, A.B. Is It Possible to Develop a “Universal” Influenza Virus Vaccine? Immunogenetic Considerations Underlying B-Cell Biology in the Development of a Pan-Subtype Influenza A Vaccine Targeting the Hemagglutinin Stem. Cold Spring Harb. Perspect. Biol. 2017
-
(2017)
Cold Spring Harb. Perspect. Biol
-
-
Andrews, S.F.1
Graham, B.S.2
Mascola, J.R.3
McDermott, A.B.4
-
3
-
-
85028548934
-
From Original Antigenic Sin to the Universal Influenza Virus Vaccine
-
Henry, C.; Palm, A.E.; Krammer, F.; Wilson, P.C. From Original Antigenic Sin to the Universal Influenza Virus Vaccine. Trends Immunol. 2018, 39, 70-79
-
(2018)
Trends Immunol
, vol.39
, pp. 70-79
-
-
Henry, C.1
Palm, A.E.2
Krammer, F.3
Wilson, P.C.4
-
5
-
-
85045463733
-
Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic Drift
-
Altman, M.O.; Angeletti, D.; Yewdell, J.W. Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic Drift. Viral Immunol. 2018
-
(2018)
Viral Immunol
-
-
Altman, M.O.1
Angeletti, D.2
Yewdell, J.W.3
-
6
-
-
43949119092
-
Safety and immunogenicity of trivalent inactivated influenza vaccine in infants
-
Halasa, N.B.; Gerber, M.A.; Chen, Q.; Wright, P.F.; Edwards, K.M. Safety and immunogenicity of trivalent inactivated influenza vaccine in infants. J. Infect. Dis. 2008, 197, 1448-1454
-
(2008)
J. Infect. Dis
, vol.197
, pp. 1448-1454
-
-
Halasa, N.B.1
Gerber, M.A.2
Chen, Q.3
Wright, P.F.4
Edwards, K.M.5
-
7
-
-
0027170483
-
Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA
-
Martinon, F.; Krishnan, S.; Lenzen, G.; Magné, R.; Gomard, E.; Guillet, J.G.; Lévy, J.P.; Meulien, P. Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA. Eur. J. Immunol. 1993, 23, 1719-1722
-
(1993)
Eur. J. Immunol
, vol.23
, pp. 1719-1722
-
-
Martinon, F.1
Krishnan, S.2
Lenzen, G.3
Magné, R.4
Gomard, E.5
Guillet, J.G.6
Lévy, J.P.7
Meulien, P.8
-
8
-
-
0029839058
-
Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo
-
Boczkowski, D.; Nair, S.K.; Snyder, D.; Gilboa, E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med. 1996, 184, 465-472
-
(1996)
J. Exp. Med.
, vol.184
, pp. 465-472
-
-
Boczkowski, D.1
Nair, S.K.2
Snyder, D.3
Gilboa, E.4
-
9
-
-
0033989908
-
In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies
-
Hoerr, I.; Obst, R.; Rammensee, H.G.; Jung, G. In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur. J. Immunol. 2000, 30, 1-7
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 1-7
-
-
Hoerr, I.1
Obst, R.2
Rammensee, H.G.3
Jung, G.4
-
10
-
-
85044634269
-
MRNA vaccines—A new era in vaccinology
-
Pardi, N.; Hogan, M.J.; Porter, F.W.; Weissman, D. mRNA vaccines—A new era in vaccinology. Nat. Rev. Drug Discov. 2018, 17, 261-279
-
(2018)
Nat. Rev. Drug Discov
, vol.17
, pp. 261-279
-
-
Pardi, N.1
Hogan, M.J.2
Porter, F.W.3
Weissman, D.4
-
11
-
-
0035341935
-
Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus
-
Fleeton, M.N.; Chen, M.; Berglund, P.; Rhodes, G.; Parker, S.E.; Murphy, M.; Atkins, G.J.; Liljeström, P. Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus. J. Infect. Dis. 2001, 183, 1395-1398
-
(2001)
J. Infect. Dis
, vol.183
, pp. 1395-1398
-
-
Fleeton, M.N.1
Chen, M.2
Berglund, P.3
Rhodes, G.4
Parker, S.E.5
Murphy, M.6
Atkins, G.J.7
Liljeström, P.8
-
12
-
-
84878664092
-
In vitro transcription of long RNA containing modified nucleosides
-
Pardi, N.; Muramatsu, H.; Weissman, D.; Kariko, K. In vitro transcription of long RNA containing modified nucleosides. Methods Mol. Biol. 2013, 969, 29-42
-
(2013)
Methods Mol. Biol
, vol.969
, pp. 29-42
-
-
Pardi, N.1
Muramatsu, H.2
Weissman, D.3
Kariko, K.4
-
13
-
-
54949112814
-
Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability
-
Kariko, K.; Muramatsu, H.; Welsh, F.A.; Ludwig, J.; Kato, H.; Akira, S.; Weissman, D. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol. Ther. 2008, 16, 1833-1840
-
(2008)
Mol. Ther
, vol.16
, pp. 1833-1840
-
-
Kariko, K.1
Muramatsu, H.2
Welsh, F.A.3
Ludwig, J.4
Kato, H.5
Akira, S.6
Weissman, D.7
-
14
-
-
3042782585
-
Codon bias and heterologous protein expression
-
Gustafsson, C.; Govindarajan, S.; Minshull, J. Codon bias and heterologous protein expression. Trends Biotechnol. 2004, 22, 346-353
-
(2004)
Trends Biotechnol
, vol.22
, pp. 346-353
-
-
Gustafsson, C.1
Govindarajan, S.2
Minshull, J.3
-
15
-
-
84878623156
-
HPLC purification of in vitro transcribed long RNA
-
Weissman, D.; Pardi, N.; Muramatsu, H.; Kariko, K. HPLC purification of in vitro transcribed long RNA. Methods Mol. Biol. 2013, 969, 43-54
-
(2013)
Methods Mol. Biol
, vol.969
, pp. 43-54
-
-
Weissman, D.1
Pardi, N.2
Muramatsu, H.3
Kariko, K.4
-
16
-
-
84945455309
-
N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
-
Andries, O.; Mc Cafferty, S.; De Smedt, S.C.; Weiss, R.; Sanders, N.N.; Kitada, T. N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J. Control. Release 2015, 217, 337-344
-
(2015)
J. Control. Release
, vol.217
, pp. 337-344
-
-
Andries, O.1
Mc Cafferty, S.2
De Smedt, S.C.3
Weiss, R.4
Sanders, N.N.5
Kitada, T.6
-
17
-
-
23844464444
-
Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
-
Kariko, K.; Buckstein, M.; Ni, H.; Weissman, D. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005, 23, 165-175
-
(2005)
Immunity
, vol.23
, pp. 165-175
-
-
Kariko, K.1
Buckstein, M.2
Ni, H.3
Weissman, D.4
-
18
-
-
82255194361
-
Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
-
Kariko, K.; Muramatsu, H.; Ludwig, J.; Weissman, D. Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA. Nucleic Acids Res. 2011, 39, e142
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Kariko, K.1
Muramatsu, H.2
Ludwig, J.3
Weissman, D.4
-
19
-
-
0022219780
-
Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes
-
Ross, J.; Sullivan, T.D. Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes. Blood 1985, 66, 1149-1154
-
(1985)
Blood
, vol.66
, pp. 1149-1154
-
-
Ross, J.1
Sullivan, T.D.2
-
20
-
-
33845497677
-
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
-
Holtkamp, S.; Kreiter, S.; Selmi, A.; Simon, P.; Koslowski, M.; Huber, C.; Türeci, Ö.; Sahin, U. Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells. Blood 2006, 108, 4009-4017
-
(2006)
Blood
, vol.108
, pp. 4009-4017
-
-
Holtkamp, S.1
Kreiter, S.2
Selmi, A.3
Simon, P.4
Koslowski, M.5
Huber, C.6
Türeci, Ö.7
Sahin, U.8
-
21
-
-
0016709353
-
Purification of mRNA guanylyltransferase and mRNA (Guanine-7-) methyltransferase from vaccinia virions
-
Martin, S.A.; Paoletti, E.; Moss, B. Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions. J. Biol. Chem.1975, 250, 9322-9329
-
(1975)
J. Biol. Chem
, vol.250
, pp. 9322-9329
-
-
Martin, S.A.1
Paoletti, E.2
Moss, B.3
-
22
-
-
0034768443
-
Synthesis and properties of mRNAs containing the novel “anti-reverse” cap analogs 7-methyl(3′-O-methyl) GpppG and 7-methyl (3′-deoxy) GpppG
-
Stepinski, J.; Waddell, C.; Stolarski, R.; Darzynkiewicz, E.; Rhoads, R.E. Synthesis and properties of mRNAs containing the novel “anti-reverse” cap analogs 7-methyl(3′-O-methyl) GpppG and 7-methyl (3′-deoxy) GpppG. RNA 2001, 7, 1486-1495
-
(2001)
RNA
, vol.7
, pp. 1486-1495
-
-
Stepinski, J.1
Waddell, C.2
Stolarski, R.3
Darzynkiewicz, E.4
Rhoads, R.E.5
-
23
-
-
84954288084
-
Materials for non-viral intracellular delivery of messenger RNA therapeutics
