메뉴 건너뛰기




Volumn 255, Issue 5, 2018, Pages 1281-1294

Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus

Author keywords

Catharanthus roseus; Sonication assisted Agrobacterium medicated transformation (SAAT); Strictosidine synthase (CrSTR); Terpenoid indole alkaloids (TIAs); Tryptophan decarboxylase (CrTDC)

Indexed keywords

ALKALOID; AROMATIC LEVO AMINO ACID DECARBOXYLASE; INDOLE; INDOLE DERIVATIVE; LYASE; STRICTOSIDINE SYNTHETASE; TERPENE; VINBLASTINE;

EID: 85045046031     PISSN: 0033183X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00709-018-1233-1     Document Type: Article
Times cited : (44)

References (69)
  • 1
    • 0032127941 scopus 로고    scopus 로고
    • Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus
    • PID: 9640666
    • Canel C, Lopes-Cardoso MI, Whitmer S, Van der Fits L, Pasquali G, Van der Heijden R, Hoge JHC, Verpoorte R (1998) Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus. Planta 205:414–419
    • (1998) Planta , vol.205 , pp. 414-419
    • Canel, C.1    Lopes-Cardoso, M.I.2    Whitmer, S.3    Van der Fits, L.4    Pasquali, G.5    Van der Heijden, R.6    Hoge, J.H.C.7    Verpoorte, R.8
  • 2
    • 38949166148 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus
    • PID: 18065566
    • Costa MMR, Hilliou F, Duarte P, Pereira LG, Almeida I, Leech M, Memelink J, Barcelo AR, Sottomayor M (2008) Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus. Plant Physiol 146:403–417
    • (2008) Plant Physiol , vol.146 , pp. 403-417
    • Costa, M.M.R.1    Hilliou, F.2    Duarte, P.3    Pereira, L.G.4    Almeida, I.5    Leech, M.6    Memelink, J.7    Barcelo, A.R.8    Sottomayor, M.9
  • 3
    • 0000331036 scopus 로고
    • Subcellular localization of enzymes involved in indole alkaloid biosynthesis in Catharanthus roseus
    • PID: 16665811
    • De Luca V, Cutler AJ (1987) Subcellular localization of enzymes involved in indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol 85:1099–1102
    • (1987) Plant Physiol , vol.85 , pp. 1099-1102
    • De Luca, V.1    Cutler, A.J.2
  • 4
    • 84897503982 scopus 로고    scopus 로고
    • Making iridoids/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation
    • PID: 24709280
    • De Luca V, Salim V, Thamm A, Masada SA, Yu F (2014) Making iridoids/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation. Curr Opin Plant Biol 19:35–42
    • (2014) Curr Opin Plant Biol , vol.19 , pp. 35-42
    • De Luca, V.1    Salim, V.2    Thamm, A.3    Masada, S.A.4    Yu, F.5
  • 5
    • 84990535259 scopus 로고
    • Biosynthesis of indole alkaloids: developmental regulation of the biosynthetic pathway from tabersonine to vindoline in Catharanthus roseus
    • De Luca V, Balsevich J, Tyler RT, Eilert U, Panchuk BD, Kurz WGW (1986) Biosynthesis of indole alkaloids: developmental regulation of the biosynthetic pathway from tabersonine to vindoline in Catharanthus roseus. J Plant Physiol 125:147–156
    • (1986) J Plant Physiol , vol.125 , pp. 147-156
    • De Luca, V.1    Balsevich, J.2    Tyler, R.T.3    Eilert, U.4    Panchuk, B.D.5    Kurz, W.G.W.6
  • 6
    • 85029093810 scopus 로고    scopus 로고
    • A tabersonine 3-reductase Catharanthus roseus mutant accumulates vindoline pathway intermediates
    • Edge A, Qu A, Easson MLAE, Thamm AMK, Kim KH, De Luca V (2017) A tabersonine 3-reductase Catharanthus roseus mutant accumulates vindoline pathway intermediates. Planta 247:155–169. 10.1007/s00425-017-2775-8
    • (2017) Planta , vol.247 , pp. 155-169
    • Edge, A.1    Qu, A.2    Easson, M.L.A.E.3    Thamm, A.M.K.4    Kim, K.H.5    De Luca, V.6
  • 7
    • 34249875679 scopus 로고    scopus 로고
