Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: A randomized pilot trial

Critical Care Medicine

Volumn 41, Issue 10, 2013, Pages 2354-2363

  Walsh, Timothy S ^a   Boyd, Julia A ^b   Watson, Douglas ^c   Hope, David ^a   Lewis, Steff ^a   Krishan, Ashma ^a,b   Forbes, John F ^a   Ramsay, Pamela ^a   Pearse, Rupert ^d   Wallis, Charles ^b   Cairns, Christopher ^e   Cole, Stephen ^f   Wyncoll, Duncan ^g  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c National Blood Transfusion Service   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e Stirling Royal Infirmary   (United Kingdom)

^f UNIVERSITY OF DUNDEE   (United Kingdom)

^g GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

anemia; blood transfusion; clinical trial; critical illness; intensive care

Indexed keywords

HEMOGLOBIN;

ADULT; AGED; APACHE; ARTICLE; ARTIFICIAL VENTILATION; CARDIOVASCULAR DISEASE; COMORBIDITY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE SEVERITY; ERYTHROCYTE TRANSFUSION; FEMALE; FOLLOW UP; HEMOGLOBIN DETERMINATION; HUMAN; INFECTION COMPLICATION; INTENSIVE CARE; INTENSIVE CARE UNIT; INTERMETHOD COMPARISON; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PARALLEL DESIGN; PRIORITY JOURNAL; PROTOCOL COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; TREATMENT DURATION; UNITED KINGDOM; VENTILATED PATIENT;

AGED; AGED, 80 AND OVER; ANEMIA; BLOOD TRANSFUSION; CONFIDENCE INTERVALS; CRITICAL ILLNESS; ERYTHROCYTE TRANSFUSION; FEMALE; GREAT BRITAIN; HEMOGLOBINS; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PILOT PROJECTS; RESPIRATION, ARTIFICIAL;

EID: 84884907227     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318291cce4     Document Type: Article

References (38)

