메뉴 건너뛰기




Volumn 50, Issue 3, 2018, Pages 401-413

A large electronic-health-record-based genome-wide study of serum lipids

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

EID: 85042876923     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0064-5     Document Type: Article
Times cited : (214)

References (86)
  • 1
    • 0023710312 scopus 로고
    • Cholesterol and lipids in the risk of coronary artery disease\-The Framingham Heart Study
    • Castelli, W. P. Cholesterol and lipids in the risk of coronary artery disease\-The Framingham Heart Study. Can. J. Cardiol. 4 (Suppl. A), 5A-10A (1988).
    • (1988) Can. J. Cardiol. , vol.4 , pp. 5A-10A
    • Castelli, W.P.1
  • 2
    • 72949132104 scopus 로고
    • Factors of risk in the development of coronary heart disease-six year follow-up experience the Framingham Study
    • Kannel, W. B., Dawber, T. R., Kagan, A., Revotskie, N. &Stokes, J. III Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study. Ann. Intern. Med. 55, 33-50 (1961).
    • (1961) Ann. Intern. Med. , vol.55 , pp. 33-50
    • Kannel, W.B.1    Dawber, T.R.2    Kagan, A.3    Revotskie, N.4    Stokes, J.5
  • 3
    • 84887099827 scopus 로고    scopus 로고
    • Discovery and refinement of loci associated with lipid levels
    • Willer, C. J. et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45, 1274-1283 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1274-1283
    • Willer, C.J.1
  • 4
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010).
    • (2010) Nature , vol.466 , pp. 707-713
    • Teslovich, T.M.1
  • 5
    • 84955263526 scopus 로고    scopus 로고
    • Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs
    • Below, J. E. et al. Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs. Sci. Rep. 6, 19429 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 19429
    • Below, J.E.1
  • 6
    • 84860014014 scopus 로고    scopus 로고
    • Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: The PAGE study
    • Buyske, S. et al. Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study. PLoS One 7, e35651 (2012).
    • (2012) PLoS One , vol.7 , pp. e35651
    • Buyske, S.1
  • 7
    • 84878828157 scopus 로고    scopus 로고
    • Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations
    • Coram, M. A. et al. Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. Am. J. Hum. Genet. 92, 904-916 (2013).
    • (2013) Am. J. Hum. Genet. , vol.92 , pp. 904-916
    • Coram, M.A.1
  • 8
    • 84870879275 scopus 로고    scopus 로고
    • Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations
    • Elbers, C. C. et al. Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. PLoS One 7, e50198 (2012).
    • (2012) PLoS One , vol.7 , pp. e50198
    • Elbers, C.C.1
  • 9
    • 84885996384 scopus 로고    scopus 로고
    • THOC5: A novel gene involved in HDL-cholesterol metabolism
    • Keller, M. et al. THOC5: A novel gene involved in HDL-cholesterol metabolism. J. Lipid Res. 54, 3170-3176 (2013).
    • (2013) J. Lipid Res. , vol.54 , pp. 3170-3176
    • Keller, M.1
  • 10
    • 84901949893 scopus 로고    scopus 로고
    • Amerindian-specific regions under positive selection harbour new lipid variants in Latinos
    • Ko, A. et al. Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Nat. Commun. 5, 3983 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 3983
    • Ko, A.1
  • 11
    • 84971330664 scopus 로고    scopus 로고
    • Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride
    • Kurano, M. et al. Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride. J. Hum. Genet. 61, 427-433 (2016).
    • (2016) J. Hum. Genet. , vol.61 , pp. 427-433
    • Kurano, M.1
  • 12
    • 84941003694 scopus 로고    scopus 로고
    • Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration
    • Lanktree, M. B. et al. Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration. J. Lipid Res. 56, 1781-1786 (2015).
    • (2015) J. Lipid Res. , vol.56 , pp. 1781-1786
    • Lanktree, M.B.1
  • 13
    • 84963837739 scopus 로고    scopus 로고
    • Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
    • van Leeuwen, E. M. et al. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. J. Med. Genet. 53, 441-449 (2016).
    • (2016) J. Med. Genet. , vol.53 , pp. 441-449
    • Van Leeuwen, E.M.1
  • 14
    • 84959476339 scopus 로고    scopus 로고
    • Genetic susceptibility to lipid levels and lipid change over time and risk of incident hyperlipidemia in Chinese populations
    • Lu, X. et al. Genetic susceptibility to lipid levels and lipid change over time and risk of incident hyperlipidemia in Chinese populations. Circ. Cardiovasc. Genet. 9, 37-44 (2016).
