Review shows that maternal obesity induces serious adverse neonatal effects and is associated with childhood obesity in their offspring

Acta Paediatrica, International Journal of Paediatrics

Volumn 107, Issue 7, 2018, Pages 1156-1165

  Mitanchez, Delphine ^a,b   Chavatte Palmer, Pascale ^c  

^a ARMAND TROUSSEAU HOSPITAL   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

Author keywords

Child obesity; Gestational diabetes; Gestational weight gain; Metabolic programming; Neonatal outcomes

Indexed keywords

ADVERSE OUTCOME; CARDIOMETABOLIC RISK; CHILDHOOD OBESITY; CONGENITAL MALFORMATION; FAT MASS; FETUS GROWTH; GESTATIONAL WEIGHT GAIN; HUMAN; MACROSOMIA; MATERNAL DIABETES MELLITUS; MATERNAL OBESITY; NONHUMAN; PERINATAL MORTALITY; PREMATURITY; PRIORITY JOURNAL; PROGENY; REVIEW; RISK ASSESSMENT; ANIMAL; ANIMAL MODEL; FEMALE; PREGNANCY; PREGNANCY COMPLICATION; PRENATAL EXPOSURE;

ANIMALS; FEMALE; HUMANS; MODELS, ANIMAL; PEDIATRIC OBESITY; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 85043359153     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/apa.14269     Document Type: Review

References (75)

