EASL Clinical Practice Guidelines on hepatitis E virus infection

Journal of Hepatology

Volumn 68, Issue 6, 2018, Pages 1256-1271

  Dalton, Harry R ^a   Kamar, Nassim ^a   Baylis, Sally A ^a   Moradpour, Darius ^a   Wedemeyer, Heiner ^a   Negro, Francesco ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE HEPATITIS; ARTICLE; CLINICAL FEATURE; CRYOGLOBULINEMIA; DIFFERENTIAL DIAGNOSIS; HEMATOLOGIC DISEASE; HEPATITIS E; HEPATITIS E VIRUS; HEPATITIS E VIRUS GENOTYPE 1; HEPATITIS E VIRUS GENOTYPE 2; HEPATITIS E VIRUS GENOTYPE 3; HEPATITIS E VIRUS GENOTYPE 4; HUMAN; IMMUNOASSAY; IMMUNOCOMPROMISED PATIENT; IMMUNOHISTOCHEMISTRY; KIDNEY INJURY; LABORATORY DIAGNOSIS; NEUROLOGIC DISEASE; NONHUMAN; ORGAN TRANSPLANTATION; PANCREATITIS; PRACTICE GUIDELINE; PRIORITY JOURNAL; VASCULARIZATION; ANIMAL; EUROPE; GENETICS; GENOTYPE; MEDICAL SOCIETY; VIROLOGY; ZOONOSIS;

ANIMALS; EUROPE; GENOTYPE; HEPATITIS E; HEPATITIS E VIRUS; HUMANS; SOCIETIES, MEDICAL; ZOONOSES;

EID: 85044575164     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2018.03.005     Document Type: Article

References (159)

1. Guyatt, G.H., Oxman, A.D., Vist, G.E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336 (2008), 924–926.
2. Balayan, M.S., Andjaparidze, A.G., Savinskaya, S.S., Ketiladze, E.S., Braginsky, D.M., Savinov, A.P., et al. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 20 (1983), 23–31.
3. Reyes, G.R., Purdy, M.A., Kim, J.P., Luk, K.C., Young, L.M., Fry, K.E., et al. Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 247 (1990), 1335–1339.
4. Dalton, H.R., Bendall, R., Ijaz, S., Banks, M., Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis 8 (2008), 698–709.
5. Kamar, N., Bendall, R., Legrand-Abravanel, F., Xia, N.S., Ijaz, S., Izopet, J., et al. Hepatitis E. Lancet 379 (2012), 2477–2488.
6. Kamar, N., Dalton, H.R., Abravanel, F., Izopet, J., Hepatitis E virus infection. Clin Microbiol Rev 27 (2014), 116–138.
7. Adlhoch, C., Avellon, A., Baylis, S.A., Ciccaglione, A.R., Couturier, E., de Sousa, R., et al. Hepatitis E virus: Assessment of the epidemiological situation in humans in Europe, 2014/15. J Clin Virol 82 (2016), 9–16.
8. Smith, D.B., Simmonds, P. International Committee on Taxonomy of Viruses Hepeviridae Study Group, Jameel, S., Emerson, S.U., Harrison, T.J., et al. Consensus proposals for classification of the family Hepeviridae. J Gen Virol 95 (2014), 2223–2232.
9. Purdy, M.A., Harrison, T.J., Jameel, S., Meng, X.J., Okamoto, H., Van der Poel, W.H.M., et al. ICTV virus taxonomy profile: hepeviridae. J Gen Virol 98 (2017), 2645–2646.
10. Abravanel, F., Lhomme, S., El Costa, H., Schvartz, B., Peron, J.M., Kamar, N., et al. Rabbit hepatitis E virus infections in humans, France. Emerg Infect Dis 23 (2017), 1191–1193.
11. Lee, G.H., Tan, B.H., Teo, E.C., Lim, S.G., Dan, Y.Y., Wee, A., et al. Chronic infection with camelid hepatitis E virus in a liver transplant recipient who regularly consumes camel meat and milk. Gastroenterology 150 (2016), 355–357 e353.
12. Debing, Y., Moradpour, D., Neyts, J., Gouttenoire, J., Update on hepatitis E virology: Implications for clinical practice. J Hepatol 65 (2016), 200–212.
13. Pischke, S., Hartl, J., Pas, S.D., Lohse, A.W., Jacobs, B.C., Van der Eijk, A.A., Hepatitis E virus: Infection beyond the liver?. J Hepatol 66 (2017), 1082–1095.
14. Takahashi, M., Tanaka, T., Takahashi, H., Hoshino, Y., Nagashima, S., Jirintai, et al. Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation. J Clin Microbiol 48 (2010), 1112–1125.
15. Feng, Z., Lemon, S.M., Peek-a-boo: membrane hijacking and the pathogenesis of viral hepatitis. Trends Microbiol 22 (2014), 59–64.
