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Volumn 128, Issue 3, 2018, Pages 657-670

Antifibrinolytic therapy and perioperative considerations

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; APROTININ; TRANEXAMIC ACID;

EID: 85045340443     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000001997     Document Type: Review
Times cited : (109)

References (96)
  • 1
    • 84922002483 scopus 로고    scopus 로고
    • Fibrinolysis and the control of blood coagulation
    • Chapin JC, Hajjar KA: Fibrinolysis and the control of blood coagulation. Blood Rev 2015; 29:17-24
    • (2015) Blood Rev , vol.29 , pp. 17-24
    • Chapin, J.C.1    Hajjar, K.A.2
  • 2
    • 84931420701 scopus 로고    scopus 로고
    • Basic mechanisms and regulation of fibrinolysis
    • Longstaff C, Kolev K: Basic mechanisms and regulation of fibrinolysis. J Thromb Haemost 2015; 13(suppl 1):S98-105
    • (2015) J Thromb Haemost , vol.13 , pp. S98-S105
    • Longstaff, C.1    Kolev, K.2
  • 3
    • 0017847923 scopus 로고
    • Molecular mechanism of physiological fibrinolysis
    • Wiman B, Collen D: Molecular mechanism of physiological fibrinolysis. Nature 1978; 272:549-50
    • (1978) Nature , vol.272 , pp. 549-550
    • Wiman, B.1    Collen, D.2
  • 5
    • 77954745372 scopus 로고    scopus 로고
    • Antifibrinolytic therapy: New data and new concepts
    • Levy JH: Antifibrinolytic therapy: New data and new concepts. Lancet 2010; 376:3-4
    • (2010) Lancet , vol.376 , pp. 3-4
    • Levy, J.H.1
  • 6
    • 18444386848 scopus 로고    scopus 로고
    • Molecular mechanisms of fibrinolysis
    • Cesarman-Maus G, Hajjar KA: Molecular mechanisms of fibrinolysis. Br J Haematol 2005; 129:307-21
    • (2005) Br J Haematol , vol.129 , pp. 307-321
    • Cesarman-Maus, G.1    Hajjar, K.A.2
  • 7
    • 0030249162 scopus 로고    scopus 로고
    • The human fibrinolytic system
    • Chandler WL: The human fibrinolytic system. Crit Rev Oncol Hematol 1996; 24:27-45
    • (1996) Crit Rev Oncol Hematol , vol.24 , pp. 27-45
    • Chandler, W.L.1
  • 8
    • 0027953315 scopus 로고
    • Structural changes in platelet glycoprotein IIb/IIIa by plasmin: Determinants and functional consequences
    • Pasche B, Ouimet H, Francis S, Loscalzo J: Structural changes in platelet glycoprotein IIb/IIIa by plasmin: Determinants and functional consequences. Blood 1994; 83:404-14
    • (1994) Blood , vol.83 , pp. 404-414
    • Pasche, B.1    Ouimet, H.2    Francis, S.3    Loscalzo, J.4
  • 10
    • 34250692681 scopus 로고    scopus 로고
    • Fibrinolysis, inflammation, and regulation of the plasminogen activating system
    • Medcalf RL: Fibrinolysis, inflammation, and regulation of the plasminogen activating system. J Thromb Haemost 2007; 5(suppl 1):132-42
    • (2007) J Thromb Haemost , vol.5 , pp. 132-142
    • Medcalf, R.L.1
  • 11
    • 2442534668 scopus 로고    scopus 로고
    • Novel aspects and new roles for the serine protease plasmin
    • Syrovets T, Simmet T: Novel aspects and new roles for the serine protease plasmin. Cell Mol Life Sci 2004; 61:873-85
    • (2004) Cell Mol Life Sci , vol.61 , pp. 873-885
    • Syrovets, T.1    Simmet, T.2
  • 12
    • 84877705084 scopus 로고    scopus 로고
    • Biology of Factor XIII and clinical manifestations of Factor XIII deficiency
    • Levy JH, Greenberg C: Biology of Factor XIII and clinical manifestations of Factor XIII deficiency. Transfusion 2013; 53:1120-31
