Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations

American Journal of Human Genetics

Volumn 95, Issue 1, 2014, Pages 49-65

  Ganesh, Santhi K ^a   Chasman, Daniel I ^b,c   Larson, Martin G ^d,e   Guo, Xiuqing ^f,g   Verwoert, Germain ^h   Bis, Joshua C ⁱ   Xiangjun, G U ^j   Smith, Albert V ^k,l   Yang, Min Lee ^a   Zhang, Yan ^m   Ehret, Georg ^n,o   Rose, Lynda M ^b   Hwang, Shih Jen ^d   Papanicolau, George J ^d   Sijbrands, Eric J ^h   Rice, Kenneth ^p   Eiriksdottir, Gudny ^k   Pihur, Vasyl ⁿ   Ridker, Paul M ^b,c   Vasan, Ramachandran S ^d,q   Newton Cheh, Christopher ^r,ae   Raffel, Leslie J ^s   Amin, Najaf ^h   Rotter, Jerome I ^f,g   Liu, Kiang ^t   Launer, Lenore J ^u   Ming, X U ^v   Caulfield, Mark ^w,x,ae   Morrison, Alanna C ^y   Johnson, Andrew D ^d   Vaidya, Dhananjay ⁿ   Dehghan, Abbas ^h   Guo, L I ⁱ   Bouchard, Claude ^z   Harris, Tamara B ^u   Zhang, He ^a   Boerwinkle, Eric ^y   Siscovick, David S ^i,p,ae   Gao, Wei ^v   Uitterlinden, Andre G ^h,aa   Rivadeneira, Fernando ^h   Hofman, Albert ^h   Willer, Cristen J ^a,ae   Franco, Oscar H ^h   Huo, Yong ^m   Witteman, Jacqueline C M ^h   Munroe, Patricia B ^w,x,ae   Gudnason, Vilmundur ^k,l   Palmas, Walter ^ab   van Duijn, Cornelia ^h,aa   Fornage, Myriam ^j,ac   Levy, Daniel ^d,q   Psaty, Bruce M ^i,p,ad   Chakravarti, Aravinda ⁿ   Johnson, Toby ^ae   Gateva, Vesela ^ae   Tobin, Martin D ^ae   Bochud, Murielle ^ae   Coin, Lachlan ^ae   Najjar, Samer S ^ae   Zhao, Jing Hua ^ae   Heath, Simon C ^ae   Eyheramendy, Susana ^ae   Papadakis, Konstantinos ^ae   Voight, Benjamin F ^ae   Scott, Laura J ^ae   Zhang, Feng ^ae   Farrall, Martin ^ae   Tanaka, Toshiko ^ae   Wallace, Chris ^ae   Chambers, John C ^ae   Khaw, Kay Tee ^ae   Nilsson, Peter ^ae   van der Harst, Pim ^ae   Polidoro, Silvia ^ae   Grobbee, Diederick E ^ae   Onland Moret, N Charlotte ^ae   Bots, Michiel L ^ae   Wain, Louise V ^ae   Elliott, Katherine S ^ae   Teumer, Alexander ^ae   Luan, Jian’an ^ae   Lucas, Gavin ^ae   Kuusisto, Johanna ^ae   Burton, Paul R ^ae   Hadley, David ^ae   McArdle, Wendy L ^ae   Brown, Morris ^ae   Dominic Zak, Anna ^ae   Newhouse, Stephen J ^ae   Samani, Nilesh J ^ae   Webster, John ^ae   Zeggini, Eleftheria ^ae   Beckmann, Jacques S ^ae   Bergmann, Sven ^ae   Lim, Noha ^ae   Song, Kijoung ^ae   Vollenweider, Peter ^ae   Waeber, Gerard ^ae   Waterworth, Dawn M ^ae   Yuan, Xin ^ae   Groop, Leif ^ae   Orho