메뉴 건너뛰기




Volumn 2, Issue 1, 2017, Pages

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85042232690     PISSN: None     EISSN: 20590105     Source Type: Journal    
DOI: 10.1038/s41541-017-0032-6     Document Type: Article
Times cited : (187)

References (35)
  • 1
    • 0033989908 scopus 로고    scopus 로고
    • In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies
    • Hoerr, I., Obst, R., Rammensee, H. G. & Jung, G. In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur. J. Immunol. 30, 1-7 (2000).
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1-7
    • Hoerr, I.1    Obst, R.2    Rammensee, H.G.3    Jung, G.4
  • 2
    • 84885113945 scopus 로고    scopus 로고
    • A novel, disruptive vaccination technology: Self-adjuvanted RNActive(®) vaccines
    • Kallen, K.-J. et al. A novel, disruptive vaccination technology: self-adjuvanted RNActive(®) vaccines. Hum. Vaccines Immunother. 9, 2263-2276 (2013).
    • (2013) Hum. Vaccines Immunother. , vol.9 , pp. 2263-2276
    • Kallen, K.J.1
  • 3
    • 84975045794 scopus 로고    scopus 로고
    • From the RNA world to the clinic
    • Sullenger, B. A. & Nair, S. From the RNA world to the clinic. Science 352, 1417-1420 (2016).
    • (2016) Science , vol.352 , pp. 1417-1420
    • Sullenger, B.A.1    Nair, S.2
  • 4
    • 84979695924 scopus 로고    scopus 로고
    • Recent innovations in mRNA vaccines
    • Ulmer, J. B. & Geall, A. J. Recent innovations in mRNA vaccines. Curr. Opin. Immunol. 41, 18-22 (2016).
    • (2016) Curr. Opin. Immunol. , vol.41 , pp. 18-22
    • Ulmer, J.B.1    Geall, A.J.2
  • 5
    • 84873506978 scopus 로고    scopus 로고
    • Designing tomorrow's vaccines
    • Nabel, G. J. Designing tomorrow's vaccines. N. Engl. J. Med 368, 551-560 (2013).
    • (2013) N. Engl. J. Med , vol.368 , pp. 551-560
    • Nabel, G.J.1
  • 6
    • 84878356025 scopus 로고    scopus 로고
    • Accelerating next-generation vaccine development for global disease prevention
    • Koff, W. C. et al. Accelerating next-generation vaccine development for global disease prevention. Science 340, 1232910 (2013).
    • (2013) Science , vol.340
    • Koff, W.C.1
  • 7
    • 84978063234 scopus 로고    scopus 로고
    • An mRNA vaccine encoding rabies virus glycoprotein induces protection against lethal infection in mice and correlates of protection in adult and newborn pigs
    • Schnee, M. et al. An mRNA vaccine encoding rabies virus glycoprotein induces protection against lethal infection in mice and correlates of protection in adult and newborn pigs. PLoS Negl. Trop. Dis. 10, e0004746 (2016).
    • (2016) PLoS Negl. Trop. Dis. , vol.10
    • Schnee, M.1
  • 8
    • 84870869040 scopus 로고    scopus 로고
    • Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
    • Petsch, B. et al. Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection. Nat. Biotechnol. 30, 1210-1216 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 1210-1216
    • Petsch, B.1
  • 9
    • 78650640612 scopus 로고    scopus 로고
    • Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity
    • Fotin-Mleczek, M. et al. Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity. J. Immunother. 34, 1-15 (2011).
    • (2011) J. Immunother. , vol.34 , pp. 1-15
    • Fotin-Mleczek, M.1
  • 10
    • 84865994357 scopus 로고    scopus 로고
    • Nonviral delivery of self-amplifying RNA vaccines
    • Geall, A. J. et al. Nonviral delivery of self-amplifying RNA vaccines. Proc. Natl. Acad. Sci. USA 109, 14604-14609 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 14604-14609
    • Geall, A.J.1
  • 11
    • 84927176976 scopus 로고    scopus 로고
    • A cationic nanoemulsion for the delivery of next-generation RNA vaccines
    • Brito, L. A. et al. A cationic nanoemulsion for the delivery of next-generation RNA vaccines. Mol. Ther. J. Am. Soc. Gene Ther. 22, 2118-2129 (2014).
