-
1
-
-
34547687734
-
Discovery of the Philadelphia chromosome: A personal perspective
-
Nowell PC. Discovery of the Philadelphia chromosome: a personal perspective. J Clin Invest 2007;117:2033-5
-
(2007)
J Clin Invest
, vol.117
, pp. 2033-2035
-
-
Nowell, P.C.1
-
2
-
-
58149398623
-
Translation of the Philadelphia chromosome into therapy for CML
-
Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008;112:4808-17
-
(2008)
Blood
, vol.112
, pp. 4808-4817
-
-
Druker, B.J.1
-
3
-
-
34249676964
-
Chronic myeloid leukaemia as a model of disease evolution in human cancer
-
Melo JV, Barnes DJ. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer 2007;7:441-53
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 441-453
-
-
Melo, J.V.1
Barnes, D.J.2
-
4
-
-
14644425319
-
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
-
Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 2005;5:172-83.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 172-183
-
-
Ren, R.1
-
5
-
-
0032533257
-
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving p210 bcr/abl-transduced bone marrow
-
Pear WS, Miller JP, Xu L,et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving p210 bcr/abl-transduced bone marrow. Blood 1998;92:3780-92
-
(1998)
Blood
, vol.92
, pp. 3780-3792
-
-
Pear, W.S.1
Miller, J.P.2
Xu, L.3
-
6
-
-
0035839842
-
Modeling Philadelphia chromosome positive leukemias
-
Wong S, Witte ON. Modeling Philadelphia chromosome positive leukemias. Oncogene 2001;20:5644-59
-
(2001)
Oncogene
, vol.20
, pp. 5644-5659
-
-
Wong, S.1
Witte, O.N.2
-
7
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005;105:2640-53
-
(2005)
Blood
, vol.105
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
8
-
-
84863011486
-
Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION)
-
Kantarjian HM, Shah NP, Cortes JE,et al. Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). Blood 2012;119:1123-9
-
(2012)
Blood
, vol.119
, pp. 1123-1129
-
-
Kantarjian, H.M.1
Shah, N.P.2
Cortes, J.E.3
-
9
-
-
84867395848
-
Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up
-
Larson RA, Hochhaus A, Hughes TP,et al. Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up. Leukemia 2012;26:2197-203
-
(2012)
Leukemia
, vol.26
, pp. 2197-2203
-
-
Larson, R.A.1
Hochhaus, A.2
Hughes, T.P.3
-
10
-
-
84870752970
-
Initial molecular response at 3 months may predict both response and event-free survival at 24 months in imatinibresistant or -intolerant patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase treated with nilotinib
-
Branford S, Kim DW, Soverini S,et al. Initial molecular response at 3 months may predict both response and event-free survival at 24 months in imatinibresistant or -intolerant patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase treated with nilotinib. J Clin Oncol 2012;30:4323-9
-
(2012)
J Clin Oncol
, vol.30
, pp. 4323-4329
-
-
Branford, S.1
Kim, D.W.2
Soverini, S.3
-
11
-
-
84857359667
-
Suboptimal responses in chronic myeloid leukemia: Implications and management strategies
-
Jabbour E, Saglio G, Hughes TP,et al. Suboptimal responses in chronic myeloid leukemia: implications and management strategies. Cancer 2012;118:1181-91
-
(2012)
Cancer
, vol.118
, pp. 1181-1191
-
-
Jabbour, E.1
Saglio, G.2
Hughes, T.P.3
-
12
-
-
84881298446
-
European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
-
Baccarani M, Deininger MW, Rosti G,et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013;122:872-84
-
(2013)
Blood
, vol.122
, pp. 872-884
-
-
Baccarani, M.1
Deininger, M.W.2
Rosti, G.3
-
13
-
-
84867405606
-
Standardized definitions of molecular response in chronic myeloid leukemia
-
Cross NC, White HE, Muller MC,et al. Standardized definitions of molecular response in chronic myeloid leukemia. Leukemia 2012;26:2172-5
-
(2012)
Leukemia
, vol.26
, pp. 2172-2175
-
-
Cross, N.C.1
White, H.E.2
Muller, M.C.3
-
14
-
-
34247470836
-
Second generation inhibitors of BCRABL for the treatment of imatinib resistant chronic myeloid leukaemia
-
