High-dose tranexamic acid reduces blood loss in postpartum haemorrhage

Critical Care

Volumn 15, Issue 2, 2011, Pages

  Ducloy Bouthors, Anne Sophie ^a   Jude, Brigitte ^a,b   Duhamel, Alain ^a,b   Broisin, Françoise ^c   Huissoud, Cyril ^c   Keita Meyer, Hawa ^d,e   Mandelbrot, Laurent ^d,e   Tillouche, Nadia ^f   Fontaine, Sylvie ^f   Le Goueff, Françoise ^g   Depret Mosser, Sandrine ^a   Vallet, Benoit ^a,h   Susen, Sophie ^a,b  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b UNIV LILLE   (France)

^c CROIX ROUSSE HOSPITAL   (France)

^d HÔPITAL LOUIS MOURIER   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f CENTRE HOSPITALIER DE VALENCIENNES   (France)

^g CENTRE HOSPITALIER DE ROUBAIX   (France)

^h France Institut Pasteur de Lille   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LOW MOLECULAR WEIGHT HEPARIN; OXYTOCIN; PROCOAGULANT; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; ANEMIA; ARTICLE; BLEEDING; COLLOID; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MULTICENTER STUDY; POSTPARTUM HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEIZURE; THROMBOSIS; VAGINAL DELIVERY; VEIN THROMBOSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; PREGNANCY; PROSPECTIVE STUDY; TREATMENT OUTCOME;

ADULT; ANTIFIBRINOLYTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; POSTPARTUM HEMORRHAGE; PREGNANCY; PROSPECTIVE STUDIES; TRANEXAMIC ACID; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79955076605     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10143     Document Type: Article

References (26)