Melander, Marju ^ae   Allione, Alessandra ^ae   Di Gregorio, Alessandra ^ae   Guarrera, Simonetta ^ae   Panico, Salvatore ^ae   Ricceri, Fulvio ^ae   Romanazzi, Valeria ^ae   Sacer Dote, Carlotta ^ae   Vineis, Paolo ^ae   Barroso, Inês ^ae   Sandhu, Manjinder S ^ae   Luben, Robert N ^ae   Crawford, Gabriel J ^ae   Jousilahti, Pekka ^ae   Perola, Markus ^ae   Boehnke, Michael ^ae   Bonnycastle, Lori L ^ae   Collins, Francis S ^ae   Jackson, Anne U ^ae   Mohlke, Karen L ^ae   Stringham, Heather M ^ae   Valle, Timo T ^ae   Bergman, Richard N ^ae   Morken, Mario A ^ae   Döring, Angela ^ae   Gieger, Christian ^ae   Illig, Thomas ^ae   Meitinger, Thomas ^ae   Org, Elin ^ae   Pfeufer, Arne ^ae   Wichmann, H Erich ^ae   Kathiresan, Sekar ^ae   Marrugat, Jaume ^ae   O’donnell, Christopher J ^ae   Schwartz, Stephen M ^ae   Subirana, Isaac ^ae   Freimer, Nelson B ^ae   Harti Kainen, Anna Liisa ^ae   McCarthy, Mark I ^ae   O’reilly, Paul F ^ae   Peltonen, Leena ^ae   Pouta, Anneli ^ae   de Jong, Paul E ^ae   Snieder, Harold ^ae   van Gilst, Wiek H ^ae   Clarke, Robert ^ae   Goel, Anuj ^ae   Hamsten, Anders ^ae   Peden, John F ^ae   Seedorf, Udo ^ae   Syvänen, Ann Christine ^ae   Tognoni, Giovanni ^ae   Lakatta, Edward G ^ae   Sanna, Serena ^ae   Scheet, Paul ^ae   Schlessinger, David ^ae   Scuteri, Angelo ^ae   Dörr, Marcus ^ae   Ernst, Florian ^ae   Felix, Stephan B ^ae   Homuth, Georg ^ae   Lorbeer, Roberto ^ae   Reffelmann, Thorsten ^ae   Rettig, Rainer ^ae   Völker, Uwe ^ae   Galan, Pilar ^ae   Gut, Ivo G ^ae   Hercberg, Serge ^ae   Lathrop, G Mark ^ae   Zeleneka, Diana ^ae   Deloukas, Panos ^ae   Soranzo, Nicole ^ae   Williams, Frances M ^ae   Zhai, Guangju ^ae   Salomaa, Veikko ^ae   Laakso, Markku ^ae   Elosua, Roberto ^ae   Forouhi, Nita G ^ae   Völzke, Henry ^ae   Uiterwaal, Cuno S ^ae   van der Schouw, Yvonne T ^ae   Numans, Mattijs E ^ae   Matullo, Giuseppe ^ae   Na Vis, Gerjan ^ae   Berglund, Göran ^ae   Bingham, Sheila A ^ae   Kooner, Jaspal S ^ae   Paterson, Andrew D ^ae   Connell, John M ^ae   Bandinelli, Stefania ^ae   Ferrucci, Luigi ^ae   Watkins, Hugh ^ae   Spector, Tim D ^ae   Tuomilehto, Jaakko ^ae   Altshuler, David ^ae   Strachan, David P ^ae   Laan, Maris ^ae   Meneton, Pierre ^ae   Wareham, Nicholas J ^ae   Uda, Manuela ^ae   Jarvelin, Marjo Riitta ^ae   Mooser, Vincent ^ae   Melander, Olle ^ae   Loos, Ruth J F ^ae   Elliott, Paul ^ae   Abecasis, Gonçalo R ^ae   more..