Weisberg E, Manley PW, Cowan-Jacob SW,et al. Second generation inhibitors of BCRABL for the treatment of imatinib resistant chronic myeloid leukaemia. Nat Rev Cancer 2007;7:345-56
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 345-356
-
-
Weisberg, E.1
Manley, P.W.2
Cowan-Jacob, S.W.3
-
15
-
-
77953691179
-
Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
-
Saglio G, Kim DW, Issaragrisil S,et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010;17:2251-9
-
(2010)
N Engl J Med
, vol.17
, pp. 2251-2259
-
-
Saglio, G.1
Kim, D.W.2
Issaragrisil, S.3
-
16
-
-
78049528573
-
Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial
-
Mahon FX, Rea D, Guilhot J,et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol 2010;11:1029-35
-
(2010)
Lancet Oncol
, vol.11
, pp. 1029-1035
-
-
Mahon, F.X.1
Rea, D.2
Guilhot, J.3
-
17
-
-
0348140591
-
Mechanisms and implications of imatinib resistance mutations in BCR-ABL
-
Nardi V, Azam M, Daley GQ. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol 2004;11:35-43
-
(2004)
Curr Opin Hematol
, vol.11
, pp. 35-43
-
-
Nardi, V.1
Azam, M.2
Daley, G.Q.3
-
18
-
-
0036090222
-
Primitive, quiescent, Philadelphiapositive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham SM, Jrgensen HG, Allan E,et al. Primitive, quiescent, Philadelphiapositive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002;99:319-25
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
Jrgensen, H.G.2
Allan, E.3
-
19
-
-
77957196195
-
Properties of CD34 CMLstem/progenitor cells that correlate with different clinical responses to imatinib mesylate
-
Jiang X, Forrest D, Nicolini F,et al. Properties of CD34 CMLstem/progenitor cells that correlate with different clinical responses to imatinib mesylate. Blood 2010;116:2112-21
-
(2010)
Blood
, vol.116
, pp. 2112-2121
-
-
Jiang, X.1
Forrest, D.2
Nicolini, F.3
-
20
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Copland M, Hamilton A, Elrick LJ,et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006;107:4532-9
-
(2006)
Blood
, vol.107
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
-
21
-
-
34247329753
-
Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells
-
Jrgensen HG, Allan EK, Jordanides NE,et al. Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. Blood 2007;109:4016-19
-
(2007)
Blood
, vol.109
, pp. 4016-4019
-
-
Jrgensen, H.G.1
Allan, E.K.2
Jordanides, N.E.3
-
22
-
-
42349116071
-
Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors
-
Konig H, Holtz M, Modi H,et al. Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors. Leukemia 2008;22:748-55
-
(2008)
Leukemia
, vol.22
, pp. 748-755
-
-
Konig, H.1
Holtz, M.2
Modi, H.3
-
23
-
-
42549142280
-
Getting to the stem of chronic myeloid leukaemia
-
Savona M, Talpaz M. Getting to the stem of chronic myeloid leukaemia. Nat Rev Cancer 2008;8:341-50.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 341-50
-
-
Savona, M.1
Talpaz, M.2
-
25
-
-
78650962299
-
BCR-ABL kinase is dead; Long live the CML stem cell
-
Perl A, Carroll M. BCR-ABL kinase is dead; long live the CML stem cell. J Clin Invest 2011;121:22-5
-
(2011)
J Clin Invest
, vol.121
, pp. 22-25
-
-
Perl, A.1
Carroll, M.2
-
26
-
-
78650949272
-
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
-
Corbin AS, Agarwal A, Loriaux M,et al. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest 2011;121:396-409
-
(2011)
J Clin Invest
, vol.121
, pp. 396-409
-
-
Corbin, A.S.1
Agarwal, A.2
Loriaux, M.3
-
27
-
-
33747155024
-
FunctionalABCG2 is overexpressed on primary CML CD34 cells and is inhibited by imatinib mesylate
-
Jordanides NE, Jorgensen HG, Holyoake TL,et al. FunctionalABCG2 is overexpressed on primary CML CD34 cells and is inhibited by imatinib mesylate. Blood 2006;108:1370-3
-
(2006)
Blood
, vol.108
, pp. 1370-1373
-
-
Jordanides, N.E.1
Jorgensen, H.G.2
Holyoake, T.L.3
-
28
-
-
67349280901
-
Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib
-
Hatziieremia S, Jordanides NE, Holyoake TL,et al. Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib. Exp Hematol 2009;37:692-700
