Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease

American Heart Journal

Volumn 200, Issue , 2018, Pages 96-101

  Carson, Jeffrey L ^a   Stanworth, Simon J ^b   Alexander, John H ^c   Roubinian, Nareg ^d   Fergusson, Dean A ^e   Triulzi, Darrell J ^f   Goodman, Shaun G ^g,h   Rao, Sunil V ^c   Doree, Carolyn ⁱ   Hebert, Paul C ^j  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^d BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^e OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^f UNIVERSITY OF PITTSBURGH   (United States)

^g ST MICHAEL'S HOSPITAL   (Canada)

^h UNIVERSITY OF ALBERTA   (Canada)

ⁱ NHS BLOOD AND TRANSPLANT   (United Kingdom)

^j CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

ACUTE HEART INFARCTION; ARTICLE; CARDIOVASCULAR DISEASE; ERYTHROCYTE TRANSFUSION; HEART SURGERY; HEMOGLOBIN DETERMINATION; HOSPITAL MORTALITY; HUMAN; MORTALITY RISK; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; ANEMIA; COMORBIDITY; HEART INFARCTION; MORTALITY; PROCEDURES; RISK ASSESSMENT; STANDARDS; TREATMENT OUTCOME;

ANEMIA; CARDIAC SURGICAL PROCEDURES; CARDIOVASCULAR DISEASES; COMORBIDITY; ERYTHROCYTE TRANSFUSION; HUMANS; MYOCARDIAL INFARCTION; RISK ADJUSTMENT; TREATMENT OUTCOME;

EID: 85045727185     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2018.04.007     Document Type: Article

References (47)

