Peroxidase activity of hemoglobin towards ascorbate and urate: A synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC)

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1784, Issue 10, 2008, Pages 1415-1420

  Cooper, Chris E ^a   Silaghi Dumitrescu, Radu ^a   Rukengwa, Martine ^a   Alayash, Abdu I ^b   Buehler, Paul W ^b  

^a UNIVERSITY OF ESSEX   (United Kingdom)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

Ascorbate; Blood substitute; Ferryl; Hemoglobin; Peroxidase; Urate

Indexed keywords

ASCORBIC ACID; BLOOD SUBSTITUTE; HEMOGLOBIN; HEMOGLOBIN BASED OXYGEN CARRIER; HYDROGEN PEROXIDE; IRON DERIVATIVE; PEROXIDASE; POLYMERIZED HEMOGLOBIN; UNCLASSIFIED DRUG; URATE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD TRANSFUSION; DRUG ACTIVITY; ENZYME ACTIVITY; GUINEA PIG; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; PH; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; PROTON TRANSPORT;

ANIMALS; ASCORBIC ACID; BLOOD SUBSTITUTES; BUFFERS; DRUG CARRIERS; FERRIC COMPOUNDS; GUINEA PIGS; HEMOGLOBINS; HUMANS; KINETICS; OXYGEN; OXYHEMOGLOBINS; PEROXIDASES; URIC ACID;

BOVINAE; CAVIA;

EID: 52049095278     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2008.03.019     Document Type: Article

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