-
(2009)
Exp Hematol
, vol.37
, pp. 692-700
-
-
Hatziieremia, S.1
Jordanides, N.E.2
Holyoake, T.L.3
-
29
-
-
70450255111
-
Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters
-
Davies A, Jordanides NE, Giannoudis A,et al. Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. Leukemia 2009;23:1999-2006
-
(2009)
Leukemia
, vol.23
, pp. 1999-2006
-
-
Davies, A.1
Jordanides, N.E.2
Giannoudis, A.3
-
30
-
-
84863124648
-
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
-
Hamilton A, Helgason GV, Schemionek M,et al. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood 2012;119:1501-10.
-
(2012)
Blood
, vol.119
, pp. 1501-1510
-
-
Hamilton, A.1
Helgason, G.V.2
Schemionek, M.3
-
31
-
-
36448975490
-
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
-
Bernardi R, Pandolfi PP. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Cancer 2007;8:1006-16
-
(2007)
Nat Rev Cancer
, vol.8
, pp. 1006-1016
-
-
Bernardi, R.1
Pandolfi, P.P.2
-
32
-
-
69949164620
-
PML: An emerging tumor suppressor and a target with therapeutic potential
-
Reineke EL, Kao HY. PML: an emerging tumor suppressor and a target with therapeutic potential. Cancer Ther 2009;7:219-26
-
(2009)
Cancer Ther
, vol.7
, pp. 219-226
-
-
Reineke, E.L.1
Kao, H.Y.2
-
33
-
-
61349187121
-
A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell
-
Ito K, Bernardi R, Pandolfi PP. A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr Opin Genet Dev 2009;19:51-9
-
(2009)
Curr Opin Genet Dev
, vol.19
, pp. 51-59
-
-
Ito, K.1
Bernardi, R.2
Pandolfi, P.P.3
-
34
-
-
44349166602
-
PML targeting eradicates quiescent leukaemia-initiating cells
-
Ito K, Bernardi R, Morotti A,et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008;453:1072-8
-
(2008)
Nature
, vol.453
, pp. 1072-1078
-
-
Ito, K.1
Bernardi, R.2
Morotti, A.3
-
35
-
-
77953620758
-
Successful imatinib and arsenic trioxide combination therapy for sudden onset promyelocytic crisis with t(15;17) in chronic myeloid leukemia
-
Kashimura M, Ohyashiki K. Successful imatinib and arsenic trioxide combination therapy for sudden onset promyelocytic crisis with t(15;17) in chronic myeloid leukemia. Leuk Res 2010;34:e213-14
-
(2010)
Leuk Res
, vol.34
-
-
Kashimura, M.1
Ohyashiki, K.2
-
36
-
-
41849119497
-
A brief introduction to FOXOlogy
-
Burgering BM. A brief introduction to FOXOlogy. Oncogene 2008;27:2258-62
-
(2008)
Oncogene
, vol.27
, pp. 2258-2262
-
-
Burgering, B.M.1
-
37
-
-
84881107561
-
Forkhead box proteins: Tuning forks for transcriptional harmony
-
Lam EW, Brosens JJ, Gomes AR,et al. Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer 2013;13:482-95.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 482-495
-
-
Lam, E.W.1
Brosens, J.J.2
Gomes, A.R.3
-
38
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, Kollipara R, Huntly BJ,et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007;128:325-39
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
-
39
-
-
76249087423
-
TGF-beta-FOXO signaling maintains leukaemia-initiating cells in chronic myeloid leukemia
-
Naka K, Hoshii T, MuraguchiT,et al. TGF-beta-FOXO signaling maintains leukaemia-initiating cells in chronic myeloid leukemia. Nature 2010;463:676-8
-
(2010)
Nature
, vol.463
, pp. 676-678
-
-
Naka, K.1
Hoshii, T.2
Muraguchi, T.3
-
40
-
-
79956305728
-
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition
-
Duy C, Hurtz C, Shojaee S,et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 2011;473:384-8
-
(2011)
Nature
, vol.473
, pp. 384-388
-
-
Duy, C.1
Hurtz, C.2
Shojaee, S.3
-
41
-
-
80055108071
-
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia
-
Hurtz C, Hatzi K, Cerchietti L,et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med 2011;208:2163-74
-
(2011)
J Exp Med
, vol.208
, pp. 2163-2174
-
-
Hurtz, C.1
Hatzi, K.2
Cerchietti, L.3
-
42
-
-
50649118068
-
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
-
Dierks C, Beigi R, Guo GR,et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008;14:238-49.