1. Walsh TS, Saleh EE: Anaemia during critical illness. Br J Anaesth 2006; 97:278-291 (Pubitemid 44295662)
2. Hayden SJ, Albert TJ, Watkins TR, et al: Anemia in critical illness: insights into etiology, consequences, and management. Am J Respir Crit Care Med 2012; 185:1049-1057
3. Hébert PC, Wells G, Blajchman MA, et al: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999; 340:409-417 (Pubitemid 29084771)
4. Hébert PC, Blajchman MA, Cook DJ, et al; Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group: Do blood transfusions improve outcomes related to mechanical ventilation? Chest 2001; 119:1850-1857 (Pubitemid 32744945)
5. Hébert PC, Yetisir E, Martin C, et al; Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group: Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Crit Care Med 2001; 29:227-234 (Pubitemid 32171763)
6. Hébert PC, Fergusson D, Blajchman MA, et al; Leukoreduction Study Investigators: Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions. JAMA 2003; 289:1941-1949 (Pubitemid 37430225)
7. Zimrin AB, Hess JR: Current issues relating to the transfusion of stored red blood cells. Vox Sang 2009; 96:93-103
8. Walsh TS, Wyncoll DL, Stanworth SJ: Managing anaemia in critically ill adults. BMJ 2010; 341:c4408
9. Napolitano LM, Kurek S, Luchette FA, et al; American College of Critical Care Medicine of the Society of Critical Care Medicine; Eastern Association for the Surgery of Trauma Practice Management Workgroup: Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. Crit Care Med 2009; 37:3124-3157
10. Carless P, Henry D, Carson J, et al: Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 2010:CD002042.
11. Update in: Cochrane Database Syst Rev 2012; 4:CD002042
12. Josephson CD, Glynn SA, Kleinman SH, et al; State-of-the Science Symposium Transfusion Medicine Committee: A multidisciplinary "think tank": The top 10 clinical trial opportunities in transfusion medicine from the National Heart, Lung, and Blood Institute-sponsored 2009 state-of-the-science symposium. Transfusion 2011; 51:828-841
13. Walsh TS, Maciver CR; Scottish Critical Care Trials Group and Scottish National Blood Transfusion Service Clinical Effectiveness Group: A clinical scenario-based survey of transfusion decisions for intensive care patients with delayed weaning from mechanical ventilation. Transfusion 2009; 49:2661-2667
14. Walsh TS, McClelland DB, Lee RJ, et al; ATICS Study Group: Prevalence of ischaemic heart disease at admission to intensive care and its influence on red cell transfusion thresholds: Multicentre Scottish Study. Br J Anaesth 2005; 94:445-452
15. Levy MM, Abraham E, Zilberberg M, et al: A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. Chest 2005; 127:928-935 (Pubitemid 40775526)
16. Hébert PC, Fergusson DA, Stather D, et al; Canadian Critical Care Trials Group: Revisiting transfusion practices in critically ill patients. Crit Care Med 2005; 33:7-12; discussion 232 (Pubitemid 40116530)
17. Sakr Y, Lobo S, Knuepfer S, et al: Anemia and blood transfusion in a surgical intensive care unit. Crit Care 2010; 14:R92
18. Vincent JL, Sakr Y, Sprung C, et al; Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators: Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study. Anesthesiology 2008; 108:31-39
19. Park DW, Chun BC, Kwon SS, et al: Red blood cell transfusions are associated with lower mortality in patients with severe sepsis and septic shock: A propensity-matched analysis. Crit Care Med 2012; 40:3140-3145
20. Deans KJ, Minneci PC, Klein HG, et al: The relevance of practice misalignments to trials in transfusion medicine. Vox Sang 2010; 99:16-23
21. Jenkinson C, Layte R: Development and testing of the UK SF-12 (short form health survey). J Health Serv Res Policy 1997; 2:14-18 (Pubitemid 27077648)
22. Lennon S, Johnson L: The modified rivermead mobility index: Validity and reliability. Disabil Rehabil 2000; 22:833-839 (Pubitemid 32014165)
23. Walsh TS, Garrioch M, Maciver C, et al; Audit of Transfusion in Intensive Care in Scotland Study Group: Red cell requirements for intensive care units adhering to evidence-based transfusion guidelines. Transfusion 2004; 44:1405-1411 (Pubitemid 39318973)
24. Vincent JL, Baron JF, Reinhart K, et al; ABC (Anemia and Blood Transfusion in Critical Care) Investigators: Anemia and blood transfusion in critically ill patients. JAMA 2002; 288:1499-1507
25. Corwin HL, Gettinger A, Pearl RG, et al: The CRIT Study: Anemia and blood transfusion in the critically ill-current clinical practice in the United States. Crit Care Med 2004; 32:39-52 (Pubitemid 38125561)
26. Papazian L, Forel JM, Gacouin A, et al; ACURASYS Study Investigators: Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010; 363:1107-1116
27. Taccone P, Pesenti A, Latini R, et al; Prone-Supine II Study Group: Prone positioning in patients with moderate and severe acute respiratory distress syndrome: A randomized controlled trial. JAMA 2009; 302:1977-1984
28. Finfer S, Chittock DR, Su SY, et al: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360:1283-1297.
29. Perner A, Haase N, Guttormsen AB, et al; 6S Trial Group; Scandinavian Critical Care Trials Group: Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med 2012; 367:124-134
30. Oeyen SG, Vandijck DM, Benoit DD, et al: Quality of life after intensive care: A systematic review of the literature. Crit Care Med 2010; 38:2386-2400
31. Iwashyna TJ, Ely EW, Smith DM, et al: Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010; 304:1787-1794
32. Bateman AP, McArdle F, Walsh TS: Time course of anemia during six months follow up following intensive care discharge and factors associated with impaired recovery of erythropoiesis. Crit Care Med 2009; 37:1906-1912
33. Claessens YE, Fontenay M, Pene F, et al: Erythropoiesis abnormalities contribute to early-onset anemia in patients with septic shock. Am J Respir Crit Care Med 2006; 174:51-57 (Pubitemid 43955244)
34. Walsh TS, Lee RJ, Maciver CR, et al: Anemia during and at discharge from intensive care: The impact of restrictive blood transfusion practice. Intensive Care Med 2006; 32:100-109 (Pubitemid 43039383)
35. Bennett-Guerrero E, Zhao Y, O'Brien SM, et al: Variation in use of blood transfusion in coronary artery bypass graft surgery. JAMA 2010; 304:1568-1575
36. Frank SM, Savage WJ, Rothschild JA, et al: Variability in blood and blood component utilization as assessed by an anesthesia information management system. Anesthesiology 2012; 117:99-106
37. Hajjar LA, Vincent JL, Galas FR, et al: Transfusion requirements after cardiac surgery: The TRACS randomized controlled trial. JAMA 2010; 304:1559-1567
38. Carson JL, Terrin ML, Noveck H, et al; FOCUS Investigators: Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 2011; 365:2453-2462