16. Naidu, S.S., Viswanathan, R., Infectious hepatitis in pregnancy during Delhi epidemic. Indian J Med Res 45 (1957), 71–76.
17. Khuroo, M.S., Study of an epidemic of non-A, non-B hepatitis. Possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type. Am J Med 68 (1980), 818–824.
18. Rein, D.B., Stevens, G.A., Theaker, J., Wittenborn, J.S., Wiersma, S.T., The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology 55 (2012), 988–997.
19. Kumar Acharya, S., Kumar Sharma, P., Singh, R., Kumar Mohanty, S., Madan, K., Kumar Jha, J., et al. Hepatitis E virus (HEV) infection in patients with cirrhosis is associated with rapid decompensation and death. J Hepatol 46 (2007), 387–394.
20. Kumar, A., Saraswat, V.A., Hepatitis E and acute-on-chronic liver failure. J Clin Exp Hepatol 3 (2013), 225–230.
21. Ramachandran, J., Eapen, C.E., Kang, G., Abraham, P., Hubert, D.D., Kurian, G., et al. Hepatitis E superinfection produces severe decompensation in patients with chronic liver disease. J Gastroenterol Hepatol 19 (2004), 134–138.
22. Shalimar, Kedia, S., Gunjan, D., Sonika, U., Mahapatra, S.J., Nayak, B., et al. Acute liver failure due to hepatitis E virus infection is associated with better survival than other etiologies in Indian patients. Dig Dis Sci 62 (2017), 1058–1066.
23. Kmush, B.L., Labrique, A.B., Dalton, H.R., Ahmed, Z.B., Ticehurst, J.R., Heaney, C.D., et al. Two generations of “Gold Standards”: the impact of a decade in hepatitis E virus testing innovation on population seroprevalence. Am J Trop Med Hyg 93 (2015), 714–717.
24. Ren, X., Wu, P., Wang, L., Geng, M., Zeng, L., Zhang, J., et al. Changing epidemiology of hepatitis A and hepatitis E viruses in China, 1990–2014. Emerg Infect Dis 23 (2017), 276–279.
25. Shrestha, A.C., Flower, R.L., Seed, C.R., Rajkarnikar, M., Shrestha, S.K., Thapa, U., et al. Hepatitis E virus seroepidemiology: a post-earthquake study among blood donors in Nepal. BMC Infect Dis, 16, 2016, 707.
26. Madden, R.G., Wallace, S., Sonderup, M., Korsman, S., Chivese, T., Gavine, B., et al. Hepatitis E virus: Western Cape, South Africa. World J Gastroenterol 22 (2016), 9853–9859.
27. Rendon, J., Hoyos, M.C., di Filippo, D., Cortes-Mancera, F., Mantilla, C., Velasquez, M.M., et al. Hepatitis E virus genotype 3 in Colombia: survey in patients with clinical diagnosis of viral hepatitis. PLoS One, 11, 2016, e0148417.
28. WHO HEV Guidelines, 2018. in press.
29. Hewitt, P.E., Ijaz, S., Brailsford, S.R., Brett, R., Dicks, S., Haywood, B., et al. Hepatitis E virus in blood components: a prevalence and transmission study in southeast England. Lancet 384 (2014), 1766–1773.
30. Bura, M., Łagiedo, M., Michalak, M., Sikora, J., Mozer-Lisewska, I., Hepatitis E virus IgG seroprevalence in HIV patients and blood donors, west-central Poland. Int J Infect Dis 61 (2017), 20–22.
31. Bouwknegt, M., Frankena, K., Rutjes, S.A., Wellenberg, G.J., de Roda Husman, A.M., van der Poel, W.H., et al. Estimation of hepatitis E virus transmission among pigs due to contact-exposure. Vet Res, 39, 2008, 40.
32. Berto, A., Martelli, F., Grierson, S., Banks, M., Hepatitis E virus in pork food chain, United Kingdom, 2009–2010. Emerg Infect Dis 18 (2012), 1358–1360.
33. Colson, P., Borentain, P., Queyriaux, B., Kaba, M., Moal, V., Gallian, P., et al. Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis 202 (2010), 825–834.
34. Maunula, L., Kaupke, A., Vasickova, P., Soderberg, K., Kozyra, I., Lazic, S., et al. Tracing enteric viruses in the European berry fruit supply chain. Int J Food Microbiol 167 (2013), 177–185.
35. Terio, V., Bottaro, M., Pavoni, E., Losio, M.N., Serraino, A., Giacometti, F., et al. Occurrence of hepatitis A and E and norovirus GI and GII in ready-to-eat vegetables in Italy. Int J Food Microbiol 249 (2017), 61–65.
36. Montalvo Villalba, M.C., Cruz Martinez, D., Ahmad, I., Rodriguez Lay, L.A., Bello Corredor, M., Guevara March, C., et al. Hepatitis E virus in bottlenose dolphins Tursiops truncatus. Dis Aquat Organ 123 (2017), 13–18.