-
(2008)
Cancer Cell
, vol.14
, pp. 238-249
-
-
Dierks, C.1
Beigi, R.2
Guo, G.R.3
-
43
-
-
78651379348
-
Activation of the hedgehog pathway in chronic myelogeneous leukemia patients
-
Long B, Zhu H, Zhu C,et al. Activation of the hedgehog pathway in chronic myelogeneous leukemia patients. J Exp Clin Cancer Res 2011;30:1-5
-
(2011)
J Exp Clin Cancer Res
, vol.30
, pp. 1-5
-
-
Long, B.1
Zhu, H.2
Zhu, C.3
-
44
-
-
64749091867
-
Hedgehog signaling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao C, Chen A, Jamieson CH,et al. Hedgehog signaling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009;458:776-80.
-
(2009)
Nature
, vol.458
, pp. 776-780
-
-
Zhao, C.1
Chen, A.2
Jamieson, C.H.3
-
45
-
-
79956141118
-
Promotion of the selfrenewal capacity of human leukemia cells by sonic hedgehog protein
-
Kawaguchi-Ihara N, Okuhashi Y, Itoh M,et al. Promotion of the selfrenewal capacity of human leukemia cells by sonic hedgehog protein. Anticancer Res 2011;31:781-4
-
(2011)
Anticancer Res
, vol.31
, pp. 781-784
-
-
Kawaguchi-Ihara, N.1
Okuhashi, Y.2
Itoh, M.3
-
46
-
-
80053217527
-
BMI1 as a novel target for drug discovery in cancer
-
Cao L, Bombard J, Cintron K,et al. BMI1 as a novel target for drug discovery in cancer. J Cell Biochem 2011;112:2729-41
-
(2011)
J Cell Biochem
, vol.112
, pp. 2729-2741
-
-
Cao, L.1
Bombard, J.2
Cintron, K.3
-
47
-
-
77950344603
-
Stem cell divisions controlled by the protooncogene BMI-1
-
Grinstein E, Mahotka C. Stem cell divisions controlled by the protooncogene BMI-1. J Stem Cells 2009;4:141-6
-
(2009)
J Stem Cells
, vol.4
, pp. 141-146
-
-
Grinstein, E.1
Mahotka, C.2
-
48
-
-
0141670822
-
Self-renewal of hematopoietic and leukemic stem cells: A central role for the Polycomb-group gene Bmi-1
-
Raaphorst FM. Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1. Trends Immunol 2003;2410:522-4
-
(2003)
Trends Immunol
, vol.2410
, pp. 522-524
-
-
Raaphorst, F.M.1
-
49
-
-
10344258563
-
Enhanced self renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
-
Iwama A, Oguro H, Negishi M,et al. Enhanced self renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 2004;21:843-51
-
(2004)
Immunity
, vol.21
, pp. 843-851
-
-
Iwama, A.1
Oguro, H.2
Negishi, M.3
-
50
-
-
0038349957
-
Bmi-1 is required for maintenance of adult selfrenewing haematopoietic stem cells
-
Park IK, Qian D, Kiel M,et al. Bmi-1 is required for maintenance of adult selfrenewing haematopoietic stem cells. Nature 2003;423:302-5
-
(2003)
Nature
, vol.423
, pp. 302-305
-
-
Park, I.K.1
Qian, D.2
Kiel, M.3
-
51
-
-
0037673984
-
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
-
Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423:255-60
-
(2003)
Nature
, vol.423
, pp. 255-260
-
-
Lessard, J.1
Sauvageau, G.2
-
52
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006;6:38-51
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
53
-
-
0038066488
-
Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571- sensitive and -resistant Bcr/Abl human myeloid leukemia cells
-
Yu C, Rahmani M, Almenara J,et al. Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571- sensitive and -resistant Bcr/Abl human myeloid leukemia cells. Cancer Res 2003;63:2118-26
-
(2003)
Cancer Res
, vol.63
, pp. 2118-2126
-
-
Yu, C.1
Rahmani, M.2
Almenara, J.3
-
54
