Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Dornier, Emmanuel ^a   Rabas, Nicolas ^a   Mitchell, Louise ^a   Novo, David ^a   Dhayade, Sandeep ^a   Marco, Sergi ^a   MacKay, Gillian ^a   Sumpton, David ^a   Pallares, Maria ^a   Nixon, Colin ^a   Blyth, Karen ^a   MacPherson, Iain R ^a,b   Rainero, Elena ^a,c   Norman, Jim C ^a,b  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 4 CARBOXY 2 METHYLPHENYLGLYCINE; ALPHA CYCLOPROPYL 4 PHOSPHONOPHENYLGLYCINE; EGLUMETAD; GLUTAMINE; ILOMASTAT; MATRIX METALLOPROTEINASE 14; METABOTROPIC RECEPTOR; QUISQUALIC ACID; RAS RELATED PROTEIN RAB 27A; SALAZOSULFAPYRIDINE; SMALL INTERFERING RNA; AMINO ACID TRANSPORTER; GLUTAMIC ACID; MMP14 PROTEIN, HUMAN; MMP14 PROTEIN, MOUSE; RAB27A PROTEIN, HUMAN; SLC7A11 PROTEIN, HUMAN; SLC7A11 PROTEIN, MOUSE;

AGGRESSIVENESS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASEMENT MEMBRANE; BREAST CANCER; BREAST EPITHELIUM CELL; CANCER GROWTH; CELL DISRUPTION; CELL MIGRATION; CONTROLLED STUDY; DNA LIBRARY; ENDOCYTOSIS; FEMALE; HUMAN; MDA-MB-231 CELL LINE; MOUSE; NMUMG CELL LINE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIMARY CULTURE; PROTEIN HOMEOSTASIS; REGULATORY MECHANISM; TUMOR INVASION; TUMOR PROMOTION; TUMOR VOLUME; UPREGULATION; WATERSHED; ANIMAL; BREAST TUMOR; EXPERIMENTAL MAMMARY NEOPLASM; EXTRACELLULAR SPACE; HOMEOSTASIS; MAMMARY GLAND; METABOLISM; PATHOLOGY; SECRETION (PROCESS); TUMOR CELL LINE;

AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; EXTRACELLULAR SPACE; FEMALE; GLUTAMIC ACID; GLUTAMINE; HOMEOSTASIS; HUMANS; MAMMARY GLANDS, HUMAN; MAMMARY NEOPLASMS, ANIMAL; MATRIX METALLOPROTEINASE 14; MICE; NEOPLASM INVASIVENESS; RAB27 GTP-BINDING PROTEINS; RECEPTORS, METABOTROPIC GLUTAMATE; UP-REGULATION;

EID: 85042382173     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-02101-2     Document Type: Article

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