Chronic myeloid leukemia: The paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy

Molecular Cancer

Volumn 17, Issue 1, 2018, Pages

  Soverini, Simona ^a   Mancini, Manuela ^a   Bavaro, Luana ^a   Cavo, Michele ^a   Martinelli, Giovanni ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

BCR ABL1; Resistance; Tyrosine kinase; Tyrosine kinase inhibitors

Indexed keywords

ASCIMINIB; BCR ABL PROTEIN; BOSUTINIB; DASATINIB; IMATINIB; NILOTINIB; PONATINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN KINASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTERY THROMBOSIS; CANCER RESISTANCE; CANCER THERAPY; CARDIOVASCULAR DISEASE; CHRONIC MYELOID LEUKEMIA; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TARGETING; EDEMA; GENE MUTATION; HEART FAILURE; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPERTRANSAMINASEMIA; LEUKEMOGENESIS; LIFE EXPECTANCY; MEDICATION COMPLIANCE; MYALGIA; NAUSEA; NONHUMAN; OUTCOME ASSESSMENT; PANCREATITIS; PLEURA EFFUSION; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; PULMONARY HYPERTENSION; QT PROLONGATION; QUALITY OF LIFE; RASH; REVIEW; RISK BENEFIT ANALYSIS; SIGNAL TRANSDUCTION; THROMBOCYTOPENIA; TREATMENT RESPONSE; VEIN THROMBOSIS; ANIMAL; DRUG EFFECT; DRUG RESISTANCE; METABOLISM;

ANIMALS; DRUG RESISTANCE, NEOPLASM; HUMANS; IMATINIB MESYLATE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 85042164288     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-018-0780-6     Document Type: Review

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