^a UNIVERSITY OF MICHIGAN   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e Boston University   (United States)

^f LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^g HARBOR UCLA MEDICAL CENTER   (United States)

^h ERASMUS MEDICAL CENTER   (Netherlands)

ⁱ UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^k ICELANDIC HEART ASSOCIATION   (Iceland)

^l UNIVERSITY OF ICELAND   (Iceland)

^m PEKING UNIVERSITY FIRST HOSPITAL   (China)

ⁿ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^p UNIVERSITY OF WASHINGTON   (United States)

^q BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^r MASSACHUSETTS GENERAL HOSPITAL   (United States)

^s CEDARS SINAI MEDICAL CENTER   (United States)

^t NORTHWESTERN UNIVERSITY   (United States)

^u NATIONAL INSTITUTE ON AGING   (United States)

^v PEKING UNIVERSITY THIRD HOSPITAL   (China)

^w QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^x QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^y UNIVERSITY OF TEXAS   (United States)

^z PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^aa Netherlands Genomics Initiative   (Netherlands)

^ab Och Spine at New York Presbyterian Hospitals   (United States)

^ac UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^ad CENTER FOR HEALTH STUDIES   (United States)

^ae NONE

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENOTYPE; HUMAN; LONGITUDINAL STUDY; MEAN ARTERIAL PRESSURE; MEASUREMENT ERROR; META ANALYSIS (TOPIC); NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PULSE PRESSURE; QUALITY CONTROL; QUANTITATIVE TRAIT; QUANTITATIVE TRAIT LOCUS; REPLICATION STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; BLOOD PRESSURE; GENETICS;

BLOOD PRESSURE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LONGITUDINAL STUDIES; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 84904048618     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2014.06.002     Document Type: Article

References (91)