    • (2016) Circ. Cardiovasc. Genet. , vol.9 , pp. 37-44
    • Lu, X.1
  • 15
    • 84861307204 scopus 로고    scopus 로고
    • Multi-ethnic analysis of lipid-associated loci: The NHLBI CARe project
    • Musunuru, K. et al. Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. PLoS One 7, e36473 (2012).
    • (2012) PLoS One , vol.7 , pp. e36473
    • Musunuru, K.1
  • 16
    • 84930090376 scopus 로고    scopus 로고
    • The impact of low-frequency and rare variants on lipid levels
    • Surakka, I. et al. The impact of low-frequency and rare variants on lipid levels. Nat. Genet. 47, 589-597 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 589-597
    • Surakka, I.1
  • 17
    • 84943182742 scopus 로고    scopus 로고
    • The UK10K project identifies rare variants in health and disease
    • UK10K Consortium
    • UK10K Consortium. The UK10K project identifies rare variants in health and disease. Nature 526, 82-90 (2015).
    • (2015) Nature , vol.526 , pp. 82-90
  • 18
    • 84875996758 scopus 로고    scopus 로고
    • Trans-ethnic fine-mapping of lipid loci identifies populationspecific signals and allelic heterogeneity that increases the trait variance explained
    • Wu, Y. et al. Trans-ethnic fine-mapping of lipid loci identifies populationspecific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet. 9, e1003379 (2013).
    • (2013) PLoS Genet. , vol.9 , pp. e1003379
    • Wu, Y.1
  • 19
    • 84945370533 scopus 로고    scopus 로고
    • Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers
    • Sidore, C. et al. Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers. Nat. Genet. 47, 1272-1281 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1272-1281
    • Sidore, C.1
  • 20
    • 85014345453 scopus 로고    scopus 로고
    • Analysis with the exome array identifies multiple new independent variants in lipid loci
    • Kanoni, S. et al. Analysis with the exome array identifies multiple new independent variants in lipid loci. Hum. Mol. Genet. 25, 4094-4106 (2016).
    • (2016) Hum. Mol. Genet. , vol.25 , pp. 4094-4106
    • Kanoni, S.1
  • 21
    • 84925860386 scopus 로고    scopus 로고
    • Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease
    • Tada, H. et al. Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease. Circ. Cardiovasc. Genet. 7, 583-587 (2014).
    • (2014) Circ. Cardiovasc. Genet. , vol.7 , pp. 583-587
    • Tada, H.1
  • 22
    • 84884167819 scopus 로고    scopus 로고
    • Heritability of metabolic syndrome traits in a large population-based sample
    • van Dongen, J., Willemsen, G., Chen, W.-M., de Geus, E. J. C. &Boomsma, D. I. Heritability of metabolic syndrome traits in a large population-based sample. J. Lipid Res. 54, 2914-2923 (2013).
    • (2013) J. Lipid Res. , vol.54 , pp. 2914-2923
    • Van Dongen, J.1    Willemsen, G.2    Chen, W.-M.3    De Geus, E.J.C.4    Boomsma, D.I.5
  • 23
    • 84904048618 scopus 로고    scopus 로고
    • Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations
    • Ganesh, S. K. et al. Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. Am. J. Hum. Genet. 95, 49-65 (2014).
    • (2014) Am. J. Hum. Genet. , vol.95 , pp. 49-65
    • Ganesh, S.K.1
  • 24
    • 84995494168 scopus 로고    scopus 로고
    • Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation
    • Hoffmann, T. J. et al. Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. Nat. Genet. 49, 54-64 (2017).
    • (2017) Nat. Genet. , vol.49 , pp. 54-64
    • Hoffmann, T.J.1
  • 25
    • 84939422197 scopus 로고    scopus 로고
    • Characterizing race/ethnicity and genetic ancestry for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort
    • Banda, Y. et al. Characterizing race/ethnicity and genetic ancestry for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. Genetics 200, 1285-1295 (2015).
    • (2015) Genetics , vol.200 , pp. 1285-1295
    • Banda, Y.1
  • 26
    • 84939426058 scopus 로고    scopus 로고
    • Genotyping informatics and quality control for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort
    • Kvale, M. N. et al. Genotyping informatics and quality control for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. Genetics 200, 1051-1060 (2015).