-
Kauffman, K.J.; Webber, M.J.; Anderson, D.G. Materials for non-viral intracellular delivery of messenger RNA therapeutics. J. Control. Release 2016, 240, 227-234
-
(2016)
J. Control. Release
, vol.240
, pp. 227-234
-
-
Kauffman, K.J.1
Webber, M.J.2
Anderson, D.G.3
-
24
-
-
84921357504
-
Lipid-based mRNA vaccine delivery systems
-
Midoux, P.; Pichon, C. Lipid-based mRNA vaccine delivery systems. Expert Rev. Vaccines 2015, 14, 221-234
-
(2015)
Expert Rev. Vaccines
, vol.14
, pp. 221-234
-
-
Midoux, P.1
Pichon, C.2
-
25
-
-
84939573509
-
Optimization of influenza A vaccine virus by reverse genetic using chimeric HA and NA genes with an extended PR8 backbone
-
Medina, J.; Boukhebza, H.; De Saint Jean, A.; Sodoyer, R.; Legastelois, I.; Moste, C. Optimization of influenza A vaccine virus by reverse genetic using chimeric HA and NA genes with an extended PR8 backbone. Vaccine 2015, 33, 4221-4227
-
(2015)
Vaccine
, vol.33
, pp. 4221-4227
-
-
Medina, J.1
Boukhebza, H.2
De Saint Jean, A.3
Sodoyer, R.4
Legastelois, I.5
Moste, C.6
-
26
-
-
85034580209
-
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains
-
Zost, S.J.; Parkhouse, K.; Gumina, M.E.; Kim, K.; Perez, S.D.; Wilson, P.C.; Treanor, J.J.; Sant, A.J.; Cobey, S.; Hensley, S.E. Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains. Proc. Natl. Acad. Sci. USA 2017, 114, 12578-12583
-
(2017)
Proc. Natl. Acad. Sci. USA
, vol.114
, pp. 12578-12583
-
-
Zost, S.J.1
Parkhouse, K.2
Gumina, M.E.3
Kim, K.4
Perez, S.D.5
Wilson, P.C.6
Treanor, J.J.7
Sant, A.J.8
Cobey, S.9
Hensley, S.E.10
-
27
-
-
85033229591
-
A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine
-
Wu, N.C.; Zost, S.J.; Thompson, A.J.; Oyen, D.; Nycholat, C.M.; McBride, R.; Paulson, J.C.; Hensley, S.E.; Wilson, I.A. A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLoS Pathog. 2017, 13, e1006682
-
(2017)
Plos Pathog
, vol.13
-
-
Wu, N.C.1
Zost, S.J.2
Thompson, A.J.3
Oyen, D.4
Nycholat, C.M.5
McBride, R.6
Paulson, J.C.7
Hensley, S.E.8
Wilson, I.A.9
-
28
-
-
84924060844
-
Advances in the development of influenza virus vaccines
-
Krammer, F.; Palese, P. Advances in the development of influenza virus vaccines. Nat. Rev. Drug Discov. 2015, 14, 167-182
-
(2015)
Nat. Rev. Drug Discov
, vol.14
, pp. 167-182
-
-
Krammer, F.1
Palese, P.2
-
29
-
-
84984822445
-
Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge
-
Magini, D.; Giovani, C.; Mangiavacchi, S.; Maccari, S.; Cecchi, R.; Ulmer, J.B.; De Gregorio, E.; Geall, A.J.; Brazzoli, M.; Bertholet, S. Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge. PLoS ONE 2016, 11, e0161193
-
(2016)
Plos ONE
, vol.11
-
-
Magini, D.1
Giovani, C.2
Mangiavacchi, S.3
Maccari, S.4
Cecchi, R.5
Ulmer, J.B.6
De Gregorio, E.7
Geall, A.J.8
Brazzoli, M.9
Bertholet, S.10
-
30
-
-
84953851839
-
Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin
-
Brazzoli, M.; Magini, D.; Bonci, A.; Buccato, S.; Giovani, C.; Kratzer, R.; Zurli, V.; Mangiavacchi, S.; Casini, D.; Brito, L.M.; et al. Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin. J. Virol. 2015, 90, 332-344
-
(2015)
J. Virol
, vol.90
, pp. 332-344
-
-
Brazzoli, M.1
Magini, D.2
Bonci, A.3
Buccato, S.4
Giovani, C.5
Kratzer, R.6
Zurli, V.7
Mangiavacchi, S.8
Casini, D.9
Brito, L.M.10
-
31
-
-
85038879224
-
Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses
-
Vogel, A.B.; Lambert, L.; Kinnear, E.; Busse, D.; Erbar, S.; Reuter, K.C.; Wicke, L.; Perkovic, M.; Beissert, T.; Haas, H.; et al. Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses. Mol. Ther. 2017, 26, 446-455
-
(2017)
Mol. Ther.