1. Mendez MA, Monteiro CA, Popkin BM. Overweight exceeds underweight among women in most developing countries. Am J Clin Nutr 2005; 81: 714–21.
2. Fisher SC, Kim SY, Sharma AJ, Rochat R, Morrow B. Is obesity still increasing among pregnant women? Prepregnancy obesity trends in 20 states, 2003–2009. Prev Med 2013; 56: 372–8.
3. Devlieger R, Benhalima K, Damm P, Van Assche A, Mathieu C, Mahmood T, et al. Maternal obesity in Europe: where do we stand and how to move forward?: a scientific paper commissioned by the European Board and College of Obstetrics and Gynaecology (EBCOG). Eur J Obstet Gynecol Reprod Biol 2016; 201: 203–8.
4. Wang Z, Wang P, Liu H, He X, Zhang J, Yan H, et al. Maternal adiposity as an independent risk factor for pre-eclampsia: a meta-analysis of prospective cohort studies. Obes Rev 2013; 14: 508–21.
5. Salihu HM, De La Cruz C, Rahman S, August EM. Does maternal obesity cause preeclampsia? A systematic review of the evidence. Minerva Ginecol 2012; 64: 259–80.
6. Torloni MR, Betran AP, Horta BL, Nakamura MU, Atallah AN, Moron AF, et al. Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis. Obes Rev 2009; 10: 194–203.
7. Oteng-Ntim E, Kopeika J, Seed P, Wandiembe S, Doyle P. Impact of obesity on pregnancy outcome in different ethnic groups: calculating population attributable fractions. PLoS One 2013; 8: e53749.
8. Catalano PM, McIntyre HD, Cruickshank JK, McCance DR, Dyer AR, Metzger BE, et al. The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes. Diabetes Care 2012; 35: 780–6.
9. Abell SK, Boyle JA, de Courten B, Soldatos G, Wallace EM, Zoungas S, et al. Impact of type 2 diabetes, obesity and glycaemic control on pregnancy outcomes. Aust N Z J Obstet Gynaecol 2017; 57: 308–14.
10. Langer O, Yogev Y, Xenakis EM, Brustman L. Overweight and obese in gestational diabetes: the impact on pregnancy outcome. Am J Obstet Gynecol 2005; 192: 1768–76.
11. Faucher MA, Barger MK. Gestational weight gain in obese women by class of obesity and select maternal/newborn outcomes: a systematic review. Women Birth 2015; 28: e70–9.
12. Faucher MA, Hastings-Tolsma M, Song JJ, Willoughby DS, Bader SG. Gestational weight gain and preterm birth in obese women: a systematic review and meta-analysis. BJOG 2016; 123: 199–206.
13. International Weight Management in Pregnancy Collaborative Group. Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials. BMJ 2017; 358: j3119.
14. Agha M, Agha RA, Sandall J. Interventions to reduce and prevent obesity in pre-conceptual and pregnant women: a systematic review and meta-analysis. PLoS One 2014; 9: e95132.
15. Yi XY, Li QF, Zhang J, Wang ZH. A meta-analysis of maternal and fetal outcomes of pregnancy after bariatric surgery. Int J Gynaecol Obstet 2015; 130: 3–9.
16. Liu P, Xu L, Wang Y, Zhang Y, Du Y, Sun Y, et al. Association between perinatal outcomes and maternal pre-pregnancy body mass index. Obes Rev 2016; 17: 1091–102.
17. Gaudet L, Ferraro ZM, Wen SW, Walker M. Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis. Biomed Res Int 2014; 2014: 640291.
18. Yu Z, Han S, Zhu J, Sun X, Ji C, Guo X. Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight/obesity: a systematic review and meta-analysis. PLoS One 2013; 8: e61627.
19. Heslehurst N, Simpson H, Ells LJ, Rankin J, Wilkinson J, Lang R, et al. The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: a meta-analysis. Obes Rev 2008; 9: 635–83.
20. Dzakpasu S, Fahey J, Kirby RS, Tough SC, Chalmers B, Heaman MI, et al. Contribution of prepregnancy body mass index and gestational weight gain to adverse neonatal outcomes: population attributable fractions for Canada. BMC Pregnancy Childbirth 2015; 15: 21.
21. McDonald SD, Han Z, Mulla S, Beyene J. Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses. BMJ 2010; 341: c3428.
22. Flenady V, Koopmans L, Middleton P, Froen JF, Smith GC, Gibbons K, et al. Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet 2011; 377: 1331–40.
23. Aune D, Saugstad OD, Henriksen T, Tonstad S. Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis. JAMA 2014; 311: 1536–46.
24. Tennant PW, Rankin J, Bell R. Maternal body mass index and the risk of fetal and infant death: a cohort study from the North of England. Hum Reprod 2011; 26: 1501–11.
25. Heslehurst N, Vieira R, Hayes L, Crowe L, Jones D, Robalino S, et al. Maternal body mass index and post-term birth: a systematic review and meta-analysis. Obes Rev 2017; 18: 293–308.