37. Mansuy, J.M., Gallian, P., Dimeglio, C., Saune, K., Arnaud, C., Pelletier, B., et al. A nationwide survey of hepatitis E viral infection in French blood donors. Hepatology 63 (2016), 1145–1154.
38. Huang, F., Li, Y., Yu, W., Jing, S., Wang, J., Long, F., et al. Excretion of infectious hepatitis E virus into milk in cows imposes high risks of zoonosis. Hepatology 64 (2016), 350–359.
39. Baechlein, C., Becher, P., No evidence for zoonotic hepatitis E virus infection through dairy milk in Germany. Hepatology 65 (2017), 394–395.
40. Bouamra, Y., Gerolami, R., Arzouni, J.P., Grimaud, J.C., Lafforgue, P., Nelli, M., et al. Emergence of autochthonous infections with hepatitis E virus of genotype 4 in Europe. Intervirology 57 (2014), 43–48.
41. Holm, D.K., Moessner, B.K., Engle, R.E., Zaaijer, H.L., Georgsen, J., Purcell, R.H., et al. Declining prevalence of hepatitis E antibodies among Danish blood donors. Transfusion 55 (2015), 1662–1667.
42. Thom K, Gilhooly P, McGowan K, Malloy K, Jarvis L, Crossan C, et al. HEV in Scotland: evidence of recent increase in viral circulation in humans. Euro Surveill. in press.
43. Ijaz, S., Said, B., Boxall, E., Smit, E., Morgan, D., Tedder, R.S., Indigenous hepatitis E in England and wales from 2003 to 2012: evidence of an emerging novel phylotype of viruses. J Infect Dis 209 (2014), 1212–1218.
44. Zaaijer, H.L., No artifact, hepatitis E is emerging. Hepatology, 62, 2015, 654.
45. Müller, B., Koch, H., Pichl, L., PCR-Screening of blood donations for hepatitis E with the cobas HEV test performed on the new Roche cobas 8800 platform in minipools of 6. Transfus Med Hemother 42 (2015), 1–66.
46. Lucarelli, C., Spada, E., Taliani, G., Chionne, P., Madonna, E., Marcantonio, C., et al. High prevalence of anti-hepatitis E virus antibodies among blood donors in central Italy, February to March 2014. Euro Surveill, 21, 2016.
47. https://ecdc.europa.eu/en/news-events/1st-hepatitis-e-virus-network-hevnet-meeting, accessed March 2018.
48. Manka, P., Bechmann, L.P., Coombes, J.D., Thodou, V., Schlattjan, M., Kahraman, A., et al. Hepatitis E virus infection as a possible cause of acute liver failure in Europe. Clin Gastroenterol Hepatol 13 (2015), 1836–1842 e1832; quiz e1157–e1838.
49. Dalton, H.R., Stableforth, W., Thurairajah, P., Hazeldine, S., Remnarace, R., Usama, W., et al. Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur J Gastroenterol Hepatol 20 (2008), 784–790.
50. Dalton, H.R., Bendall, R.P., Rashid, M., Ellis, V., Ali, R., Ramnarace, R., et al. Host risk factors and autochthonous hepatitis E infection. Eur J Gastroenterol Hepatol 23 (2011), 1200–1205.
51. Blasco-Perrin, H., Madden, R.G., Stanley, A., Crossan, C., Hunter, J.G., Vine, L., et al. Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study. Aliment Pharmacol Ther 42 (2015), 574–581.
52. Haim-Boukobza, S., Coilly, A., Sebagh, M., Bouamoud, M., Antonini, T., Roche, B., et al. Hepatitis E infection in patients with severe acute alcoholic hepatitis. Liver Int 35 (2015), 870–875.
53. Kamar, N., Selves, J., Mansuy, J.M., Ouezzani, L., Peron, J.M., Guitard, J., et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med 358 (2008), 811–817.
54. Kamar, N., Mansuy, J.M., Cointault, O., Selves, J., Abravanel, F., Danjoux, M., et al. Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients. Am J Transplant 8 (2008), 1744–1748.
55. Gerolami, R., Moal, V., Colson, P., Chronic hepatitis E with cirrhosis in a kidney-transplant recipient. N Engl J Med 358 (2008), 859–860.
56. Kamar, N., Rostaing, L., Legrand-Abravanel, F., Izopet, J., How should hepatitis E virus infection be defined in organ-transplant recipients?. Am J Transplant 13 (2013), 1935–1936.
57. Meisner, S., Polywka, S., Memmler, M., Nashan, B., Lohse, A.W., Sterneck, M., et al. Definition of chronic hepatitis E after liver transplant conforms to convention. Am J Transplant 15 (2015), 3011–3012.
58. Kamar, N., Garrouste, C., Haagsma, E.B., Garrigue, V., Pischke, S., Chauvet, C., et al. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology 140 (2011), 1481–1489.
