Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

PLoS ONE

Volumn 13, Issue 4, 2018, Pages

  Belcher, John D ^a   Chen, Chunsheng ^a   Nguyen, Julia ^a   Abdulla, Fuad ^a   Zhang, Ping ^a   Nguyen, Hao ^a   Nguyen, Phong ^a   Killeen, Trevor ^a   Miescher, Sylvia M ^b   Brinkman, Nathan ^c   Nath, Karl A ^d   Steer, Clifford J ^a   Vercellotti, Gregory M ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b ZLB Behring AG   (Switzerland)

^c Research and Development   (United States)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ALBUMIN; CARBON MONOXIDE; GAMMA INTERFERON; HAPTOGLOBIN; HEME OXYGENASE 1; HEMOGLOBIN; HEMOPEXIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; PADGEM PROTEIN; PLATELET ENDOTHELIAL CELL ADHESION MOLECULE 1; PROTOPORPHYRIN TIN; RANTES; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1; VON WILLEBRAND FACTOR; 4-HYDROXY-2-NONENAL; ALDEHYDE; CYTOKINE; METALLOPORPHYRIN; PROTOPORPHYRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; CELL PROTECTION; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUVEC CELL LINE; HYPOXIA; INFLAMMATION; KIDNEY; LIVER; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; REOXYGENATION; SICKLE CELL ANEMIA; SKIN; WEIBEL PALADE BODY; ANIMAL; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION; METABOLISM; PATHOLOGY;

ALDEHYDES; ANEMIA, SICKLE CELL; ANIMALS; CARBON MONOXIDE; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; HAPTOGLOBINS; HEME OXYGENASE-1; HEMOPEXIN; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MALE; METALLOPORPHYRINS; MICE; MICROSOMES, LIVER; PROTOPORPHYRINS; SKIN; TRANSCRIPTION FACTOR RELA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 85045926616     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0196455     Document Type: Article

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