    • (2014) Mol. Ther. J. Am. Soc. Gene Ther. , vol.22 , pp. 2118-2129
    • Brito, L.A.1
  • 12
    • 85013067893 scopus 로고    scopus 로고
    • Modified mRNA vaccines protect against zika virus infection
    • Richner, J. M. et al. Modified mRNA vaccines protect against zika virus infection. Cell. https://doi.org/10.1016/j.cell.2017.02.017 (2017).
    • (2017) Cell
    • Richner, J.M.1
  • 13
    • 85023598743 scopus 로고    scopus 로고
    • Vaccine mediated protection against zika virus-induced congenital disease
    • Richner, J. M. et al. Vaccine mediated protection against zika virus-induced congenital disease. Cell 170, 273-283.e12 (2017).
    • (2017) Cell , vol.170 , pp. 273-273e12
    • Richner, J.M.1
  • 14
    • 85015230578 scopus 로고    scopus 로고
    • Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
    • Pardi, N. et al. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature https://doi.org/10.1038/nature21428 (2017).
    • (2017) Nature
    • Pardi, N.1
  • 15
    • 85018162127 scopus 로고    scopus 로고
    • Preclinical and clinical demonstration of immunogenicity by mRNA vaccines against H10N8 and H7N9 Influenza Viruses
    • Bahl, K. et al. Preclinical and clinical demonstration of immunogenicity by mRNA vaccines against H10N8 and H7N9 Influenza Viruses. Mol. Ther. J. Am. Soc. Gene Ther. 25, 1316-1327 (2017).
    • (2017) Mol. Ther. J. Am. Soc. Gene Ther. , vol.25 , pp. 1316-1327
    • Bahl, K.1
  • 16
    • 84940720241 scopus 로고    scopus 로고
    • Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals
    • Thess, A. et al. Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals. Mol. Ther. J. Am. Soc. Gene Ther. 23, 1456-1464 (2015).
    • (2015) Mol. Ther. J. Am. Soc. Gene Ther. , vol.23 , pp. 1456-1464
    • Thess, A.1
  • 18
    • 84901728580 scopus 로고    scopus 로고
    • Innate immunity and vaccines
    • Platt, A. & Wetzler, L. Innate immunity and vaccines. Curr. Top. Med. Chem. 13, 2597-2608 (2013).
    • (2013) Curr. Top. Med. Chem. , vol.13 , pp. 2597-2608
    • Platt, A.1    Wetzler, L.2
  • 19
    • 84945466813 scopus 로고    scopus 로고
    • Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
    • Pardi, N. et al. Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes. J. Control Release 217, 345-351 (2015).
    • (2015) J. Control Release , vol.217 , pp. 345-351
    • Pardi, N.1
  • 20
    • 79951944636 scopus 로고    scopus 로고
    • CXCR3 ligands: Redundant, collaborative and antagonistic functions
    • Groom, J. R. & Luster, A. D. CXCR3 ligands: redundant, collaborative and antagonistic functions. Immunol. Cell Biol. 89, 207-215 (2011).
    • (2011) Immunol. Cell Biol. , vol.89 , pp. 207-215
    • Groom, J.R.1    Luster, A.D.2
  • 21
    • 47549116006 scopus 로고    scopus 로고
    • Vaccines: Correlates of vaccine-induced immunity
    • Plotkin, S. A. Vaccines: correlates of vaccine-induced immunity. Clin. Infect. Dis. 47, 401-409 (2008).
    • (2008) Clin. Infect. Dis. , vol.47 , pp. 401-409
    • Plotkin, S.A.1
  • 22
    • 85042216498 scopus 로고    scopus 로고
    • Novartis Vaccines and Diagnostics GmbH & Co. KG
    • Novartis Vaccines and Diagnostics GmbH & Co. KG. Package leaflet RABIPUR®. (2006).
