Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease

Circulation: Cardiovascular Genetics

Volumn 7, Issue 5, 2014, Pages 583-587

  Tada, Hayato ^b   Won, Hong Hee ^a,b   Melander, Olle ^c,d   Yang, Jian ^e   Peloso, Gina M ^a,b   Kathiresan, Sekar ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c LUND UNIVERSITY   (Sweden)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Coronary artery disease; Genetics; Genome wide association study; Lipids

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN A4; APOLIPOPROTEIN A5; APOLIPOPROTEIN C3; CHOLESTEROL ESTER TRANSFER PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; LIPID;

ALLELE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 11; CORONARY ARTERY DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; GENE CLUSTER; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HERITABILITY; HUMAN; LIPID BLOOD LEVEL; META ANALYSIS (TOPIC); PHENOTYPIC VARIATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; BIOLOGICAL MODEL; BLOOD; GENETIC PREDISPOSITION; GENETICS; META ANALYSIS; PHENOTYPE; REFERENCE VALUE;

CHOLESTEROL, HDL; CHOLESTEROL, LDL; CORONARY ARTERY DISEASE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; LIPIDS; MODELS, GENETIC; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES;

EID: 84925860386     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000420     Document Type: Article

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