    • (2015) Genetics , vol.200 , pp. 1051-1060
    • Kvale, M.N.1
  • 27
    • 81955167912 scopus 로고    scopus 로고
    • Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm
    • Hoffmann, T. J. et al. Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm. Genomics 98, 422-430 (2011).
    • (2011) Genomics , vol.98 , pp. 422-430
    • Hoffmann, T.J.1
  • 28
    • 79960700796 scopus 로고    scopus 로고
    • Next generation genome-wide association tool: Design and coverage of a high-throughput European-optimized SNP array
    • Hoffmann, T. J. et al. Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics 98, 79-89 (2011).
    • (2011) Genomics , vol.98 , pp. 79-89
    • Hoffmann, T.J.1
  • 29
    • 84924060689 scopus 로고    scopus 로고
    • Efficient Bayesian mixed-model analysis increases association power in large cohorts
    • Loh, P.-R. et al. Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat. Genet. 47, 284-290 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 284-290
    • Loh, P.-R.1
  • 30
    • 79955860273 scopus 로고    scopus 로고
    • Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies
    • Han, B. &Eskin, E. Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies. Am. J. Hum. Genet. 88, 586-598 (2011).
    • (2011) Am. J. Hum. Genet. , vol.88 , pp. 586-598
    • Han, B.1    Eskin, E.2
  • 31
    • 79959241413 scopus 로고    scopus 로고
    • Genomic inflation factors under polygenic inheritance
    • Yang, J. et al. Genomic inflation factors under polygenic inheritance. Eur. J. Hum. Genet. 19, 807-812 (2011).
    • (2011) Eur. J. Hum. Genet. , vol.19 , pp. 807-812
    • Yang, J.1
  • 32
    • 84921782559 scopus 로고    scopus 로고
    • Fast and accurate imputation of summary statistics enhances evidence of functional enrichment
    • Pasaniuc, B. et al. Fast and accurate imputation of summary statistics enhances evidence of functional enrichment. Bioinformatics 30, 2906-2914 (2014).
    • (2014) Bioinformatics , vol.30 , pp. 2906-2914
    • Pasaniuc, B.1
  • 33
    • 84926430250 scopus 로고    scopus 로고
    • UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age
    • Sudlow, C. et al. UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).
    • (2015) PLoS Med. , vol.12 , pp. e1001779
    • Sudlow, C.1
  • 34
    • 33745700802 scopus 로고    scopus 로고
    • Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol
    • Huedo-Medina, T. B., Sánchez-Meca, J., Marín-Martínez, F. &Botella, J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol. Methods 11, 193-206 (2006).
    • (2006) Methods , vol.11 , pp. 193-206
    • Huedo-Medina, T.B.1    Sánchez-Meca, J.2    Marín-Martínez, F.3    Botella, J.4
  • 35
    • 0032747981 scopus 로고    scopus 로고
    • Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism
    • Sijbrands, E. J. G. et al. Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism. Arterioscler. Thromb. Vasc. Biol. 19, 2722-2729 (1999).
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 2722-2729
    • Sijbrands, E.J.G.1
  • 36
    • 84898478242 scopus 로고    scopus 로고
    • Sex-specific association of the zinc finger protein 259 rs2075290 polymorphism and serum lipid levels
    • Aung, L. H. H. et al. Sex-specific association of the zinc finger protein 259 rs2075290 polymorphism and serum lipid levels. Int. J. Med. Sci. 11, 471-478 (2014).
    • (2014) Int. J. Med. Sci. , vol.11 , pp. 471-478
    • Aung, L.H.H.1
  • 38
    • 84901060300 scopus 로고    scopus 로고
    • Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression
    • Chen, G.-B. Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression. Stat. Genet. 5, 107 (2014).
    • (2014) Stat. Genet. , vol.5 , pp. 107
    • Chen, G.-B.1
  • 40
    • 84929001104 scopus 로고    scopus 로고
    • The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
    • GTEx Consortium
    • GTEx Consortium. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348, 648-660 (2015).