1. S. Lewington, R. Clarke, N. Qizilbash, R. Peto, R. Collins Prospective Studies Collaboration Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies Lancet 360 2002 1903 1913 (Pubitemid 35472129)
2. G.B. Ehret, P.B. Munroe, K.M. Rice, M. Bochud, A.D. Johnson, D.I. Chasman, A.V. Smith, M.D. Tobin, G.C. Verwoert, S.J. Hwang International Consortium for Blood Pressure Genome-Wide Association Studies CARDIoGRAM consortium CKDGen Consortium KidneyGen Consortium EchoGen consortium CHARGE-HF consortium Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk Nature 478 2011 103 109
3. S.K. Ganesh, V. Tragante, W. Guo, Y. Guo, M.B. Lanktree, E.N. Smith, T. Johnson, B.A. Castillo, J. Barnard, J. Baumert CARDIOGRAM, METASTROKE LifeLines Cohort Study Loci influencing blood pressure identified using a cardiovascular gene-centric array Hum. Mol. Genet. 22 2013 1663 1678
4. D. Levy, G.B. Ehret, K. Rice, G.C. Verwoert, L.J. Launer, A. Dehghan, N.L. Glazer, A.C. Morrison, A.D. Johnson, and T. Aspelund et al. Genome-wide association study of blood pressure and hypertension Nat. Genet. 41 2009 677 687
5. C. Newton-Cheh, T. Johnson, V. Gateva, M.D. Tobin, M. Bochud, L. Coin, S.S. Najjar, J.H. Zhao, S.C. Heath, S. Eyheramendy Wellcome Trust Case Control Consortium Genome-wide association study identifies eight loci associated with blood pressure Nat. Genet. 41 2009 666 676
6. A.V. Chobanian, G.L. Bakris, H.R. Black, W.C. Cushman, L.A. Green, J.L. Izzo Jr., D.W. Jones, B.J. Materson, S. Oparil, J.T. Wright Jr., E.J. Roccella National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure National High Blood Pressure Education Program Coordinating Committee The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report J. Am. Med. Assoc. 289 2003 2560 2572 (Pubitemid 37430158)
7. B.M. Psaty, C.J. O'Donnell, V. Gudnason, K.L. Lunetta, A.R. Folsom, J.I. Rotter, A.G. Uitterlinden, T.B. Harris, J.C. Witteman, E. Boerwinkle CHARGE Consortium Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts Circ Cardiovasc Genet 2 2009 73 80
8. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, D. Bender, J. Maller, P. Sklar, P.I. de Bakker, M.J. Daly, and P.C. Sham PLINK: a tool set for whole-genome association and population-based linkage analyses Am. J. Hum. Genet. 81 2007 559 575 (Pubitemid 47330214)
9. M.H. Chen, and Q. Yang GWAF: an R package for genome-wide association analyses with family data Bioinformatics 26 2010 580 581
10. B. Devlin, and K. Roeder Genomic control for association studies Biometrics 55 1999 997 1004
11. A.D. Johnson, R.E. Handsaker, S.L. Pulit, M.M. Nizzari, C.J. O'Donnell, and P.I. de Bakker SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap Bioinformatics 24 2008 2938 2939
12. M. Rantalainen, B.M. Herrera, G. Nicholson, R. Bowden, Q.F. Wills, J.L. Min, M.J. Neville, A. Barrett, M. Allen, and N.W. Rayner et al. MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven PLoS ONE 6 2011 e27338
13. H. Lin, E.V. Dolmatova, M.P. Morley, K.L. Lunetta, D.D. McManus, J.W. Magnani, K.B. Margulies, H. Hakonarson, F. del Monte, and E.J. Benjamin et al. Gene expression and genetic variation in human atria Heart Rhythm 11 2014 266 271
14. G.T. Consortium GTEx Consortium The Genotype-Tissue Expression (GTEx) project Nat. Genet. 45 2013 580 585
15. W. Qiu, M.H. Cho, J.H. Riley, W.H. Anderson, D. Singh, P. Bakke, A. Gulsvik, A.A. Litonjua, D.A. Lomas, J.D. Crapo ECLIPSE Investigators Genetics of sputum gene expression in chronic obstructive pulmonary disease PLoS ONE 6 2011 e24395
16. M. Gutierrez-Arcelus, T. Lappalainen, S.B. Montgomery, A. Buil, H. Ongen, A. Yurovsky, J. Bryois, T. Giger, L. Romano, and A. Planchon et al. Passive and active DNA methylation and the interplay with genetic variation in gene regulation Elife 2 2013 e00523
17. A.S. Dimas, S. Deutsch, B.E. Stranger, S.B. Montgomery, C. Borel, H. Attar-Cohen, C. Ingle, C. Beazley, M. Gutierrez Arcelus, and M. Sekowska et al. Common regulatory variation impacts gene expression in a cell type-dependent manner Science 325 2009 1246 1250
