Value of progression of coronary artery calcification for risk prediction of coronary and cardiovascular events: Result of the hnr study (heinz nixdorf recall)

Circulation

Volumn 137, Issue 7, 2018, Pages 665-679

  Lehmann, Nils ^a   Erbel, Raimund ^a   Mahabadi, Amir A ^b   Rauwolf, Michael ^b   Möhlenkamp, Stefan ^c   Moebus, Susanne ^a   Kälsch, Hagen ^d,e   Budde, Thomas ^d   Schmermund, Axel ^f   Stang, Andreas ^g   Führer Sakel, Dagmar ^a   Weimar, Christian ^a   Roggenbuck, Ulla ^a   Dragano, Nico ^h   Jöckel, Karl Heinz ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c Krankenhaus Bethanien   (Germany)

^d ALFRIED KRUPP KRANKENHAUS   (Germany)

^e UNIVERSITY OF WITTEN HERDECKE   (Germany)

^f Cardioangiological Center Bethanien   (Germany)

^g BOSTON UNIVERSITY   (United States)

^h HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Atherosclerosis; Coronary disease; Disease progression; Risk assessment; Tomography; Vascular calcification

Indexed keywords

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY CALCIFICATION; CORONARY ARTERY CALCIUM SCORE; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DISEASE EXACERBATION; EVALUATION STUDY; FEMALE; FOLLOW UP; HEART MUSCLE REVASCULARIZATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PREDICTIVE VALUE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; ALGORITHM; BLOOD VESSEL CALCIFICATION; CLINICAL TRIAL; DIAGNOSTIC IMAGING; DISEASE FREE SURVIVAL; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PATHOPHYSIOLOGY; SURVIVAL RATE; X-RAY COMPUTED TOMOGRAPHY;

AGED; ALGORITHMS; CORONARY ARTERY DISEASE; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; SURVIVAL RATE; TOMOGRAPHY, X-RAY COMPUTED; VASCULAR CALCIFICATION;

EID: 85044322965     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.027034     Document Type: Article

References (51)