59. Kamar, N., Abravanel, F., Selves, J., Garrouste, C., Esposito, L., Lavayssiere, L., et al. Influence of immunosuppressive therapy on the natural history of genotype 3 hepatitis-E virus infection after organ transplantation. Transplantation 89 (2010), 353–360.
60. Pischke, S., Stiefel, P., Franz, B., Bremer, B., Suneetha, P.V., Heim, A., et al. Chronic hepatitis e in heart transplant recipients. Am J Transplant 12 (2012), 3128–3133.
61. Legrand-Abravanel, F., Kamar, N., Sandres-Saune, K., Garrouste, C., Dubois, M., Mansuy, J.M., et al. Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. J Infect Dis 202 (2010), 835–844.
62. Kamar, N., Bendall, R.P., Peron, J.M., Cintas, P., Prudhomme, L., Mansuy, J.M., et al. Hepatitis E virus and neurologic disorders. Emerg Infect Dis 17 (2011), 173–179.
63. Dalton, H.R., Kamar, N., van Eijk, J.J., McLean, B.N., Cintas, P., Bendall, R.P., et al. Hepatitis E virus and neurological injury. Nat Rev Neurol 12 (2016), 77–85.
64. Kamar, N., Weclawiack, H., Guilbeaud-Frugier, C., Legrand-Abravanel, F., Cointault, O., Ribes, D., et al. Hepatitis E virus and the kidney in solid-organ-transplant patients. Transplantation 93 (2012), 617–623.
65. Dalton, H.R., Bendall, R., Keane, F., Tedder, R., Ijaz, S., Persistent carriage of hepatitis E virus in patients with HIV infection. N Engl J Med 361 (2009), 1025–1027.
66. Woolson, K.L., Forbes, A., Vine, L., Beynon, L., McElhinney, L., Panayi, V., et al. Extra-hepatic manifestations of autochthonous hepatitis E infection. Aliment Pharmacol Ther 40 (2014), 1282–1291.
67. van Eijk, J.J., Madden, R.G., van der Eijk, A.A., Hunter, J.G., Reimerink, J.H., Bendall, R.P., et al. Neuralgic amyotrophy and hepatitis E virus infection. Neurology 82 (2014), 498–503.
68. van Eijk, J.J.J., Dalton, H.R., Ripellino, P., Madden, R.G., Jones, C., Fritz, M., et al. Clinical phenotype and outcome of hepatitis E virus-associated neuralgic amyotrophy. Neurology 89:9 (2017), 909–991.
69. Dalton, H.R., van Eijk, J.J., Cintas, P., Madden, R., Jones, C., Webb, G., et al. Hepatitis E infection and acute non-traumatic neurological injury: A prospective pilot multicenter study. J Hepatol 67 (2017), 925–932.
70. Dalton, H.R., Seghatchian, J., Hepatitis E virus: Emerging from the shadows in developed countries. Transfus Apher Sci 55 (2016), 271–274.
71. van den Berg, B., van der Eijk, A.A., Pas, S.D., Hunter, J.G., Madden, R.G., Tio-Gillen, A.P., et al. Guillain-Barre syndrome associated with preceding hepatitis E virus infection. Neurology 82 (2014), 491–497.
72. Geurtsvankessel, C.H., Islam, Z., Mohammad, Q.D., Jacobs, B.C., Endtz, H.P., Osterhaus, A.D., Hepatitis E and Guillain-Barre syndrome. Clin Infect Dis 57 (2013), 1369–1370.
73. Fukae, J., Tsugawa, J., Ouma, S., Umezu, T., Kusunoki, S., Tsuboi, Y., Guillain-Barre and Miller Fisher syndromes in patients with anti-hepatitis E virus antibody: a hospital-based survey in Japan. Neurol Sci 37 (2016), 1849–1851.
74. Stevens, O., Claeys, K.G., Poesen, K., Saegeman, V., Van Damme, P., Diagnostic challenges and clinical characteristics of hepatitis E virus-associated Guillain-Barre syndrome. JAMA Neurol 74 (2017), 26–33.
75. Kamar, N., Izopet, J., Cintas, P., Garrouste, C., Uro-Coste, E., Cointault, O., et al. Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis. Am J Transplant 10 (2010), 1321–1324.
76. Dalton, H.R, Keane, F., Bendall, R., Mathew, J., Ijaz, S., Treatment of chronic hepatitis E in a HIV positive patient. Ann Intern Med 155 (2011), 479–480.
77. Zhou, X., Huang, F., Xu, L., Lin, Z., de Vrij, F.M.S., Ayo-Martin, A.C., et al. Hepatitis E virus infects neurons and brains. J Infect Dis 214 (2017), 361–368.
78. Ali, G., Kumar, M., Bali, S., Wadhwa, W., Hepatitis E associated immune thrombocytopenia and membranous glomerulonephritis. Indian J Nephrol 11 (2001), 70–72.