    • (2006) Package Leaflet RABIPUR®
  • 23
    • 41149096579 scopus 로고    scopus 로고
    • T-cell quality in memory and protection: Implications for vaccine design
    • Seder, R. A., Darrah, P. A. & Roederer, M. T-cell quality in memory and protection: implications for vaccine design. Nat. Rev. Immunol. 8, 247-258 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 247-258
    • Seder, R.A.1    Darrah, P.A.2    Roederer, M.3
  • 24
    • 84888059493 scopus 로고    scopus 로고
    • The who's who of T-cell differentiation: Human memory T-cell subsets
    • Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M. & Lugli, E. The who's who of T-cell differentiation: human memory T-cell subsets. Eur. J. Immunol. 43, 2797-2809 (2013).
    • (2013) Eur. J. Immunol. , vol.43 , pp. 2797-2809
    • Mahnke, Y.D.1    Brodie, T.M.2    Sallusto, F.3    Roederer, M.4    Lugli, E.5
  • 25
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Karikó, K., Buckstein, M., Ni, H. & Weissman, D. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165-175 (2005).
    • (2005) Immunity , vol.23 , pp. 165-175
    • Karikó, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 26
    • 84945455309 scopus 로고    scopus 로고
    • N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
    • Andries, O. et al. N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J. Control. Release 217, 337-344 (2015).
    • (2015) J. Control. Release , vol.217 , pp. 337-344
    • Andries, O.1
  • 27
    • 84865079107 scopus 로고    scopus 로고
    • Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
    • Jayaraman, M. et al. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew. Chem. Int. Ed. Engl. 51, 8529-8533 (2012).
    • (2012) Angew. Chem. Int. Ed. Engl. , vol.51 , pp. 8529-8533
    • Jayaraman, M.1
  • 29
    • 84899076595 scopus 로고    scopus 로고
    • Circumventing antivector immunity: Potential use of nonhuman adenoviral vectors
    • Lopez-Gordo, E., Podgorski, I. I., Downes, N. & Alemany, R. Circumventing antivector immunity: potential use of nonhuman adenoviral vectors. Hum. Gene Ther. 25, 285-300 (2014).
    • (2014) Hum. Gene Ther. , vol.25 , pp. 285-300
    • Lopez-Gordo, E.1    Podgorski, I.I.2    Downes, N.3    Alemany, R.4
  • 30
    • 84883118140 scopus 로고    scopus 로고
    • Safety and efficacy of rnai therapy for transthyretin amyloidosis
    • Coelho, T. et al. Safety and efficacy of rnai therapy for transthyretin amyloidosis. N. Engl. J. Med. 369, 819-829 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 819-829
    • Coelho, T.1
  • 31
    • 84924405861 scopus 로고    scopus 로고
    • Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion
    • Bogers, W. M. et al. Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying rna vaccine expressing hiv type 1 envelope with a cationic nanoemulsion. J. Infect. Dis. 211, 947-955 (2015).
    • (2015) J. Infect. Dis. , vol.211 , pp. 947-955
    • Bogers, W.M.1
  • 32
    • 33750110852 scopus 로고    scopus 로고
    • Vaccination with messenger RNA
    • Pascolo, S. Vaccination with messenger RNA. Methods Mol. Med. 127, 23-40 (2006).
    • (2006) Methods Mol. Med. , vol.127 , pp. 23-40
    • Pascolo, S.1
  • 33
    • 39349103969 scopus 로고    scopus 로고
    • Vaccination with messengerRNA (mRNA)
    • Pascolo, S. Vaccination with messengerRNA (mRNA). Handb. Exp. Pharmacol. https://doi.org/10.1007/978-3-540-72167-3-11 (2008).
    • (2008) Handb. Exp. Pharmacol.
    • Pascolo, S.1
  • 34
    • 84881292568 scopus 로고    scopus 로고
    • Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics
    • Maier, M. A. et al. Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Mol. Ther. J. Am. Soc. Gene Ther. 21, 1570-1578 (2013).
    • (2013) Mol. Ther. J. Am. Soc. Gene Ther. , vol.21 , pp. 1570-1578
    • Maier, M.A.1
  • 35
    • 84977497384 scopus 로고    scopus 로고
    • Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity
    • Kowalczyk, A. et al. Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity. Vaccine 34, 3882-3893 (2016).
    • (2016) Vaccine , vol.34 , pp. 3882-3893
    • Kowalczyk, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.