Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity

Science Immunology

Volumn 2, Issue 17, 2017, Pages

  Xia, Houjun ^a   Wang, Wei ^a,b   Crespo, Joel ^a   Kryczek, Ilona ^a   Li, Wei ^a   Wei, Shuang ^a   Bian, Zhaoqun ^a,c   Maj, Tomasz ^a   He, Mingxiao ^d   Liu, Rebecca J ^a   He, Youwen ^d   Rattan, Ramandeep ^e   Munkarah, Adnan ^e   Guan, Jun Lin ^c   Zou, Weiping ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; PROTEIN TYROSINE KINASE; RB1CC1 PROTEIN, HUMAN; RB1CC1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL; APOPTOSIS; AUTOPHAGY; C57BL MOUSE; DRUG EFFECT; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; OVARY TUMOR; PATHOLOGY; T LYMPHOCYTE; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTIC ACID; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASMS, EXPERIMENTAL; OVARIAN NEOPLASMS; PROTEIN-TYROSINE KINASES; T-LYMPHOCYTES;

EID: 85044591072     PISSN: None     EISSN: 24709468     Source Type: Journal    
DOI: 10.1126/sciimmunol.aan4631     Document Type: Article

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