1. Carson, J.L., Stanworth, S.J., Roubinian, N., et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev, 10, 2016, CD002042.
2. Carson, J.L., Guyatt, G., Heddle, N.M., et al. Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage. JAMA 316 (2016), 2025–2035.
3. Murphy, G.J., Pike, K., Rogers, C.A., et al. Liberal or restrictive transfusion after cardiac surgery. N Engl J Med 372 (2015), 997–1008.
4. Docherty, A.B., O'Donnell, R., Brunskill, S., et al. Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. BMJ, 352, 2016, i1351.
5. DeZern, A.E., Williams, K., Zahurak, M., et al. Red blood cell transfusion triggers in acute leukemia: a randomized pilot study. Transfusion (Paris) 56 (2016), 1750–1757.
6. Bergamin, F.S., Almeida, J.P., Landoni, G., et al. Liberal versus restrictive transfusion strategy in critically ill oncologic patients: the transfusion requirements in critically ill oncologic patients randomized controlled trial. Crit Care Med 45 (2017), 766–773.
7. Koch, C.G., Sessler, D.I., Mascha, E.J., et al. A randomized clinical trial of red blood cell transfusion triggers in cardiac surgery. Ann Thorac Surg 104 (2017), 1243–1250.
8. Mazer, C.D., Whitlock, R.P., Fergusson, D.A., et al. Red-cell transfusion threshold for cardiac surgery. N Engl J Med 377 (2017), 2133–2144.
9. Palmieri, T.L., Holmes, JH4th, Arnoldo, B., et al. Transfusion requirement in burn care evaluation (TRIBE): a multicenter randomized prospective trial of blood transfusion in major burn injury. Ann Surg 266 (2017), 595–602.
10. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011], 2011.
11. Higgins, J.P., Altman, D.G., Gotzsche, P.C., et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, 2011, d5928.
12. Review Manager 5 [computer program], 2014, Nordic Cochrane Centre, the Cochrane Colloboration, Copenhagen.
13. DerSimonian, R., Laird, N., Meta-analysis in clinical trials. Control Clin Trials 7 (1986), 177–188.
14. Jairath, V., Kahan, B.C., Gray, A., et al. Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial. Lancet 386 (2015), 137–144.
15. Laine, A., Niemi, T., Schramko, A., Transfusion threshold of hemoglobin 80 g/L is comparable to 100 g/L in terms of bleeding in cardiac surgery: a prospective randomized study. J Cardiothorac Vasc Anesth 32 (2018), 131–139.
16. Villanueva, C., Colomo, A., Bosch, A., et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 368 (2013), 11–21.
17. Webert, K.E., Cook, R.J., Couban, S., et al. A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation. Transfusion (Paris) 48 (2008), 81–91.
18. Johnson, R.G., Thurer, R.L., Kruskall, M.S., et al. Comparison of two transfusion strategies after elective operations for myocardial revascularization. J Thorac Cardiovasc Surg 104 (1992), 307–314.
19. Bracey, A.W., Radovancevic, R., Riggs, S.A., et al. Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. Transfusion (Paris) 39 (1999), 1070–1077.
20. Hajjar, L.A., Vincent, J.L., Galas, F.R., et al. Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA 304 (2010), 1559–1567.
21. Shehata, N., Burns, L.A., Nathan, H., et al. A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery. Transfusion (Paris) 52 (2012), 91–99.
22. Carson, J.L., Brooks, M.M., Abbott, J.D., et al. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 165 (2013), 964–971.
23. Cooper, H.A., Rao, S.V., Greenberg, M.D., et al. Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). Am J Cardiol 108 (2011), 1108–1111.
24. Bush, R.L., Pevec, W.C., Holcroft, J.W., A prospective, randomized trial limiting perioperative red blood cell transfusions in vascular patients. Am J Surg 174 (1997), 143–148.
25. Carson, J.L., Terrin, M.L., Barton, F.B., et al. A pilot randomized trial comparing symptomatic vs. hemoglobin-level-driven red blood cell transfusions following hip fracture. Transfusion (Paris) 38 (1998), 522–529.
26. Carson, J.L., Terrin, M.L., Noveck, H., et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 365 (2011), 2453–2462.
27. Fan, Y.-X., Liu, F.-F., Jia, M., et al. Comparison of restrictive and liberal transfusion strategy on postoperative delirium in aged patients following total hip replacement: a preliminary study. Arch Gerontol Geriatr 59 (2014), 181–185.
28. Foss, N.B., Kristensen, M.T., Jensen, P.S., et al. The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. Transfusion (Paris) 49 (2009), 227–234.
29. Gregersen, M., Borris, L.C., Damsgaard, E.M., Postoperative blood transfusion strategy in frail, anemic elderly patients with hip fracture. Acta Orthop 86 (2015), 1–10.
30. Grover, M., Talwalkar, S., Casbard, A., et al. Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty. Vox Sang 90 (2006), 105–112.
31. Lotke, P.A., Barth, P., Garino, J.P., et al. Predonated autologous blood transfusions after total knee arthroplasty: immediate versus delayed administration. J Arthroplast 14 (1999), 647–650.
32. Nielsen, K., Johansson, P.I., Dahl, B., et al. Perioperative transfusion threshold and ambulation after hip revision surgery—a randomized trial. BMC Anesthesiol, 14, 2014, 89.
33. Parker, M.J., Randomised trial of blood transfusion versus a restrictive transfusion policy after hip fracture surgery. Injury 44 (2013), 1916–1918.
34. So-Osman, C., Nelissen, R., Brand, R., et al. The impact of a restrictive transfusion trigger on post-operative complication rate and well-being following elective orthopaedic surgery: a post-hoc analysis of a randomised study. Blood Transfus 11 (2013), 289–295.
35. Hebert, P.C., Wells, G., Blajchman, M.A., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group [see comments]. N Engl J Med 340 (1999), 409–417.
36. Hebert, P.C., Wells, G., Marshall, J., et al. Transfusion requirements in critical care. A pilot study. Canadian Critical Care Trials Group [published erratum appears in JAMA 1995 Sep 27; 274(12):944]. JAMA 273 (1995), 1439–1444.
37. Holst, L.B., Haase, N., Wetterslev, J., et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 371 (2014), 1381–1391.
38. Lacroix, J., Hebert, P.C., Hutchison, J.S., et al. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 356 (2007), 1609–1619.
39. Pinheiro de Almeida, J., Vincent, J.L., Barbosa Gomes Galas, F.R., et al. Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology 122 (2015), 29–38.
40. Walsh, T.S., Boyd, J.A., Watson, D., et al. Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: a randomized pilot trial*. Crit Care Med 41 (2013), 2354–2363.
41. Blair, S.D., Janvrin, S.B., McCollum, C.N., et al. Effect of early blood transfusion on gastrointestinal haemorrhage. Br J Surg 73 (1986), 783–785.
42. Prick, B.W., Jansen, A.J., Steegers, E.A., et al. Transfusion policy after severe postpartum haemorrhage: a randomised non-inferiority trial. BJOG 121 (2014), 1005–1014.
43. Topley, E., Fischer, M.R., The illness of trauma. Br J Clin Pract 1 (1956), 770–776.
44. Akyildiz, B., Ulgen Tekerek, N., Pamukcu, O., et al. Comprehensive analysis of liberal and restrictive transfusion strategies in pediatric intensive care unit. J Trop Pediatr 64 (2018), 118–125.
45. Steg, P.G., Clinicaltrials.gov: cost-effectiveness and cost-utility of liberal vs restrictive red blood cell transfusion strategies in patients with acute myocardial infarction and anaemia (REALITY). NCT02648113. 2017, 2017.
46. Carson, J.L., Clinicaltrials.gov: myocardial ischemia and transfusion (MINT). NCT02981407. 2017, 2017.
47. Rohde, J.M., Dimcheff, D.E., Blumberg, N., et al. Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. JAMA 311 (2014), 1317–1326.