18. E. Grundberg, K.S. Small, A.K. Hedman, A.C. Nica, A. Buil, S. Keildson, J.T. Bell, T.P. Yang, E. Meduri, A. Barrett Multiple Tissue Human Expression Resource (MuTHER) Consortium Mapping cis- and trans-regulatory effects across multiple tissues in twins Nat. Genet. 44 2012 1084 1089
19. J. Ding, J.E. Gudjonsson, L. Liang, P.E. Stuart, Y. Li, W. Chen, M. Weichenthal, E. Ellinghaus, A. Franke, and W. Cookson et al. Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals Am. J. Hum. Genet. 87 2010 779 789
20. C. Gao, N.L. Tignor, J. Salit, Y. Strulovici-Barel, N.R. Hackett, R.G. Crystal, and J.G. Mezey HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors Bioinformatics 30 2014 369 376
21. K. Hao, Y. Bossé, D.C. Nickle, P.D. Paré, D.S. Postma, M. Laviolette, A. Sandford, T.L. Hackett, D. Daley, and J.C. Hogg et al. Lung eQTLs to help reveal the molecular underpinnings of asthma PLoS Genet. 8 2012 e1003029
22. D.A. Quigley, E. Fiorito, S. Nord, P. Van Loo, G.G. Alnæs, T. Fleischer, J. Tost, H.K. Moen Vollan, T. Tramm, and J. Overgaard et al. The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors Mol. Oncol. 8 2014 273 284
23. S. Keildson, J. Fadista, C. Ladenvall, A.K. Hedman, T. Elgzyri, K.S. Small, E. Grundberg, A.C. Nica, D. Glass, J.B. Richards MAGIC Consortium DIAGRAM Consortium MuTHER Consortium Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity Diabetes 63 2014 1154 1165
24. B. Kabakchiev, and M.S. Silverberg Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine Gastroenterology 144 2013 1488 1496.e1-e3
25. E. Grundberg, T. Kwan, B. Ge, K.C. Lam, V. Koka, A. Kindmark, H. Mallmin, J. Dias, D.J. Verlaan, and M. Ouimet et al. Population genomics in a disease targeted primary cell model Genome Res. 19 2009 1942 1952
26. A. Schröder, K. Klein, S. Winter, M. Schwab, M. Bonin, A. Zell, and U.M. Zanger Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver Pharmacogenomics J. 13 2013 12 20
27. F. Innocenti, G.M. Cooper, I.B. Stanaway, E.R. Gamazon, J.D. Smith, S. Mirkov, J. Ramirez, W. Liu, Y.S. Lin, and C. Moloney et al. Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue PLoS Genet. 7 2011 e1002078
28. D.M. Greenawalt, R. Dobrin, E. Chudin, I.J. Hatoum, C. Suver, J. Beaulaurier, B. Zhang, V. Castro, J. Zhu, and S.K. Sieberts et al. A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort Genome Res. 21 2011 1008 1016
29. E.E. Schadt, C. Molony, E. Chudin, K. Hao, X. Yang, P.Y. Lum, A. Kasarskis, B. Zhang, S. Wang, and C. Suver et al. Mapping the genetic architecture of gene expression in human liver PLoS Biol. 6 2008 e107
30. B. Zhang, C. Gaiteri, L.G. Bodea, Z. Wang, J. McElwee, A.A. Podtelezhnikov, C. Zhang, T. Xie, L. Tran, and R. Dobrin et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease Cell 153 2013 707 720
31. E.R. Gamazon, J.A. Badner, L. Cheng, C. Zhang, D. Zhang, N.J. Cox, E.S. Gershon, J.R. Kelsoe, T.A. Greenwood, and C.M. Nievergelt et al. Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants Mol. Psychiatry 18 2013 340 346
32. F. Zou, H.S. Chai, C.S. Younkin, M. Allen, J. Crook, V.S. Pankratz, M.M. Carrasquillo, C.N. Rowley, A.A. Nair, S. Middha Alzheimer's Disease Genetics Consortium Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants PLoS Genet. 8 2012 e1002707
33. S. Kim, H. Cho, D. Lee, and M.J. Webster Association between SNPs and gene expression in multiple regions of the human brain Transcult. Psychiatry 2 2012 e113
34. J.R. Gibbs, M.P. van der Brug, D.G. Hernandez, B.J. Traynor, M.A. Nalls, S.L. Lai, S. Arepalli, A. Dillman, I.P. Rafferty, and J. Troncoso et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain PLoS Genet. 6 2010 e1000952
35. C. Liu, L. Cheng, J.A. Badner, D. Zhang, D.W. Craig, M. Redman, and E.S. Gershon Whole-genome association mapping of gene expression in the human prefrontal cortex Mol. Psychiatry 15 2010 779 784