-
-
0043016178
-
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells
-
Nimmanapalli R, Fuino L, Bali P,et al. Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res 2003;63:5126-35
-
(2003)
Cancer Res
, vol.63
, pp. 5126-5135
-
-
Nimmanapalli, R.1
Fuino, L.2
Bali, P.3
-
55
-
-
0038620379
-
Cotreatment with the histone deacteylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells
-
Nimmanapalli R, Fuino L, Stobaugh C,et al. Cotreatment with the histone deacteylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. Blood 2003;101:3236-9
-
(2003)
Blood
, vol.101
, pp. 3236-3239
-
-
Nimmanapalli, R.1
Fuino, L.2
Stobaugh, C.3
-
56
-
-
0038079767
-
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP/WAF1
-
Rosato RR, Almenara JA, Grant S. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP/WAF1. Cancer Res 2003;63:3637-45
-
(2003)
Cancer Res
, vol.63
, pp. 3637-3645
-
-
Rosato, R.R.1
Almenara, J.A.2
Grant, S.3
-
57
-
-
33644505789
-
Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells
-
Morotti A, Cilloni D, Messa F,et al. Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells. Cancer 2006;106:1188-96
-
(2006)
Cancer
, vol.106
, pp. 1188-1196
-
-
Morotti, A.1
Cilloni, D.2
Messa, F.3
-
58
-
-
77952105211
-
Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
-
Zhang B, Strauss AC, Chu S,et al. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 2010;18:427-42.
-
(2010)
Cancer Cell
, vol.18
, pp. 427-442
-
-
Zhang, B.1
Strauss, A.C.2
Chu, S.3
-
59
-
-
66149183002
-
Beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells
-
Nemeth MJ, Mak KK, Yang Y,et al. beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells. Stem Cells 2009;27:1109-19
-
(2009)
Stem Cells
, vol.27
, pp. 1109-1119
-
-
Nemeth, M.J.1
Mak, K.K.2
Yang, Y.3
-
60
-
-
28644439005
-
A dual-kinase mechanism for Wnt coreceptor phosphorylation and activation
-
Zeng X, Tamai K, Doble B,et al. A dual-kinase mechanism for Wnt coreceptor phosphorylation and activation. Nature 2005;438:873-7
-
(2005)
Nature
, vol.438
, pp. 873-877
-
-
Zeng, X.1
Tamai, K.2
Doble, B.3
-
61
-
-
58249120738
-
Beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia
-
Hu Y, Chen Y, Douglas L,et al. beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia. Leukemia 2009;23:109-16
-
(2009)
Leukemia
, vol.23
, pp. 109-116
-
-
Hu, Y.1
Chen, Y.2
Douglas, L.3
-
62
-
-
84859523707
-
Genetic and pharmacologic inhibition of b-Catenin targets imatinib-resistant leukemia stem cells in CML
-
Heidel FH, Bullinger L, Feng Z,et al. Genetic and pharmacologic inhibition of b-Catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell 2012;10:412-24
-
(2012)
Cell Stem Cell
, vol.10
, pp. 412-424
-
-
Heidel, F.H.1
Bullinger, L.2
Feng, Z.3
-
63
-
-
84862644443
-
Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: Key role of stromal microenvironment
-
Seke Etet PF, Vecchio L, Nwabo Kamdje AH. Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: key role of stromal microenvironment. Cell Signal 2012;24:1883-8
-
(2012)
Cell Signal
, vol.24
, pp. 1883-8
-
-
Seke Etet, P.F.1
Vecchio, L.2
Nwabo Kamdje, A.H.3
-
64
-
-
84898466234
-
Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: In vitro and in vivo studies
-
doi:10.1038/leu.2013.254
-
