A Randomized Clinical Trial of Red Blood Cell Transfusion Triggers in Cardiac Surgery

Annals of Thoracic Surgery

Volumn 104, Issue 4, 2017, Pages 1243-1250

  Koch, Colleen G ^a   Sessler, Daniel I ^a   Mascha, Edward J ^a   Sabik, Joseph F ^a   Li, Liang ^a   Duncan, Andra I ^a   Zimmerman, Nicole M ^a   Blackstone, Eugene H ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ASCENDING AORTA SURGERY; CARDIAC PATIENT; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; ERYTHROCYTE TRANSFUSION; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEMATOCRIT; HOSPITAL MORTALITY; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORBIDITY; NEW YORK HEART ASSOCIATION CLASS; OPERATING ROOM; PATIENT SAFETY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESOURCE MANAGEMENT; SURGICAL MORTALITY; SURGICAL PATIENT; THERAPY EFFECT; TREATMENT OUTCOME; ADVERSE EFFECTS; AGED; BLOODLESS CARE; CLINICAL TRIAL; HEART SURGERY; HEART VALVE; MULTICENTER STUDY; POSTOPERATIVE COMPLICATION; PROCEDURES; QUALITY OF LIFE; SURGERY;

ADULT; AGED; BLOODLESS MEDICAL AND SURGICAL PROCEDURES; CARDIAC SURGICAL PROCEDURES; CORONARY ARTERY BYPASS; ERYTHROCYTE TRANSFUSION; FEMALE; HEART VALVES; HEMATOCRIT; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; QUALITY OF LIFE;

EID: 85027413712     PISSN: 00034975     EISSN: 15526259     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2017.05.048     Document Type: Article

References (31)

1. Koch, C.G., Tolerating anemia: taking aim at the right target before pulling the transfusion trigger. Transfusion 54 (2014), 2595–2597.
2. Robich, M.P., Koch, C.G., Johnston, D.R., et al. Trends in blood utilization in United States cardiac surgical patients. Transfusion 55 (2015), 805–814.
3. Bennett-Guerrero, E., Zhao, Y., O'Brien, S.M., et al. Variation in use of blood transfusion in coronary artery bypass graft surgery. JAMA 304 (2010), 1568–1575.
4. Ferraris, V.A., Ferraris, S.P., Saha, S.P., et al. Perioperative blood transfusion and blood conservation in cardiac surgery: The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists clinical practice guideline. Ann Thorac Surg 83:Suppl (2007), 27–86.
5. Hare, G.M., Mu, A., Romaschin, A., et al. Plasma methemoglobin as a potential biomarker of anemic stress in humans. Can J Anaesth 59 (2012), 348–356.
6. Hare, G.M., Tsui, A.K., Ozawa, S., Shander, A., Anaemia: can we define haemoglobin thresholds for impaired oxygen homeostasis and suggest new strategies for treatment?. Best Pract Res Clin Anaesthesiol 27 (2013), 85–98.
7. van Bommel, J., Siegemund, M., Henny, ChP., Ince, C., Heart, kidney, and intestine have different tolerances for anemia. Transl Res 151 (2008), 110–117.
8. Tsui, A.K., Dattani, N.D., Marsden, P.A., et al. Reassessing the risk of hemodilutional anemia: some new pieces to an old puzzle. Can J Anaesth 57 (2010), 779–791.
9. Murphy, G.J., Pike, K., Rogers, C.A., et al. Liberal or restrictive transfusion after cardiac surgery. N Engl J Med 372 (2015), 997–1008.
10. Hajjar, L.A., Vincent, J.L., Galas, F.R., et al. Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA 304 (2010), 1559–1567.
11. Alghamdi, A.A., Davis, A., Brister, S., Corey, P., Logan, A., Development and validation of Transfusion Risk Understanding Scoring Tool (TRUST) to stratify cardiac surgery patients according to their blood transfusion needs. Transfusion 46 (2006), 1120–1129.
12. Loor, G., Li, L., Sabik, J.F., Rajeswaran, J., Blackstone, E.H., Koch, C.G., Nadir hematocrit during cardiopulmonary bypass: end-organ dysfunction and mortality. J Thorac Cardiovasc Surg 144 (2012), 654–662.
13. Koch, C.G., Li, L., Duncan, A.I., et al. Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting. Crit Care Med 34 (2006), 1608–1616.
14. Lefkopoulou, M., Ryan, L., Global tests for multiple binary outcomes. Biometrics 49 (1993), 975–988.
15. Hwang, I.K., Shih, W.J., De Cani, J.S., Group sequential designs using a family of type I error probability spending functions. Stat Med 9 (1990), 1439–1445.
16. Koch, C.G., Li, L., Duncan, A.I., et al. Transfusion in coronary artery bypass grafting is associated with reduced long-term survival. Ann Thorac Surg 81 (2006), 1650–1657.
17. Loor, G., Rajeswaran, J., Li, L., et al. The least of 3 evils: exposure to red blood cell transfusion, anemia, or both?. J Thorac Cardiovasc Surg 146 (2013), 1480–1487.
18. Habib, R.H., Zacharias, A., Schwann, T.A., et al. Role of hemodilutional anemia and transfusion during cardiopulmonary bypass in renal injury after coronary revascularization: implications on operative outcome. Crit Care Med 33 (2005), 1749–1756.
19. Koch, C.G., Li, L., Sun, Z., et al. Hospital-acquired anemia: prevalence, outcomes, and healthcare implications. J Hosp Med 8 (2013), 506–512.
20. Loor, G., Koch, C.G., Sabik, J.F., Li, L., Blackstone, E.H., Implications and management of anemia in cardiac surgery: current state of knowledge. J Thorac Cardiovasc Surg 144 (2012), 538–546.
21. Koch, C., Li, L., Figueroa, P., Mihaljevic, T., Svensson, L., Blackstone, E.H., Transfusion and pulmonary morbidity after cardiac surgery. Ann Thorac Surg 88 (2009), 1410–1418.
22. Koch, C.G., Li, L., Sessler, D.I., et al. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 358 (2008), 1229–1239.
23. Koch, C.G., Li, L., van Wagoner, D.R., Duncan, A.I., Gillinov, A.M., Blackstone, E.H., Red cell transfusion is associated with an increased risk for postoperative atrial fibrillation. Ann Thorac Surg 82 (2006), 1747–1756.
24. Clifford, L., Jia, Q., Subramanian, A., et al. Characterizing the epidemiology of postoperative transfusion-related acute lung injury. Anesthesiology 122 (2015), 12–20.
25. Clifford, L., Jia, Q., Yadav, H., et al. Characterizing the epidemiology of perioperative transfusion-associated circulatory overload. Anesthesiology 122 (2015), 21–28.
26. de Almeida, J.P., Vincent, J.L., Galas, F.R., et al. Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology 122 (2015), 29–38.
27. Park, D.W., Chun, B.C., Kwon, S.S., et al. Red blood cell transfusions are associated with lower mortality in patients with severe sepsis and septic shock: a propensity-matched analysis. Crit Care Med 40 (2012), 3140–3145.
28. Hogervorst, E., Rosseel, P., van der Bom, J., et al. Tolerance of intraoperative hemoglobin decrease during cardiac surgery. Transfusion 54 (2014), 2696–2704.
29. Carson, J.L., Duff, A., Poses, R.M., et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 348 (1996), 1055–1060.
30. Carson, J.L., Sieber, F., Cook, D.R., et al. Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial. Lancet 385 (2015), 1183–1189.
31. Shehata, N., Burns, L.A., Nathan, H., et al. A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery. Transfusion 52 (2012), 91–99.