36. C. Colantuoni, B.K. Lipska, T. Ye, T.M. Hyde, R. Tao, J.T. Leek, E.A. Colantuoni, A.G. Elkahloun, M.M. Herman, D.R. Weinberger, and J.E. Kleinman Temporal dynamics and genetic control of transcription in the human prefrontal cortex Nature 478 2011 519 523
37. J.A. Webster, J.R. Gibbs, J. Clarke, M. Ray, W. Zhang, P. Holmans, K. Rohrer, A. Zhao, L. Marlowe, M. Kaleem NACC-Neuropathology Group Genetic control of human brain transcript expression in Alzheimer disease Am. J. Hum. Genet. 84 2009 445 458
38. E.L. Heinzen, D. Ge, K.D. Cronin, J.M. Maia, K.V. Shianna, W.N. Gabriel, K.A. Welsh-Bohmer, C.M. Hulette, T.N. Denny, and D.B. Goldstein Tissue-specific genetic control of splicing: implications for the study of complex traits PLoS Biol. 6 2008 e1
39. Q. Li, J.H. Seo, B. Stranger, A. McKenna, I. Pe'er, T. Laframboise, M. Brown, S. Tyekucheva, and M.L. Freedman Integrative eQTL-based analyses reveal the biology of breast cancer risk loci Cell 152 2013 633 641
40. K.S. Kompass, and J.S. Witte Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer BMC Med. Genomics 4 2011 6
41. V. Emilsson, G. Thorleifsson, B. Zhang, A.S. Leonardson, F. Zink, J. Zhu, S. Carlson, A. Helgason, G.B. Walters, and S. Gunnarsdottir et al. Genetics of gene expression and its effect on disease Nature 452 2008 423 428 (Pubitemid 351450845)
42. D.V. Zhernakova, E. de Klerk, H.J. Westra, A. Mastrokolias, S. Amini, Y. Ariyurek, R. Jansen, B.W. Penninx, J.J. Hottenga, and G. Willemsen et al. DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts PLoS Genet. 9 2013 e1003594
43. H.J. Westra, M.J. Peters, T. Esko, H. Yaghootkar, C. Schurmann, J. Kettunen, M.W. Christiansen, B.P. Fairfax, K. Schramm, and J.E. Powell et al. Systematic identification of trans eQTLs as putative drivers of known disease associations Nat. Genet. 45 2013 1238 1243
44. D. Sasayama, H. Hori, S. Nakamura, R. Miyata, T. Teraishi, K. Hattori, M. Ota, N. Yamamoto, T. Higuchi, N. Amano, and H. Kunugi Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population PLoS ONE 8 2013 e54967
45. D. Mehta, K. Heim, C. Herder, M. Carstensen, G. Eckstein, C. Schurmann, G. Homuth, M. Nauck, U. Völker, and M. Roden et al. Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood Eur. J. Hum. Genet. 21 2013 48 54
46. L. Liang, N. Morar, A.L. Dixon, G.M. Lathrop, G.R. Abecasis, M.F. Moffatt, and W.O. Cookson A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines Genome Res. 23 2013 716 726
47. H. Landmark-Høyvik, V. Dumeaux, D. Nebdal, E. Lund, J. Tost, Y. Kamatani, V. Renault, A.L. Børresen-Dale, V. Kristensen, and H. Edvardsen Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II Genomics 102 2013 278 287
48. T. Kwan, D. Benovoy, C. Dias, S. Gurd, C. Provencher, P. Beaulieu, T.J. Hudson, R. Sladek, and J. Majewski Genome-wide analysis of transcript isoform variation in humans Nat. Genet. 40 2008 225 231 (Pubitemid 351171391)
49. Y. Idaghdour, W. Czika, K.V. Shianna, S.H. Lee, P.M. Visscher, H.C. Martin, K. Miclaus, S.J. Jadallah, D.B. Goldstein, R.D. Wolfinger, and G. Gibson Geographical genomics of human leukocyte gene expression variation in southern Morocco Nat. Genet. 42 2010 62 67
50. G.A. Heap, G. Trynka, R.C. Jansen, M. Bruinenberg, M.A. Swertz, L.C. Dinesen, K.A. Hunt, C. Wijmenga, D.A. Vanheel, and L. Franke Complex nature of SNP genotype effects on gene expression in primary human leucocytes BMC Med. Genomics 2 2009 1
51. H.H. Göring, J.E. Curran, M.P. Johnson, T.D. Dyer, J. Charlesworth, S.A. Cole, J.B. Jowett, L.J. Abraham, D.L. Rainwater, and A.G. Comuzzie et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes Nat. Genet. 39 2007 1208 1216 (Pubitemid 47482685)
52. R.S. Fehrmann, R.C. Jansen, J.H. Veldink, H.J. Westra, D. Arends, M.J. Bonder, J. Fu, P. Deelen, H.J. Groen, and A. Smolonska et al. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA PLoS Genet. 7 2011 e1002197