Frassanito MA, Rao L, Moschetta M,et al. Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies. Leukemia 2013, doi:10.1038/leu.2013.254
-
(2013)
Leukemia
-
-
Ma, F.1
Rao, L.2
Moschetta, M.3
-
65
-
-
69849104865
-
The leukemic stem cell niche: Current concepts and therapeutic opportunities
-
Lane SW, Scadden DT, Gilliland DG. The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood 2009;114:1150-7
-
(2009)
Blood
, vol.114
, pp. 1150-1157
-
-
Lane, S.W.1
Scadden, D.T.2
Gilliland, D.G.3
-
66
-
-
0034893416
-
Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation
-
Damiano JS, Hazlehurst LA, Dalton WS. Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation. Leukemia 2001;15:1232-9
-
(2001)
Leukemia
, vol.15
, pp. 1232-1239
-
-
Damiano, J.S.1
Hazlehurst, L.A.2
Dalton, W.S.3
-
67
-
-
0034038689
-
Differential effect of interferon alpha on chronic myelogenous leukaemia and normal haematopoietic progenitors in a stromal cell co-culture context: Role of the flt3 ligand
-
Solanilla A, El Andaloussi A, Grosset C,et al. Differential effect of interferon alpha on chronic myelogenous leukaemia and normal haematopoietic progenitors in a stromal cell co-culture context: role of the flt3 ligand. Br J Haematol 2000;109:382-7
-
(2000)
Br J Haematol
, vol.109
, pp. 382-387
-
-
Solanilla, A.1
El Andaloussi, A.2
Grosset, C.3
-
68
-
-
77954215485
-
Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis
-
Vianello F, Villanova F, Tisato V,et al. Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis. Haematologica 2010;95:1081-9
-
(2010)
Haematologica
, vol.95
, pp. 1081-1089
-
-
Vianello, F.1
Villanova, F.2
Tisato, V.3
-
69
-
-
16844380143
-
P210BCR-ABL inhibits SDF-1 chemotactic response via alteration of CXCR4 signaling and down-regulation of CXCR4 expression
-
Geay JF, Buet D, Zhang Y,et al. p210BCR-ABL inhibits SDF-1 chemotactic response via alteration of CXCR4 signaling and down-regulation of CXCR4 expression. Cancer Res 2005;65:2676-83
-
(2005)
Cancer Res
, vol.65
, pp. 2676-2683
-
-
Geay, J.F.1
Buet, D.2
Zhang, Y.3
-
70
-
-
38349086394
-
CXCR4 upregulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
-
Jin L, Tabe Y, Konoplev S,et al. CXCR4 upregulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther 2008;7:48-58
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 48-58
-
-
Jin, L.1
Tabe, Y.2
Konoplev, S.3
-
71
-
-
51649128399
-
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction
-
Devine SM, Vij R, Rettig M,et al. Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction. Blood 2008;112:990-8
-
(2008)
Blood
, vol.112
, pp. 990-998
-
-
Devine, S.M.1
Vij, R.2
Rettig, M.3
-
72
-
-
84860767803
-
Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib
-
Weisberg E, Azab AK, Manley PW,et al. Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib. Leukemia 2012;26:985-90
-
(2012)
Leukemia
, vol.26
, pp. 985-990
-
-
Weisberg, E.1
Azab, A.K.2
Manley, P.W.3
-
73
-
-
84866876169
-
Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML
-
Agarwal A, Fleischman AG, Petersen CL,et al. Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML. Blood 2012;120:2658-68
-
(2012)
Blood
, vol.120
, pp. 2658-2668
-
-
Agarwal, A.1
Fleischman, A.G.2
Petersen, C.L.3
-
74
-
-
77956224494
-
Oxygen in stem cell biology: A critical component of the stem cell niche
-
Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 2010;7:150-61.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 150-161
-
-
Mohyeldin, A.1
Garzon-Muvdi, T.2
Quinones-Hinojosa, A.3
-
75
-
-
73949121249
-
The Hematopoietic stem cell niche: Low in oxygen but a nice place to be
-
Eliasson P, Nsson J. The Hematopoietic stem cell niche: low in oxygen but a nice place to be. J Cell Physiol 2010;222:17-22
-
(2010)
J Cell Physiol
, vol.222
, pp. 17-22
-
-
Eliasson, P.1
Nsson, J.2
-
76
-
-
84863338358
-
HIF1alpha is required for survival maintenance of chronic myeloid leukemia stem cells
-
Zhang H, Li H, Xi HS,et al. HIF1alpha is required for survival maintenance of chronic myeloid leukemia stem cells. Blood 2012;119:2595-607
-
(2012)
Blood
, vol.119
, pp. 2595-2607
-
-
Zhang, H.1
Li, H.2
Xi, H.S.3
-
77
-
-
80052164677
-
Kill one bird with two stones: Potential efficacy of BCR-ABL and autophagy inhibition in CML
-
Helgason GV, Karvela M, Holyoake TL. Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML. Blood 2011;118:2035-43
-
(2011)
Blood
, vol.118
, pp. 2035-2043
-
-
Helgason, G.V.1
Karvela, M.2
Holyoake, T.L.3
-
79
-
-
66449122303
-
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
-
Bellodi C, Lidonnici MR, Hamilton A,et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009;119:1109-23
-
(2009)
J Clin Invest
, vol.119
, pp. 1109-1123
-
-
Bellodi, C.1
Lidonnici, M.R.2
Hamilton, A.3
-
80
-
-
67649861052
-
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
-
Chen Y, Hu Y, Zhang H,et al. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet 2009;41:783-92.
-
(2009)
Nat Genet
, vol.41
, pp. 783-792
-
-
Chen, Y.1
Hu, Y.2
Zhang, H.3
-
81
-
-
70449715255
-
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia
-
Chen Y, Li D, Li S. The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia. Cell Cycle 2009;8:3488-92
-
(2009)
Cell Cycle
, vol.8
, pp. 3488-3492
-
-
Chen, Y.1
Li, D.2
Li, S.3
-
82
-
-
84875165288
-
BCL-2 inhibition - Stemming the tide of myeloid malignancies
-
Hogdal LJ, Letai A. BCL-2 inhibition - stemming the tide of myeloid malignancies. Cell Stem Cell 2013;12:269-70
-
(2013)
Cell Stem Cell
, vol.12
, pp. 269-270
-
-
Hogdal, L.J.1
Letai, A.2
-
83
-
-
84881091005
-
Decoding and unlocking the BCL2 dependency of cancer cells
-
Juin P, Geneste O, Gautier F,et al. Decoding and unlocking the BCL2 dependency of cancer cells. Nat Rev Cancer 2013;13:455-65.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 455-465
-
-
Juin, P.1
Geneste, O.2
Gautier, F.3
-
84
-
-
84875131206
-
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition
-
Goff DJ, Recart AC, Sadarangani A,et al. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell 2013;12:316-28
-
(2013)
Cell Stem Cell
, vol.12
, pp. 316-328
-
-
Goff, D.J.1
Recart, A.C.2
Sadarangani, A.3
-
85
-
-
84885085996
-
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
-
Neviani P, Harb JG, Oaks JJ,et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest 2013;123:4144-57
-
(2013)
J Clin Invest
, vol.123
, pp. 4144-4157
-
-
Neviani, P.1
Harb, J.G.2
Oaks, J.J.3
-
86
-
-
84858032395
-
Targeting of GSK3b promotes imatinibmediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells
-
Reddiconto G, Toto C, Palama I,et al. Targeting of GSK3b promotes imatinibmediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. Blood 2012;119:2335-234