    • (2013) Transfusion , vol.53 , pp. 1120-1131
    • Levy, J.H.1    Greenberg, C.2
  • 13
    • 2942755757 scopus 로고    scopus 로고
    • Thrombin activatable fibrinolysis inhibitor: Not just an inhibitor of fibrinolysis
    • Bajzar L, Jain N, Wang P, Walker JB: Thrombin activatable fibrinolysis inhibitor: Not just an inhibitor of fibrinolysis. Crit Care Med 2004; 32(suppl 5):S320-4
    • (2004) Crit Care Med , vol.32 , pp. S320-S324
    • Bajzar, L.1    Jain, N.2    Wang, P.3    Walker, J.B.4
  • 14
    • 0022201001 scopus 로고
    • The postoperative fibrinolytic shutdown: A rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma
    • Kluft C, Verheijen JH, Jie AF, Rijken DC, Preston FE, Sue-Ling HM, Jespersen J, Aasen AO: The postoperative fibrinolytic shutdown: A rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma. Scand J Clin Lab Invest 1985; 45:605-10
    • (1985) Scand J Clin Lab Invest , vol.45 , pp. 605-610
    • Kluft, C.1    Verheijen, J.H.2    Jie, A.F.3    Rijken, D.C.4    Preston, F.E.5    Sue-Ling, H.M.6    Jespersen, J.7    Aasen, A.O.8
  • 15
    • 84918534965 scopus 로고    scopus 로고
    • Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: The spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy
    • discussion 817
    • Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A: Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: The spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg 2014; 77:811-7; discussion 817
    • (2014) J Trauma Acute Care Surg , vol.77 , pp. 811-817
    • Moore, H.B.1    Moore, E.E.2    Gonzalez, E.3    Chapman, M.P.4    Chin, T.L.5    Silliman, C.C.6    Banerjee, A.7    Sauaia, A.8
  • 17
    • 84964407529 scopus 로고    scopus 로고
    • Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient
    • Moore EE, Moore HB, Gonzalez E, Sauaia A, Banerjee A, Silliman CC: Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient. Transfusion 2016; 56(suppl 2):S110-4
    • (2016) Transfusion , vol.56 , pp. S110-S114
    • Moore, E.E.1    Moore, H.B.2    Gonzalez, E.3    Sauaia, A.4    Banerjee, A.5    Silliman, C.C.6
  • 18
    • 70350459505 scopus 로고    scopus 로고
    • Hyperfibrinolysis after major trauma: Differential diagnosis of lysis patterns and prognostic value of thrombelastometry
    • Schöchl H, Frietsch T, Pavelka M, Jámbor C: Hyperfibrinolysis after major trauma: Differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 2009; 67:125-31
    • (2009) J Trauma , vol.67 , pp. 125-131
    • Schöchl, H.1    Frietsch, T.2    Pavelka, M.3    Jámbor, C.4
  • 20
    • 84872768104 scopus 로고    scopus 로고
    • Point of care devices for assessing bleeding and coagulation in the trauma patient
    • Theusinger OM, Levy JH: Point of care devices for assessing bleeding and coagulation in the trauma patient. Anesthesiol Clin 2013; 31:55-65
    • (2013) Anesthesiol Clin , vol.31 , pp. 55-65
    • Theusinger, O.M.1    Levy, J.H.2
  • 23
    • 84921451901 scopus 로고    scopus 로고
    • Tranexamic acid-An old drug still going strong and making a revival
    • Tengborn L, Blombäck M, Berntorp E: Tranexamic acid-An old drug still going strong and making a revival. Thromb Res 2015; 135:231-42
    • (2015) Thromb Res , vol.135 , pp. 231-242
    • Tengborn, L.1    Blombäck, M.2    Berntorp, E.3
  • 24
    • 84864409676 scopus 로고    scopus 로고