1. Budoff MJ, Raggi P, Coronary artery disease progression assessed by electron-beam computed tomography. Am J Cardiol 2001 88 2A 46E 50E
2. Kronmal RA, McClelland RL, Detrano R, Shea S, Lima JA, Cushman M, Bild DE, Burke GL, Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2007 115 2722 2730. doi: 10.1161/CIRCULATIONAHA.106.674143.
3. Erbel R, Lehmann N, Churzidse S, Rauwolf M, Mahabadi AA, Möhlenkamp S, Moebus S, Bauer M, Kälsch H, Budde T, Montag M, Schmermund A, Stang A, Führer-Sakel D, Weimar C, Roggenbuck U, Dragano N, Jöckel KH, Heinz Nixdorf Recall Study Investigators Progression of coronary artery calcification seems to be inevitable, but predictable: results of the Heinz Nixdorf Recall (HNR) study. Eur Heart J 2014 35 2960 2971. doi: 10.1093/eurheartj/ehu288.
4. Gassett AJ, Sheppard L, McClelland RL, Olives C, Kronmal R, Blaha MJ, Budoff M, Kaufman JD, Risk factors for long-Term coronary artery calcium progression in the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 2015 4 e001726. doi: 10.1161/JAHA.114.001726.
5. Schindler TH, Cadenas J, Facta AD, Li Y, Olschewski M, Sayre J, Goldin J, Schelbert HR, Improvement in coronary endothelial function is independently associated with a slowed progression of coronary artery calcification in type 2 diabetes mellitus. Eur Heart J 2009 30 3064 3073. doi: 10.1093/eurheartj/ehp482.
6. Raggi P, Callister TQ, Shaw LJ, Progression of coronary artery calcium and risk of first myocardial infarction in patients receiving cholesterol-lowering therapy. Arterioscler Thromb Vasc Biol 2004 24 1272 1277. doi: 10.1161/01.ATV.0000127024.40516.ef.
7. Budoff MJ, Young R, Lopez VA, Kronmal RA, Nasir K, Blumenthal RS, Detrano RC, Bild DE, Guerci AD, Liu K, Shea S, Szklo M, Post W, Lima J, Bertoni A, Wong ND, Progression of coronary calcium and incident coronary heart disease events: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2013 61 1231 1239. doi: 10.1016/j.jacc.2012.12.035.
8. Budoff MJ, Hokanson JE, Nasir K, Shaw LJ, Kinney GL, Chow D, Demoss D, Nuguri V, Nabavi V, Ratakonda R, Berman DS, Raggi P, Progression of coronary artery calcium predicts all-cause mortality. JACC Cardiovasc Imaging 2010 3 1229 1236. doi: 10.1016/j.jcmg.2010.08.018.
9. Radford NB, DeFina LF, Barlow CE, Lakoski SG, Leonard D, Paixao AR, Khera A, Levine BD, Progression of CAC Score and Risk of Incident CVD. JACC Cardiovasc Imaging 2016 9 1420 1429. doi: 10.1016/j.jcmg.2016.03.010.
10. McEvoy JW, Blaha MJ, Defilippis AP, Budoff MJ, Nasir K, Blumenthal RS, Jones SR, Coronary artery calcium progression: An important clinical measurement? A review of published reports. J Am Coll Cardiol 2010 56 1613 1622. doi: 10.1016/j.jacc.2010.06.038.
11. Lehmann N, Erbel R, Mahabadi AA, Kälsch H, Möhlenkamp S, Moebus S, Stang A, Roggenbuck U, Strucksberg KH, Führer-Sakel D, Dragano N, Budde T, Seibel R, Grönemeyer D, Jöckel KH, Heinz Nixdorf Recall Study Investigators Accelerated progression of coronary artery calcification in hypertension but also prehypertension. J Hypertens 2016 4 2233 2242. doi: 10.1097/HJH.0000000000001080.
12. Paixao ARM, Chakravorty R, Khera A, Leonard D, DeFina LF, Barlow CE, Radford NB, Levine BD, Disagreement between different definitions of coronary artery calcium progression. JACC Cardiovasc Imaging 2015 10 743 745. doi: 10.1016/j.jcmg.2014.07.019.
13. Stang A, Moebus S, Dragano N, Beck EM, Möhlenkamp S, Schmermund A, Siegrist J, Erbel R, Jöckel KH, Heinz Nixdorf Recall Study Investigation Group Baseline recruitment and analyses of nonresponse of the Heinz Nixdorf Recall Study: identifiability of phone numbers as the major determinant of response. Eur J Epidemiol 2005 20 489 496
