Gut bacteria-derived molecules as mediators and markers in cardiovascular diseases. The role of the gut-blood barrier

Kardiologia Polska

Volumn 76, Issue 2, 2018, Pages 320-327

  Nowiński, Artur ^a,b   Ufnal, Marcin ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b GROCHOWSKI HOSPITAL   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN SULFIDE; INDOLE DERIVATIVE; SHORT CHAIN FATTY ACID; TRIMETHYLAMINE OXIDE; BIOLOGICAL MARKER;

ACUTE CORONARY SYNDROME; BACTERIAL METABOLISM; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CHRONIC KIDNEY FAILURE; CORONARY ARTERY DISEASE; GUT BLOOD BARRIER; HOMEOSTASIS; HUMAN; INTESTINE FLORA; NONHUMAN; PATHOGENESIS; PERMEABILITY BARRIER; REVIEW; BACTERIUM; BLOOD; METABOLISM; MICROBIOLOGY;

BACTERIA; BIOMARKERS; CARDIOVASCULAR DISEASES; HUMANS;

EID: 85042094914     PISSN: 00229032     EISSN: 18974279     Source Type: Journal    
DOI: 10.5603/KP.a2017.0204     Document Type: Review

References (50)

1. Jiménez E, Marín ML, Martín R, et al. Is meconium from healthy newborns actually sterile? Res Microbiol. 2008; 159(3): 187-193, doi: 10.1016/j.resmic.2007.12.007, indexed in Pubmed: 18281199.
2. Liu Z, Roy NC, Guo Y, et al. Human Breast Milk and Infant Formulas Differentially Modify the Intestinal Microbiota in Human Infants and Host Physiology in Rats. J Nutr. 2016; 146(2): 191-199, doi: 10.3945/jn.115.223552, indexed in Pubmed: 26674765.
3. Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography. Nature. 2012; 486(7402): 222-227, doi: 10.1038/nature11053, indexed in Pubmed: 22699611.
4. Yang T, Santisteban MM, Rodriguez V, et al. Gut dysbiosis is linked to hypertension. Hypertension. 2015; 65(6): 1331-1340, doi: 10.1161/HYPERTENSIONAHA.115.05315, indexed in Pubmed: 25870193.
5. Durgan DJ, Ganesh BP, Cope JL, et al. Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension. Hypertension. 2016; 67(2): 469-474, doi: 10.1161/HYPERTENSIONAHA.115.06672, indexed in Pubmed: 26711739.
6. Tomasova L, Konopelski P, Ufnal M. Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis. Molecules. 2016; 21(11), doi: 10.3390/molecules21111558, indexed in Pubmed: 27869680.
7. Ufnal M, Sikora M. The role of brain gaseous transmitters in the regulation of the circulatory system. Curr Pharm Biotechnol. 2011; 12(9): 1322-1333, doi: 10.2174/138920111798281126, indexed in Pubmed: 21235452.
8. Nowiński A, Ufnal M. Trimethylamine N-oxide: A harmful, protective or diagnostic marker in lifestyle diseases? Nutrition. 2018; 46: 7-12, doi: 10.1016/j.nut.2017.08.001.
9. Lekawanvijit S. Role of Gut-Derived Protein-Bound Uremic Toxins in Cardiorenal Syndrome and Potential Treatment Modalities. Circ J. 2015; 79(10): 2088-2097, doi: 10.1253/circj. CJ-15-0749, indexed in Pubmed: 26346172.
10. Gomez-Arango LF, Barrett HL, McIntyre HD, et al. SPRING Trial Group. Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early Pregnancy. Hypertension. 2016; 68(4): 974-981, doi: 10.1161/HYPERTENSIONAHA.116.07910, indexed in Pubmed: 27528065.
11. Tomasova L, Dobrowolski L, Jurkowska H, et al. Intracolonic hydrogen sulfide lowers blood pressure in rats. Nitric Oxide. 2016; 60: 50-58, doi: 10.1016/j.niox.2016.09.007, indexed in Pubmed: 27667183.
12. Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011; 108(38): 16050-16055, doi: 10.1073/pnas.1102999108, indexed in Pubmed: 21876150.
13. Ufnal M, Pham K. The gut-blood barrier permeability-A new marker in cardiovascular and metabolic diseases? Med Hypoth-eses. 2017; 98: 35-37, doi: 10.1016/j.mehy.2016.11.012, indexed in Pubmed: 28012600.
14. Farhadi A, Banan A, Fields J, et al. Intestinal barrier: an interface between health and disease. J Gastroenterol Hepatol. 2003; 18(5): 479-497, doi: 10.1046/j.1440-1746.2003.03032.x, indexed in Pubmed: 12702039.
15. Sandek A, Bauditz J, Swidsinski A, et al. Altered intestinal function in patients with chronic heart failure. J Am Coll Cardiol. 2007; 50(16): 1561-1569, doi: 10.1016/j.jacc.2007.07.016, indexed in Pubmed: 17936155.
