Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 12, Issue 3, 2016, Pages 711-722

  Démoulins, Thomas ^a   Milona, Panagiota ^a   Englezou, Pavlos C ^a   Ebensen, Thomas ^b   Schulze, Kai ^b   Suter, Rolf ^a   Pichon, Chantal ^c   Midoux, Patrick ^c   Guzmán, Carlos A ^b   Ruggli, Nicolas ^a   McCullough, Kenneth C ^a  

^a INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

Adjuvant; Blood dendritic cells; Humoral and cellular immunity; Influenza vaccines; Intracellular delivery; Polyplexes; Replicon RNA; Self replicating vaccine

Indexed keywords

ANTIGENS; CELLS; CRASHWORTHINESS; MOLECULES; NUCLEIC ACIDS; RNA; VIRUSES;

ADJUVANT; DENDRITIC CELLS; HUMORAL AND CELLULAR IMMUNITY; INFLUENZA VACCINES; INTRACELLULAR DELIVERY; POLYPLEXES;

VACCINES;

CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INFLUENZA VIRUS HEMAGGLUTININ; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; POLYETHYLENEIMINE; POLYPLEX; RNA VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIGEN; RNA; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CLINICAL ASSESSMENT; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; HUMORAL IMMUNITY; IN VIVO STUDY; MOUSE; NONHUMAN; PARTICLE SIZE; REPLICON; RNA REPLICATION; RNA TRANSLATION; TRANSLATION INITIATION; VACCINATION; VIRUS NUCLEOCAPSID; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; GENETICS; IMMUNOLOGY; PIG; PROTEIN SYNTHESIS;

ANIMALS; ANTIGENS; CELL LINE; DENDRITIC CELLS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; MICE, INBRED BALB C; POLYETHYLENEIMINE; PROTEIN BIOSYNTHESIS; REPLICON; RNA; SWINE; VACCINES;

EID: 84959335738     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2015.11.001     Document Type: Article

References (47)

