Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): A pragmatic, open-label, cluster randomised feasibility trial

The Lancet

Volumn 386, Issue 9989, 2015, Pages 137-144

  Jairath, Vipul ^a,b   Kahan, Brennan C ^c   Gray, Alasdair ^d   Doré, Caroline J ^c   Mora, Ana ^a   James, Martin W ^e   Stanley, Adrian J ^g   Everett, Simon M ^h   Bailey, Adam A ^b   Dallal, Helen ⁱ   Greenaway, John ⁱ   Le Jeune, Ivan ^f   Darwent, Melanie ^j   Church, Nicholas ^d   Reckless, Ian ^j   Hodge, Renate ^a   Dyer, Claire ^a   Meredith, Sarah ^c   Llewelyn, Charlotte ^a   Palmer, Kelvin R ^k   Logan, Richard F ^e   Travis, Simon P ^b   Walsh, Timothy S ^l   Murphy, Michael F ^a,m   more..

^a NHS BLOOD AND TRANSPLANT   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^e NIHR NOTTINGHAM BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^f NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^g GLASGOW ROYAL INFIRMARY   (United Kingdom)

^h ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

ⁱ JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^j OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^k WESTERN GENERAL HOSPITAL   (United Kingdom)

^l UNIVERSITY OF EDINBURGH   (United Kingdom)

^m NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLUSTER ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; ECONOMIC EVALUATION; ERYTHROCYTE TRANSFUSION; ESOPHAGITIS; ESOPHAGUS VARICES; FEASIBILITY STUDY; FEMALE; HEALTH CARE POLICY; HEMOGLOBIN DETERMINATION; HOSPITAL DISCHARGE; HUMAN; LIBERAL ERYTHROCYTE TRANSFUSION; MAJOR CLINICAL STUDY; MALE; MALLORY WEISS SYNDROME; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; OPEN STUDY; PEPTIC ULCER; PHASE 3 CLINICAL TRIAL; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTOCOL COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; RESTRICTIVE ERYTHROCYTE TRANSFUSION; SELECTION BIAS; UNITED KINGDOM; UNIVERSITY HOSPITAL; UPPER GASTROINTESTINAL BLEEDING; ACUTE DISEASE; AGED; BLOOD; CLINICAL TRIAL; GASTROINTESTINAL HEMORRHAGE; METABOLISM; METHODOLOGY; PATIENT SELECTION; PROCEDURES; VERY ELDERLY;

HEMOGLOBIN;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ERYTHROCYTE TRANSFUSION; FEASIBILITY STUDIES; FEMALE; GASTROINTESTINAL HEMORRHAGE; GUIDELINE ADHERENCE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; PATIENT SELECTION; RESEARCH DESIGN; SELECTION BIAS;

EID: 84938508860     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(14)61999-1     Document Type: Article

References (32)