    • The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients
    • Kim H, Szlam F, Tanaka KA, van de Locht A, Ogawa S, Levy JH: The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients. Anesth Analg 2012; 115:244-52
    • (2012) Anesth Analg , vol.115 , pp. 244-252
    • Kim, H.1    Szlam, F.2    Tanaka, K.A.3    Van De Locht, A.4    Ogawa, S.5    Levy, J.H.6
  • 25
    • 0030034663 scopus 로고    scopus 로고
    • Nafamostat mesilate, a broad spectrum protease inhibitor, modulates platelet, neutrophil and contact activation in simulated extracorporeal circulation
    • Sundaram S, Gikakis N, Hack CE, Niewiarowski S, Edmunds LH Jr, Koneti Rao A, Sun L, Cooper SL, Colman RW: Nafamostat mesilate, a broad spectrum protease inhibitor, modulates platelet, neutrophil and contact activation in simulated extracorporeal circulation. Thromb Haemost 1996; 75:76-82
    • (1996) Thromb Haemost , vol.75 , pp. 76-82
    • Sundaram, S.1    Gikakis, N.2    Hack, C.E.3    Niewiarowski, S.4    Edmunds, L.H.5    Koneti Rao, A.6    Sun, L.7    Cooper, S.L.8    Colman, R.W.9
  • 27
    • 84937393992 scopus 로고    scopus 로고
    • Antifibrinolytic therapy for cardiac surgery: An update
    • Koster A, Faraoni D, Levy JH: Antifibrinolytic therapy for cardiac surgery: An update. ANESTHESIOLOGY 2015; 123:214-21
    • (2015) Anesthesiology , vol.123 , pp. 214-221
    • Koster, A.1    Faraoni, D.2    Levy, J.H.3
  • 28
    • 0035118319 scopus 로고    scopus 로고
    • Aprotinin and the systemic inflammatory response after cardiopulmonary bypass
    • Mojcik CF, Levy JH: Aprotinin and the systemic inflammatory response after cardiopulmonary bypass. Ann Thorac Surg 2001; 71:745-54
    • (2001) Ann Thorac Surg , vol.71 , pp. 745-754
    • Mojcik, C.F.1    Levy, J.H.2
  • 29
    • 7544236615 scopus 로고    scopus 로고
    • Clinical inhibition of the seven-transmembrane thrombin receptor (PAR1) by intravenous aprotinin during cardiothoracic surgery
    • Day JR, Punjabi PP, Randi AM, Haskard DO, Landis RC, Taylor KM: Clinical inhibition of the seven-transmembrane thrombin receptor (PAR1) by intravenous aprotinin during cardiothoracic surgery. Circulation 2004; 110:2597-600
    • (2004) Circulation , vol.110 , pp. 2597-2600
    • Day, J.R.1    Punjabi, P.P.2    Randi, A.M.3    Haskard, D.O.4    Landis, R.C.5    Taylor, K.M.6
  • 30
    • 0028792021 scopus 로고
    • A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting
    • Levy JH, Pifarre R, Schaff HV, Horrow JC, Albus R, Spiess B, Rosengart TK, Murray J, Clark RE, Smith P: A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting. Circulation 1995; 92:2236-44
    • (1995) Circulation , vol.92 , pp. 2236-2244
    • Levy, J.H.1    Pifarre, R.2    Schaff, H.V.3    Horrow, J.C.4    Albus, R.5    Spiess, B.6    Rosengart, T.K.7    Murray, J.8    Clark, R.E.9    Smith, P.10
  • 31
    • 3342939227 scopus 로고    scopus 로고
    • Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes
    • Spiess BD, Royston D, Levy JH, Fitch J, Dietrich W, Body S, Murkin J, Nadel A: Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes. Transfusion 2004; 44:1143-8
    • (2004) Transfusion , vol.44 , pp. 1143-1148
    • Spiess, B.D.1    Royston, D.2    Levy, J.H.3    Fitch, J.4    Dietrich, W.5    Body, S.6    Murkin, J.7    Nadel, A.8
  • 32
    • 84942612381 scopus 로고    scopus 로고
    • Aprotinin: Is it time to reconsider?