    • Catharanthus terpenoid indole alkaloids: biosynthesis and regulation
    • El-Sayed M, Verpoorte R (2007) Catharanthus terpenoid indole alkaloids: biosynthesis and regulation. Phytochem Rev 6:277–305
    • (2007) Phytochem Rev , vol.6 , pp. 277-305
    • El-Sayed, M.1    Verpoorte, R.2
  • 8
    • 43549115911 scopus 로고    scopus 로고
    • Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants
    • PID: 18476877
    • Facchini PJ, De Luca V (2008) Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants. Plant J 54:763–784
    • (2008) Plant J , vol.54 , pp. 763-784
    • Facchini, P.J.1    De Luca, V.2
  • 9
    • 26844465113 scopus 로고    scopus 로고
    • Synthesis and trafficking of biosynthetic enzymes
    • PID: 16182601
    • Facchini PJ, St-Pierre B (2005) Synthesis and trafficking of biosynthetic enzymes. Curr Opin Plant Biol 8:657–666
    • (2005) Curr Opin Plant Biol , vol.8 , pp. 657-666
    • Facchini, P.J.1    St-Pierre, B.2
  • 10
    • 0039596881 scopus 로고    scopus 로고
    • Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus
    • PID: 10652285
    • Geerlings A, Ibañez MM, Memelink J, van der Heijden R, Verpoorte R (2000) Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J Biol Chem 275:3051–3056
    • (2000) J Biol Chem , vol.275 , pp. 3051-3056
    • Geerlings, A.1    Ibañez, M.M.2    Memelink, J.3    van der Heijden, R.4    Verpoorte, R.5
  • 11
    • 0029360669 scopus 로고
    • Overexpression of a tryptophan decarboxylase cDNA in Catharanthus roseus crown gall calluses results in increased tryptamine levels but not in increased terpenoid indole alkaloid production
    • PID: 8589734
    • Goddijn OJM, Pennings EJM, van der Helm P, Verpoorte R, Hoge JHC (1995) Overexpression of a tryptophan decarboxylase cDNA in Catharanthus roseus crown gall calluses results in increased tryptamine levels but not in increased terpenoid indole alkaloid production. Transgenic Res 4:315–323
    • (1995) Transgenic Res , vol.4 , pp. 315-323
    • Goddijn, O.J.M.1    Pennings, E.J.M.2    van der Helm, P.3    Verpoorte, R.4    Hoge, J.H.C.5
  • 12
    • 69449106943 scopus 로고    scopus 로고
    • Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethyl butenyl 4-diphosphate synthase and geraniol 10-hydroxylase
    • PID: 19504099
    • Guirimand G, Burlat V, Oudin A, Lanoue A, St-Pierre B, Courdavault V (2009) Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethyl butenyl 4-diphosphate synthase and geraniol 10-hydroxylase. Plant Cell Rep 28:1215–1234
    • (2009) Plant Cell Rep , vol.28 , pp. 1215-1234
    • Guirimand, G.1    Burlat, V.2    Oudin, A.3    Lanoue, A.4    St-Pierre, B.5    Courdavault, V.6
  • 14
    • 79951935714 scopus 로고    scopus 로고
    • The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites
    • PID: 21205206
    • Guirimand G, Guihur A, Ginis O, Poutrain P, Héricourt F, Oudin A, Lanoue A, St-Pierre B, Burlat V, Courdavault V (2011a) The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites. FEBS J 278:749–763
    • (2011) FEBS J , vol.278 , pp. 749-763
    • Guirimand, G.1    Guihur, A.2    Ginis, O.3    Poutrain, P.4    Héricourt, F.5    Oudin, A.6    Lanoue, A.7    St-Pierre, B.8    Burlat, V.9    Courdavault, V.10
  • 16
    • 0036332024 scopus 로고    scopus 로고
    • Metabolic engineering of plants for alkaloid production
    • PID: 11800573
    • Hughes RH, Shanks JV (2002) Metabolic engineering of plants for alkaloid production. Metab Eng 4:41–48
    • (2002) Metab Eng , vol.4 , pp. 41-48
    • Hughes, R.H.1    Shanks, J.V.2
  • 17
    • 2542488359 scopus 로고    scopus 로고
    • Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels
    • PID: 15137084
