Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

Blood

Volumn 120, Issue 18, 2012, Pages 3822-3828

  Bean, Christopher J ^a   Boulet, Sheree L ^a   Ellingsen, Dorothy ^a   Pyle, Meredith E ^a   Barron Casella, Emily A ^b   Casella, James F ^b   Payne, Amanda B ^a   Driggers, Jennifer ^a   Trau, Heidi A ^a   Yang, Genyan ^a   Jones, Kimberly ^b   Ofori Acquah, Solomon F ^c   Hooper, W Craig ^a   DeBaun, Michael R ^d  

^a NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN F;

ACUTE CHEST SYNDROME; ADOLESCENT; ADVERSE OUTCOME; AGE; ALLELE; ARTICLE; ASTHMA; CHILD; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENE DELETION; GENETIC ANALYSIS; GENETIC VARIABILITY; HOSPITALIZATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEX; SICKLE CELL ANEMIA; THORAX PAIN;

EID: 84868583137     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-06-361642     Document Type: Article

References (36)

1. Chies JA, Nardi NB. Sickle cell disease: a chronic inflammatory condition. Med Hypotheses. 2001; 57(1):46-50.
2. Weatherall D, Hofman K, Rodgers G, Ruffin J, Hrynkow S. A case for developing North-South partnerships for research in sickle cell disease. Blood. 2005;105(3):921-923. (Pubitemid 40170855)
3. Balla J, Vercellotti GM, Jeney V, et al. Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment. Antioxid Redox Signal. 2007;9(12): 2119-2137. (Pubitemid 350059014)
4. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997;37:517-554. (Pubitemid 27238886)
5. Gozzelino R, Jeney V, Soares MP. Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol. 2010;50:323-354.
6. Otterbein LE, Soares MP, Yamashita K, Bach FH. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003;24(8): 449-455. (Pubitemid 36928103)
7. Belcher JD, Mahaseth H, Welch TE, Otterbein LE, Hebbel RP, Vercellotti GM. Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. J Clin Invest. 2006; 116(3):808-816. (Pubitemid 43326890)
8. Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med. 2004;37(8):1097-1104. (Pubitemid 39296737)
9. Ono K, Goto Y, Takagi S, et al. A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese. Atherosclerosis. 2004;173(2):315-319.
10. Yamada N, Yamaya M, Okinaga S, et al. Micro-satellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet. 2000;66(1):187-195. (Pubitemid 30481482)
11. Hirai H, Kubo H, Yamaya M, et al. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood. 2003;102(5):1619-1621. (Pubitemid 37022551)
12. Taha H, Skrzypek K, Guevara I, et al. Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants. Arterioscler Thromb Vasc Biol. 2010;30(8):1634-1641.
13. Casella JF, King AA, Barton B, et al. Design of the silent cerebral infarct transfusion (SIT) trial. Pediatr Hematol Oncol. 2010;27(2):69-89.
14. An P, Barron-Casella EA, Strunk RC, Hamilton RG, Casella JF, Debaun MR. Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity. J Allergy Clin Immunol. 2011;127(6):1440-1446.
15. Castro O, Brambilla DJ, Thorington B, et al. The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease. Blood. 1994;84(2):643-649. (Pubitemid 24215969)
16. Vichinsky EP, Styles LA, Colangelo LH, Wright EC, Castro O, Nickerson B. Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease. Blood. 1997;89(5):1787-1792. (Pubitemid 27097475)
17. Vichinsky EP, Neumayr LD, Earles AN, et al. Causes and outcomes of the acute chest syndrome in sickle cell disease: National Acute Chest Syndrome Study Group. N Engl J Med. 2000;342(25):1855-1865. (Pubitemid 30419049)
18. Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey Questionnaire. Hyattsville, MD: US Department of Health and Human Services, Centers for Disease Control and Prevention; 1994.
19. Bloom B, Dey AN, Freeman G. Summary health statistics for U.S. children: National Health Interview Survey, 2005. Vital Health Stat 10. 2006; 231:1-84.
20. Fagan JK, Scheff PA, Hryhorczuk D, Ramakrishnan V, Ross M, Persky V. Prevalence of asthma and other allergic diseases in an adolescent population: association with gender and race. Ann Allergy Asthma Immunol. 2001;86(2):177-184. (Pubitemid 32167842)
21. Mvula M, Larzelere M, Kraus M, et al. Prevalence of asthma and asthma-like symptoms in inner-city schoolchildren. J Asthma. 2005;42(1):9-16. (Pubitemid 40365723)
22. Liu YT, Old JM, Miles K, Fisher CA, Weatherall DJ, Clegg JB. Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions. Br J Haematol. 2000;108(2):295-299. (Pubitemid 30143644)
23. Tan AS, Quah TC, Low PS, Chong SS. A rapid and reliable 7-deletion multiplex polymerase chain reaction assay for alpha-thalassemia. Blood. 2001;98(1):250-251.
24. Stephens M, Scheet P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet. 2005; 76(3):449-462. (Pubitemid 40250525)
25. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 2001;68(4): 978-989. (Pubitemid 32289743)
26. The International HapMap Project. Nature. 2003; 426(6968):789-796.
27. Fredenburgh LE, Perrella MA, Mitsialis SA. The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol. 2007;36(2):158-165. (Pubitemid 46233468)
28. Raval CM, Lee PJ. Heme oxygenase-1 in lung disease. Curr Drug Targets. 2010;11(12):1532-1540.
29. Ono K, Mannami T, Iwai N. Association of a promoter variant of the haeme oxygenase-1 gene with hypertension in women. J Hypertens. 2003; 21(8):1497-1503. (Pubitemid 36994128)
30. Ghosh S, Ofori-Acquah SF. Acute chest syndrome in transgenic mouse models of sickle cell disease triggered by free heme [abstract]. Blood (ASH Annual Meeting Abstracts). 2010;116(21): 944.
31. Balla G, Jacob HS, Balla J, et al. Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem. 1992;267(25):18148-18153.
32. Ballas SK, Marcolina MJ. Hyperhemolysis during the evolution of uncomplicated acute painful episodes in patients with sickle cell anemia. Transfusion. 2006;46(1):105-110. (Pubitemid 43381792)
33. Shriver MD, Jin L, Ferrell RE, Deka R. Microsatellite data support an early population expansion in Africa. Genome Res. 1997;7(6):586-591. (Pubitemid 27313607)
34. Sun JX, Mullikin JC, Patterson N, Reich DE. Microsatellites are molecular clocks that support accurate inferences about history. Mol Biol Evol. 2009;26(5):1017-1027.
35. Garcia-Santos D, Chies JA. HO-1 polymorphism as a genetic determinant behind the malaria resistance afforded by haemolytic disorders. Med Hypotheses. 2010;74(5):807-813.
36. Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM. Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans. Genes Immun. 2012;13(3): 258-267.