Human liver chimeric mice as a new model of chronic hepatitis e virus infection and preclinical drug evaluation

Journal of Hepatology

Volumn 64, Issue 5, 2016, Pages 1033-1040

  Allweiss, Lena ^a   Gass, Sofia ^a   Giersch, Katja ^a   Groth, Anne ^a   Kah, Janine ^a   Volz, Tassilo ^a   Rapp, Gianna ^a   Schöbel, Anja ^b   Lohse, Ansgar W ^a,c   Polywka, Susanne ^a   Pischke, Sven ^a   Herker, Eva ^b   Dandri, Maura ^a,c   Lütgehetmann, Marc ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c German Center for Infection Research   (Germany)

Author keywords

Chronic viral hepatitis; Hepatitis E Virus (HEV); Humanized mice; Preclinical drug testing; Ribavirin.; uPA SCID beige

Indexed keywords

ALANINE AMINOTRANSFERASE; CASPASE 3; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEPATITIS E VIRUS OPEN READING FRAME 2 PROTEIN; HEPATITIS E VIRUS OPEN READING FRAME 3 PROTEIN; HUMAN SERUM ALBUMIN; KI 67 ANTIGEN; RIBAVIRIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; ANTIVIRUS AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BLOOD ANALYSIS; CELL COUNT; CELL LEVEL; CELLULAR DISTRIBUTION; CHRONIC HEPATITIS; CHRONIC HEPATITIS E; CHRONIC HEPATITIS E GENOTYPE 1 INFECTION; CHRONIC HEPATITIS E GENOTYPE 3 INFECTION; CONTROLLED STUDY; DENSITY; DISEASE COURSE; DISEASE DURATION; DISEASE TRANSMISSION; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; FECES ANALYSIS; FECES LEVEL; HEPATITIS B VIRUS GENOTYPE 1; HEPATITIS B VIRUS GENOTYPE 3; HEPATITIS E; HEPATITIS E VIRUS; HUMAN; HUMAN CELL; IN VIVO STUDY; INTRAHEPATIC BILE DUCT; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; RNA ANALYSIS; RNA CELL LEVEL; RNA FECES LEVEL; RNA TISSUE LEVEL; SIGNAL TRANSDUCTION; TISSUE LEVEL; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; VIRION; VIRUS CHARACTERIZATION; VIRUS INHIBITION; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENETICS; IN SITU HYBRIDIZATION; LIVER; PATHOLOGY; PRECLINICAL STUDY; REAL TIME POLYMERASE CHAIN REACTION; SCID MOUSE; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HEPATITIS E; HEPATITIS E VIRUS; HUMANS; IN SITU HYBRIDIZATION; LIVER; MICE; MICE, SCID; REAL-TIME POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRUS REPLICATION;

EID: 84962938618     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2016.01.011     Document Type: Article

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