Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

Journal of General Virology

Volumn 99, Issue 5, 2018, Pages 619-630

  Sisk, Jeanne M ^a   Frieman, Matthew B ^b   Machamer, Carolyn E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Abl kinase; Abl1; Abl2; Cell cell fusion; Coronavirus; GNF2; GNF5; IBV; Imatinib; MERS CoV; SARS CoV; Virus cell fusion

Indexed keywords

ABELSON KINASE; GNF 2; GNF 5; IMATINIB; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS RECEPTOR; VIRUS SPIKE PROTEIN; ANTIVIRUS AGENT; BENZAMIDE DERIVATIVE; CORONAVIRUS SPIKE GLYCOPROTEIN; GNF-2 COMPOUND; N-(2-HYDROXYETHYL)-3-(6-((4-(TRIFLUOROMETHOXY)PHENYL)AMINO)-4-PYRIMIDINYL)BENZAMIDE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CORONAVIRUS INFECTION; ENDOCYTOSIS; ENZYME ACTIVITY; HOST CELL; MEMBRANE FUSION; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RECEPTOR BINDING; SARS CORONAVIRUS; SYNCYTIUM; VIRUS ATTACHMENT; VIRUS CELL INTERACTION; VIRUS TITRATION; ANIMAL; ANTAGONISTS AND INHIBITORS; AVIAN INFECTIOUS BRONCHITIS VIRUS; CELL MEMBRANE; CHLOROCEBUS AETHIOPS; ENDOSOME; GENETICS; METABOLISM; VERO CELL LINE; VIROLOGY; VIRUS ENTRY; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; BENZAMIDES; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; ENDOSOMES; IMATINIB MESYLATE; INFECTIOUS BRONCHITIS VIRUS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES; SPIKE GLYCOPROTEIN, CORONAVIRUS; VERO CELLS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 85046402518     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/jgv.0.001047     Document Type: Article

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