Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

Science

Volumn 359, Issue 6382, 2018, Pages 1376-1383

  Thaiss, Christoph A ^a   Levy, Maayan ^a   Grosheva, Inna ^a   Zheng, Danping ^a   Soffer, Eliran ^a   Blacher, Eran ^a   Braverman, Sofia ^a   Tengeler, Anouk C ^a   Barak, Oren ^a,b   Elazar, Maya ^a   Ben Zeev, Rotem ^a   Lehavi Regev, Dana ^a   Katz, Meirav N ^a   Pevsner Fischer, Meirav ^a   Gertler, Arieh ^c   Halpern, Zamir ^d   Harmelin, Alon ^a   Aamar, Suhail ^e   Serradas, Patricia ^f   Grosfeld, Alexandra ^f   Shapiro, Hagit ^a   Geiger, Benjamin ^a   Elinav, Eran ^a   more..

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HEBREW UNIVERSITY   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^e HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^f SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; DEOXYGLUCOSE; GLUCOSE TRANSPORTER 2; GLYCOSYLATED HEMOGLOBIN; INTERLEUKIN 22; LEPTIN; LEPTIN RECEPTOR; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; PATTERN RECOGNITION RECEPTOR; GLUCOSE; LEPTIN RECEPTOR, MOUSE; SLC2A2 PROTEIN, MOUSE; STREPTOZOCIN;

CELL; DIABETES; GLUCOSE; HEMOGLOBIN; INFECTIOUS DISEASE; INHIBITION; METABOLISM; OBESITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CELL ADHESION; CITROBACTER RODENTIUM; CONTROLLED STUDY; DB/DB MOUSE; DIABETES MELLITUS; GASTROINTESTINAL TRACT FUNCTION; GENE EXPRESSION; GENETIC DISORDER; GLUCOSE METABOLISM; HEMOGLOBIN BLOOD LEVEL; HOST RESISTANCE; HUMAN; HYPERGLYCEMIA; HYPERPHAGIA; INFECTION RISK; INFECTION SENSITIVITY; INFLAMMATION; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; INTESTINE FUNCTION DISORDER; INTESTINE INFECTION; INTESTINE MUCOSA PERMEABILITY; METABOLIC INHIBITION; MOUSE; NONHUMAN; NORMAL HUMAN; NUCLEAR REPROGRAMMING; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA SEQUENCE; TIGHT JUNCTION; ANIMAL; CACO-2 CELL LINE; ENTEROPATHOGENIC ESCHERICHIA COLI; ENTEROPATHY; ESCHERICHIA COLI INFECTION; EXPERIMENTAL DIABETES MELLITUS; GENE DELETION; GENETICS; GLUCOSE BLOOD LEVEL; INBRED MOUSE STRAIN; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY; PERMEABILITY;

BACTERIA (MICROORGANISMS);

ANIMALS; BLOOD GLUCOSE; CACO-2 CELLS; CELLULAR REPROGRAMMING; CITROBACTER RODENTIUM; DIABETES MELLITUS, EXPERIMENTAL; ENTEROPATHOGENIC ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; GASTROINTESTINAL MICROBIOME; GENE DELETION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; HUMANS; HYPERGLYCEMIA; INTESTINAL DISEASES; INTESTINAL MUCOSA; MICE; MICE, INBRED STRAINS; OBESITY; PERMEABILITY; RECEPTORS, LEPTIN; STREPTOZOCIN;

EID: 85043240875     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aar3318     Document Type: Article

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