Oxidized ferric and ferryl forms of hemoglobin trigger mitochondrial dysfunction and injury in alveolar type i cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 55, Issue 2, 2016, Pages 288-298

  Chintagari, Narendranath Reddy ^a   Jana, Sirsendu ^a   Alayash, Abdu I ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Hemoglobin; lung epithelium; mitochondria; heme oxygenase; hemolysis

Indexed keywords

FERROUS HEMOGLOBIN; HAPTOGLOBIN; HEME OXYGENASE 1; HEMOGLOBIN; HEMOPEXIN; METHEMOGLOBIN; UNCLASSIFIED DRUG; IRON;

ANIMAL CELL; ARTICLE; BASAL METABOLIC RATE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; LUNG ALVEOLUS CELL TYPE 1; LUNG ALVEOLUS EPITHELIUM CELL; MOUSE; NONHUMAN; OXIDATION; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; ADULT; ANIMAL; BIOLOGICAL MODEL; CELL LINE; DRUG EFFECTS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATION REDUCTION REACTION; PATHOLOGY; PROTEIN TRANSPORT; UPREGULATION;

ADULT; ALVEOLAR EPITHELIAL CELLS; ANIMALS; CELL LINE; HEME OXYGENASE-1; HEMOGLOBINS; HUMANS; IRON; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; PROTEIN TRANSPORT; UP-REGULATION;

EID: 84988933228     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2015-0197OC     Document Type: Article

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