, vol.26
, pp. 446-455
-
-
Vogel, A.B.1
Lambert, L.2
Kinnear, E.3
Busse, D.4
Erbar, S.5
Reuter, K.C.6
Wicke, L.7
Perkovic, M.8
Beissert, T.9
Haas, H.10
-
32
-
-
84978919993
-
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
-
Chahal, J.S.; Khan, O.F.; Cooper, C.L.; McPartlan, J.S.; Tsosie, J.K.; Tilley, L.D.; Sidik, S.M.; Lourido, S.; Langer, R.; Bavari, S.; et al. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose. Proc. Natl. Acad. Sci. USA 2016, 113, E4133-E4142
-
(2016)
Proc. Natl. Acad. Sci. USA
, vol.113
, pp. E4133-E4142
-
-
Chahal, J.S.1
Khan, O.F.2
Cooper, C.L.3
McPartlan, J.S.4
Tsosie, J.K.5
Tilley, L.D.6
Sidik, S.M.7
Lourido, S.8
Langer, R.9
Bavari, S.10
-
33
-
-
84870869040
-
Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
-
Petsch, B.; Schnee, M.; Vogel, A.B.; Lange, E.; Hoffmann, B.; Voss, D.; Schlake, T.; Thess, A.; Kallen, K.J.; Stitz, L.; et al. Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection. Nat. Biotechnol. 2012, 30, 1210-1216
-
(2012)
Nat. Biotechnol
, vol.30
, pp. 1210-1216
-
-
Petsch, B.1
Schnee, M.2
Vogel, A.B.3
Lange, E.4
Hoffmann, B.5
Voss, D.6
Schlake, T.7
Thess, A.8
Kallen, K.J.9
Stitz, L.10
-
34
-
-
85018162127
-
Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
-
Bahl, K.; Senn, J.J.; Yuzhakov, O.; Bulychev, A.; Brito, L.A.; Hassett, K.J.; Laska, M.E.; Smith, M.; Almarsson, Ö.; Thompson, J.; et al. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses. Mol. Ther. 2017, 25, 1316-1327
-
(2017)
Mol. Ther
, vol.25
, pp. 1316-1327
-
-
Bahl, K.1
Senn, J.J.2
Yuzhakov, O.3
Bulychev, A.4
Brito, L.A.5
Hassett, K.J.6
Laska, M.E.7
Smith, M.8
Almarsson, Ö.9
Thompson, J.10
-
35
-
-
0141521625
-
An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector
-
Perri, S.; Greer, C.E.; Thudium, K.; Doe, B.; Legg, H.; Liu, H.; Romero, R.E.; Tang, Z.; Bin, Q.; Dubensky, T.W.; et al. An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector. J. Virol. 2003, 77, 10394-10403
-
(2003)
J. Virol
, vol.77
, pp. 10394-10403
-
-
Perri, S.1
Greer, C.E.2
Thudium, K.3
Doe, B.4
Legg, H.5
Liu, H.6
Romero, R.E.7
Tang, Z.8
Bin, Q.9
Dubensky, T.W.10
-
36
-
-
84921498605
-
Self-amplifying mRNA vaccines
-
Brito, L.A.; Kommareddy, S.; Maione, D.; Uematsu, Y.; Giovani, C.; Scorza, F.B.; Otten, G.R.; Yu, D.; Mandl, C.W.; Mason, P.W.; et al. Self-amplifying mRNA vaccines. Adv. Genet. 2015, 89, 179-233
-
(2015)
Adv. Genet
, vol.89
, pp. 179-233
-
-
Brito, L.A.1
Kommareddy, S.2
Maione, D.3
Uematsu, Y.4
Giovani, C.5
Scorza, F.B.6
Otten, G.R.7
Yu, D.8
Mandl, C.W.9
Mason, P.W.10
-
37
-
-
84883230210
-
Rapidly produced SAM®vaccine against H7N9 influenza is immunogenic in mice
-
Hekele, A.; Bertholet, S.; Archer, J.; Gibson, D.G.; Palladino, G.; Brito, L.A.; Otten, G.R.; Brazzoli, M.; Buccato, S.; Bonci, A.; et al. Rapidly produced SAM®vaccine against H7N9 influenza is immunogenic in mice. Emerg. Microbes Infect. 2013, 2, e52
-
(2013)
Emerg. Microbes Infect
, vol.2
-
-
Hekele, A.1
Bertholet, S.2
Archer, J.3
Gibson, D.G.4
Palladino, G.5
Brito, L.A.6
Otten, G.R.7
Brazzoli, M.8
Buccato, S.9
Bonci, A.10
-
38
-
-
84903789916
-
Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo
-
McCullough, K.C.; Bassi, I.; Milona, P.; Suter, R.; Thomann-Harwood, L.; Englezou, P.; Démoulins, T.; Ruggli, N. Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo. Mol. Ther. Nucleic Acids 2014, 3, e173
-
(2014)
Mol. Ther. Nucleic Acids
, vol.3
-
-
McCullough, K.C.1
Bassi, I.2
Milona, P.3
Suter, R.4
Thomann-Harwood, L.5
Englezou, P.6
Démoulins, T.7
Ruggli, N.8
-
39
-
-
84959335738
-
Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines
-
Démoulins, T.; Milona, P.; Englezou, P.C.; Ebensen, T.; Schulze, K.; Suter, R.; Pichon, C.; Midoux, P.; Guzmán, C.A.; Ruggli, N.; et al. Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines. Nanomedicine 2016, 12, 711-722
-
(2016)
Nanomedicine
, vol.12
, pp. 711-722
-