-
(2012)
Blood
, vol.119
, pp. 2335-3234
-
-
Reddiconto, G.1
Toto, C.2
Palama, I.3
-
87
-
-
79953109597
-
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors
-
Nelson EA, Walker SR, Weisberg E,et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood 2011;117:3421-9
-
(2011)
Blood
, vol.117
, pp. 3421-3429
-
-
Nelson, E.A.1
Walker, S.R.2
Weisberg, E.3
-
88
-
-
84859865097
-
Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice
-
Walz C, Ahmed W, Lazarides K,et al. Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice. Blood 2012;119:3550-60
-
(2012)
Blood
, vol.119
, pp. 3550-3560
-
-
Walz, C.1
Ahmed, W.2
Lazarides, K.3
-
89
-
-
84875611495
-
Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-Bcr-ABl-JAK2 complex
-
Chen M, Gallipoli P, DeGeer D,et al. Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-Bcr-ABl-JAK2 complex. J Natl Cancer Inst 2013;105:405-23
-
(2013)
J Natl Cancer Inst
, vol.105
, pp. 405-423
-
-
Chen, M.1
Gallipoli, P.2
Degeer, D.3
-
90
-
-
79960279190
-
The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells
-
Pellicano F, Simara P, Sinclair A,et al. The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells. Leukemia 2011;25:1159-67
-
(2011)
Leukemia
, vol.25
, pp. 1159-1167
-
-
Pellicano, F.1
Simara, P.2
Sinclair, A.3
-
91
-
-
84856019858
-
The DNA damage response and cancer therapy
-
Lord CJ, Ashworth A. The DNA damage response and cancer therapy. Nature 2012;481:287-94
-
(2012)
Nature
, vol.481
, pp. 287-294
-
-
Lord, C.J.1
Ashworth, A.2
-
92
-
-
84870218588
-
DNA repair dysregulation from cancer driver to therapeutic target
-
Curtin NJ. DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer 2012;12:801-17
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 801-817
-
-
Curtin, N.J.1
-
93
-
-
84863530603
-
Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining
-
Chakraborty S, Stark JM, Sun CL,et al. Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining. Blood 2012;119:6187-97
-
(2012)
Blood
, vol.119
, pp. 6187-6197
-
-
Chakraborty, S.1
Stark, J.M.2
Sun, C.L.3
-
94
-
-
84881017449
-
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells
-
Bolton-Gillespie E, Schemionek M, Klein HU,et al. Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells. Blood 2013;121:4175-83
-
(2013)
Blood
, vol.121
, pp. 4175-4183
-
-
Bolton-Gillespie, E.1
Schemionek, M.2
Klein, H.U.3
-
95
-
-
84887156264
-
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile
-
Cramer-Moralesv K, Nieborowska-Skorska M, Scheibner K,et al. Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood 2013;122:1293-304
-
(2013)
Blood
, vol.122
, pp. 1293-1304
-
-
Cramer-Moralesv, K.1
Nieborowska-Skorska, M.2
Scheibner, K.3
-
96
-
-
47649097577
-
Feasibility of administering oblimersen (G3139; Genasense) with imatinib mesylate in patients with imatinib resistant chronic myeloid leukemia-cancer and leukemia group B study 10107
-
Wetzler M, Donohue KA, Odenike OM,et al. Feasibility of administering oblimersen (G3139; Genasense) with imatinib mesylate in patients with imatinib resistant chronic myeloid leukemia-cancer and leukemia group B study 10107. Leuk Lymphoma 2008;49:1274-8
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 1274-1278
-
-
Wetzler, M.1
Donohue, K.A.2
Odenike, O.M.3
|