Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin

Experimental Eye Research

Volumn 170, Issue , 2018, Pages 51-57

  Lobysheva, E ^a   Taylor, C M ^b,c   Marshall, G R ^b   Kisselev, O G ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MONSANTO COMPANY   (United States)

Author keywords

Bile acid; Chemical biology; G protein; G protein coupled receptor (GPCR); Molecular docking; Photoreceptor; Phototransduction; Retina; Rhodopsin; Signal transduction

Indexed keywords

CHOLESTEROL; DEOXYCHOLIC ACID; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; OPSIN; RHODOPSIN; TAUROURSODEOXYCHOLIC ACID; TRANSDUCIN; TRANSDUCIN ALPHA SUBUNIT; UNCLASSIFIED DRUG; CHOLAGOGUE; METARHODOPSINS; PROTEIN BINDING; TAUROCHENODEOXYCHOLIC ACID;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MOLECULAR DOCKING; NONHUMAN; PHOTOACTIVATION; PHOTORECEPTOR; PHOTOTRANSDUCTION; PRIORITY JOURNAL; RETINA; RETINAL ROD OUTER SEGMENT; SIGNAL TRANSDUCTION; ANIMAL; BOVINE; CHEMISTRY; LIGHT; METABOLISM; PROTEIN SECONDARY STRUCTURE; RADIATION RESPONSE;

ANIMALS; CATTLE; CHOLAGOGUES AND CHOLERETICS; GTP-BINDING PROTEINS; LIGHT; OPSINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED; RHODOPSIN; SIGNAL TRANSDUCTION; TAUROCHENODEOXYCHOLIC ACID;

EID: 85042218026     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2018.02.015     Document Type: Article

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