79. Taton, B., Moreau, K., Lepreux, S., Bachelet, T., Trimoulet, P., De Ledinghen, V., et al. Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation. Transpl Infect Dis 15 (2013), E211–E215.
80. Del Bello, A., Guilbeau-Frugier, C., Josse, A.G., Rostaing, L., Izopet, J., Kamar, N., Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin. Transpl Infect Dis 17 (2015), 279–283.
81. Guinault, D., Ribes, D., Delas, A., Milongo, D., Abravanel, F., Puissant Lubrano, B., et al. Hepatitis E virus-induced cryglobulinemic glomerulonephritis in a non-immunocompromised person. Am J Kidney Dis 67 (2016), 660–663.
82. Pischke, S., Polywka, S., Haag, F., Iking-Konert, C., Sterneck, M., Lutgehetmann, M., et al. Association of hepatitis E virus and essential cryoglobulinemia?. J Clin Virol 67 (2015), 23–24.
83. Bazerbachi, F., Leise, M.D., Watt, K.D., Murad, M.H., Prokop, L.J., Haffar, S., Systematic review of mixed cryoglobulinemia associated with hepatitis E virus infection: association or causation?. Gastroenterol Rep 5 (2017), 178–184.
84. Pischke, S., Behrendt, P., Manns, M.P., Wedemeyer, H., HEV-associated cryoglobulinaemia and extrahepatic manifestations of hepatitis E. Lancet Infect Dis 14 (2014), 678–679.
85. Sinha, S., Jha, R., Lakhtakia, S., Narayan, G., Acute pancreatitis following kidney transplantation - role of viral infections. Clin Transplant 17 (2003), 32–36.
86. Bhagat, S., Wadhawan, M., Sud, R., Arora, A., Hepatitis viruses causing pancreatitis and hepatitis: a case series and review of literature. Pancreas 36 (2008), 424–427.
87. Deniel, C., Coton, T., Brardjanian, S., Guisset, M., Nicand, E., Simon, F., Acute pancreatitis: a rare complication of acute hepatitis E. J Clin Virol 51 (2011), 202–204.
88. Singh, N.K., Gangappa, M., Acute immune thrombocytopenia associated with hepatitis E in an adult. Am J Hematol 82 (2007), 942–943.
89. Colson, P., Payraudeau, E., Leonnet, C., De Montigny, S., Villeneuve, L., Motte, A., et al. Severe thrombocytopenia associated with acute hepatitis E virus infection. J Clin Microbiol 46 (2008), 2450–2452.
90. Thapa, R., Mallick, D., Ghosh, A., Childhood hepatitis E infection complicated by acute immune thrombocytopenia. J Pediatr Hematol Oncol, 31, 2009, 151.
91. Fourquet, E., Mansuy, J.M., Bureau, C., Recher, C., Vinel, J.P., Izopet, J., et al. Severe thrombocytopenia associated with acute autochthonous hepatitis E. J Clin Virol 48 (2010), 73–74.
92. Abid, S., Khan, A.H., Severe hemolysis and renal failure in glucose-6-phosphate dehydrogenase deficient patients with hepatitis E. Am J Gastroenterol 97 (2002), 1544–1547.
93. Mishra, P., Mahapatra, M., Kumar, R., Pati, H.P., Autoimmune hemolytic anemia and erythroid hypoplasia associated with hepatitis E. Indian J Gastroenterol 26 (2007), 195–196.
94. Shah, S.A., Lal, A., Idrees, M., Hussain, A., Jeet, C., Malik, F.A., et al. Hepatitis E virus-associated aplastic anaemia: the first case of its kind. J Clin Virol 54 (2012), 96–97.
95. Goyal, A., Mishra, D.K., Kawar, R., Kalmath, B.C., Sharma, A., Gautam, S., Hepatitis E associated myocarditis: an unusual entity. Bombay Hosp J 51 (2009), 361–362.
96. Dumoulin, F.L., Liese, H., Acute hepatitis E virus infection and autoimmune thyroiditis: yet another trigger?. BMJ Case Rep, 2012, 2012.
97. Thapa, R., Biswas, B., Mallick, D., Henoch-Schonlein purpura triggered by acute hepatitis E virus infection. J Emerg Med 39 (2010), 218–219.
98. Belbezier, A., Deroux, A., Sarrot-Reynauld, F., Larrat, S., Bouillet, L., Myasthenia gravis associated with acute hepatitis E infection in immunocompetent woman. Emerg Infect Dis 20 (2014), 908–910.
99. Baylis, S.A., Hanschmann, K.M., Blumel, J., Nubling, C.M., HEV Collaborative Study Group. Standardization of hepatitis E virus (HEV) nucleic acid amplification technique-based assays: an initial study to evaluate a panel of HEV strains and investigate laboratory performance. J Clin Microbiol 49 (2011), 1234–1239.