1. McCullough K.C., Bassi I., Milona P., Suter R., Thomann-Harwood L., Englezou P., et al. Self-replicating replicon-RNA delivery to dendritic cells by chitosan-nanoparticles for translation in vitro and in vivo. Mol Ther Nucleic Acids 2014, 3:e173.
2. Tratschin J.D., Ruggli N., McCullough K.C. Pestivirus replicons providing an RNA-based viral vector system. PCT/EP2009/003892 WO 2009146867 2008.
3. Platta H.W., Stenmark H. Endocytosis and signaling. Curr Opin Cell Biol 2011, 23:393-403.
4. Kumari S., Mg S., Mayor S. Endocytosis unplugged: multiple ways to enter the cell. Cell Res 2010, 20:256-275.
5. Sorkin A., von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol 2009, 10:609-622.
6. McCullough K.C., Bassi I., Démoulins T., Thomann-Harwood L.J., Ruggli N. Functional RNA delivery targeted to dendritic cells by synthetic nanoparticles. Ther Deliv 2012, 3:1077-1099.
7. Randolph G.J., Jakubzick C., Qu C. Antigen presentation by monocytes and monocyte-derived cells. Curr Opin Immunol 2008, 20:52-60.
8. Thery C., Amigorena S. The cell biology of antigen presentation in dendritic cells. Curr Opin Immunol 2001, 13:45-51.
9. Vyas J.M., Van der Veen A.G., Ploegh H.L. The known unknowns of antigen processing and presentation. Nat Rev Immunol 2008, 8:607-618.
10. Kutzler M.A., Weiner D.B. DNA vaccines: ready for prime time?. Nat Rev Genet 2008, 9:776-788.
11. Suter R., Summerfield A., Thomann-Harwood L.J., McCullough K.C., Tratschin J.D., Ruggli N. Immunogenic and replicative properties of classical swine fever virus replicon particles modified to induce IFN-alpha/beta and carry foreign genes. Vaccine 2011, 29:1491-1503.
12. Kim D.Y., Atasheva S., McAuley A.J., Plante J.A., Frolova E.I., Beasley D.W., et al. Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs. Proc Natl Acad Sci U S A 2014, 111:10708-10713.
13. Ljungberg K., Liljestrom P. Self-replicating alphavirus RNA vaccines. Expert Rev Vaccines 2015, 14:177-194.
14. Atkins G.J., Fleeton M.N., Sheahan B.J. Therapeutic and prophylactic applications of alphavirus vectors. Expert Rev Mol Med 2008, 10:e33.
15. Pijlman G.P., Suhrbier A., Khromykh A.A. Kunjin virus replicons: an RNA-based, non-cytopathic viral vector system for protein production, vaccine and gene therapy applications. Expert Opin Biol Ther 2006, 6:135-145.
16. Khromykh A.A. Replicon-based vectors of positive strand RNA viruses. Curr Opin Mol Ther 2000, 2:555-569.
17. Lundstrom K. Alphavirus-based vaccines. Curr Opin Mol Ther 2002, 4:28-34.
18. Perche F., Benvegnu T., Berchel M., Lebegue L., Pichon C., Jaffres P.A., et al. Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA. Nanomedicine 2011, 7:445-453.
19. Pichon C., Goncalves C., Midoux P. Histidine-rich peptides and polymers for nucleic acids delivery. Adv Drug Deliv Rev 2001, 53:75-94.
20. Bertrand E., Goncalves C., Billiet L., Gomez J.P., Pichon C., Cheradame H., et al. Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer. Chem Commun (Camb) 2011, 47:12547-12549.
21. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 1995, 92:7297-7301.
22. Akinc A., Thomas M., Klibanov A.M., Langer R. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 2005, 7:657-663.
23. Retamal-Diaz A., Riquelme-Neira R., Saez D., Rivera A., Fernandez P., Cabrera A., et al. Use of S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy polyethylene glycol as an adjuvant improved protective immunity associated with a DNA vaccine encoding Cu,Zn superoxide dismutase of Brucella abortus in mice. Clin Vaccine Immunol 2014, 21:1474-1480.
24. Rharbaoui F., Drabner B., Borsutzky S., Winckler U., Morr M., Ensoli B., et al. The mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant. Eur J Immunol 2002, 32:2857-2865.
25. Ebensen T., Libanova R., Schulze K., Yevsa T., Morr M., Guzman C.A. Bis-(3',5')-cyclic dimeric adenosine monophosphate: strong Th1/Th2/Th17 promoting mucosal adjuvant. Vaccine 2011, 29:5210-5220.
26. Stettler P., Devos R., Moser C., Tratschin J.D., Hofmann M.A. Establishment and application of bicistronic classical swine fever virus genomes for foreign gene expression and complementation of E2 deletion mutants. Virus Res 2002, 85:173-185.
27. Frey C.F., Bauhofer O., Ruggli N., Summerfield A., Hofmann M.A., Tratschin J.D. Classical swine fever virus replicon particles lacking the Erns gene: a potential marker vaccine for intradermal application. Vet Res 2006, 37:655-670.
28. Eymann-Hani R., Leifer I., McCullough K.C., Summerfield A., Ruggli N. Propagation of classical swine fever virus in vitro circumventing heparan sulfate-adaptation. J Virol Methods 2011, 176:85-95.
29. Démoulins T., Bassi I., Thomann-Harwood L., Jandus C., Kaeuper P., Simon H.U., et al. Alginate-coated chitosan nanogel capacity to modulate the effect of TLR ligands on blood dendritic cells. Nanomedicine 2013, 9:806-817.
30. Démoulins T., Milona P., McCullough K.C. Alginate-coated chitosan nanogels differentially modulate class-A and class-B CpG-ODN targeting of dendritic cells and intracellular delivery. Nanomedicine 2014, 10:1739-1749.
31. Guzylack-Piriou L., Balmelli C., McCullough K.C., Summerfield A. Type-A CpG oligonucleotides activate exclusively porcine natural interferon-producing cells to secrete interferon-alpha, tumour necrosis factor-alpha and interleukin-12. Immunology 2004, 112:28-37.
32. Sharma R., Ghasparian A., Robinson J.A., McCullough K.C. Synthetic virus-like particles target dendritic cell lipid rafts for rapid endocytosis primarily but not exclusively by macropinocytosis. PLoS One 2012, 7:e43248.
33. Mayer D., Hofmann M.A., Tratschin J.D. Attenuation of classical swine fever virus by deletion of the viral N(pro) gene. Vaccine 2004, 22:317-328.
34. Mittal A., Schulze K., Ebensen T., Weissmann S., Hansen S., Guzman C.A., et al. Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination. J Control Release 2015, 206:140-152.
35. Mittal A., Schulze K., Ebensen T., Weissmann S., Hansen S., Lehr C.M., et al. Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation. Nanomedicine 2015, 11:147-154.
36. Araki N., Hamasaki M., Egami Y., Hatae T. Effect of 3-methyladenine on the fusion process of macropinosomes in EGF-stimulated A431 cells. Cell Struct Funct 2006, 31:145-157.
37. Walsh M., Tangney M., O'Neill M.L., Larkin J.O., Soden D.M., McKenna S.L., et al. Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy. Mol Pharm 2006, 3:644-653.
38. Christoforidis S., McBride H.M., Burgoyne R.D., Zerial M. The Rab5 effector EEA1 is a core component of endosome docking. Nature 1999, 397:621-625.
39. Gilleron J., Querbes W., Zeigerer A., Borodovsky A., Marsico G., Schubert U., et al. Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape. Nat Biotechnol 2013, 31:638-646.
40. ur Rehman Z., Hoekstra D., Zuhorn I.S. Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. ACS Nano 2013, 7:3767-3777.
41. McCullough K.C., Milona P., Thomann-Harwood L., Démoulins T., Englezou P., Suter R., et al. Self-amplifying replicon RNA vaccine delivery to dendritic cells by synthetic nanoparticles. Vaccines 2014, 2:735-754.
42. McCullough K.C., Milona P., Démoulins T., Englezou P., Ruggli N. Dendritic cell targets for self-replicating RNA vaccines. J Blood Lymph 2015, 5:132. 10.4172/2165-7831.1000132.
43. Mockey M., Bourseau E., Chandrashekhar V., Chaudhuri A., Lafosse S., Le Cam E., et al. mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes. Cancer Gene Ther 2007, 14:802-814.
44. Goncalves C., Berchel M., Gosselin M.P., Malard V., Cheradame H., Jaffres P.A., et al. Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection. Int J Pharm 2014, 460:264-272.
45. Geall A.J., Verma A., Otten G.R., Shaw C.A., Hekele A., Banerjee K., et al. Nonviral delivery of self-amplifying RNA vaccines. Proc Natl Acad Sci U S A 2012, 109:14604-14609.
46. Brito L.A., Chan M., Shaw C.A., Hekele A., Carsillo T., Schaefer M., et al. A cationic nanoemulsion for the delivery of next-generation RNA vaccines. Mol Ther 2014, 22:2118-2129.
47. von Gersdorff K., Sanders N.N., Vandenbroucke R., De Smedt S.C., Wagner E., Ogris M. The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type. Mol Ther 2006, 14:745-753.