    • Hughes EH, Hong SB, Gibson SI, Shanks JV, San KY (2004a) Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels. Biotechnol Bioeng 86:718–727
    • (2004) Biotechnol Bioeng , vol.86 , pp. 718-727
    • Hughes, E.H.1    Hong, S.B.2    Gibson, S.I.3    Shanks, J.V.4    San, K.Y.5
  • 18
    • 6044269447 scopus 로고    scopus 로고
    • Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine
    • PID: 15491856
    • Hughes EH, Hong SB, Gibson SI, Shanks JV, San KY (2004b) Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine. Metab Eng 6:268–276
    • (2004) Metab Eng , vol.6 , pp. 268-276
    • Hughes, E.H.1    Hong, S.B.2    Gibson, S.I.3    Shanks, J.V.4    San, K.Y.5
  • 19
    • 0002925918 scopus 로고
    • Tryptophan decarboxylase activity in transformed roots from Catharanthus roseus and its relationship to tryptamine, ajmalicine, and catharanthine accumulation during the culture cycle
    • Islas I, Loyola-Vargas VM, Miranda-Ham ML (1994) Tryptophan decarboxylase activity in transformed roots from Catharanthus roseus and its relationship to tryptamine, ajmalicine, and catharanthine accumulation during the culture cycle. In Vitro Cell Dev Biol 30:81–83
    • (1994) In Vitro Cell Dev Biol , vol.30 , pp. 81-83
    • Islas, I.1    Loyola-Vargas, V.M.2    Miranda-Ham, M.L.3
  • 20
    • 0342444416 scopus 로고
    • GUS fusions: β-glucuronidase as a sensitive and versatile gene fusion marker in higher plants
    • Jefferson RA, Kavanagh TA, Bevan MW (1987) GUS fusions: β-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. EMBO J 13:3901–3907
    • (1987) EMBO J , vol.13 , pp. 3901-3907
    • Jefferson, R.A.1    Kavanagh, T.A.2    Bevan, M.W.3
  • 21
    • 0004272995 scopus 로고
    • Mc. Graw Hill Book. Co., New York
    • Johanson DA (1940) Plant Microtechnique. Mc. Graw Hill Book. Co., New York, p 523
    • (1940) Plant Microtechnique , pp. 523
    • Johanson, D.A.1
  • 22
    • 84987881017 scopus 로고    scopus 로고
    • A polymorphic (GA/CT)n- SSR influences promoter activity of tryptophan decarboxylase gene in Catharanthus roseus L. Don
    • PID: 27623355
    • Kumar S, Bhatia S (2016) A polymorphic (GA/CT)n- SSR influences promoter activity of tryptophan decarboxylase gene in Catharanthus roseus L. Don. Sci Rep 6:33280
    • (2016) Sci Rep , vol.6 , pp. 33280
    • Kumar, S.1    Bhatia, S.2
  • 23
    • 79953049581 scopus 로고    scopus 로고
    • Cloning and characterization of two new class III peroxidase genes from Catharanthus roseus
    • PID: 21320785
    • Kumar S, Jaggi M, Taneja J, Sinha AK (2011) Cloning and characterization of two new class III peroxidase genes from Catharanthus roseus. Plant Physiol Biochem 49:404–412
    • (2011) Plant Physiol Biochem , vol.49 , pp. 404-412
    • Kumar, S.1    Jaggi, M.2    Taneja, J.3    Sinha, A.K.4
  • 24
    • 79955587604 scopus 로고    scopus 로고
    • Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpression of transcriptional factor ORCA2
    • Liu DH, Ren WW, Cui LJ, Zhang LD, Sun XF, Tang KX (2011) Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpression of transcriptional factor ORCA2. Afr J Biotechnol 10:3260–3268
    • (2011) Afr J Biotechnol , vol.10 , pp. 3260-3268
    • Liu, D.H.1    Ren, W.W.2    Cui, L.J.3    Zhang, L.D.4    Sun, X.F.5    Tang, K.X.6
  • 25
    • 85008214590 scopus 로고    scopus 로고
    • Transcriptional regulation and transport of terpenoid indole alkaloid in Catharanthus roseus: exploration of new research directions
    • Liu J, Cai J, Wang R, Yang S (2017) Transcriptional regulation and transport of terpenoid indole alkaloid in Catharanthus roseus: exploration of new research directions. Int J Mol Sci 18:53
    • (2017) Int J Mol Sci , vol.18 , pp. 53