100. Baylis, S.A., Blumel, J., Mizusawa, S., Matsubayashi, K., Sakata, H., Okada, Y., et al. World Health Organization International Standard to harmonize assays for detection of hepatitis E virus RNA. Emerg Infect Dis 19 (2013), 729–735.
101. Baylis, S.A., Crossan, C., Corman, V.M., Blumel, J., Scobie, L., Dalton, H.R., Unusual serological response to hepatitis E virus in plasma donors consistent with re-infection. Vox Sang 109 (2015), 406–409.
102. Lan, X., Yang, B., Li, B.Y., Yin, X.P., Li, X.R., Liu, J.X., Reverse transcription-loop-mediated isothermal amplification assay for rapid detection of hepatitis E virus. J Clin Microbiol 47 (2009), 2304–2306.
103. Jothikumar, N., Cromeans, T.L., Robertson, B.H., Meng, X.J., Hill, V.R., A broadly reactive one-step real-time RT-PCR assay for rapid and sensitive detection of hepatitis E virus. J Virol Methods 131 (2006), 65–71.
104. Garson, J.A., Ferns, R.B., Grant, P.R., Ijaz, S., Nastouli, E., Szypulska, R., et al. Minor groove binder modification of widely used TaqMan probe for hepatitis E virus reduces risk of false negative real-time PCR results. J Virol Methods 186 (2012), 157–160.
105. Hyams, C., Mabayoje, D.A., Copping, R., Maranao, D., Patel, M., Labbett, W., et al. Serological cross reactivity to CMV and EBV causes problems in the diagnosis of acute hepatitis E virus infection. J Med Virol 86 (2014), 478–483.
106. Bendall, R., Ellis, V., Ijaz, S., Ali, R., Dalton, H.R, A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J Med Virol 82 (2010), 799–805.
107. Zhang, F., Li, X., Li, Z., Harrison, T.J., Chong, H., Qiao, S., et al. Detection of HEV antigen as a novel marker for the diagnosis of hepatitis E. J Med Virol 78 (2006), 1441–1448.
108. Wen, G.P., Tang, Z.M., Yang, F., Zhang, K., Ji, W.F., Cai, W., et al. A valuable antigen detection method for diagnosis of acute hepatitis E. J Clin Microbiol 53 (2015), 782–788.
109. Zhao, C., Geng, Y., Harrison, T.J., Huang, W., Song, A., Wang, Y., Evaluation of an antigen-capture EIA for the diagnosis of hepatitis E virus infection. J Viral Hepat 22 (2015), 957–963.
110. Behrendt, P., Bremer, B., Todt, D., Brown, R.J., Heim, A., Manns, M.P., et al. Hepatitis E virus (HEV) ORF2 antigen levels differentiate between acute and chronic HEV infection. J Infect Dis 214 (2016), 361–368.
111. Montpellier, C., Wychowski, C., Sayed, I.M., Meunier, J.C., Saliou, J.M., Ankavay, M., et al. Hepatitis E virus lifecycle and identification of 3 forms of the ORF2 capsid protein. Gastroenterology 154 (2018), 211–223 e218.
112. Lenggenhager, D., Gouttenoire, J., Malehmir, M., Bawohl, M., Honcharova-Biletska, H., Kreutzer, S., et al. Visualization of hepatitis E virus RNA and proteins in the human liver. J Hepatol 215 (2017), 1197–1206.
113. Davern, T.J., Chalasani, N., Fontana, R.J., Hayashi, P.H., Protiva, P., Kleiner, D.E., et al. Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury. Gastroenterology 141 (2011), 1665–1672 e1661–e1669.
114. Dalton, H.R., Fellows, H.J., Stableforth, W., Joseph, M., Thurairajah, P.H., Warshow, U., et al. The role of hepatitis E virus testing in drug-induced liver injury. Aliment Pharmacol Ther 26 (2007), 1429–1435.
115. Satake, M., Matsubayashi, K., Hoshi, Y., Taira, R., Furui, Y., Kokudo, N., et al. Unique clinical courses of transfusion-transmitted hepatitis E in patients with immunosuppression. Transfusion 57 (2017), 280–288.
116. Peron, J.M., Dalton, H.R, Izopet, J., Kamar, N., Acute autochthonous hepatitis E in western patients with underlying chronic liver disease: a role for ribavirin?. J Hepatol 54 (2011), 1323–1324 [Author reply 1324–1325].
117. Zhou, X., Wang, Y., Metselaar, H.J., Janssen, H.L., Peppelenbosch, M.P., Pan, Q., Rapamycin and everolimus facilitate hepatitis E virus replication: revealing a basal defense mechanism of PI3K-PKB-mTOR pathway. J Hepatol 61 (2014), 746–754.
118. Wang, Y., Zhou, X., Debing, Y., Chen, K., Van Der Laan, L.J., Neyts, J., et al. Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. Gastroenterology 146 (2014), 1775–1783.