1. Waterstone M, Bewley S, Wolfe C. Incidence and predictors of severe obstetric morbidity: case-control study. BMJ 2001, 322:1089-1094. 10.1136/bmj.322.7294.1089, 31259, 11337436.
2. Hogan MC, Foreman KJ, Naghavi M, Ahn SY, Wang M, Makela SM, Lopez AD, Lozano R, Murray CJ. Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millenium Development Goal 5. Lancet 2010, 375:1609-1623. 10.1016/S0140-6736(10)60518-1, 20382417.
3. Dupont C, Touzet S, Colin C, Deneux-Tharaux C, Rabilloud M, Clement HJ, Lansac J, Colle MH, Rudigoz RC, . Groupe PITHAGORE 6 Incidence and management of postpartum haemorrhage following the dissemination of guidelines in a network of 16 maternity units in France. Int J Obstet Anesth 2009, 18:320-327. 10.1016/j.ijoa.2009.02.017, 19733052, Groupe PITHAGORE 6.
4. Lewis G, . (Ed) The Confidential Enquiry into Maternal and Child Health (CEMACH). Saving Mothers Lives: Reviewing Maternal Deaths to Make Childhood Safer: 2003-2005. 2007, London: CEMACH, (Ed)., http://www.cemach.org.uk/getattachment/26dae364-1fc9-4a29-a6cb-afb3f251f8f7/Saving-Mothers%E2%80%99-Lives-2003-2005-%28Full-report%29.aspx
5. Mercier FJ, Van de Velde M. Major obstetric hemorrhage. Anesthesiol Clin 2008, 26:53-66. 10.1016/j.anclin.2007.11.008, 18319179.
6. Department of Reproductive Health and Research, World Health Organization WHO Guidelines for the Management of Postpartum Haemorrhage and Retained Placenta. Geneva: WHO Library Cataloguing-in-Publication Data NLM classification: WQ 330, Department of Reproductive Health and Research, World Health Organization.
7. Pfanner G, Kilgert K. [Haemorrhagic complications in obstetrics] [in German]. Hämostaseologie 2006, 26(3 Suppl 1):S56-S63.
8. Charbit B, Mandelbrot L, Samain E, Baron G, Haddaoui B, Keita H, Sibony O, Mahieu-Caputo D, Hurtaud-Roux MF, Huisse MG, Denninger MH, de Prost D, . PPH Study Group The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. J Thromb Haemost 2007, 5:266-273. 10.1111/j.1538-7836.2007.02297.x, 17087729, PPH Study Group.
9. Levy JH, Dutton RP, Hemphill JC, Shander A, Cooper D, Paidas MJ, Kessler CM, Holcomb JB, Lawson JH, . Hemostasis Summit Participants Multidisciplinary approach to the challenge of hemostasis. Anesth Analg 2010, 110:354-364. 10.1213/ANE.0b013e3181c84ba5, 20007735, Hemostasis Summit Participants.
10. Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, McClelland B, Laupacis A, Fergusson D. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2007, 4:CD001886.
11. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera H, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. CRASH-2 trial collaborators Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010, 376:23-32. CRASH-2 trial collaborators.
12. Gai MY, Wu LF, Su QF, Tatsumoto K. Clinical observation of blood loss reduced by tranexamic acid during and after caesarean section: a multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 2004, 112:154-157. 10.1016/S0301-2115(03)00287-2, 14746950.
13. Gohel M, Patel P, Ashoo G, Desai P. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: a randomized case controlled prospective study. J Obstet Gynecol India 2007, 57:227-230.
14. Yang H, Zheng S, Shi C. [Clinical study on the efficacy of tranexamic acid in reducing postpartum blood loss: a randomized, comparative, multicenter trial] [in Chinese]. Zhonghua Fu Chan Ke Za Zhi 2001, 36:590-592.
15. Ferrer P, Roberts I, Sydenham E, Blackhall K, Shakur H. Anti-fibrinolytic agents in post partum haemorrhage: a systematic review. BMC Pregnancy Childbirth 2009, 9:29. 10.1186/1471-2393-9-29, 2727491, 19604358.
16. Levy G, Goffinet F, Carbonne B, Courtois F, Dosquet P, Laissy JP, Mercier F, Revel C, Tessier V, Teurnier F. Recommandations pour la pratique Clinique Hémorragies du post-partum immediate. J Gynecol Obstet Biol Reprod 2004, 33 Suppl:8.
17. Karski JM, Teasdale SJ, Norman PH, Carroll JA, Weisel RD, Glynn MF. Prevention of postbypass bleeding with tranexamic acid and ε-aminocaproic acid. J Cardiothorac Vasc Anesth 1993, 7:431-435. 10.1016/1053-0770(93)90165-H, 8104526.
18. Karski JM, Teasdale SJ, Norman P, Carroll J, VanKessel K, Wong P, Glynn MF. Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid: double-blind, randomized clinical trial. J Thorac Cardiovasc Surg 1995, 110:835-842. 10.1016/S0022-5223(95)70118-4, 7564453.
19. Conover WJ, Iman RL. Rank transformations as a bridge between parametric and nonparametric statistics. Am Stat 1981, 35:124-133.
20. Novikova N, Hofmeyr GJ. Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database Syst Rev 2010, 7:CD007872.
21. Karski JM, Dowd NP, Joiner R, Carroll J, Peniston C, Bailey K, Glynn MF, Teasdale SJ, Cheng DC. The effect of three different doses of tranexamic acid on blood loss after cardiac surgery with mild systemic hypothermia (32 degrees C). J Cardiothorac Vasc Anesth 1998, 12:642-646. 10.1016/S1053-0770(98)90235-X, 9854660.
22. Karkouti K, Beattie WS, Dattilo KM, McCluskey SA, Ghannam M, Hamdy A, Wijeysundera DN, Fedorko L, Yau TM. A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery. Transfusion 2006, 46:327-338. 10.1111/j.1537-2995.2006.00724.x, 16533273.
23. Fergusson DA, Hébert PC, Mazer CD, Fremes S, MacAdams C, Murkin JM, Teoh K, Duke PC, Arellano R, Blajchman MA, Bussières JS, Côté D, Karski J, Martineau R, Robblee JA, Rodger M, Wells G, Clinch J, Pretorius R, . BART Investigators A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 2008, 358:2319-2331. 10.1056/NEJMoa0802395, 18480196, BART Investigators.
24. Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W. Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res 2009, 123:687-696. 10.1016/j.thromres.2008.09.015, 19007970.
25. Aronson JK. Tranexamic acid. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 2006, 3476-3479. New York: Elsevier, 15.
26. Shakur H, Elbourne D, Gülmezoglu M, Alfirevic Z, Ronsmans C, Allen E, Roberts I. The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of post-partum haemorrhage: an international randomized, double blind placebo controlled trial. Trials 2010, 11:40. 10.1186/1745-6215-11-40, 2864262, 20398351.