    • (2015) Science , vol.348 , pp. 648-660
  • 42
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy-A genomewide study
    • Link, E. et al. SLCO1B1 variants and statin-induced myopathy-A genomewide study. N. Engl. J. Med. 359, 789-799 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 789-799
    • Link, E.1
  • 43
    • 84864619335 scopus 로고    scopus 로고
    • A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation
    • Coviello, A. D. et al. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genet. 8, e1002805 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. e1002805
    • Coviello, A.D.1
  • 44
    • 67649838598 scopus 로고    scopus 로고
    • Genome-wide association meta-analysis for total serum bilirubin levels
    • Johnson, A. D. et al. Genome-wide association meta-analysis for total serum bilirubin levels. Hum. Mol. Genet. 18, 2700-2710 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2700-2710
    • Johnson, A.D.1
  • 46
    • 0040368659 scopus 로고    scopus 로고
    • Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
    • Abe, T. et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 274, 17159-17163 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 17159-17163
    • Abe, T.1
  • 47
    • 0033601257 scopus 로고    scopus 로고
    • A novel human hepatic organic anion transporting polypeptide (OATP2) Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
    • Hsiang, B. et al. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J. Biol. Chem. 274, 37161-37168 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 37161-37168
    • Hsiang, B.1
  • 48
    • 80053102580 scopus 로고    scopus 로고
    • Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
    • Yu, E. A. &Weaver, D. R. Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging 3, 479-493 (2011).
    • (2011) Aging , vol.3 , pp. 479-493
    • Yu, E.A.1    Weaver, D.R.2
  • 49
    • 80053054824 scopus 로고    scopus 로고
    • Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation
    • Shimba, S. et al. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One 6, e25231 (2011).
    • (2011) PLoS One , vol.6 , pp. e25231
    • Shimba, S.1
  • 50
    • 84934932181 scopus 로고    scopus 로고
    • A metabolomic study of adipose tissue in mice with a disruption of the circadian system
    • Castro, C., Briggs, W., Paschos, G. K., FitzGerald, G. A. &Griffin, J. L. A metabolomic study of adipose tissue in mice with a disruption of the circadian system. Mol. Biosyst. 11, 1897-1906 (2015).
    • (2015) Mol. Biosyst. , vol.11 , pp. 1897-1906
    • Castro, C.1    Briggs, W.2    Paschos, G.K.3    FitzGerald, G.A.4    Griffin, J.L.5
  • 51
    • 0033591387 scopus 로고    scopus 로고
    • Bile acids: Natural ligands for an orphan nuclear receptor
    • Parks, D. J. et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 284, 1365-1368 (1999).
    • (1999) Science , vol.284 , pp. 1365-1368
    • Parks, D.J.1
  • 52
    • 0028031001 scopus 로고
    • Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates
    • Green, M. D., Oturu, E. M. &Tephly, T. R. Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. Drug Metab. Dispos. 22, 799-805 (1994).
    • (1994) Drug Metab. Dispos. , vol.22 , pp. 799-805
    • Green, M.D.1    Oturu, E.M.2    Tephly, T.R.3
  • 53
    • 0029809062 scopus 로고    scopus 로고
    • Isolation and characterization of a novel cDNA encoding a human UDPglucuronosyltransferase active on C19 steroids
    • Beaulieu, M., Lévesque, E., Hum, D. W. &Bélanger, A. Isolation and characterization of a novel cDNA encoding a human UDPglucuronosyltransferase active on C19 steroids. J. Biol. Chem. 271, 22855-22862 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 22855-22862
    • Beaulieu, M.1    Lévesque, E.2    Hum, D.W.3    Bélanger, A.4
  • 55
    • 84865626577 scopus 로고    scopus 로고
    • Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis
    • Liao, Y.-J. et al. Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. Mol. Med. 18, 412-422 (2012).
    • (2012) Mol. Med. , vol.18 , pp. 412-422
    • Liao, Y.-J.1
  • 56
    • 36349011287 scopus 로고    scopus 로고
    • Glycine N-methyltransferase-/-mice develop chronic hepatitis and glycogen storage disease in the liver
    • Liu, S.-P. et al. Glycine N-methyltransferase-/-mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology 46, 1413-1425 (2007).
    • (2007) Hepatology , vol.46 , pp. 1413-1425
    • Liu, S.-P.1
  • 57
    • 84927126103 scopus 로고    scopus 로고
    • Cholesterol transport through lysosome-peroxisome membrane contacts
    • Chu, B.-B. et al. Cholesterol transport through lysosome-peroxisome membrane contacts. Cell 161, 291-306 (2015).
    • (2015) Cell , vol.161 , pp. 291-306
    • Chu, B.-B.1
  • 58
    • 79955583542 scopus 로고    scopus 로고
    • Mapping and analysis of chromatin state dynamics in nine human cell types
    • Ernst, J. et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473, 43-49 (2011).