1. C Crooks, T Card, J West Reductions in 28-day mortality following hospital admission for upper gastrointestinal hemorrhage Gastroenterology 141 2011 62 70
2. H Tinegate, S Chattree, A Iqbal, D Plews, J Whitehead, JP Wallis Ten-year pattern of red blood cell use in the North of England Transfusion 53 2013 483 489
3. V Jairath Acute upper gastrointestinal bleeding - time for some new triggers? Transfus Med 23 2013 139 141
4. LA Hajjar, JL Vincent, FR Galas et al. Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial JAMA 304 2010 1559 1567
5. PC Hebert, G Wells, MA Blajchman et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group N Engl J Med 340 1999 409 417
6. JL Carson, ML Terrin, H Noveck et al. Liberal or restrictive transfusion in high-risk patients after hip surgery N Engl J Med 365 2011 2453 2462
7. TS Walsh, DL Wyncoll, SJ Stanworth Managing anaemia in critically ill adults BMJ 341 2010 c4408
8. TS Walsh, JA Boyd, D Watson et al. Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: a randomized pilot trial Crit Care Med 41 2013 2354 2363
9. LM Napolitano, S Kurek, FA Luchette et al. Clinical practice guideline: red blood cell transfusion in adult trauma and critical care Crit Care Med 37 2009 3124 3157
10. JL Carson, MM Brooks, JD Abbott et al. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease Am Heart J 165 2013 964 971 e1.
11. CJ Crooks, J West, TR Card Comorbidities affect risk of nonvariceal upper gastrointestinal bleeding Gastroenterology 144 2013 1384 1393 1393. e1-2; quiz e18-19.
12. SA Hearnshaw, RF Logan, KR Palmer, TR Card, SP Travis, MF Murphy Outcomes following early red blood cell transfusion in acute upper gastrointestinal bleeding Aliment Pharmacol Ther 32 2010 215 224
13. S Restellini, O Kherad, V Jairath, M Martel, AN Barkun Red blood cell transfusion is associated with increased rebleeding in patients with nonvariceal upper gastrointestinal bleeding Aliment Pharmacol Ther 37 2013 316 322
14. C Villanueva, A Colomo, A Bosch et al. Transfusion strategies for acute upper gastrointestinal bleeding N Engl J Med 368 2013 11 21
15. V Jairath, BC Kahan, A Gray et al. Restrictive vs liberal blood transfusion for acute upper gastrointestinal bleeding: rationale and protocol for a cluster randomized feasibility trial Transfus Med Rev 27 2013 146 153
16. AN Barkun International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding Ann Intern Med 152 2010 101 113
17. R de Franchis Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension J Hepatol 53 2010 762 768
18. TA Rockall, RF Logan, HB Devlin, TC Northfield Risk assessment after acute upper gastrointestinal haemorrhage Gut 38 1996 316 321
19. BC Kahan, V Jairath, MF Murphy, CJ Dore Update on the transfusion in gastrointestinal bleeding (TRIGGER) trial: statistical analysis plan for a cluster-randomised feasibility trial Trials 14 2013 206
20. A Donner, N Klar Design and analysis of cluster randomization trials in health research 2000 Oxford University Press New York
21. RJ Hayes, LH Moulton Cluster randomised trials 2009 Chapman & Hall/Chemical Rubber Company Boca Raton
22. V Jairath, S Hearnshaw, SJ Brunskill et al. Red cell transfusion for the management of upper gastrointestinal haemorrhage Cochrane Database Syst Rev 9 2010 CD006613.
23. S Blair, S Janvrin, C McCollum et al. Effects of early blood transfusion on gastrointestinal haemorrhage Br J Surg 73 1986 783 785
24. J Elizalde, E Moitinho, J Garcia-Pagan et al. Effects of increasing blood hemoglobin levels on systemic hemodynamics of acutely anemic cirrhotic patients J Hepatol 29 1998 789 795
25. D Villarejo, M Rizzolo, E Lopez et al. Acute anemia in high digestive hemorrhage. Margins of security for their handling without transfusion of red globules Acta Gastroenterol Latinoam 29 1999 261 270
26. PA Carless, DA Henry, JL Carson, PP Hebert, B McClelland, K Ker Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion Cochrane Database Syst Rev 10 2010 CD002042.
27. British Society of Gastroenterology UK comparative audit of upper gastrointestinal bleeding and the use of blood www.bsg.org.uk/pdf-word-docs/blood-audit-report-07.pdf Dec, 2007 (accessed May 1, 2014).
28. A Dechartres, I Boutron, L Trinquart, P Charles, P Ravaud Single-center trials show larger treatment effects than multicenter trials: evidence from a meta-epidemiologic study Ann Intern Med 155 2011 39 51
29. R Bellomo, SJ Warrillow, MC Reade Why we should be wary of single-center trials Crit Care Med 37 2009 3114 3119
30. BC Kahan, V Jairath, CJ Dore, TP Morris The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies Trials 15 2014 139
31. V Jairath, BC Kahan, RF Logan, SP Travis, KR Palmer, MF Murphy Red blood cell transfusion practice in patients presenting with acute upper gastrointestinal bleeding: a survey of 815 UK clinicians Transfusion 51 2011 1940 1948
32. NHS Blood and Transplant Annual Review 2012-2013, Blood supply www.nhsbt.nhs.uk/annualreview/blood-supply (accessed May 1, 2014).