53. A.L. Dixon, L. Liang, M.F. Moffatt, W. Chen, S. Heath, K.C. Wong, J. Taylor, E. Burnett, I. Gut, and M. Farrall et al. A genome-wide association study of global gene expression Nat. Genet. 39 2007 1202 1207 (Pubitemid 47482680)
54. D.A. Cusanovich, C. Billstrand, X. Zhou, C. Chavarria, S. De Leon, K. Michelini, A.A. Pai, C. Ober, and Y. Gilad The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes Hum. Mol. Genet. 21 2012 2111 2123
55. M.C. Benton, R.A. Lea, D. Macartney-Coxson, M.A. Carless, H.H. Göring, C. Bellis, M. Hanna, D. Eccles, G.K. Chambers, and J.E. Curran et al. Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits Am. J. Hum. Genet. 93 2013 1087 1099
56. A. Battle, S. Mostafavi, X. Zhu, J.B. Potash, M.M. Weissman, C. McCormick, C.D. Haudenschild, K.B. Beckman, J. Shi, and R. Mei et al. Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals Genome Res. 24 2014 14 24
57. T. Zeller, P. Wild, S. Szymczak, M. Rotival, A. Schillert, R. Castagne, S. Maouche, M. Germain, K. Lackner, and H. Rossmann et al. Genetics and beyond - the transcriptome of human monocytes and disease susceptibility PLoS ONE 5 2010 e10693
58. K.R. van Eijk, S. de Jong, M.P. Boks, T. Langeveld, F. Colas, J.H. Veldink, C.G. de Kovel, E. Janson, E. Strengman, and P. Langfelder et al. Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects BMC Genomics 13 2012 636
59. B.E. Stranger, A.C. Nica, M.S. Forrest, A. Dimas, C.P. Bird, C. Beazley, C.E. Ingle, M. Dunning, P. Flicek, and D. Koller et al. Population genomics of human gene expression Nat. Genet. 39 2007 1217 1224 (Pubitemid 47482691)
60. A. Murphy, J.H. Chu, M. Xu, V.J. Carey, R. Lazarus, A. Liu, S.J. Szefler, R. Strunk, K. Demuth, and M. Castro et al. Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes Hum. Mol. Genet. 19 2010 4745 4757
61. Variability of blood pressure and the results of screening in the hypertension detection and follow-up program J. Chronic Dis. 31 1978 651 667
62. Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 2007 661 678
63. D.I. Chasman, G. Paré, and P.M. Ridker Population-based genomewide genetic analysis of common clinical chemistry analytes Clin. Chem. 55 2009 39 51
64. T.D. Wang, and W.H. Sheu From casual blood pressure measurement to long-term blood pressure burden: better elucidation of the association between versatile blood pressures and cardiovascular events Hypertens. Res. 34 2011 49 51
65. B. Rosner, W.C. Willett, and D. Spiegelman Correction of logistic regression relative risk estimates and confidence intervals for systematic within-person measurement error Stat. Med. 8 1989 1051 1069 discussion 1071-1073 (Pubitemid 19233679)
66. M.W. Gillman, B. Rosner, D.A. Evans, M.E. Keough, L.A. Smith, J.O. Taylor, and C.H. Hennekens Use of multiple visits to increase blood pressure tracking correlations in childhood Pediatrics 87 1991 708 711
67. S.H. Zinner, H.S. Margolius, B. Rosner, and E.H. Kass Stability of blood pressure rank and urinary kallikrein concentration in childhood: an eight-year follow-up Circulation 58 1978 908 915 (Pubitemid 9042776)
68. P. Rossignol, J. Cridlig, P. Lehert, M. Kessler, and F. Zannad Visit-to-visit blood pressure variability is a strong predictor of cardiovascular events in hemodialysis: insights from FOSIDIAL Hypertension 60 2012 339 346
69. P.W. Wilson, J.M. Hoeg, R.B. D'Agostino, H. Silbershatz, A.M. Belanger, H. Poehlmann, D. O'Leary, and P.A. Wolf Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis N. Engl. J. Med. 337 1997 516 522 (Pubitemid 27352017)
70. W.B. Kannel, T. Gordon, and M.J. Schwartz Systolic versus diastolic blood pressure and risk of coronary heart disease. The Framingham study Am. J. Cardiol. 27 1971 335 346
71. R.S. Vasan, J.M. Massaro, P.W. Wilson, S. Seshadri, P.A. Wolf, D. Levy, R.B. D'Agostino Framingham Heart Study Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study Circulation 105 2002 48 53 (Pubitemid 34049141)
72. R.M. Carey, R.A. Reid, C.R. Ayers, S.S. Lynch, W.L. McLain 3rd, and E.D. Vaughan Jr. The Charlottesville Blood-Pressure Survey. Value of repeated blood-pressure measurements J. Am. Med. Assoc. 236 1976 847 851