-
Démoulins, T.1
Milona, P.2
Englezou, P.C.3
Ebensen, T.4
Schulze, K.5
Suter, R.6
Pichon, C.7
Midoux, P.8
Guzmán, C.A.9
Ruggli, N.10
-
40
-
-
84885113945
-
A novel, disruptive vaccination technology: Self-adjuvanted RNActive® vaccines
-
Kallen, K.J.; Heidenreich, R.; Schnee, M.; Petsch, B.; Schlake, T.; Thess, A.; Baumhof, P.; Scheel, B.; Koch, S.D.; Fotin-Mleczek, M. A novel, disruptive vaccination technology: Self-adjuvanted RNActive® vaccines. Hum. Vaccines Immunother. 2013, 9, 2263-2276
-
(2013)
Hum. Vaccines Immunother
, vol.9
, pp. 2263-2276
-
-
Kallen, K.J.1
Heidenreich, R.2
Schnee, M.3
Petsch, B.4
Schlake, T.5
Thess, A.6
Baumhof, P.7
Scheel, B.8
Koch, S.D.9
Fotin-Mleczek, M.10
-
41
-
-
84978063234
-
An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs
-
Schnee, M.; Vogel, A.B.; Voss, D.; Petsch, B.; Baumhof, P.; Kramps, T.; Stitz, L. An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs. PLoS Negl. Trop. Dis. 2016, 10, e0004746
-
(2016)
Plos Negl. Trop. Dis
, vol.10
-
-
Schnee, M.1
Vogel, A.B.2
Voss, D.3
Petsch, B.4
Baumhof, P.5
Kramps, T.6
Stitz, L.7
-
42
-
-
84975832642
-
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
-
Kranz, L.M.; Diken, M.; Haas, H.; Kreiter, S.; Loquai, C.; Reuter, K.C.; Meng, M.; Fritz, D.; Vascotto, F.; Hefesha, H.; et al. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature 2016, 534, 396-401
-
(2016)
Nature
, vol.534
, pp. 396-401
-
-
Kranz, L.M.1
Diken, M.2
Haas, H.3
Kreiter, S.4
Loquai, C.5
Reuter, K.C.6
Meng, M.7
Fritz, D.8
Vascotto, F.9
Hefesha, H.10
-
43
-
-
84886261520
-
Delivery materials for siRNA therapeutics
-
Kanasty, R.; Dorkin, J.R.; Vegas, A.; Anderson, D. Delivery materials for siRNA therapeutics. Nat. Mater. 2013, 12, 967-977
-
(2013)
Nat. Mater
, vol.12
, pp. 967-977
-
-
Kanasty, R.1
Dorkin, J.R.2
Vegas, A.3
Anderson, D.4
-
44
-
-
84940720241
-
Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals
-
Thess, A.; Grund, S.; Mui, B.L.; Hope, M.J.; Baumhof, P.; Fotin-Mleczek, M.; Schlake, T. Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals. Mol. Ther. 2015, 23, 1456-1464
-
(2015)
Mol. Ther
, vol.23
, pp. 1456-1464
-
-
Thess, A.1
Grund, S.2
Mui, B.L.3
Hope, M.J.4
Baumhof, P.5
Fotin-Mleczek, M.6
Schlake, T.7
-
45
-
-
85042232690
-
Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines
-
Lutz, J.; Lazzaro, S.; Habbeddine, M.; Schmidt, K.E.; Baumhof, P.; Mui, B.L.; Tam, Y.K.; Madden, T.D.; Hope, M.J.; Heidenreich, R.; et al. Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines. NPJ Vaccines 2017, 2, 29
-
(2017)
NPJ Vaccines
, vol.2
, pp. 29
-
-
Lutz, J.1
Lazzaro, S.2
Habbeddine, M.3
Schmidt, K.E.4
Baumhof, P.5
Mui, B.L.6
Tam, Y.K.7
Madden, T.D.8
Hope, M.J.9
Heidenreich, R.10
-
46
-
-
85041227397
-
Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease
-
Meyer, M.; Huang, E.; Yuzhakov, O.; Ramanathan, P.; Ciaramella, G.; Bukreyev, A. Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease. J. Infect. Dis. 2018, 217, 451-455
-
(2018)
J. Infect. Dis
, vol.217
, pp. 451-455
-
-
Meyer, M.1
Huang, E.2
Yuzhakov, O.3
Ramanathan, P.4
Ciaramella, G.5
Bukreyev, A.6
-
47
-
-
85015230578
-
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
-
Pardi, N.; Hogan, M.J.; Pelc, R.S.; Muramatsu, H.; Andersen, H.; DeMaso, C.R.; Dowd, K.A.; Sutherland, L.L.; Scearce, R.M.; Parks, R.; et al. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature 2017, 543, 248-251
-
(2017)
Nature
, vol.543
, pp. 248-251
-
-
Pardi, N.1
Hogan, M.J.2
Pelc, R.S.3
Muramatsu, H.4
Andersen, H.5
Demaso, C.R.6
Dowd, K.A.7
Sutherland, L.L.8
Scearce, R.M.9
Parks, R.10
-
48
-
-
85013067893
-
Modified mRNA Vaccines Protect against Zika Virus Infection
-
Richner, J.M.; Himansu, S.; Dowd, K.A.; Butler, S.L.; Salazar, V.; Fox, J.M.; Julander, J.G.; Tang, W.W.; Shresta, S.; Pierson, T.C.; et al. Modified mRNA Vaccines Protect against Zika Virus Infection. Cell 2017, 168, 1114-1125
