Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Nature

Volumn 556, Issue 7701, 2018, Pages 381-385

  Pao, Kuan Chuan ^a   Wood, Nicola T ^a   Knebel, Axel ^a   Rafie, Karim ^a   Stanley, Mathew ^a   Mabbitt, Peter D ^a   Sundaramoorthy, Ramasubramanian ^a   Hofmann, Kay ^b   Van Aalten, Daan M F ^a   Virdee, Satpal ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; MYC BINDING PROTEIN 2; THREONINE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; LYSINE; MYCBP2 PROTEIN, HUMAN; SERINE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; THIOESTER;

AMINO ACID; CATALYSIS; CHEMICAL REACTION; ENZYME; ENZYME ACTIVITY; PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYTIC EFFICIENCY; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ESTERIFICATION; HYDROPHOBICITY; MUTANT; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEOMICS; UBIQUITINATION; WILD TYPE; X RAY CRYSTALLOGRAPHY; BIOCATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR MODEL; PROTEIN DOMAIN; TUMOR CELL LINE; ALPHA HELIX; ALZHEIMER DISEASE; CRYSTALLOGRAPHY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; LETTER; MUTATIONAL ANALYSIS; NERVE INJURY; PARKINSON DISEASE; PROTEIN FINGERPRINTING; SIZE EXCLUSION CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EUKARYOTA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BIOCATALYSIS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ESTERIFICATION; HEK293 CELLS; HUMANS; LYSINE; MODELS, MOLECULAR; PROTEIN DOMAINS; PROTEOMICS; SERINE; SUBSTRATE SPECIFICITY; THREONINE; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 85045950070     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-018-0026-1     Document Type: Article

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