73. Blood pressure studies in 14 communities. A two-stage screen for hypertension J. Am. Med. Assoc. 237 1977 2385 2391
74. B. Rosner, and B.F. Polk The implications of blood pressure variability for clinical and screening purposes J. Chronic Dis. 32 1979 451 461 (Pubitemid 9253378)
75. B. Rosner, and B.F. Polk The instability of blood pressure variability over time J. Chronic Dis. 34 1981 135 139 (Pubitemid 11156526)
76. L. Ma, D. Roman-Campos, E.D. Austin, M. Eyries, K.S. Sampson, F. Soubrier, M. Germain, D.A. Trégouët, A. Borczuk, and E.B. Rosenzweig et al. A novel channelopathy in pulmonary arterial hypertension N. Engl. J. Med. 369 2013 351 361
77. L.A. Davies, C. Hu, N.A. Guagliardo, N. Sen, X. Chen, E.M. Talley, R.M. Carey, D.A. Bayliss, and P.Q. Barrett TASK channel deletion in mice causes primary hyperaldosteronism Proc. Natl. Acad. Sci. USA 105 2008 2203 2208 (Pubitemid 351439489)
78. S. Muhammad, M.I. Aller, C. Maser-Gluth, M. Schwaninger, and W. Wisden Expression of the kcnk3 potassium channel gene lessens the injury from cerebral ischemia, most likely by a general influence on blood pressure Neuroscience 167 2010 758 764
79. B.L. Wolfe, C.B. Rich, H.D. Goud, A.J. Terpstra, M. Bashir, J. Rosenbloom, G.E. Sonenshein, and J.A. Foster Insulin-like growth factor-I regulates transcription of the elastin gene J. Biol. Chem. 268 1993 12418 12426 (Pubitemid 23182397)
80. C. Lofqvist, J. Chen, K.M. Connor, A.C. Smith, C.M. Aderman, N. Liu, J.E. Pintar, T. Ludwig, A. Hellstrom, and L.E. Smith IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth Proc. Natl. Acad. Sci. USA 104 2007 10589 10594 (Pubitemid 47185709)
81. J.P. Zachariah, V. Xanthakis, M.G. Larson, J.A. Vita, L.M. Sullivan, H.M. Smith, R. Safa, X. Peng, N. Hamburg, and D. Levy et al. Circulating vascular growth factors and central hemodynamic load in the community Hypertension 59 2012 773 779
82. R.C. Kaplan, A.K. Petersen, M.H. Chen, A. Teumer, N.L. Glazer, A. Döring, C.S. Lam, N. Friedrich, A. Newman, and M. Müller et al. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3 Hum. Mol. Genet. 20 2011 1241 1251
83. C.S. Lam, M.H. Chen, S.M. Lacey, Q. Yang, L.M. Sullivan, V. Xanthakis, R. Safa, H.M. Smith, X. Peng, D.B. Sawyer, and R.S. Vasan Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community Arterioscler. Thromb. Vasc. Biol. 30 2010 1479 1484
84. L.A. Beckett, B. Rosner, A.F. Roche, and S. Guo Serial changes in blood pressure from adolescence into adulthood Am. J. Epidemiol. 135 1992 1166 1177
85. X. Chen, and Y. Wang Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis Circulation 117 2008 3171 3180
86. X. Chen, Y. Wang, L.J. Appel, and J. Mi Impacts of measurement protocols on blood pressure tracking from childhood into adulthood: a metaregression analysis Hypertension 51 2008 642 649 (Pubitemid 351301515)
87. N.R. Cook, B.A. Rosner, W. Chen, S.R. Srinivasan, and G.S. Berenson Using the area under the curve to reduce measurement error in predicting young adult blood pressure from childhood measures Stat. Med. 23 2004 3421 3435 (Pubitemid 39467861)
88. M.W. Gillman, N.R. Cook, B. Rosner, D.A. Evans, M.E. Keough, J.O. Taylor, and C.H. Hennekens Assessing the validity of childhood blood pressure screening: unbiased estimates of sensitivity, specificity, and predictive values Epidemiology 3 1992 40 46
89. A. Kollias, K. Pantsiotou, N. Karpettas, L. Roussias, and G.S. Stergiou Tracking of blood pressure from childhood to adolescence in a Greek cohort Eur. J. Public Health 22 2012 389 393
90. J. Sundström, L. Sullivan, R.B. D'Agostino, D. Levy, W.B. Kannel, and R.S. Vasan Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence Hypertension 45 2005 28 33 (Pubitemid 40066409)
91. S.S. Franklin, W. Gustin 4th, N.D. Wong, M.G. Larson, M.A. Weber, W.B. Kannel, and D. Levy Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study Circulation 96 1997 308 315 (Pubitemid 27298437)