Serological cross reactivity to CMV and EBV causes problems in the diagnosis of acute hepatitis E virus infection

Journal of Medical Virology

Volumn 86, Issue 3, 2014, Pages 478-483

  Hyams, Catherine ^a   Mabayoje, Diana A ^a   Copping, Ruth ^a   Maranao, Desmond ^a   Patel, Mauli ^a   Labbett, Wendy ^a   Haque, Tanzina ^a   Webster, Daniel P ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Cytomegalovirus; Epstein Barr virus; Hepatitis E virus; Serology

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; VIRUS RNA;

ACUTE HEPATITIS; ARTICLE; CONTROLLED STUDY; CROSS REACTION; CYTOMEGALOVIRUS; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPSTEIN BARR VIRUS; HEPATITIS A; HEPATITIS E; HUMAN; HUMAN TISSUE; HYPERTRANSAMINASEMIA; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SEROLOGY; SEROPREVALENCE; WESTERN BLOTTING;

CYTOMEGALOVIRUS; HEPATITIS E VIRUS; HUMAN HERPESVIRUS 4;

CYTOMEGALOVIRUS; EPSTEIN-BARR VIRUS; HEPATITIS E VIRUS; SEROLOGY;

ANTIBODIES, VIRAL; CROSS REACTIONS; CYTOMEGALOVIRUS; FALSE POSITIVE REACTIONS; HEPATITIS E; HEPATITIS E VIRUS; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LONDON; RETROSPECTIVE STUDIES; TERTIARY CARE CENTERS;

EID: 84891936766     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.23827     Document Type: Article

References (32)