    • Liu, J.1    Cai, J.2    Wang, R.3    Yang, S.4
  • 26
    • 0000920714 scopus 로고
    • Commercially-feasible micropropagation of mountain laurel, Kalmia atifolia, by use of shoot-tip culture. Comb
    • Lloyd G, McCown BH (1980) Commercially-feasible micropropagation of mountain laurel, Kalmia atifolia, by use of shoot-tip culture. Comb. Proc Int Plant Prop Soc Proc 30:421–427
    • (1980) Proc Int Plant Prop Soc Proc , vol.30 , pp. 421-427
    • Lloyd, G.1    McCown, B.H.2
  • 27
    • 85007357558 scopus 로고    scopus 로고
    • Plant metabolic engineering strategies for the production of pharmaceutical terpenoids
    • Lu X, Tang K, Li P (2016) Plant metabolic engineering strategies for the production of pharmaceutical terpenoids. Front Plant Sci 7:1647. 10.3389/fpls.2016.01647
    • (2016) Front Plant Sci , vol.7 , pp. 1647
    • Lu, X.1    Tang, K.2    Li, P.3
  • 28
    • 34447109108 scopus 로고    scopus 로고
    • Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots
    • PID: 17574634
    • Magnotta M, Murata J, Chen J, De Luca V (2007) Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots. Phytochemistry 68:1922–1931
    • (2007) Phytochemistry , vol.68 , pp. 1922-1931
    • Magnotta, M.1    Murata, J.2    Chen, J.3    De Luca, V.4
  • 29
    • 33947418152 scopus 로고    scopus 로고
    • Cellular and subcellular organisation of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
    • Mahroug S, Burlat V, St-Pierre B (2007) Cellular and subcellular organisation of the monoterpenoid indole alkaloid pathway in Catharanthus roseus. Phytochem Rev 6:363–381
    • (2007) Phytochem Rev , vol.6 , pp. 363-381
    • Mahroug, S.1    Burlat, V.2    St-Pierre, B.3
  • 30
    • 85040151874 scopus 로고    scopus 로고
    • Biotechnological interventions in designing specialty medicinal herbs for twenty-first century: some emerging trends in pathway modulation through metabolic engineering
    • Sharma RK, Arora R, (eds), Jaypee Brothers Medical Publishers, New Delhi
    • Mathur AK, Mathur A, Seth R, Verma P, Vyas D (2006) Biotechnological interventions in designing specialty medicinal herbs for twenty-first century: some emerging trends in pathway modulation through metabolic engineering. In: Sharma RK, Arora R (eds) Herbal drugs: a twenty-first century perspective. Jaypee Brothers Medical Publishers, New Delhi, pp 83–94
    • (2006) Herbal drugs: a twenty-first century perspective , pp. 83-94
    • Mathur, A.K.1    Mathur, A.2    Seth, R.3    Verma, P.4    Vyas, D.5
  • 31
    • 0000688846 scopus 로고
    • Expression of enzymatically active and correctly targeted strictosidine synthase in transgenic tobacco plants
    • PID: 24186336
    • McKnight TD, Bergey DR, Burnett RJ, Nessler CL (1991) Expression of enzymatically active and correctly targeted strictosidine synthase in transgenic tobacco plants. Planta 185:148–152
    • (1991) Planta , vol.185 , pp. 148-152
    • McKnight, T.D.1    Bergey, D.R.2    Burnett, R.J.3    Nessler, C.L.4
  • 34
    • 84960410200 scopus 로고    scopus 로고
    • RNAi and homologous over-expression based functional approaches reveal triterpenoid synthase gene- cycloartenol synthase is involved in downstream withanolide biosynthesis in Withania somnifera
    • Mishra S, Bansal S, Mishra B, Sangwan RS, Asha, Jadaun JS, Sangwan NS (2016) RNAi and homologous over-expression based functional approaches reveal triterpenoid synthase gene- cycloartenol synthase is involved in downstream withanolide biosynthesis in Withania somnifera. PLoS One 11(2):e0149691. 10.1371/journal.pone.0149691
    • (2016) PLoS One , vol.11 , Issue.2
    • Mishra, S.1    Bansal, S.2    Mishra, B.3    Sangwan, R.S.4    Asha5    Jadaun, J.S.6    Sangwan, N.S.7