26. Torloni MR, Betran AP, Daher S, Widmer M, Dolan SM, Menon R, et al. Maternal BMI and preterm birth: a systematic review of the literature with meta-analysis. J Matern Fetal Neonatal Med 2009; 22: 957–70.
27. Correa A, Marcinkevage J. Prepregnancy obesity and the risk of birth defects: an update. Nutr Rev 2013; 71(Suppl 1): S68–77.
28. Stothard KJ, Tennant PW, Bell R, Rankin J. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 2009; 301: 636–50.
29. Blomberg MI, Kallen B. Maternal obesity and morbid obesity: the risk for birth defects in the offspring. Birth Defects Res A Clin Mol Teratol 2010; 88: 35–40.
30. Zhu T, Tang J, Zhao F, Qu Y, Mu D. Association between maternal obesity and offspring Apgar score or cord pH: a systematic review and meta-analysis. Sci Rep 2015; 5: 18386.
31. Villamor E, Tedroff K, Peterson M, Johansson S, Neovius M, Petersson G, et al. Association between maternal body mass index in early pregnancy and incidence of cerebral palsy. JAMA 2017; 317: 925–36.
32. Blomberg M. Maternal obesity, mode of delivery, and neonatal outcome. Obstet Gynecol 2013; 122: 50–5.
33. Hyperglycaemia and Adverse Pregnancy Outcome. (HAPO) Study: associations with maternal body mass index. BJOG 2010; 117: 575–84.
34. Barker DJ. The fetal and infant origins of adult disease. BMJ 1990; 301: 1111.
35. Godfrey KM, Reynolds RM, Prescott SL, Nyirenda M, Jaddoe VW, Eriksson JG, et al. Influence of maternal obesity on the long-term health of offspring. Lancet Diabetes Endocrinol 2017; 5: 53–64.
36. Mamun AA, Mannan M, Doi SA. Gestational weight gain in relation to offspring obesity over the life course: a systematic review and bias-adjusted meta-analysis. Obes Rev 2014; 15: 338–47.
37. Sorensen T, Ajslev TA, Angquist L, Morgen CS, Ciuchi IG, Davey Smith G. Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics from birth through age 7 y assessed in the Danish National Birth Cohort. Am J Clin Nutr 2016; 104: 389–96.
38. Hivert MF, Rifas-Shiman SL, Gillman MW, Oken E. Greater early and mid-pregnancy gestational weight gains are associated with excess adiposity in mid-childhood. Obesity (Silver Spring) 2016; 24: 1546–53.
39. Robinson SM, Crozier SR, Harvey NC, Barton BD, Law CM, Godfrey KM, et al. Modifiable early-life risk factors for childhood adiposity and overweight: an analysis of their combined impact and potential for prevention. Am J Clin Nutr 2015; 101: 368–75.
40. Daraki V, Georgiou V, Papavasiliou S, Chalkiadaki G, Karahaliou M, Koinaki S, et al. Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the Rhea pregnancy cohort Crete, Greece. PLoS One 2015; 10: e0126327.
41. Castillo H, Santos IS, Matijasevich A. Relationship between maternal pre-pregnancy body mass index, gestational weight gain and childhood fatness at 6-7 years by air displacement plethysmography. Matern Child Nutr 2015; 11: 606–17.
42. Kaar JL, Crume T, Brinton JT, Bischoff KJ, McDuffie R, Dabelea D. Maternal obesity, gestational weight gain, and offspring adiposity: the exploring perinatal outcomes among children study. J Pediatr 2014; 165: 509–15.
43. Oostvogels AJ, Stronks K, Roseboom TJ, van der Post JA, van Eijsden M, Vrijkotte TG. Maternal prepregnancy BMI, offspring's early postnatal growth, and metabolic profile at age 5-6 years: the ABCD Study. J Clin Endocrinol Metab 2014; 99: 3845–54.
44. Gaillard R, Steegers EA, Duijts L, Felix JF, Hofman A, Franco OH, et al. Childhood cardiometabolic outcomes of maternal obesity during pregnancy: the Generation R Study. Hypertension 2014; 63: 683–91.
45. Gaillard R, Steegers EA, Franco OH, Hofman A, Jaddoe VW. Maternal weight gain in different periods of pregnancy and childhood cardio-metabolic outcomes. The generation R study. Int J Obes (Lond) 2015; 39: 677–85.
46. Crozier SR, Inskip HM, Godfrey KM, Cooper C, Harvey NC, Cole ZA, et al. Weight gain in pregnancy and childhood body composition: findings from the Southampton Women's Survey. Am J Clin Nutr 2010; 91: 1745–51.
47. Fraser A, Tilling K, Macdonald-Wallis C, Sattar N, Brion MJ, Benfield L, et al. Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood. Circulation 2010; 121: 2557–64.
48. Philipps LH, Santhakumaran S, Gale C, Prior E, Logan KM, Hyde MJ, et al. The diabetic pregnancy and offspring BMI in childhood: a systematic review and meta-analysis. Diabetologia 2011; 54: 1957–66.
49. Schellong K, Schulz S, Harder T, Plagemann A. Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PLoS One 2012; 7: e47776.
50. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 2005; 115: e290–6.