14. Schmermund A, Möhlenkamp S, Berenbein S, Pump H, Moebus S, Roggenbuck U, Stang A, Seibel R, Grönemeyer D, Jöckel KH, Erbel R, Population-based assessment of subclinical coronary atherosclerosis using electron-beam computed tomography. Atherosclerosis 2006 185 177 182. doi: 10.1016/j.atherosclerosis.2005.06.003.
15. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R, Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990 15 827 832
16. Detrano RC, Anderson M, Nelson J, Wong ND, Carr JJ, McNitt-Gray M, Bild DE, Coronary calcium measurements: effect of CT scanner type and calcium measure on rescan reproducibility-MESA study. Radiology 2005 236 477 484. doi: 10.1148/radiol.2362040513.
17. Erbel R, Möhlenkamp S, Moebus S, Schmermund A, Lehmann N, Stang A, Dragano N, Grönemeyer D, Seibel R, Kälsch H, Bröcker-Preuss M, Mann K, Siegrist J, Jöckel KH, Heinz Nixdorf Recall Study Investigative Group Coronary risk stratification, discrimination, and reclassification improvement based on quantification of subclinical coronary atherosclerosis: The Heinz Nixdorf Recall study. J Am Coll Cardiol 2010 56 1397 1406. doi: 10.1016/j.jacc.2010.06.030.
18. Jöckel KH, Lehmann N, Jaeger BR, Moebus S, Möhlenkamp S, Schmermund A, Dragano N, Stang A, Grönemeyer D, Seibel R, Mann K, Volbracht L, Siegrist J, Erbel R, Smoking cessation and subclinical atherosclerosis-results from the Heinz Nixdorf Recall Study. Atherosclerosis 2009 203 221 227. doi: 10.1016/j.atherosclerosis.2008.05.041.
19. Stang A, Moebus S, Möhlenkamp S, Dragano N, Schmermund A, Beck EM, Siegrist J, Erbel R, Jöckel KH, Heinz Nixdorf Recall Study Investigative Group Algorithms for converting random-zero to automated oscillometric blood pressure values, and vice versa. Am J Epidemiol 2006 164 85 94. doi: 10.1093/aje/kwj160.
20. Erbel R, Lehmann N, Möhlenkamp S, Churzidse S, Bauer M, Kälsch H, Schmermund A, Moebus S, Stang A, Roggenbuck U, Bröcker-Preuss M, Dragano N, Weimar C, Siegrist J, Jöckel KH, Heinz Nixdorf Recall Study Investigators Subclinical coronary atherosclerosis predicts cardiovascular risk in different stages of hypertension: result of the Heinz Nixdorf Recall Study. Hypertension 2012 59 44 53. doi: 10.1161/HYPERTENSIONAHA.111.180489.
21. Moebus S, Stang A, Möhlenkamp S, Dragano N, Schmermund A, Slomiany U, Hoffmann B, Bauer M, Broecker-Preuss M, Mann K, Siegrist J, Erbel R, Jöckel KH, Heinz Nixdorf Recall Study Group Association of impaired fasting glucose and coronary artery calcification as a marker of subclinical atherosclerosis in a population-based cohort-results of the Heinz Nixdorf Recall Study. Diabetologia 2009 52 81 89. doi: 10.1007/s00125-008-1173-y.
22. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB, Prediction of coronary heart disease using risk factor categories. Circulation 1998 97 1837 1847
23. Kowall B, Lehmann N, Mahabadi AA, Moebus S, Budde T, Seibel R, Grönemeyer D, Erbel R, Jöckel KH, Stang A, Progression of coronary artery calcification is stronger in poorly than in well controlled diabetes: Results from the Heinz Nixdorf Recall Study. J Diabetes Complications 2017 31 234 240. doi: 10.1016/j.jdiacomp.2016.08.011.
24. Lehmann N, Möhlenkamp S, Mahabadi AA, Schmermund A, Roggenbuck U, Seibel R, Grönemeyer D, Budde T, Dragano N, Stang A, Mann K, Moebus S, Erbel R, Jöckel KH, Effect of smoking and other traditional risk factors on the onset of coronary artery calcification: results of the Heinz Nixdorf Recall study. Atherosclerosis 2014 232 339 345. doi: 10.1016/j.atherosclerosis.2013.11.045.