  • 35
    • 84982358134 scopus 로고
    • A revised medium for rapid growth and bioassays with tobacco tissue cultures
    • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15:473–497
    • (1962) Physiol Plant , vol.15 , pp. 473-497
    • Murashige, T.1    Skoog, F.2
  • 36
    • 34547838647 scopus 로고    scopus 로고
    • Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene secoiridoid pathways in Catharanthus roseus
    • PID: 17611800
    • Oudin A, Mahroug S, Courdavault V, Hervouet N, Zelwer C, Rodriguez-Conception M, St-Pierre B, Burlat V (2007) Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene secoiridoid pathways in Catharanthus roseus. Plant Mol Biol 65:13–30
    • (2007) Plant Mol Biol , vol.65 , pp. 13-30
    • Oudin, A.1    Mahroug, S.2    Courdavault, V.3    Hervouet, N.4    Zelwer, C.5    Rodriguez-Conception, M.6    St-Pierre, B.7    Burlat, V.8
  • 37
    • 84865167953 scopus 로고    scopus 로고
    • Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics
    • Pan Q, Wang Q, Yuan F, Xing S, Zhao J, Choi YH, Verpoorte R, Tian Y, Wang G, Tang K (2012) Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. PLoS One 7:1–14
    • (2012) PLoS One , vol.7 , pp. 1-14
    • Pan, Q.1    Wang, Q.2    Yuan, F.3    Xing, S.4    Zhao, J.5    Choi, Y.H.6    Verpoorte, R.7    Tian, Y.8    Wang, G.9    Tang, K.10
  • 38
    • 84961364607 scopus 로고    scopus 로고
    • Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites
    • Pan Q, Rianika N, Mustafa Tang K, Choi YH, Verpoorte R (2016) Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites. Phytochem Rev 15:221–250
    • (2016) Phytochem Rev , vol.15 , pp. 221-250
    • Pan, Q.1    Rianika, N.2    Mustafa Tang, K.3    Choi, Y.H.4    Verpoorte, R.5
  • 39
    • 84971276137 scopus 로고    scopus 로고
    • Fungal endophyte of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloids biosynthesis
    • Pandey SS, Singh S, Babu CSV, Shanker K, Srivastava NK, Shukla AK, Kalra A (2016) Fungal endophyte of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloids biosynthesis. Sci Rep 6:26583. 10.1038/srep26583
    • (2016) Sci Rep , vol.6 , pp. 26583
    • Pandey, S.S.1    Singh, S.2    Babu, C.S.V.3    Shanker, K.4    Srivastava, N.K.5    Shukla, A.K.6    Kalra, A.7
  • 40
    • 33745767359 scopus 로고    scopus 로고
    • Metabolic engineering of cell cultures versus whole plant complexity in the production of bioactive monoterpene indole alkaloids: recent progress related to an old dilemma
    • PID: 16716935
    • Pasquali G, Porto DD, Fett-Neto AG (2006) Metabolic engineering of cell cultures versus whole plant complexity in the production of bioactive monoterpene indole alkaloids: recent progress related to an old dilemma. J Biosci Bioeng 101:287–296
    • (2006) J Biosci Bioeng , vol.101 , pp. 287-296
    • Pasquali, G.1    Porto, D.D.2    Fett-Neto, A.G.3
  • 41
    • 79952103915 scopus 로고    scopus 로고
    • The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots
    • PID: 21144909
    • Peebles CAM, Sander GW, Hughes EH, Peacock R, Shanks JV, San KY (2011) The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. Metab Eng 13:234–240
    • (2011) Metab Eng , vol.13 , pp. 234-240
    • Peebles, C.A.M.1    Sander, G.W.2    Hughes, E.H.3    Peacock, R.4    Shanks, J.V.5    San, K.Y.6
  • 42
    • 84929224113 scopus 로고    scopus 로고
    • Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast
    • PID: 25918424
    • Qu Y, Michael LAEE, Jordan F, Razvan S, Tomas H, Luca VD (2015) Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast. PNAS 112:6224–6229
    • (2015) PNAS , vol.112 , pp. 6224-6229