-
(2017)
Cell
, vol.168
, pp. 1114-1125
-
-
Richner, J.M.1
Himansu, S.2
Dowd, K.A.3
Butler, S.L.4
Salazar, V.5
Fox, J.M.6
Julander, J.G.7
Tang, W.W.8
Shresta, S.9
Pierson, T.C.10
-
49
-
-
85029684223
-
Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
-
Liang, F.; Lindgren, G.; Lin, A.; Thompson, E.A.; Ols, S.; Röhss, J.; John, S.; Hassett, K.; Yuzhakov, O.; Bahl, K.; et al. Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques. Mol. Ther. 2017, 25, 2635-2647
-
(2017)
Mol. Ther
, vol.25
, pp. 2635-2647
-
-
Liang, F.1
Lindgren, G.2
Lin, A.3
Thompson, E.A.4
Ols, S.5
Röhss, J.6
John, S.7
Hassett, K.8
Yuzhakov, O.9
Bahl, K.10
-
50
-
-
85038583616
-
Rhesus Macaque Myeloid-Derived Suppressor Cells Demonstrate T Cell Inhibitory Functions and Are Transiently Increased after Vaccination
-
Lin, A.; Liang, F.; Thompson, E.A.; Vono, M.; Ols, S.; Lindgren, G.; Hassett, K.; Salter, H.; Ciaramella, G.; Loré, K. Rhesus Macaque Myeloid-Derived Suppressor Cells Demonstrate T Cell Inhibitory Functions and Are Transiently Increased after Vaccination. J. Immunol. 2018, 200, 286-294
-
(2018)
J. Immunol
, vol.200
, pp. 286-294
-
-
Lin, A.1
Liang, F.2
Thompson, E.A.3
Vono, M.4
Ols, S.5
Lindgren, G.6
Hassett, K.7
Salter, H.8
Ciaramella, G.9
Loré, K.10
-
51
-
-
85034057681
-
Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells
-
Lindgren, G.; Ols, S.; Liang, F.; Thompson, E.; Lin, A.; Hellgren, F.; Bahl, K.; John, S.; Yuzhakov, O.; Hassett, K.; et al. Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells. Front. Immunol. 2017, 8, 1539
-
(2017)
Front. Immunol.
, vol.8
, pp. 1539
-
-
Lindgren, G.1
Ols, S.2
Liang, F.3
Thompson, E.4
Lin, A.5
Hellgren, F.6
Bahl, K.7
John, S.8
Yuzhakov, O.9
Hassett, K.10
-
52
-
-
85017333605
-
Advancing new vaccines against pandemic influenza in low-resource countries
-
Berlanda Scorza, F. Advancing new vaccines against pandemic influenza in low-resource countries. Vaccine 2017, 35, 5397-5402
-
(2017)
Vaccine
, vol.35
, pp. 5397-5402
-
-
Berlanda Scorza, F.1
-
53
-
-
54249154153
-
Safety and immunogenicity of an inactivated influenza A/H5N1 vaccine given with or without aluminum hydroxide to healthy adults: Results of a phase I-II randomized clinical trial
-
Keitel, W.A.; Campbell, J.D.; Treanor, J.J.; Walter, E.B.; Patel, S.M.; He, F.; Noah, D.L.; Hill, H. Safety and immunogenicity of an inactivated influenza A/H5N1 vaccine given with or without aluminum hydroxide to healthy adults: Results of a phase I-II randomized clinical trial. J. Infect. Dis. 2008, 198, 1309-1316
-
(2008)
J. Infect. Dis
, vol.198
, pp. 1309-1316
-
-
Keitel, W.A.1
Campbell, J.D.2
Treanor, J.J.3
Walter, E.B.4
Patel, S.M.5
He, F.6
Noah, D.L.7
Hill, H.8
-
54
-
-
85042231990
-
H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
-
Wong, S.S.; DeBeauchamp, J.; Zanin, M.; Sun, Y.; Tang, L.; Webby, R. H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines. NPJ Vaccines 2017, 2, 16
-
(2017)
NPJ Vaccines
, vol.2
, pp. 16
-
-
Wong, S.S.1
Debeauchamp, J.2
Zanin, M.3
Sun, Y.4
Tang, L.5
Webby, R.6
-
55
-
-
85025815073
-
Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: An open-label, non-randomised, prospective, first-in-human phase 1 clinical trial
-
Alberer, M.; Gnad-Vogt, U.; Hong, H.S.; Mehr, K.T.; Backert, L.; Finak, G.; Gottardo, R.; Bica, M.A.; Garofano, A.; Koch, S.D.; et al. Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: An open-label, non-randomised, prospective, first-in-human phase 1 clinical trial. Lancet 2017, 390, 1511-1520
-
(2017)
Lancet
, vol.390
, pp. 1511-1520
-
-
Alberer, M.1
Gnad-Vogt, U.2
Hong, H.S.3
Mehr, K.T.4
Backert, L.5
Finak, G.6
Gottardo, R.7
Bica, M.A.8
Garofano, A.9
Koch, S.D.10
-
56
-
-
85046396648
-
-
(accessed on 20 February 2018)
-
Mass General News. Mass. Available online: http://www.massgeneral.org/News/pressrelease.aspx?id=1816 (accessed on 20 February 2018).