25. Harrell FE , Lee KL, Mark DB, Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996 15 361 387. doi: 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4.
26. Risk Prediction Modeling: SAS Macros. http://ncook.bwh.harvard.edu/sas-macros.html. Accessed July 19, 2017
27. Pencina MJ, Dagostino RB Jr, Dagostino RB Jr, Vasan RS, Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 2008 27 157 172. discussion 207. doi: 10.1002/sim.2929.
28. Goff DC Jr, Lloyd-Jones DM, Bennett G, Coady S, D'Agostino RB, Gibbons R, Greenland P, Lackland DT, Levy D, O'Donnell CJ, Robinson JG, Schwartz JS, Shero ST, Smith SC Jr, Sorlie P, Stone NJ, Wilson PW, Jordan HS, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF, American College of Cardiology/American Heart Association Task Force on Practice Guidelines 2013 ACC/AHA guideline on the assessment of cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014 129 25 suppl 2 S49 S73. doi: 10.1161/01.cir.0000437741.48606.98. Erratum in: Circulation. 2014;129(25 suppl 2):S74-S75.
29. Kennedy KF, Pencina MJ, A SAS Macro to Compute Added Predictive Ability of New Markers Predicting a Dichotomous Outcome. 2010. http://www.analytics.ncsu.edu/sesug/2010/SDA07.Kennedy.pdf. Accessed January 23, 2018
30. Ambrose JA, Tannenbaum MA, Alexopoulos D, Hjemdahl-Monsen CE, Leavy J, Weiss M, Borrico S, Gorlin R, Fuster V, Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 1988 12 56 62
31. Little WC, Constantinescu M, Applegate RJ, Kutcher MA, Burrows MT, Kahl FR, Santamore WP, Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-To-moderate coronary artery disease? Circulation 1988 78 5 pt 1 1157-1166
32. Budoff MJ, McClelland RL, Nasir K, Greenland P, Kronmal RA, Kondos GT, Shea S, Lima JA, Blumenthal RS, Cardiovascular events with absent or minimal coronary calcification: The Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J 2009 158 554 561. doi: 10.1016/j.ahj.2009.08.007.
33. Min JK, Lin FY, Gidseg DS, Weinsaft JW, Berman DS, Shaw LJ, Rozanski A, Callister TQ, Determinants of coronary calcium conversion among patients with a normal coronary calcium scan: what is the "warranty period" for remaining normal? J Am Coll Cardiol 2010 55 1110 1117. doi: 10.1016/j.jacc.2009.08.088.
34. Blaha MJ, Cainzos-Achirica M, Greenland P, McEvoy JW, Blankstein R, Budoff MJ, Dardari Z, Sibley CT, Burke GL, Kronmal RA, Szklo M, Blumenthal RS, Nasir K, Role of coronary artery calcium score of zero and other negative risk markers for cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2016 133 849 858. doi: 10.1161/CIRCULATIONAHA.115.018524.
35. Hartiala O, Magnussen CG, Kajander S, Knuuti J, Ukkonen H, Saraste A, Rinta-Kiikka I, Kainulainen S, Kähönen M, Hutri-Kähönen N, Laitinen T, Lehtimäki T, Viikari JS, Hartiala J, Juonala M, Raitakari OT, Adolescence risk factors are predictive of coronary artery calcification at middle age: The cardiovascular risk in young Finns study. J Am Coll Cardiol 2012 60 1364 1370. doi: 10.1016/j.jacc.2012.05.045.
36. Hecht HS, A zero coronary artery calcium score: priceless. J Am Coll Cardiol 2010 55 1118 1120. doi: 10.1016/j.jacc.2009.09.064.
37. Schmermund A, Erbel R, Unstable coronary plaque and its relation to coronary calcium. Circulation 2001 104 1682 1687
38. Egan BM, Li J, White K, Fleming DO, Connell K, Hernandez GT, Jones DW7, Ferdinand KC, Sinopoli A, 2013 ACC/AHA Cholesterol Guideline and Implications for Healthy People 2020 Cardiovascular Disease Prevention Goals. J Am Heart Assoc 2016 5 8 e003558. doi: 10.1161/JAHA.116.003558.