    • (2011) Nature , vol.473 , pp. 43-49
    • Ernst, J.1
  • 59
    • 84948761469 scopus 로고    scopus 로고
    • Glucagon receptor antagonism induces increased cholesterol absorption
    • Guan, H.-P. et al. Glucagon receptor antagonism induces increased cholesterol absorption. J. Lipid Res. 56, 2183-2195 (2015).
    • (2015) J. Lipid Res. , vol.56 , pp. 2183-2195
    • Guan, H.-P.1
  • 60
    • 84884407233 scopus 로고    scopus 로고
    • Fat depots, free fatty acids, and dyslipidemia
    • Ebbert, J. O. &Jensen, M. D. Fat depots, free fatty acids, and dyslipidemia. Nutrients 5, 498-508 (2013).
    • (2013) Nutrients , vol.5 , pp. 498-508
    • Ebbert, J.O.1    Jensen, M.D.2
  • 61
    • 78651507377 scopus 로고    scopus 로고
    • Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: A magnetic resonance imaging study
    • Hoenig, M. R., Cowin, G., Buckley, R., McHenery, C. &Coulthard, A. Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: A magnetic resonance imaging study. Lipids Health Dis. 10, 12 (2011).
    • (2011) Lipids Health Dis. , vol.10 , pp. 12
    • Hoenig, M.R.1    Cowin, G.2    Buckley, R.3    McHenery, C.4    Coulthard, A.5
  • 62
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: The case of the missing heritability
    • Maher, B. Personal genomes: the case of the missing heritability. Nature 456, 18-21 (2008).
    • (2008) Nature , vol.456 , pp. 18-21
    • Maher, B.1
  • 63
    • 85007028930 scopus 로고    scopus 로고
    • Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
    • Dewey, F. E. et al. Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study. Science 354, aaf6814 (2016).
    • (2016) Science , vol.354 , pp. aaf6814
    • Dewey, F.E.1
  • 64
    • 84922421928 scopus 로고    scopus 로고
    • Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension
    • Lu, X. et al. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. Hum. Mol. Genet. 24, 865-874 (2015).
    • (2015) Hum. Mol. Genet. , vol.24 , pp. 865-874
    • Lu, X.1
  • 65
    • 85035766416 scopus 로고    scopus 로고
    • Exome-wide association study of plasma lipids in ≥ 300,000 individuals
    • Liu, D. J. et al. Exome-wide association study of plasma lipids in ≥ 300,000 individuals. Nat. Genet. 49, 1758-1766 (2017).
    • (2017) Nat. Genet. , vol.49 , pp. 1758-1766
    • Liu, D.J.1
  • 66
    • 85035814059 scopus 로고    scopus 로고
    • Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease
    • Lu, X. et al. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat. Genet. 49, 1722-1730 (2017).
    • (2017) Nat. Genet. , vol.49 , pp. 1722-1730
    • Lu, X.1
  • 67
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald, W. T., Levy, R. I. &Fredrickson, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499-502 (1972).
    • (1972) Clin. Chem. , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 68
    • 84856478855 scopus 로고    scopus 로고
    • A linear complexity phasing method for thousands of genomes
    • Delaneau, O., Marchini, J. &Zagury, J.-F. A linear complexity phasing method for thousands of genomes. Nat. Methods 9, 179-181 (2011).
    • (2011) Nat. Methods , vol.9 , pp. 179-181
    • Delaneau, O.1    Marchini, J.2    Zagury, J.-F.3
  • 69
    • 84863845193 scopus 로고    scopus 로고
    • Genotype imputation with thousands of genomes
    • Howie, B., Marchini, J. &Stephens, M. Genotype imputation with thousands of genomes. G3 1, 457-470 (2011).
    • (2011) G3 , vol.1 , pp. 457-470
    • Howie, B.1    Marchini, J.2    Stephens, M.3
  • 70
    • 84864417548 scopus 로고    scopus 로고
    • Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
    • Howie, B., Fuchsberger, C., Stephens, M., Marchini, J. &Abecasis, G. R. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat. Genet. 44, 955-959 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 955-959
    • Howie, B.1    Fuchsberger, C.2    Stephens, M.3    Marchini, J.4    Abecasis, G.R.5
  • 71
    • 67651222400 scopus 로고    scopus 로고
    • A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
    • Howie, B. N., Donnelly, P. &Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).