119. Kamar, N., Rostaing, L., Abravanel, F., Garrouste, C., Esposito, L., Cardeau-Desangles, I., et al. Pegylated interferon-alpha for treating chronic hepatitis E virus infection after liver transplantation. Clin Infect Dis 50 (2010), e30–e33.
120. Haagsma, E.B., Riezebos-Brilman, A., van den Berg, A.P., Porte, R.J., Niesters, H.G., Treatment of chronic hepatitis E in liver transplant recipients with pegylated interferon alpha-2b. Liver Transpl 16 (2010), 474–477.
121. Kamar, N., Abravanel, F., Garrouste, C., Cardeau-Desangles, I., Mansuy, J.M., Weclawiak, H., et al. Three-month pegylated interferon-alpha-2a therapy for chronic hepatitis E virus infection in a haemodialysis patient. Nephrol Dial Transplant 25 (2010), 2792–2795.
122. Rostaing, L., Izopet, J., Baron, E., Duffaut, M., Puel, J., Durand, D., Treatment of chronic hepatitis C with recombinant interferon alpha in kidney transplant recipients. Transplantation 59 (1995), 1426–1431.
123. Mallet, V., Nicand, E., Sultanik, P., Chakvetadze, C., Tesse, S., Thervet, E., et al. Brief communication: case reports of ribavirin treatment for chronic hepatitis E. Ann Intern Med 153 (2010), 85–89.
124. Kamar, N., Rostaing, L., Abravanel, F., Garrouste, C., Lhomme, S., Esposito, L., et al. Ribavirin therapy inhibits viral replication in patients with chronic hepatitis E virus infection. Gastroenterology 139 (2010), 1612–1618.
125. Pischke, S., Hardkte, S., Bode, U., Birkner, S., Chatzikyrkou, C., Kauffmann, W., et al. Ribavirin treatment of acute and chronic hepatitis E: a single-centre experience. Liver Int 33 (2013), 722–726.
126. Kamar, N., Mallet, V., Izopet, J., Ribavirin for chronic hepatitis E virus infection. N Engl J Med 370 (2014), 2447–2448.
127. Kamar, N., Chatelut, E., Manolis, E., Lafont, T., Izopet, J., Rostaing, L., Ribavirin pharmacokinetics in renal and liver transplant patients: evidence that it depends on renal function. Am J Kidney Dis 43 (2004), 140–146.
128. Debing, Y., Emerson, S.U., Wang, Y., Pan, Q., Balzarini, J., Dallmeier, K., et al. Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon. Antimicrob Agents Chemother 58 (2014), 267–273.
129. Pischke, S., Wedemeyer, H., Hepatitis E virus infection: multiple faces of an underestimated problem. J Hepatol 58 (2013), 1045–1046.
130. Kamar, N., Lhomme, S., Abravanel, F., Cointault, O., Esposito, L., Cardeau-Desangles, I., et al. An early viral response predicts the virological response to ribavirin in hepatitis E virus organ transplant patients. Transplantation 99 (2015), 2124–2131.
131. Debing, Y., Gisa, A., Dallmeier, K., Pischke, S., Bremer, B., Manns, M., et al. A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients. Gastroenterology 147 (2014), 1008–1011.
132. Lhomme, S., Kamar, N., Nicot, F., Ducos, J., Bismuth, M., Garrigue, V., et al. Mutation in the hepatitis E virus polymerase and outcome of ribavirin therapy. Antimicrob Agents Chemother 60 (2015), 1608–1614.
133. Todt, D., Gisa, A., Radonic, A., Nitsche, A., Behrendt, P., Suneetha, P.V., et al. In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. Gut 65 (2016), 1733–1743.
134. Debing, Y., Ramiere, C., Dallmeier, K., Piorkowski, G., Trabaud, M.A., Lebosse, F., et al. Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity. J Hepatol 147 (2016), 1008–1011.
135. Kamar, N., Izopet, J., Tripon, S., Bismuth, M., Hillaire, S., Dumortier, J., et al. Ribavirin for chronic hepatitis E virus infection in transplant recipients. N Engl J Med 370 (2014), 1111–1120.
136. Abravanel, F., Lhomme, S., Rostaing, L., Kamar, N., Izopet, J., Protracted fecal shedding of HEV during ribavirin therapy predicts treatment relapse. Clin Infect Dis 60 (2015), 96–99.
137. Kamar, N., Wang, W., Dalton, H.R., Pan, Q., Direct-acting antiviral therapy for hepatitis E virus?. Lancet Gastroenterol Hepatol 2 (2017), 154–155.
138. van der Valk, M., Zaaijer, H.L., Kater, A.P., Schinkel, J., Sofosbuvir shows antiviral activity in a patient with chronic hepatitis E virus infection. J Hepatol 66 (2017), 242–243.
