Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans

Virology Journal

Volumn 12, Issue 1, 2015, Pages

  Watson, Jeannette M ^a   Francis, James N ^a   Mesens, Sofie ^b   Faiman, Gabriel A ^a   Makin, Jill ^c   Patriarca, Peter ^d   Treanor, John J ^e   Georges, Bertrand ^a   Bunce, Campbell J ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b SGS LSS Clinical Pharmacology Unit   (Belgium)

^c Jill Makin Consulting Ltd   (United Kingdom)

^d Biologics Consulting Group Inc   (United States)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Challenge agent; Clinical trial; Influenza A H1N1 virus; Vaccine

Indexed keywords

INFLUENZA VACCINE; ANTIVIRUS AGENT;

ADULT; ARTICLE; CHILL; CLINICAL TRIAL; COUGHING; CRACKLE; DIARRHEA; DYSPNEA; EYE PAIN; FACE PAIN; FATIGUE; FEVER; FLU LIKE SYNDROME; HEADACHE; HOARSENESS; HUMAN; IMMUNE RESPONSE; INFLUENZA VIRUS A H1N1; INOCULATION; LABORATORY TEST; MYALGIA; NAUSEA; NORMAL HUMAN; NOSE MUCUS; NOSE OBSTRUCTION; OPEN STUDY; OTALGIA; OTITIS; PERCUSSION; PHARYNGITIS; PHYSICAL EXAMINATION; PROVOCATION TEST; RHINORRHEA; RIGOR; SNEEZING; SORE THROAT; VIRUS SHEDDING; VIRUS STRAIN; VOMITING; WHEEZING; ADOLESCENT; CASE REPORT; FEMALE; IMMUNOLOGY; INFLUENZA; INFLUENZA A VIRUS (H1N1); ISOLATION AND PURIFICATION; MALE; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; THERAPEUTIC RESEARCH; VIROLOGY; YOUNG ADULT;

ORTHOMYXOVIRIDAE;

ADOLESCENT; ADULT; ANTIVIRAL AGENTS; CHILD, PRESCHOOL; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MIDDLE AGED; THERAPEUTIC HUMAN EXPERIMENTATION; VIRUS SHEDDING; YOUNG ADULT;

EID: 84924124804     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/s12985-015-0240-5     Document Type: Article

References (16)

1. Gasparini R, Amicizia D, Lai PL, Panatto D. Clinical and socioeconomic impact of seasonal and pandemic influenza in adults and the elderly. Hum Vaccin Immunother. 2012;8:21-8.
2. Simonsen L, Clarke MJ, Schonberger LB, Arden NH, Cox NJ, Fukuda K. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. J Infect Dis. 1998;178:53-60.
3. Kang SM, Song JM, Compans RW. Novel vaccines against influenza viruses. Virus Res. 2011;162:31-8.
4. Osterhaus A, Fouchier R, Rimmelzwaan G. Towards universal influenza vaccines? Philos Trans R Soc Lond B Biol Sci. 2011;366:2766-73.
5. Gilbert SC. Advances in the development of universal influenza vaccines. Influenza Other Respir Viruses. 2013;7:750-8.
6. Hurt AC. The epidemiology and spread of drug resistant human influenza viruses. Curr Opin Virol. 2014;8 C:22-9.
7. Carrat F, Vergu E, Ferguson NM, Lemaitre M, Cauchemez S, Leach S, et al. Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am J Epidemiol. 2008;167:775-85.
8. Killingley B, Enstone J, Booy R, Hayward A, Oxford J, Ferguson N, et al. Potential role of human challenge studies for investigation of influenza transmission. Lancet Infect Dis. 2011;11:879-86.
9. Lillie PJ, Berthoud TK, Powell TJ, Lambe T, Mullarkey C, Spencer AJ, et al. Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP + M1, in humans. Clin Infect Dis. 2012;55:19-25.
10. Huang KY, Li CK, Clutterbuck E, Chui C, Wilkinson T, Gilbert A, et al. Virus-specific antibody secreting cell, memory B-cell, and sero-antibody responses in the human influenza challenge model. J Infect Dis. 2014;209:1354-61.
11. McClain MT, Park LP, Nicholson B, Veldman T, Zaas AK, Turner R, et al. Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections. J Clin Virol. 2013;58:689-95.
12. Wilkinson TM, Li CK, Chui CS, Huang AK, Perkins M, Liebner JC, et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med. 2012;18:274-80.
13. Bagga B, Woods CW, Veldman TH, Gilbert A, Mann A, Balaratnam G, et al. Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals. Antivir Ther. 2013;18:785-91.
14. Piralla A, Daleno C, Pariani E, Conaldi P, Esposito S, Zanetti A, et al. Virtual quantification of influenza A virus load by real-time RT-PCR. J Clin Virol. 2013;56:65-8.
15. Spearman C. The method of 'right and wrong cases' ('constant stimuli') without Gauss's formulae. Br J Psychol. 1908;2:227-42.
16. Kaerber G. Beitrag zur Kollektiven Behandlung Pharmakologischer Reihenversuche. Arch Exp Path Pharma. 1931;162:480-7.