    • (2009) PLoS Genet. , vol.5 , pp. e1000529
    • Howie, B.N.1    Donnelly, P.2    Marchini, J.3
  • 72
    • 77953808087 scopus 로고    scopus 로고
    • Genotype imputation for genome-wide association studies
    • Marchini, J. &Howie, B. Genotype imputation for genome-wide association studies. Nat. Rev. Genet. 11, 499-511 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 499-511
    • Marchini, J.1    Howie, B.2
  • 73
    • 62649089065 scopus 로고    scopus 로고
    • Genotype-imputation accuracy across worldwide human populations
    • Huang, L. et al. Genotype-imputation accuracy across worldwide human populations. Am. J. Hum. Genet. 84, 235-250 (2009).
    • (2009) Am. J. Hum. Genet. , vol.84 , pp. 235-250
    • Huang, L.1
  • 74
    • 84989838868 scopus 로고    scopus 로고
    • Reference-based phasing using the Haplotype Reference Consortium panel
    • Loh, P.-R. et al. Reference-based phasing using the Haplotype Reference Consortium panel. Nat. Genet. 48, 1443-1448 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 1443-1448
    • Loh, P.-R.1
  • 75
    • 84984598118 scopus 로고    scopus 로고
    • Next-generation genotype imputation service and methods
    • Das, S. et al. Next-generation genotype imputation service and methods. Nat. Genet. 48, 1284-1287 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 1284-1287
    • Das, S.1
  • 76
    • 84865760395 scopus 로고    scopus 로고
    • GENCODE: The reference human genome annotation for the ENCODE Project
    • Harrow, J. et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res. 22, 1760-1774 (2012).
    • (2012) Genome Res. , vol.22 , pp. 1760-1774
    • Harrow, J.1
  • 77
    • 84858779229 scopus 로고    scopus 로고
    • HaploReg: A resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
    • Ward, L. D. &Kellis, M. HaploReg: A resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 40, D930-D934 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. D930-D934
    • Ward, L.D.1    Kellis, M.2
  • 78
    • 77956534324 scopus 로고    scopus 로고
    • ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
    • Wang, K., Li, M. &Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. e164
    • Wang, K.1    Li, M.2    Hakonarson, H.3
  • 79
    • 45149108420 scopus 로고    scopus 로고
    • Mapping the genetic architecture of gene expression in human liver
    • Schadt, E. E. et al. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 6, e107 (2008).
    • (2008) PLoS Biol. , vol.6 , pp. e107
    • Schadt, E.E.1
  • 80
    • 84885018609 scopus 로고    scopus 로고
    • Systematic identification of trans eQTLs as putative drivers of known disease associations
    • Westra, H.-J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238-1243 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1238-1243
    • Westra, H.-J.1
  • 81
    • 84885645853 scopus 로고    scopus 로고
    • Transcriptome and genome sequencing uncovers functional variation in humans
    • Lappalainen, T. et al. Transcriptome and genome sequencing uncovers functional variation in humans. Nature 501, 506-511 (2013).
    • (2013) Nature , vol.501 , pp. 506-511
    • Lappalainen, T.1
  • 82
    • 79959916375 scopus 로고    scopus 로고
    • A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort
    • Greenawalt, D. M. et al. A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res. 21, 1008-1016 (2011).
    • (2011) Genome Res. , vol.21 , pp. 1008-1016
    • Greenawalt, D.M.1
  • 83
    • 79952489475 scopus 로고    scopus 로고
    • Estimating missing heritability for disease from genome-wide association studies
    • Lee, S. H., Wray, N. R., Goddard, M. E. &Visscher, P. M. Estimating missing heritability for disease from genome-wide association studies. Am. J. Hum. Genet. 88, 294-305 (2011).
    • (2011) Am. J. Hum. Genet. , vol.88 , pp. 294-305
    • Lee, S.H.1    Wray, N.R.2    Goddard, M.E.3    Visscher, P.M.4
  • 84
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell, S. et al. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1
  • 85
    • 84930213392 scopus 로고    scopus 로고
    • Second-generation PLINK: Rising to the challenge of larger and richer datasets
    • Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).
    • (2015) Gigascience , vol.4 , pp. 7
    • Chang, C.C.1
  • 86
    • 77951439152 scopus 로고    scopus 로고
    • Trait-associated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS
    • Nicolae, D. L. et al. Trait-associated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS. PLoS Genet. 6, e1000888 (2010).
    • (2010) PLoS Genet. , vol.6 , pp. e1000888
    • Nicolae, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.