139. Donnelly, M.C., Imlach, S.N., Abravanel, F., Ramalingam, S., Johannessen, I., Petrik, J., et al. Sofosbuvir and daclatasvir anti-viral therapy fails to clear HEV viremia and restore reactive T cells in a HEV/HCV co-infected liver transplant recipient. Gastroenterology 152 (2017), 300–301.
140. Alric, L., Bonnet, D., Laurent, G., Kamar, N., Izopet, J., Chronic hepatitis E virus infection: successful virologic response to pegylated interferon-{alpha} therapy. Ann Intern Med 153 (2010), 135–136.
141. Alric, L., Bonnet, D., Beynes-Rauzy, O., Izopet, J., Kamar, N., Definitive clearance of a chronic hepatitis E virus infection with ribavirin treatment. Am J Gastroenterol 106 (2011), 1562–1563.
142. Tavitian, S., Peron, J.M., Huguet, F., Kamar, N., Abravanel, F., Beyne-Rauzy, O., et al. Ribavirin for chronic hepatitis prevention among patients with hematologic malignancies. Emerg Infect Dis 21 (2015), 1466–1469.
143. Neukam, K., Barreiro, P., Macias, J., Avellon, A., Cifuentes, C., Martin-Carbonero, L., et al. Chronic hepatitis E in HIV patients: rapid progression to cirrhosis and response to oral ribavirin. Clin Infect Dis 57 (2013), 465–468.
144. Hajji, H., Gerolami, R., Solas, C., Moreau, J., Colson, P., Chronic hepatitis E resolution in a human immunodeficiency virus (HIV)-infected patient treated with ribavirin. Int J Antimicrob Agents 46 (2013), 595–597.
145. Johne, R., Trojnar, E., Filter, M., Hofmann, J., Thermal stability of hepatitis E virus as estimated by a cell culture method. Appl Environ Microbiol 82 (2016), 4225–4231.
146. Dalton, H.R., Bendall, R.P., Pritchard, C., Henley, W., Melzer, D., National mortality rates from chronic liver disease and consumption of alcohol and pig meat. Epidemiol Infect 138 (2010), 174–182.
147. Montella, F., Rezza, G., Di Sora, F., Pezzotti, P., Recchia, O., Association between hepatitis E virus and HIV infection in homosexual men. Lancet, 344, 1994, 1433.
148. Payne, B.A., Medhi, M., Ijaz, S., Valappil, M., Savage, E.J., Gill, O.N., et al. Hepatitis E virus seroprevalence among men who have sex with men, United Kingdom. Emerg Infect Dis 19 (2013), 333–335.
149. Keane, F., Gompels, M., Bendall, R., Drayton, R., Jennings, L., Black, J., et al. Hepatitis E virus coinfection in patients with HIV infection. HIV Med 13 (2012), 83–88.
150. Sayed, I.M., Verhoye, L., Cocquerel, L., Abravanel, F., Foquet, L., Montpellier, C., et al. Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver. Gut 66 (2017), 920–929.
151. Allweiss, L., Gass, S., Giersch, K., Groth, A., Kah, J., Volz, T., et al. Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation. J Hepatol 64 (2016), 1033–1040.
152. Geng, Y., Zhao, C., Huang, W., Harrison, T.J., Zhang, H., Geng, K., et al. Detection and assessment of infectivity of hepatitis E virus in urine. J Hepatol 64 (2016), 37–43.
153. Zhu, F.C., Zhang, J., Zhang, X.F., Zhou, C., Wang, Z.Z., Huang, S.J., et al. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet 376 (2010), 895–902.
154. Zhang, J., Zhang, X.F., Huang, S.J., Wu, T., Hu, Y.M., Wang, Z.Z., et al. Long-term efficacy of a hepatitis E vaccine. N Engl J Med 372 (2015), 914–922.
155. Brown, A., Halliday, J.S., Swadling, L., Madden, R.G., Bendall, R., Hunter, J.G., et al. Characterization of the specificity, functionality, and durability of host T-cell responses against the full-length hepatitis E virus. Hepatology 64 (2016), 1934–1950.
156. Wu, T., Zhu, F.C., Huang, S.J., Zhang, X.F., Wang, Z.Z., Zhang, J., et al. Safety of the hepatitis E vaccine for pregnant women: a preliminary analysis. Hepatology, 55, 2012, 2038.
157. Baylis, S.A., Koc, O., Nick, S., Blumel, J., Widespread distribution of hepatitis E virus in plasma fractionation pools. Vox Sang 102 (2012), 182–183.
158. Cleland, A., Smith, L., Crossan, C., Blatchford, O., Dalton, H.R., Scobie, L., et al. Hepatitis E virus in Scottish blood donors. Vox Sang 105 (2013), 283–289.
159. Stramer, S.L., Moritz, E.D., Foster, G.A., Ong, E., Linnen, J.M., Hogema, B.M., et al. Hepatitis E virus: seroprevalence and frequency of viral RNA detection among US blood donors. Transfusion 56 (2016), 481–488.