39. Mahabadi AA, Möhlenkamp S, Lehmann N, Kälsch H, Dykun I, Pundt N, Moebus S, Jöckel KH, Erbel R, Heinz Nixdorf Recall Study Investigators CAC score improves coronary and CV risk assessment above statin indication by ESC and AHA/ACC primary prevention guidelines. JACC Cardiovasc Imaging 2017 10 143 153. doi: 10.1016/j.jcmg.2016.03.022.
40. Puri R, Nicholls SJ, Shao M, Kataoka Y, Uno K, Kapadia SR, Tuzcu EM, Nissen SE, Impact of statins on serial coronary calcification during atheroma progression and regression. J Am Coll Cardiol 2015 65 1273 1282. doi: 10.1016/j.jacc.2015.01.036.
41. Dykun I, Lehmann N, Kälsch H, Möhlenkamp S, Moebus S, Budde T, Seibel R, Grönemeyer D, Jöckel KH, Erbel R, Mahabadi AA, Statin medication enhances progression of coronary artery calcification: The Heinz Nixdorf Recall Study. J Am Coll Cardiol 2016 68 2123 2125. doi: 10.1016/j.jacc.2016.08.040.
42. Friedewald VE, Ambrose JA, Stone GW, Roberts WC, Willerson JT, The editor's roundtable: The vulnerable plaque. Am J Cardiol 2008 102 1644 1653. doi: 10.1016/j.amjcard.2008.09.001.
43. Rodriguez-Granillo GA, Carrascosa P, Bruining N, Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis? Cardiovasc Diagn Ther 2016 6 250 258. doi: 10.21037/cdt.2016.03.03.
44. Budoff MJ, Achenbach S, Blumenthal RS, Carr JJ, Goldin JG, Greenland P, Guerci AD, Lima JA, Rader DJ, Rubin GD, Shaw LJ, Wiegers SE, American Heart Association Committee on Cardiovascular Imaging and Intervention; American Heart Association Council on Cardiovascular Radiology and Intervention; American Heart Association Committee on Cardiac Imaging, Council on Clinical Cardiology Assessment of coronary artery disease by cardiac computed tomography: A scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation 2006 114 1761 1791. doi: 10.1161/CIRCULATIONAHA.106.178458.
45. Budoff MJ, Nasir K, McClelland RL, Detrano R, Wong N, Blumenthal RS, Kondos G, Kronmal RA, Coronary calcium predicts events better with absolute calcium scores than age-sex-race/ethnicity percentiles: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2009 53 345 352. doi: 10.1016/j.jacc.2008.07.072.
46. Ferencik M, Ferullo A, Achenbach S, Abbara S, Chan RC, Booth SL, Brady TJ, Hoffmann U, Coronary calcium quantification using various calibration phantoms and scoring thresholds. Invest Radiol 2003 38 559 566. doi: 10.1097/01.RLI.0000073449.90302.75.
47. Schmermund A, Baumgart D, Möhlenkamp S, Kriener P, Pump H, Grönemeyer D, Seibel R, Erbel R, Natural history and topographic pattern of progression of coronary calcification in symptomatic patients: An electron-beam CT study. Arterioscler Thromb Vasc Biol 2001 21 421 426
48. Brown ER, Kronmal RA, Bluemke DA, Guerci AD, Carr JJ, Goldin J, Detrano R, Coronary calcium coverage score: determination, correlates, and predictive accuracy in the Multi-Ethnic Study of Atherosclerosis. Radiology 2008 247 669 675. doi: 10.1148/radiol.2473071469.
49. Liang CJ, Budoff MJ, Kaufman JD, Kronmal RA, Brown ER, An alternative method for quantifying coronary artery calcification: The multi-ethnic study of atherosclerosis (MESA). BMC Med Imaging 2012 12 14. doi: 10.1186/1471-2342-12-14.
50. Becker A, Leber A, Becker C, Knez A, Predictive value of coronary calcifications for future cardiac events in asymptomatic individuals. Am Heart J 2008 155 154 160. doi: 10.1016/j.ahj.2007.08.024.
51. McClelland RL, Chung H, Detrano R, Post W, Kronmal RA, Distribution of coronary artery calcium by race, gender, and age: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2006 113 30 37. doi: 10.1161/CIRCULATIONAHA.105.580696.