-
Mass
-
-
-
57
-
-
85032837562
-
The Pathway to a Universal Influenza Vaccine
-
Paules, C.I.; Marston, H.D.; Eisinger, R.W.; Baltimore, D.; Fauci, A.S. The Pathway to a Universal Influenza Vaccine. Immunity 2017, 47, 599-603
-
(2017)
Immunity
, vol.47
, pp. 599-603
-
-
Paules, C.I.1
Marston, H.D.2
Eisinger, R.W.3
Baltimore, D.4
Fauci, A.S.5
-
59
-
-
84935480388
-
Validation of the wild-type influenza A human challenge model H1N1pdMIST: An A(H1N1)pdm09 dose-finding investigational new drug study
-
Memoli, M.J.; Czajkowski, L.; Reed, S.; Athota, R.; Bristol, T.; Proudfoot, K.; Fargis, S.; Stein, M.; Dunfee, R.L.; Shaw, P.A.; et al. Validation of the wild-type influenza A human challenge model H1N1pdMIST: An A(H1N1)pdm09 dose-finding investigational new drug study. Clin. Infect. Dis. 2015, 60, 693-702
-
(2015)
Clin. Infect. Dis.
, vol.60
, pp. 693-702
-
-
Memoli, M.J.1
Czajkowski, L.2
Reed, S.3
Athota, R.4
Bristol, T.5
Proudfoot, K.6
Fargis, S.7
Stein, M.8
Dunfee, R.L.9
Shaw, P.A.10
-
60
-
-
84924124804
-
Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans
-
Watson, J.M.; Francis, J.N.; Mesens, S.; Faiman, G.A.; Makin, J.; Patriarca, P.; Treanor, J.J.; Georges, B.; Bunce, C.J. Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans. Virol. J.2015, 12, 13
-
(2015)
Virol. J
, vol.12
, pp. 13
-
-
Watson, J.M.1
Francis, J.N.2
Mesens, S.3
Faiman, G.A.4
Makin, J.5
Patriarca, P.6
Treanor, J.J.7
Georges, B.8
Bunce, C.J.9
-
61
-
-
84955298270
-
Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model
-
Fullen, D.J.; Noulin, N.; Catchpole, A.; Fathi, H.; Murray, E.J.; Mann, A.; Eze, K.; Balaratnam, G.; Borley, D.W.; Gilbert, A.; et al. Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model. PLoS ONE 2016, 11, e0145902
-
(2016)
Plos ONE
, vol.11
-
-
Fullen, D.J.1
Noulin, N.2
Catchpole, A.3
Fathi, H.4
Murray, E.J.5
Mann, A.6
Eze, K.7
Balaratnam, G.8
Borley, D.W.9
Gilbert, A.10
-
62
-
-
84901753162
-
A live attenuated influenza A(H5N1) vaccine induces long-term immunity in the absence of a primary antibody response
-
Talaat, K.R.; Luke, C.J.; Khurana, S.; Manischewitz, J.; King, L.R.; McMahon, B.A.; Karron, R.A.; Lewis, K.D.; Qin, J.; Follmann, D.A.; et al. A live attenuated influenza A(H5N1) vaccine induces long-term immunity in the absence of a primary antibody response. J. Infect. Dis. 2014, 209, 1860-1869
-
(2014)
J. Infect. Dis.
, vol.209
, pp. 1860-1869
-
-
Talaat, K.R.1
Luke, C.J.2
Khurana, S.3
Manischewitz, J.4
King, L.R.5
McMahon, B.A.6
Karron, R.A.7
Lewis, K.D.8
Qin, J.9
Follmann, D.A.10
-
63
-
-
85046492138
-
-
(accessed on 20 February 2018)
-
U.S. Food and Drug Administration (FDA). Available online: https://www.fda.gov/downloads/biologicsbloodvaccines/vaccines/approvedproducts/ucm294307.pdf (accessed on 20 February 2018).