    • European Society of Anaesthesiology Task Force Reports on Place of Aprotinin in Clinical Anaesthesia
    • European Society of Anaesthesiology Task Force Reports on Place of Aprotinin in Clinical Anaesthesia: Aprotinin: Is it time to reconsider? Eur J Anaesthesiol 2015; 32:591-5
    • (2015) Eur J Anaesthesiol , vol.32 , pp. 591-595
  • 33
    • 0013863828 scopus 로고
    • Epsilon-aminocaproic acid (E-ACA) as a therapeutic agent based on 5 year's clinical experience
    • Nilsson IM, Andersson L, Björkman SE: Epsilon-aminocaproic acid (E-ACA) as a therapeutic agent based on 5 year's clinical experience. Acta Med Scand Suppl 1966; 448:1-46
    • (1966) Acta Med Scand Suppl , vol.448 , pp. 1-46
    • Nilsson, I.M.1    Andersson, L.2    Björkman, S.E.3
  • 34
    • 0002919970 scopus 로고
    • Antifibrinolytic activity and metabolism of 6-aminocaproic acid in man
    • Nilsson IM, Sjoerdsma A, Waldenstrom J: Antifibrinolytic activity and metabolism of 6-aminocaproic acid in man. Lancet 1960; 1:1322-6
    • (1960) Lancet , vol.1 , pp. 1322-1326
    • Nilsson, I.M.1    Sjoerdsma, A.2    Waldenstrom, J.3
  • 35
    • 0013634922 scopus 로고
    • Epsilon-aminocaproic acid and other inhibitors of fibrinolysis
    • McNicol GP, Douglas AS: Epsilon-aminocaproic acid and other inhibitors of fibrinolysis. Br Med Bull 1964; 20:233-9
    • (1964) Br Med Bull , vol.20 , pp. 233-239
    • McNicol, G.P.1    Douglas, A.S.2
  • 36
    • 0019267976 scopus 로고
    • Clinical pharmacology of aminocaproic and tranexamic acids
    • Nilsson IM: Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol Suppl (R Coll Pathol) 1980; 14:41-7
    • (1980) J Clin Pathol Suppl (R Coll Pathol) , vol.14 , pp. 41-47
    • Nilsson, I.M.1
  • 37
    • 0031032742 scopus 로고    scopus 로고
    • Rhabdomyolysis induced by epsilon-aminocaproic acid
    • Seymour BD, Rubinger M: Rhabdomyolysis induced by epsilon-aminocaproic acid. Ann Pharmacother 1997; 31:56-8
    • (1997) Ann Pharmacother , vol.31 , pp. 56-58
    • Seymour, B.D.1    Rubinger, M.2
  • 38
    • 0019989396 scopus 로고
    • Epsilon-aminocaproic acid myopathy Report of a case and literature review
    • Vanneste JA, van Wijngaarden GK: Epsilon-aminocaproic acid myopathy. Report of a case and literature review. Eur Neurol 1982; 21:242-8
    • (1982) Eur Neurol , vol.21 , pp. 242-248
    • Vanneste, J.A.1    Van Wijngaarden, G.K.2
  • 39
    • 0016289814 scopus 로고
    • Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers
    • Eriksson O, Kjellman H, Pilbrant A, Schannong M: Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers. Eur J Clin Pharmacol 1974; 7:375-80
    • (1974) Eur J Clin Pharmacol , vol.7 , pp. 375-380
    • Eriksson, O.1    Kjellman, H.2    Pilbrant, A.3    Schannong, M.4
  • 40
    • 0014432942 scopus 로고
    • Role of urokinase and tissue activator in sustaining bleeding and the management thereof with EACA and AMCA
    • Andersson L, Nilsoon IM, Colleen S, Granstrand B, Melander B: Role of urokinase and tissue activator in sustaining bleeding and the management thereof with EACA and AMCA. Ann NY Acad Sci 1968; 146:642-58
    • (1968) Ann NY Acad Sci , vol.146 , pp. 642-658
    • Andersson, L.1    Nilsoon, I.M.2    Colleen, S.3    Granstrand, B.4    Melander, B.5
  • 42
    • 84922015923 scopus 로고    scopus 로고
    • Efficacy and safety of tranexamic acid administration for the prevention and/or the treatment of post-partum haemorrhage: A systematic review with meta-analysis [article in French]
    • Faraoni D, Carlier C, Samama CM, Levy JH, Ducloy-Bouthors AS: Efficacy and safety of tranexamic acid administration for the prevention and/or the treatment of post-partum haemorrhage: a systematic review with meta-analysis [article in French]. Ann Fr Anesth Reanim 2014; 33:563-71
    • (2014) Ann Fr Anesth Reanim , vol.33 , pp. 563-571
    • Faraoni, D.1    Carlier, C.2    Samama, C.M.3    Levy, J.H.4    Ducloy-Bouthors, A.S.5
  • 43
    • 0029007803 scopus 로고