    • Qu, Y.1    Michael, L.A.E.E.2    Jordan, F.3    Razvan, S.4    Tomas, H.5    Luca, V.D.6
  • 45
    • 85013137866 scopus 로고    scopus 로고
    • Optimization of a Bacopa monnieri-based genetic transformation model for testing the expression efficiency of pathway gene constructs of medicinal crops
    • Sharma A, Verma N, Verma P, Verma RK, Mathur A, Mathur AK (2017a) Optimization of a Bacopa monnieri-based genetic transformation model for testing the expression efficiency of pathway gene constructs of medicinal crops. In Vitro Cell Dev Bio Plants 53:22–32
    • (2017) In Vitro Cell Dev Bio Plants , vol.53 , pp. 22-32
    • Sharma, A.1    Verma, N.2    Verma, P.3    Verma, R.K.4    Mathur, A.5    Mathur, A.K.6
  • 46
    • 85028535575 scopus 로고    scopus 로고
    • Genetic engineering approach using early Vinca alkaloid biosynthesis genes led to increased tryptamine and terpenoid indole alkaloids biosynthesis in differentiating cultures of Catharanthus roseus
    • Sharma A, Verma P, Mathur A, Mathur AK (2017b) Genetic engineering approach using early Vinca alkaloid biosynthesis genes led to increased tryptamine and terpenoid indole alkaloids biosynthesis in differentiating cultures of Catharanthus roseus. Protoplasma 255:425–435. 10.1007/s00709-017-1151-7
    • (2017) Protoplasma , vol.255 , pp. 425-435
    • Sharma, A.1    Verma, P.2    Mathur, A.3    Mathur, A.K.4
  • 47
    • 0001754861 scopus 로고
    • Subcellular localization of tryptophan decarboxylase, strictosidine synthase and strictosidine glucosidase in suspension cultured cells of Catharanthus roseus and Tabernaemontana divaricata
    • PID: 24201788
    • Stevens LH, Blom TJM, Verpoorte R (1993) Subcellular localization of tryptophan decarboxylase, strictosidine synthase and strictosidine glucosidase in suspension cultured cells of Catharanthus roseus and Tabernaemontana divaricata. Plant Cell Rep 12:573–576
    • (1993) Plant Cell Rep , vol.12 , pp. 573-576
    • Stevens, L.H.1    Blom, T.J.M.2    Verpoorte, R.3
  • 48
    • 0030880173 scopus 로고    scopus 로고
    • SAAT: sonication assisted Agrobacterium-mediated transformation
    • Trick HN, Finer JJ (1997) SAAT: sonication assisted Agrobacterium-mediated transformation. Transgenic Res 6:329–336
    • (1997) Transgenic Res , vol.6 , pp. 329-336
    • Trick, H.N.1    Finer, J.J.2
  • 49
    • 84966295039 scopus 로고    scopus 로고
    • Discovery and metabolic engineering of iridoid/secoiridoid and monoterpenoid indole alkaloid biosynthesis
    • Thamm AMK, Qu Y, De Luca V (2016) Discovery and metabolic engineering of iridoid/secoiridoid and monoterpenoid indole alkaloid biosynthesis. Phytochem Rev 15(3):339–361
    • (2016) Phytochem Rev , vol.15 , Issue.3 , pp. 339-361
    • Thamm, A.M.K.1    Qu, Y.2    De Luca, V.3
  • 51
    • 33847073370 scopus 로고    scopus 로고
    • Expanding the metabolic engineering toolbox: more options to engineer cells
    • PID: 17254656
    • Tyo KE, Alper HS, Stephanopoulos GN (2007) Expanding the metabolic engineering toolbox: more options to engineer cells. Trends Biotechnol 25:132–147
    • (2007) Trends Biotechnol , vol.25 , pp. 132-147
    • Tyo, K.E.1    Alper, H.S.2    Stephanopoulos, G.N.3
  • 54
    • 0025159194 scopus 로고
    • Construction of an intron-containing marker gene: splicing of the intron in transgenic plants and its use in monitoring early events in Agrobacterium-mediated plant transformation
    • PID: 2325623
    • Vancanneyt G, Schmidt R, O’Connor-Sanchez A, Willmitzer L, Rocha-Sosa M (1990) Construction of an intron-containing marker gene: splicing of the intron in transgenic plants and its use in monitoring early events in Agrobacterium-mediated plant transformation. Mol Gen Genet 220:245–250