-
-
-
-
64
-
-
85010219814
-
Adjuvant effects of a sequence-engineered mRNA vaccine: Translational profiling demonstrates similar human and murine innate response
-
Edwards, D.K.; Jasny, E.; Yoon, H.; Horscroft, N.; Schanen, B.; Geter, T.; Fotin-Mleczek, M.; Petsch, B.; Wittman, V. Adjuvant effects of a sequence-engineered mRNA vaccine: Translational profiling demonstrates similar human and murine innate response. J. Transl. Med. 2017, 15, 1
-
(2017)
J. Transl. Med
, vol.15
, pp. 1
-
-
Edwards, D.K.1
Jasny, E.2
Yoon, H.3
Horscroft, N.4
Schanen, B.5
Geter, T.6
Fotin-Mleczek, M.7
Petsch, B.8
Wittman, V.9
-
65
-
-
85019702720
-
Induction of an IFN-mediated antiviral response by a self-amplifying RNA vaccine: Implications for vaccine design
-
Pepini, T.; Pulichino, A.M.; Carsillo, T.; Carlson, A.L.; Sari-Sarraf, F.; Ramsauer, K.; Debasitis, J.C.; Maruggi, G.; Otten, G.R.; Geall, A.J.; et al. Induction of an IFN-mediated antiviral response by a self-amplifying RNA vaccine: Implications for vaccine design. J. Immunol. 2017, 198, 4012-4024
-
(2017)
J. Immunol
, vol.198
, pp. 4012-4024
-
-
Pepini, T.1
Pulichino, A.M.2
Carsillo, T.3
Carlson, A.L.4
Sari-Sarraf, F.5
Ramsauer, K.6
Debasitis, J.C.7
Maruggi, G.8
Otten, G.R.9
Geall, A.J.10
-
66
-
-
34447322451
-
Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation
-
Kannemeier, C.; Shibamiya, A.; Nakazawa, F.; Trusheim, H.; Ruppert, C.; Markart, P.; Song, Y.; Tzima, E.; Kennerknecht, E.; Niepmann, M.; et al. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc. Natl. Acad. Sci. USA 2007, 104, 6388-6393
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 6388-6393
-
-
Kannemeier, C.1
Shibamiya, A.2
Nakazawa, F.3
Trusheim, H.4
Ruppert, C.5
Markart, P.6
Song, Y.7
Tzima, E.8
Kennerknecht, E.9
Niepmann, M.10
-
67
-
-
34948826463
-
Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor
-
Fischer, S.; Gerriets, T.; Wessels, C.; Walberer, M.; Kostin, S.; Stolz, E.; Zheleva, K.; Hocke, A.; Hippenstiel, S.; Preissner, K.T. Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor. Blood 2007, 110, 2457-2465
-
(2007)
Blood
, vol.110
, pp. 2457-2465
-
-
Fischer, S.1
Gerriets, T.2
Wessels, C.3
Walberer, M.4
Kostin, S.5
Stolz, E.6
Zheleva, K.7
Hocke, A.8
Hippenstiel, S.9
Preissner, K.T.10
-
68
-
-
84898414022
-
Bringing influenza vaccines into the 21st century
-
Settembre, E.C.; Dormitzer, P.R.; Rappuoli, R. Bringing influenza vaccines into the 21st century. Hum. Vaccines Immunother. 2014, 10, 600-604
-
(2014)
Hum. Vaccines Immunother
, vol.10
, pp. 600-604
-
-
Settembre, E.C.1
Dormitzer, P.R.2
Rappuoli, R.3
-
69
-
-
84881141968
-
Comparative Glycomics Analysis of Influenza Hemagglutinin (H5N1) Produced in Vaccine Relevant Cell Platforms
-
An, Y.; Rininger, J.A.; Jarvis, D.L.; Jing, X.; Ye, Z.; Aumiller, J.J.; Eichelberger, M.; Cipollo, J.F. Comparative Glycomics Analysis of Influenza Hemagglutinin (H5N1) Produced in Vaccine Relevant Cell Platforms. J. Proteome Res. 2013, 12, 3707-3720
-
(2013)
J. Proteome Res
, vol.12
, pp. 3707-3720
-
-
An, Y.1
Rininger, J.A.2
Jarvis, D.L.3
Jing, X.4
Ye, Z.5
Aumiller, J.J.6
Eichelberger, M.7
Cipollo, J.F.8
-
71
-
-
84963957477
-
Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies
-
Schotsaert, M.; Ysenbaert, T.; Smet, A.; Schepens, B.; Vanderschaeghe, D.; Stegalkina, S.; Vogel, T.U.; Callewaert, N.; Fiers, W.; Saelens, X. Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies. Sci. Rep. 2016, 6, 24402
-
(2016)
Sci. Rep
, vol.6
, pp. 24402
-
-
Schotsaert, M.1
Ysenbaert, T.2
Smet, A.3
Schepens, B.4
Vanderschaeghe, D.5
Stegalkina, S.6
Vogel, T.U.7
Callewaert, N.8
Fiers, W.9
Saelens, X.10
-
72
-
-
84959349464
-
Novel universal influenza virus vaccine approaches
-
Krammer, F. Novel universal influenza virus vaccine approaches. Curr. Opin. Virol. 2016, 17, 95-103
-
(2016)
Curr. Opin. Virol
, vol.17
, pp. 95-103
-
-
Krammer, F.1
-
73
-
-
84939835607
-
Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection
-
Monto, A.S.; Petrie, J.G.; Cross, R.T.; Johnson, E.; Liu, M.; Zhong, W.; Levine, M.; Katz, J.M.; Ohmit, S.E. Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection. J. Infect. Dis. 2015, 212, 1191-1199
-
(2015)
J. Infect. Dis
, vol.212
, pp. 1191-1199
-
-
Monto, A.S.1
Petrie, J.G.2
Cross, R.T.3
Johnson, E.4
Liu, M.5
Zhong, W.6
Levine, M.7
Katz, J.M.8
Ohmit, S.E.9
|