    • Comparative study of tranexamic acid and norethisterone in the treatment of ovulatory menorrhagia
    • Preston JT, Cameron IT, Adams EJ, Smith SK: Comparative study of tranexamic acid and norethisterone in the treatment of ovulatory menorrhagia. Br J Obstet Gynaecol 1995; 102:401-6
    • (1995) Br J Obstet Gynaecol , vol.102 , pp. 401-406
    • Preston, J.T.1    Cameron, I.T.2    Adams, E.J.3    Smith, S.K.4
  • 44
    • 0034903952 scopus 로고    scopus 로고
    • No increased risk of venous thrombosis in women taking tranexamic acid
    • Berntorp E, Follrud C, Lethagen S: No increased risk of venous thrombosis in women taking tranexamic acid. Thromb Haemost 2001; 86:714-5
    • (2001) Thromb Haemost , vol.86 , pp. 714-715
    • Berntorp, E.1    Follrud, C.2    Lethagen, S.3
  • 45
    • 0026582004 scopus 로고
    • Platelet-dependent thrombin generation after in vitro fibrinolytic treatment
    • Aronson DL, Chang P, Kessler CM: Platelet-dependent thrombin generation after in vitro fibrinolytic treatment. Circulation 1992; 85:1706-12
    • (1992) Circulation , vol.85 , pp. 1706-1712
    • Aronson, D.L.1    Chang, P.2    Kessler, C.M.3
  • 46
    • 0024448496 scopus 로고
    • Induction of marked thrombin activity by pharmacologic concentrations of plasminogen activators in nonanticoagulated whole blood
    • Eisenberg PR, Miletich JP: Induction of marked thrombin activity by pharmacologic concentrations of plasminogen activators in nonanticoagulated whole blood. Thromb Res 1989; 55:635-43
    • (1989) Thromb Res , vol.55 , pp. 635-643
    • Eisenberg, P.R.1    Miletich, J.P.2
  • 47
    • 0023942410 scopus 로고
    • Differential effects of activation of prothrombin by streptokinase compared with urokinase and tissue-type plasminogen activator (t-PA)
    • Eisenberg PR, Miletich JP, Sobel BE, Jaffe AS: Differential effects of activation of prothrombin by streptokinase compared with urokinase and tissue-type plasminogen activator (t-PA). Thromb Res 1988; 50:707-17
    • (1988) Thromb Res , vol.50 , pp. 707-717
    • Eisenberg, P.R.1    Miletich, J.P.2    Sobel, B.E.3    Jaffe, A.S.4
  • 48
    • 0025951501 scopus 로고
    • Relative importance of thrombin compared with plasmin-mediated platelet activation in response to plasminogen activation with streptokinase
    • Winters KJ, Santoro SA, Miletich JP, Eisenberg PR: Relative importance of thrombin compared with plasmin-mediated platelet activation in response to plasminogen activation with streptokinase. Circulation 1991; 84:1552-60
    • (1991) Circulation , vol.84 , pp. 1552-1560
    • Winters, K.J.1    Santoro, S.A.2    Miletich, J.P.3    Eisenberg, P.R.4
  • 50
    • 78651225746 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement
    • Sukeik M, Alshryda S, Haddad FS, Mason JM: Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br 2011; 93:39-46
    • (2011) J Bone Joint Surg Br , vol.93 , pp. 39-46
    • Sukeik, M.1    Alshryda, S.2    Haddad, F.S.3    Mason, J.M.4
  • 52
    • 84906351131 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement
    • Alshryda S, Sukeik M, Sarda P, Blenkinsopp J, Haddad FS, Mason JM: A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J 2014; 96-B:1005-15
    • (2014) Bone Joint J , vol.96 , pp. 1005-1015
    • Alshryda, S.1    Sukeik, M.2    Sarda, P.3    Blenkinsopp, J.4    Haddad, F.S.5    Mason, J.M.6
  • 53
    • 84867651181 scopus 로고    scopus 로고
    • The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: Systematic review and meta-analysis of observational studies and randomized trials
    • Ross J, Al-Shahi Salman R: The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: Systematic review and meta-analysis of observational studies and randomized trials. Curr Drug Saf 2012; 7:44-54
    • (2012) Curr Drug Saf , vol.7 , pp. 44-54
    • Ross, J.1    Al-Shahi Salman, R.2
  • 54
    • 60449090703 scopus 로고    scopus 로고
    • Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials
    • Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W: Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials. Thromb Res 2009; 123:687-96
    • (2009) Thromb Res , vol.123 , pp. 687-696
    • Kagoma, Y.K.1    Crowther, M.A.2    Douketis, J.3    Bhandari, M.4    Eikelboom, J.5    Lim, W.6
  • 55
    • 33845651348 scopus 로고    scopus 로고
    • Efficacy and safety of antifibrinolytic drugs in liver transplantation: A systematic review and meta-analysis
    • Molenaar IQ, Warnaar N, Groen H, Tenvergert EM, Slooff MJ, Porte RJ: Efficacy and safety of antifibrinolytic drugs in liver transplantation: A systematic review and meta-analysis. Am J Transplant 2007; 7:185-94
    • (2007) Am J Transplant , vol.7 , pp. 185-194
    • Molenaar, I.Q.1    Warnaar, N.2    Groen, H.3    Tenvergert, E.M.4    Slooff, M.J.5    Porte, R.J.6
  • 56
    • 85008316411 scopus 로고    scopus 로고
    • Plasmin(ogen) at the nexus of fibrinolysis, inflammation, and complement
    • Foley JH: Plasmin(ogen) at the nexus of fibrinolysis, inflammation, and complement. Semin Thromb Hemost 2017; 43:135-42
    • (2017) Semin Thromb Hemost , vol.43 , pp. 135-142
    • Foley, J.H.1
  • 57
    • 0035877968 scopus 로고    scopus 로고
    • Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation
    • Syrovets T, Jendrach M, Rohwedder A, Schüle A, Simmet T: Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation. Blood 2001; 97:3941-50
    • (2001) Blood , vol.97 , pp. 3941-3950
    • Syrovets, T.1    Jendrach, M.2    Rohwedder, A.3    Schüle, A.4    Simmet, T.5
  • 58
    • 0037031851 scopus 로고    scopus 로고
    • The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways
    • Burysek L, Syrovets T, Simmet T: The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways. J Biol Chem 2002; 277:33509-17
    • (2002) J Biol Chem , vol.277 , pp. 33509-33517
    • Burysek, L.1    Syrovets, T.2    Simmet, T.3
  • 59
    • 51349089060 scopus 로고    scopus 로고
    • Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice
    • Gong Y, Hart E, Shchurin A, Hoover-Plow J: Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice. J Clin Invest 2008; 118:3012-24
    • (2008) J Clin Invest , vol.118 , pp. 3012-3024
    • Gong, Y.1    Hart, E.2    Shchurin, A.3    Hoover-Plow, J.4
  • 66
    • 76249100902 scopus 로고    scopus 로고
    • High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients
    • Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M: High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg 2010; 110:350-3
    • (2010) Anesth Analg , vol.110 , pp. 350-353
    • Murkin, J.M.1    Falter, F.2    Granton, J.3    Young, B.4    Burt, C.5    Chu, M.6
  • 69
    • 85020842129 scopus 로고    scopus 로고
    • Understanding potential drug side effects: Can we translate molecular mechanisms to clinical applications?
    • Koster A, Levy JH: Understanding potential drug side effects: Can we translate molecular mechanisms to clinical applications? ANESTHESIOLOGY 2017; 127:6-8
    • (2017) Anesthesiology , vol.127 , pp. 6-8
    • Koster, A.1    Levy, J.H.2
  • 70
    • 85020442210 scopus 로고    scopus 로고
    • Seizures associated with tranexamic acid for cardiac surgery: A meta-analysis of randomized and non-randomized studies
    • All-Literature Investigation of Cardiovascular Evidence (ALICE) group
    • Takagi H, Ando T, Umemoto T; All-Literature Investigation of Cardiovascular Evidence (ALICE) group: Seizures associated with tranexamic acid for cardiac surgery: A meta-analysis of randomized and non-randomized studies. J Cardiovasc Surg (Torino) 2017; 58:633-41
    • (2017) J Cardiovasc Surg (Torino) , vol.58 , pp. 633-641
    • Takagi, H.1    Ando, T.2    Umemoto, T.3
  • 72
    • 77949413099 scopus 로고    scopus 로고
    • Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation
    • Roullet S, Pillot J, Freyburger G, Biais M, Quinart A, Rault A, Revel P, Sztark F: Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation. Br J Anaesth 2010; 104:422-8
