Improvement in coronary endothelial function is independently associated with a slowed progression of coronary artery calcification in type 2 diabetes mellitus

European Heart Journal

Volumn 30, Issue 24, 2009, Pages 3064-3073

  Schindler, Thomas H ^a,b   Cadenas, Jerson ^a   Facta, Alvaro D ^a   Li, Yanjie ^c   Olschewski, Manfred ^d   Sayre, James ^a   Goldin, Jonathan ^a   Schelbert, Heinrich R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Cardiovascular disease prevention; Carotid IMT; Coronary artery calcification; Coronary circulation; Diabetes mellitus; Endothelium; Positron emission tomography

Indexed keywords

ADENOSINE; GLIBENCLAMIDE; GLUCOSE; METFORMIN;

ADULT; ARTERIAL WALL THICKNESS; ARTERY CALCIFICATION; ARTERY WALL; ARTICLE; BLOOD CHEMISTRY; CAROTID ARTERY; CLINICAL ARTICLE; COLD PRESSOR TEST; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; ECHOGRAPHY; ELECTRON BEAM TOMOGRAPHY; ENDOTHELIUM; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HEART MUSCLE BLOOD FLOW; HUMAN; MALE; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REST; STRUCTURE ANALYSIS;

ADULT; CALCINOSIS; CAROTID ARTERY DISEASES; CORONARY ARTERY DISEASE; CORONARY CIRCULATION; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; TUNICA INTIMA; TUNICA MEDIA;

EID: 72649099809     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp482     Document Type: Article

References (15)

1. Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H. Prevention Conference VI: diabetes and cardiovascular disease. Writing Group II: pathogenesis of atherosclerosis in diabetes. Circulation 2002;105:e138-e143.
2. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation 2005;111: 363-368.
3. Recio-Mayoral A, Mason JC, Kaski JC, Rubens MB, Harari OA, Camici PG. Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease. Eur Heart J 2009;30:1837-1843.
4. Juonala M, Kahonen M, Laitinen T, Hutri-Kahonen N, Jokinen E, Taittonen L, Pietikainen M, Helenius H, Viikari JS, Raitakari OT. Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: the cardiovascular risk in Young Finns Study. Eur Heart J 2008; 29:1198-1206. (Pubitemid 351844875) (Pubitemid 351844875)
5. Anand DV, Lim E, Hopkins D, Corder R, Shaw LJ, Sharp P, Lipkin D, Lahiri A. Risk stratification in uncomplicated type 2 diabetes: prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy. Eur Heart J 2006;27:713-721.
6. Prior JO, Quinones MJ, Hernandez-Pampaloni M, Facta AD, Schindler TH, Sayre JW, Hsueh WA, Schelbert HR. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation 2005;111:2291-2298.
7. Schindler TH, Facta AD, Prior JO, Cadenas J, Hsueh WA, Quinones MJ, Schelbert HR. Improvement in coronary vascular dysfunction produced with euglycaemic control in patients with type 2 diabetes. Heart 2007;93:345-349.
8. Nissen SE, Nicholls SJ, Wolski K, Nesto R, Kupfer S, Perez A, Jure H, De Larochelliere R, Staniloae CS, Mavromatis K, Saw J, Hu B, Lincoff AM, Tuzcu EM. Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial. JAMA 2008;299:1561-1573.
9. Schindler TH, Facta AD, Prior JO, Cadenas J, Zhang XL, Li Y, Sayre J, Goldin J, Schelbert HR. Structural alterations of the coronary arterial wall are associated with myocardial flow heterogeneity in type 2 diabetes mellitus. Eur J Nucl Med Mol Imaging 2009;36:219-229.
10. Hodis HN, Mack WJ, Zheng L, Li Y, Torres M, Sevilla D, Stewart Y, Hollen B, Garcia K, Alaupovic P, Buchanan TA. Effect of peroxisome proliferator- activated receptor gamma agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetes. Diabetes Care 2006;29:1545-1553.
11. Detrano RC, Anderson M, Nelson J, Wong ND, Carr JJ, McNitt-Gray M, Bild DE. Coronary calcium measurements: effect of CT scanner type and calcium measure on rescan reproducibility-MESA study. Radiology 2005;236:477-484.
12. Schindler TH, Campisi R, Dorsey D, Prior JO, Olschewski M, Sayre J, Schelbert HR. Effect of hormone replacement therapy on vasomotor function of the coronary microcirculation in post-menopausal women with medically treated cardiovascular risk factors. Eur Heart J 2009;30:978-986.
13. Simon A, Chironi G, Levenson J. Comparative performance of subclinical atherosclerosis tests in predicting coronary heart disease in asymptomatic individuals. Eur Heart J 2007;28:2967-2971.
14. Schmermund A, Baumgart D, Sack S, Mohlenkamp S, Gronemeyer D, Seibel R, Erbel R. Assessment of coronary calcification by electron-beam computed tomography in symptomatic patients with normal, abnormal or equivocal exercise stress test. Eur Heart J 2000;21:1674-1682.
15. Nicholls SJ, Tuzcu EM, Kalidindi S, Wolski K, Moon KW, Sipahi I, Schoenhagen P, Nissen SE. Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling: a pooled analysis of 5 intravascular ultrasound trials. J Am Coll Cardiol 2008;52:255-262.