    • (1990) Mol Gen Genet , vol.220 , pp. 245-250
    • Vancanneyt, G.1    Schmidt, R.2    O’Connor-Sanchez, A.3    Willmitzer, L.4    Rocha-Sosa, M.5
  • 55
    • 80052032793 scopus 로고    scopus 로고
    • Direct shoot bud organogenesis and plant regeneration from leaf explants in Catharanthus roseus
    • Verma P, Mathur AK (2011a) Direct shoot bud organogenesis and plant regeneration from leaf explants in Catharanthus roseus. Plant Cell Tissue Organ Cult 106:401–408
    • (2011) Plant Cell Tissue Organ Cult , vol.106 , pp. 401-408
    • Verma, P.1    Mathur, A.K.2
  • 56
    • 79955081677 scopus 로고    scopus 로고
    • Agrobacterium tumefaciens mediated transgenic plant production via direct shoot bud organogenesis from pre-plasmolyzed leaf explants of Catharanthus roseus
    • PID: 21207108
    • Verma P, Mathur AK (2011b) Agrobacterium tumefaciens mediated transgenic plant production via direct shoot bud organogenesis from pre-plasmolyzed leaf explants of Catharanthus roseus. Biotechnol Lett 33:1053–1060
    • (2011) Biotechnol Lett , vol.33 , pp. 1053-1060
    • Verma, P.1    Mathur, A.K.2
  • 57
    • 84858338693 scopus 로고    scopus 로고
    • Emerging trends in research on spatial and temporal organization of terpenoid indole alkaloid pathway in Catharanthus roseus: a literature update
    • PID: 21630129
    • Verma P, Mathur AK, Srivastava A, Mathur A (2012) Emerging trends in research on spatial and temporal organization of terpenoid indole alkaloid pathway in Catharanthus roseus: a literature update. Protoplasma 249:255–268
    • (2012) Protoplasma , vol.249 , pp. 255-268
    • Verma, P.1    Mathur, A.K.2    Srivastava, A.3    Mathur, A.4
  • 58
    • 84939881969 scopus 로고    scopus 로고
    • Over-expression of Catharanthus roseus tryptophan decarboxylase and strictosidine synthase in rol gene integrated transgenic cell suspensions of Vinca minor
    • PID: 25106473
    • Verma P, Sharma A, Khan SA, Shanker K, Mathur AK (2015a) Over-expression of Catharanthus roseus tryptophan decarboxylase and strictosidine synthase in rol gene integrated transgenic cell suspensions of Vinca minor. Protoplasma 252:373–381
    • (2015) Protoplasma , vol.252 , pp. 373-381
    • Verma, P.1    Sharma, A.2    Khan, S.A.3    Shanker, K.4    Mathur, A.K.5
  • 59
    • 84946141920 scopus 로고    scopus 로고
    • Transgenic studies for modulating terpenoid indole alkaloids pathway in Catharanthus roseus: present status and future options
    • Verma P, Mathur AK, Khan SA, Verma N, Sharma A (2015b) Transgenic studies for modulating terpenoid indole alkaloids pathway in Catharanthus roseus: present status and future options. Phytochem Rev 16:19–54. 10.1007/s11101-015-9447-8
    • (2015) Phytochem Rev , vol.16 , pp. 19-54
    • Verma, P.1    Mathur, A.K.2    Khan, S.A.3    Verma, N.4    Sharma, A.5
  • 60
    • 84920620380 scopus 로고    scopus 로고
    • Morphogenetic and chemical stability of long-term maintained -mediated transgenic plants
    • PID: 25102992
    • Verma P, Sharma A, Khan SA, Mathur AK, Shanker K (2014) Morphogenetic and chemical stability of long-term maintained -mediated transgenic plants. Nat Prod Res 29(4):315–320
    • (2014) Nat Prod Res , vol.29 , Issue.4 , pp. 315-320
    • Verma, P.1    Sharma, A.2    Khan, S.A.3    Mathur, A.K.4    Shanker, K.5
  • 62
    • 10844277123 scopus 로고    scopus 로고
    • Biosynthesis of terpenoid indole alkaloids in Catharanthus roseuscells
    • Cordell GA, (ed), Academic, San Diego
    • Verpoorte R, van der Heijden R, Moreno PRH (1997) Biosynthesis of terpenoid indole alkaloids in Catharanthus roseuscells. In: Cordell GA (ed) The alkaloids, vol 49. Academic, San Diego, pp 221–299