51. Woo Baidal JA, Locks LM, Cheng ER, Blake-Lamb TL, Perkins ME, Taveras EM. Risk factors for childhood obesity in the first 1,000 days: a systematic review. Am J Prev Med 2016; 50: 761–79.
52. Chavatte-Palmer P, Tarrade A, Rousseau-Ralliard D. Diet before and during pregnancy and offspring health: the importance of animal models and what can be learned from them. Int J Environ Res Public Health 2016; 13: 586.
53. Myatt L, Maloyan A. Obesity and placental function. Semin Reprod Med 2016; 34: 42–9.
54. Zhang L, Long NM, Hein SM, Ma Y, Nathanielsz PW, Ford SP. Maternal obesity in ewes results in reduced fetal pancreatic beta-cell numbers in late gestation and decreased circulating insulin concentration at term. Domest Anim Endocrinol 2011; 40: 30–9.
55. Farley D, Tejero ME, Comuzzie AG, Higgins PB, Cox L, Werner SL, et al. Feto-placental adaptations to maternal obesity in the baboon. Placenta 2009; 30: 752–60.
56. Zambrano E, Ibanez C, Martinez-Samayoa PM, Lomas-Soria C, Durand-Carbajal M, Rodriguez-Gonzalez GL. Maternal obesity: lifelong metabolic outcomes for offspring from poor developmental trajectories during the perinatal period. Arch Med Res 2016; 47: 1–12.
57. Wankhade UD, Thakali KM, Shankar K. Persistent influence of maternal obesity on offspring health: mechanisms from animal models and clinical studies. Mol Cell Endocrinol 2016; 435: 7–19.
58. Tarrade A, Panchenko P, Junien C, Gabory A. Placental contribution to nutritional programming of health and diseases: epigenetics and sexual dimorphism. J Exp Biol 2015; 218: 50–8.
59. Sferruzzi-Perri AN, Camm EJ. The programming power of the placenta. Front Physiol 2016; 7: 33.
60. Mao J, Zhang X, Sieli PT, Falduto MT, Torres KE, Rosenfeld CS. Contrasting effects of different maternal diets on sexually dimorphic gene expression in the murine placenta. Proc Natl Acad Sci USA 2010; 107: 5557–62.
61. Mitanchez D, Jacqueminet S, Nizard J, Tanguy ML, Ciangura C, Lacorte JM, et al. Effect of maternal obesity on birthweight and neonatal fat mass: a prospective clinical trial. PLoS One 2017; 12: e0181307.
62. Watkins AJ, Lucas ES, Fleming TP. Impact of the periconceptional environment on the programming of adult disease. J Dev Orig Health Dis 2010; 1: 87–95.
63. Dahlhoff M, Pfister S, Blutke A, Rozman J, Klingenspor M, Deutsch MJ, et al. Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring. Biochim Biophys Acta 2014; 1842: 304–17.
64. Shankar K, Zhong Y, Kang P, Lau F, Blackburn ML, Chen JR, et al. Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst. Endocrinology 2011; 152: 4158–70.
65. Sasson IE, Vitins AP, Mainigi MA, Moley KH, Simmons RA. Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice. Diabetologia 2015; 58: 615–24.
66. Panchenko PE, Voisin S, Jouin M, Jouneau L, Prezelin A, Lecoutre S, et al. Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice. Clin Epigenetics 2016; 8: 22.
67. Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, et al. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol 2008; 41: 91–102.
68. Waterland RA, Kellermayer R, Laritsky E, Rayco-Solon P, Harris RA, Travisano M, et al. Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet 2010; 6: e1001252.
69. Waterland RA, Travisano M, Tahiliani KG, Rached MT, Mirza S. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond) 2008; 32: 1373–9.
70. Bourdon A, Parnet P, Nowak C, Tran NT, Winer N, Darmaun D. L-citrulline supplementation enhances fetal growth and protein synthesis in rats with intrauterine growth restriction. J Nutr 2016; 146: 532–41.
71. Miczke A, Suliburska J, Pupek-Musialik D, Ostrowska L, Jablecka A, Krejpcio Z, et al. Effect of L-arginine supplementation on insulin resistance and serum adiponectin concentration in rats with fat diet. Int J Clin Exp Med 2015; 8: 10358–66.
72. Suliburska J, Bogdanski P, Szulinska M, Pupek-Musialik D, Jablecka A. Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation. Eur J Nutr 2014; 53: 387–93.
73. Heerwagen MJ, Stewart MS, de la Houssaye BA, Janssen RC, Friedman JE. Transgenic increase in N-3/n-6 Fatty Acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice. PLoS One 2013; 8: e67791.
74. Nathanielsz PW, Ford SP, Long NM, Vega CC, Reyes-Castro LA, Zambrano E. Interventions to prevent adverse fetal programming due to maternal obesity during pregnancy. Nutr Rev 2013; 71(Suppl 1): S78–87.
75. Navarro E, Funtikova AN, Fito M, Schroder H. Prenatal nutrition and the risk of adult obesity: long-term effects of nutrition on epigenetic mechanisms regulating gene expression. J Nutr Biochem 2017; 39: 1–14.