    • (2010) Br J Anaesth , vol.104 , pp. 422-428
    • Roullet, S.1    Pillot, J.2    Freyburger, G.3    Biais, M.4    Quinart, A.5    Rault, A.6    Revel, P.7    Sztark, F.8
  • 75
    • 31844435169 scopus 로고    scopus 로고
    • Perioperative parenteral tranexamic acid in liver tumor resection: A prospective randomized trial toward a "blood transfusion"-free hepatectomy
    • Wu CC, Ho WM, Cheng SB, Yeh DC, Wen MC, Liu TJ, P'eng FK: Perioperative parenteral tranexamic acid in liver tumor resection: A prospective randomized trial toward a "blood transfusion"-free hepatectomy. Ann Surg 2006; 243:173-80
    • (2006) Ann Surg , vol.243 , pp. 173-180
    • Wu, C.C.1    Ho, W.M.2    Cheng, S.B.3    Yeh, D.C.4    Wen, M.C.5    Liu, T.J.6    P'Eng, F.K.7
  • 77
    • 84883875521 scopus 로고    scopus 로고
    • A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty
    • Tan J, Chen H, Liu Q, Chen C, Huang W: A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res 2013; 184:880-7
    • (2013) J Surg Res , vol.184 , pp. 880-887
    • Tan, J.1    Chen, H.2    Liu, Q.3    Chen, C.4    Huang, W.5
  • 78
    • 84885326541 scopus 로고    scopus 로고
    • Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials
    • Li ZJ, Fu X, Xing D, Zhang HF, Zang JC, Ma XL: Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials. Eur Spine J 2013; 22:1950-7
    • (2013) Eur Spine J , vol.22 , pp. 1950-1957
    • Li, Z.J.1    Fu, X.2    Xing, D.3    Zhang, H.F.4    Zang, J.C.5    Ma, X.L.6
  • 79
    • 84990215858 scopus 로고    scopus 로고
    • Comparing σ-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total knee arthroplasty
    • Churchill JL, Puca KE, Meyer E, Carleton M, Anderson MJ: Comparing σ-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total knee arthroplasty. J Knee Surg 2017; 30:460-6
    • (2017) J Knee Surg , vol.30 , pp. 460-466
    • Churchill, J.L.1    Puca, K.E.2    Meyer, E.3    Carleton, M.4    Anderson, M.J.5
  • 80
    • 84973535594 scopus 로고    scopus 로고
    • Comparison of σ-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total hip arthroplasty
    • e1
    • Churchill JL, Puca KE, Meyer ES, Carleton MC, Truchan SL, Anderson MJ: Comparison of σ-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total hip arthroplasty. J Arthroplasty 2016; 31:2795-2799.e1
    • (2016) J Arthroplasty , vol.31 , pp. 2795-2799
    • Churchill, J.L.1    Puca, K.E.2    Meyer, E.S.3    Carleton, M.C.4    Truchan, S.L.5    Anderson, M.J.6
  • 81
    • 85022225320 scopus 로고    scopus 로고
    • Intravenous tranexamic acid bolus plus infusion is not more effective than a single bolus in primary hip arthroplasty: A randomized controlled trial
    • investigators of the PeriOpeRative Tranexamic acid in hip arthrOplasty (PORTO) Study
    • Zufferey PJ, Lanoiselée J, Chapelle C, Borisov DB, Bien JY, Lambert P, Philippot R, Molliex S, Delavenne X; investigators of the PeriOpeRative Tranexamic acid in hip arthrOplasty (PORTO) Study: Intravenous tranexamic acid bolus plus infusion is not more effective than a single bolus in primary hip arthroplasty: A randomized controlled trial. ANESTHESIOLOGY 2017; 127:413-22
    • (2017) Anesthesiology , vol.127 , pp. 413-422
    • Zufferey, P.J.1    Lanoiselée, J.2    Chapelle, C.3    Borisov, D.B.4    Bien, J.Y.5    Lambert, P.6    Philippot, R.7    Molliex, S.8    Delavenne, X.9
  • 82
    • 77955497501 scopus 로고    scopus 로고
    • Tranexamic acid for preventing postpartum haemorrhage
    • Novikova N, Hofmeyr GJ: Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database Syst Rev 2010:CD007872
    • (2010) Cochrane Database Syst Rev , pp. CD007872
    • Novikova, N.1    Hofmeyr, G.J.2
  • 83
    • 80955158449 scopus 로고    scopus 로고
    • Tranexamic acid for postpartum bleeding
    • Roberts I, Ker K: Tranexamic acid for postpartum bleeding. Int J Gynaecol Obstet 2011; 115:220-1
    • (2011) J Gynaecol Obstet , vol.115 , pp. 220-221