1. Aggarwal R. 2010. The global prevalence of hepatitis E virus infection and susceptibility: A systematic review. Immunization, Vaccines and Biologicals. Geneva, Switzerland: WHO/IVB/10, p 14.
2. Aggarwal R, Naik SR. 1997. Epidemiology of hepatitis E: Past, present and future. Trop Gastroenterol 18:49-56.
3. Bendall R, Ellis V, Ijaz S, Ali R, Dalton H. 2010. A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J Med Virol 82:799-805.
4. Bryan JP, Tsarev SA, Iqbal M, Ticehurst J, Emerson S, Ahmed A, Duncan J, Rafiqui AR, Malik IA, Purcell RH. 1994. Epidemic hepatitis E in Pakistan: Patterns of serologic response and evidence that antibody to hepatitis E virus protects against disease. J Infect Dis 170:517-521.
5. Dalton HR, Hazeldine S, Banks M, Ijaz S, Bendall R. 2007. Locally acquired hepatitis E in chronic liver disease. Lancet 369:1260.
6. Dalton HR, Bendall R, Ijaz S, Banks M. 2008a. Hepatitis E: An emerging infection in developed countries. Lancet Infect Dis 8:698-709.
7. Dalton HR, Stableforth W, Thurairajah P, Hazeldine S, Remnarace R, Usama W, Farrington L, Hamad N, Sieberhagen C, Ellis V, Mitchell J, Hussaini SH, Banks M, Ijaz S, Bendall RP. 2008b. Autochthonous hepatitis E in Southwest England natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur J Gastroenterol Hepatol 20:784-790.
8. Dawson GJ, Chau KH, Cabal CM, Yarbough PO, Reyes GR, Mushahwar IK. 1992. Solid-phase enzyme-linked immunosorbent assay for hepatitis E virus IgG and IgM antibodies utilizing recombinant antigens and synthetic peptides. J Virol Methods 38:175-186.
9. Drobeniuc J, Meng J, Reuter G, Greene-Montfort T, Khudyakova N, Dimitrova Z, Kamili S, Teo CG. 2010. Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: Pangenotypic evaluation of performances. Clin Infect Dis 51:24-27.
10. Emerson SU, Purcell RH. 2003. Hepatitis E virus. Rev Med Virol 13:145-154.
11. Favorov MO, Fields HA, Purdy MA, Yashina TL, Aleksandrov AG, Alter MJ, Yarasheva DM, Bradley DW, Margolis HS. 1992. Serologic identification of hepatitis E virus infections in epidemic and endemic settings. J Med Virol 36:246-250.
12. Fogeda M, de Ory F, Avellon A, Echevarria JM. 2009. Differential diagnosis of hepatitis E virus, cytomegalovirus and Epstein-Barr virus infection in patients with suspected hepatitis E. J Clin Virol 45:259-261.
13. Ghinoiu M, Naveau S, Barri-Ova N, Thaury J, Grangeot-Keros L, Perlemuter G. 2009. Acute hepatitis E infection associated with a false-positive serology against Epstein-Barr virus. Eur J Gastroenterol Hepatol 21:1433-1435.
14. Gray JJ, Caldwell J, Sillis M. 1992. The rapid serological diagnosis of infectious mononucleosis. J Infect 25:39-46.
15. Ijaz S, Arnold E, Banks M, Bendall RP, Cramp ME, Cunningham R, Dalton HR, Harrison TJ, Hill SF, Macfarlane L, Meigh RE, Shafi S, Sheppard MJ, Smithson J, Wilson MP, Teo CG. 2005. Non-travel-associated hepatitis E in England and Wales: Demographic, clinical, and molecular epidemiological characteristics. J Infect Dis 192:1166-1172.
16. Ijaz S, Vyse AJ, Morgan D, Pebody RG, Tedder RS, Brown D. 2009. Indigenous hepatitis E virus infection in England more common than it seems. J Clin Virol 44:272-276.
17. Karner W, Bauer G. 1994. Activation of a varicella-zoster virus-specific IgA response during acute Epstein-Barr virus infection. J Med Virol 44:258-262.
18. Khudyakov Y, Kamili S. 2011. Serological diagnostics of hepatitis E virus infection. Virus Res 161:84-92.
19. Khuroo MS, Kamili S, Dar MY, Moecklii R, Jameel S. 1993. Hepatitis E and long-term antibody status. Lancet 341:1355.
20. Kneitz RH, Schubert J, Tollmann F, Zens W, Hedman K, Weissbrich B. 2004. A new method for determination of varicella-zoster virus immunoglobulin G avidity in serum and cerebrospinal fluid. BMC Infect Dis 4:33.
21. Li RC, Ge SX, Li YP, Zheng YJ, Nong Y, Guo QS, Zhang J, Ng MH, Xia NS. 2006. Seroprevalence of hepatitis E virus infection, rural southern People's Republic of China. Emerg Infect Dis 12:1682-1688.
22. Lu L, Li C, Hagedorn CH. 2006. Phylogenetic analysis of global hepatitis E virus sequences: Genetic diversity, subtypes and zoonosis. Rev Med Virol 16:5-36.
23. Meng XJ, Halbur PG, Shapiro MS, Govindarajan S, Bruna JD, Mushahwar IK, Purcell RH, Emerson SU. 1998. Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. J Virol 72:9714-9721.
24. Peron JM, Bureau C, Poirson H, Mansuy JM, Alric L, Selves J, Dupuis E, Izopet J, Vinel JP. 2007. Fulminant liver failure from acute autochthonous hepatitis E in France description of seven patients with acute hepatitis E and encephalopathy. J Viral Hepat 14:298-303.
25. Prince HE, Wilson M. 2001. Simplified assay for measuring Toxoplasma gondii immunoglobulin G avidity. Clin Diagn Lab Immunol 8:904-908.
26. Schwartz E, Jenks NP, Van Damme P, Galun E. 1999. Hepatitis E virus infection in travelers. Clin Infect Dis 29:1312-1314.
27. Seriwatana J, Shrestha MP, Scott RM, Tsarev SA, Vaughn DW, Myint KS, Innis BL. 2002. Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M. Clin Diagn Lab Immunol 9:1072-1078.
28. Srivastava R, Aggarwal R, Sachdeva S, Alam MI, Jameel S, Naik S. 2011. Adaptive immune responses during acute uncomplicated and fulminant hepatitis E. J Gastroenterol Hepatol 26:306-311.
29. Thomas HI, Barrett E, Hesketh LM, Wynne A, Morgan-Capner P. 1999. Simultaneous IgM reactivity by EIA against more than one virus in measles, parvovirus B19 and rubella infection. J Clin Virol 14:107-118.
30. Yu C, Engle RE, Bryan JP, Emerson SU, Purcell RH. 2003. Detection of immunoglobulin M antibodies to hepatitis E virus by class capture enzyme immunoassay. Clin Diagn Lab Immunol 10:579-586.
31. Zhang JZ, Im SW, Lau SH, Chau TN, Lai ST, Ng SP, Peiris M, Tse C, Ng TK, Ng MH. 2002. Occurrence of hepatitis E virus IgM, low avidity IgG serum antibodies, and viremia in sporadic cases of non-A, -B, and -C acute hepatitis. J Med Virol 66:40-48.
32. Zhang J, Ge SX, Huang GY, Li SW, He ZQ, Wang YB, Zheng YJ, Gu Y, Ng MH, Xia NS. 2003. Evaluation of antibody-based and nucleic acid-based assays for diagnosis of hepatitis E virus infection in a rhesus monkey model. J Med Virol 71:518-526.