    • (1997) The alkaloids , vol.49 , pp. 221-299
    • Verpoorte, R.1    van der Heijden, R.2    Moreno, P.R.H.3
  • 63
    • 84862994822 scopus 로고    scopus 로고
    • Development of efficient Catharanthus roseus regeneration and transformation system using Agrobacterium tumefaciens and hypocotyls as explants
    • Wang Q, Xing S, Pan Q, Yuan F, Zhao J, Tian Y, Chen Y, Wang G, Tang K (2012) Development of efficient Catharanthus roseus regeneration and transformation system using Agrobacterium tumefaciens and hypocotyls as explants. BMC Biotechol 12:34–46
    • (2012) BMC Biotechol , vol.12 , pp. 34-46
    • Wang, Q.1    Xing, S.2    Pan, Q.3    Yuan, F.4    Zhao, J.5    Tian, Y.6    Chen, Y.7    Wang, G.8    Tang, K.9
  • 64
    • 84975258298 scopus 로고    scopus 로고
    • Ethylene-induced vinblastine accumulation is related to activated expression of downstream TIA pathway genes in Catharanthus roseus
    • Wang X, Pan YJ, Chang BW, Hu YB, Guo XR, Tang ZH (2016) Ethylene-induced vinblastine accumulation is related to activated expression of downstream TIA pathway genes in Catharanthus roseus. Bio Med Res Int 2016:1–8. 10.1155/2016/3708187
    • (2016) Bio Med Res Int , vol.2016 , pp. 1-8
    • Wang, X.1    Pan, Y.J.2    Chang, B.W.3    Hu, Y.B.4    Guo, X.R.5    Tang, Z.H.6
  • 65
    • 0000326239 scopus 로고    scopus 로고
    • Influence of precursor availability on alkaloid accumulation by transgenic cell line of Catharanthus roseus
    • PID: 9490777
    • Whitmer S, Canel C, Hallard D, Goncalves C, Verpoorte R (1998) Influence of precursor availability on alkaloid accumulation by transgenic cell line of Catharanthus roseus. Plant Physiol 116:853–857
    • (1998) Plant Physiol , vol.116 , pp. 853-857
    • Whitmer, S.1    Canel, C.2    Hallard, D.3    Goncalves, C.4    Verpoorte, R.5
  • 66
    • 0036232568 scopus 로고    scopus 로고
    • Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseus
    • Whitmer S, van der Heijden R, Verpoorte R (2002) Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseus. Plant Cell Tissue Organ Cult 69:85–93
    • (2002) Plant Cell Tissue Organ Cult , vol.69 , pp. 85-93
    • Whitmer, S.1    van der Heijden, R.2    Verpoorte, R.3
  • 67
    • 0037178212 scopus 로고    scopus 로고
    • Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase overexpressing transgenic cell line T22 of Catharanthus roseus
    • Whitmer S, van der Heijden R, Verpoorte R (2003) Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase overexpressing transgenic cell line T22 of Catharanthus roseus. J Biotechnol 96:193–203
    • (2003) J Biotechnol , vol.96 , pp. 193-203
    • Whitmer, S.1    van der Heijden, R.2    Verpoorte, R.3
  • 68
    • 0038558546 scopus 로고    scopus 로고
    • Long-term instability of alkaloid production by stably transformed cell lines of Catharanthus roseus
    • Whitmer S, Canel C, van der Heijden R, Verpoorte R (2004) Long-term instability of alkaloid production by stably transformed cell lines of Catharanthus roseus. Plant Cell Tissue Organ Cult 74:73–80
    • (2004) Plant Cell Tissue Organ Cult , vol.74 , pp. 73-80
    • Whitmer, S.1    Canel, C.2    van der Heijden, R.3    Verpoorte, R.4
  • 69
    • 34249872436 scopus 로고    scopus 로고
    • Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: from biochemical processing to metabolic engineering
    • Zhao J, Verpoorte R (2007) Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: from biochemical processing to metabolic engineering. Phytochem Rev 6:435–457
    • (2007) Phytochem Rev , vol.6 , pp. 435-457
    • Zhao, J.1    Verpoorte, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.