    • Roberts, I.1    Ker, K.2
  • 84
    • 85018171360 scopus 로고    scopus 로고
    • Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): An international, randomised, double-blind, placebo-controlled trial
    • Collaborators WT: Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): An international, randomised, double-blind, placebo-controlled trial. Lancet 2017; 389: 2105-16
    • (2017) Lancet , vol.389 , pp. 2105-2116
    • Collaborators, W.T.1
  • 86
    • 84984848445 scopus 로고    scopus 로고
    • Advances in the understanding of trauma-induced coagulopathy
    • Chang R, Cardenas JC, Wade CE, Holcomb JB: Advances in the understanding of trauma-induced coagulopathy. Blood 2016; 128:1043-9
    • (2016) Blood , vol.128 , pp. 1043-1049
    • Chang, R.1    Cardenas, J.C.2    Wade, C.E.3    Holcomb, J.B.4
  • 88
    • 84855891431 scopus 로고    scopus 로고
    • Rebleeding after aneurysmal subarachnoid hemorrhage
    • Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid H
    • Starke RM, Connolly ES Jr, Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid H: Rebleeding after aneurysmal subarachnoid hemorrhage. Neurocrit Care 2011; 15:241-6
    • (2011) Neurocrit Care , vol.15 , pp. 241-246
    • Starke, R.M.1    Connolly, E.S.2
  • 89
    • 0023199110 scopus 로고
    • The risk of rebleeding from ruptured intracranial aneurysms
    • Rosenørn J, Eskesen V, Schmidt K, Rønde F: The risk of rebleeding from ruptured intracranial aneurysms. J Neurosurg 1987; 67:329-32
    • (1987) J Neurosurg , vol.67 , pp. 329-332
    • Rosenørn, J.1    Eskesen, V.2    Schmidt, K.3    Rønde, F.4
  • 90
    • 0042418462 scopus 로고    scopus 로고
    • Antifibrinolytic therapy for aneurysmal subarachnoid hemorrhage: A major update of a cochrane review
    • Roos Y, Rinkel G, Vermeulen M, Algra A, van Gijn J: Antifibrinolytic therapy for aneurysmal subarachnoid hemorrhage: A major update of a cochrane review. Stroke 2003; 34:2308-9
    • (2003) Stroke , vol.34 , pp. 2308-2309
    • Roos, Y.1    Rinkel, G.2    Vermeulen, M.3    Algra, A.4    Van Gijn, J.5
  • 92
    • 0033962206 scopus 로고    scopus 로고
    • Antifibrinolytic treatment in subarachnoid hemorrhage: A randomized placebo-controlled trial STAR Study Group
    • Roos Y: Antifibrinolytic treatment in subarachnoid hemorrhage: A randomized placebo-controlled trial. STAR Study Group. Neurology 2000; 54:77-82
    • (2000) Neurology , vol.54 , pp. 77-82
    • Roos, Y.1
  • 93
    • 0036801577 scopus 로고    scopus 로고
    • Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: A prospective randomized study
    • Hillman J, Fridriksson S, Nilsson O, Yu Z, Saveland H, Jakobsson KE: Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: A prospective randomized study. J Neurosurg 2002; 97:771-8
    • (2002) J Neurosurg , vol.97 , pp. 771-778
    • Hillman, J.1    Fridriksson, S.2    Nilsson, O.3    Yu, Z.4    Saveland, H.5    Jakobsson, K.E.6
  • 95
    • 77957988787 scopus 로고    scopus 로고
    • Shortterm antifibrinolytic therapy before early aneurysm treatment in subarachnoid hemorrhage: Effects on rehemorrhage, cerebral ischemia, and hydrocephalus
    • discussion 939-40
    • Harrigan MR, Rajneesh KF, Ardelt AA, Fisher WS III: Shortterm antifibrinolytic therapy before early aneurysm treatment in subarachnoid hemorrhage: Effects on rehemorrhage, cerebral ischemia, and hydrocephalus. Neurosurgery 2010; 67:935-9; discussion 939-40
    • (2010) Neurosurgery , vol.67 , pp. 935-939
    • Harrigan, M.R.1    Rajneesh, K.F.2    Ardelt, A.A.3    Fisher, W.S.4
  • 96
    • 85048493774 scopus 로고    scopus 로고
    • Topical application of tranexamic acid for the reduction of bleeding
    • Ker K, Beecher D, Roberts I: Topical application of tranexamic acid for the reduction of bleeding. Cochrane Database Syst Rev 2013:CD010562
    • (2013) Cochrane Database Syst Rev , pp. CD010562
    • Ker, K.1    Beecher, D.2    Roberts, I.3


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