16. Santisteban MM, Qi Y, Zubcevic J, et al. Hypertension-Linked Pathophysiological Alterations in the Gut. Circ Res. 2017; 120(2): 312-323, doi: 10.1161/CIRCRESAHA.116.309006, indexed in Pubmed: 27799253.
17. Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes athero-sclerosis. Nat Med. 2013; 19(5): 576-585, doi: 10.1038/nm.3145, indexed in Pubmed: 23563705.
18. Ufnal M, Jazwiec R, Dadlez M, et al. Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats. Can J Cardiol. 2014; 30(12): 1700-1705, doi: 10.1016/j.cjca.2014.09.010, indexed in Pubmed: 25475471.
19. Sun X, Jiao X, Ma Y, et al. Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome. Biochem Biophys Res Commun. 2016; 481(1-2): 63-70, doi: 10.1016/j.bbrc.2016.11.017, indexed in Pubmed: 27833015.
20. Makrecka-Kuka M, Volska K, Antone U, et al. Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicol Lett. 2017; 267: 32-38, doi: 10.1016/j. toxlet.2016.12.017, indexed in Pubmed: 28049038.
21. Zhu W, Gregory JC, Org E, et al. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell. 2016; 165(1): 111-124, doi: 10.1016/j.cell.2016.02.011, indexed in Pubmed: 26972052.
22. Dambrova M, Latkovskis G, Kuka J, et al. Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels. Exp Clin Endocrinol Diabetes. 2016; 124(4): 251-256, doi: 10.1055/s-0035-1569330, indexed in Pubmed: 27123785.
23. Cho CE, Taesuwan S, Malysheva OV, et al. Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial. Mol Nutr Food Res. 2017; 61(1), doi: 10.1002/mnfr.201600324, indexed in Pubmed: 27377678.
24. Collins HL, Drazul-Schrader D, Sulpizio AC, et al. L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE(-/-) transgenic mice expressing CETP. Atherosclerosis. 2016; 244: 29-37, doi: 10.1016/j.athero-sclerosis.2015.10.108, indexed in Pubmed: 26584136.
25. Lupachyk S, Watcho P, Stavniichuk R, et al. Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy. Diabetes. 2013; 62(3): 944-952, doi: 10.2337/db12-0716, indexed in Pubmed: 23364451.
26. Sikora M, Pham K, Ufnal M. Hypotensive effect of S-adenosyl-L-methionine in hypertensive rats is reduced by autonomic ganglia and KATP channel blockers. Amino Acids. 2016; 48(7): 1581-1590, doi: 10.1007/s00726-016-2213-4, indexed in Pub-med: 27108137.
27. Olson KR, Dombkowski RA, Russell MJ, et al. Hydrogen sulfide as an oxygen sensor/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation. J Exp Biol. 2006; 209(Pt 20): 4011-4023, doi: 10.1242/jeb.02480, indexed in Pubmed: 17023595.
28. Yang G, Wu L, Jiang Bo, et al. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008; 322(5901): 587-590, doi: 10.1126/science.1162667, indexed in Pubmed: 18948540.
29. Palego L, Betti L, Rossi A, et al. Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and Medical Aspects in Humans. J Amino Acids. 2016; 2016: 8952520, doi: 10.1155/2016/8952520, indexed in Pubmed: 26881063.
30. Kim J, Park W. Indole: a signaling molecule or a mere metabolic byproduct that alters bacterial physiology at a high concentra-tion? J Microbiol. 2015; 53(7): 421-428, doi: 10.1007/s12275-015-5273-3, indexed in Pubmed: 26115989.
31. Lekawanvijit S, Kompa AR, Manabe M, et al. Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate. PLoS One. 2012; 7(7): e41281, doi: 10.1371/journal. pone.0041281, indexed in Pubmed: 22829936.
32. Lekawanvijit S, Adrahtas A, Kelly DJ, et al. Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes? Eur Heart J. 2010; 31(14): 1771-1779, doi: 10.1093/eurheartj/ehp574, indexed in Pubmed: 20047993.
33. Mortensen FV, Nielsen H, Mulvany MJ, et al. Short chain fatty acids dilate isolated human colonic resistance arteries. Gut. 1990; 31(12): 1391-1394, doi: 10.1136/gut.31.12.1391, indexed in Pubmed: 2265780.
34. Hülsmann WC. Coronary vasodilation by fatty acids. Basic Res Cardiol. 1976; 71(2): 179-191, doi: 10.1007/bf01927870, indexed in Pubmed: 131547.
35. Nutting CW, Islam S, Daugirdas JT. Vasorelaxant effects of short chain fatty acid salts in rat caudal artery. Am J Physiol. 1991; 261(2 Pt 2): H561-H567, doi: 10.1152/ajpheart.1991.261.2.H561, indexed in Pubmed: 1877681.
36. Aaronson PI, McKinnon W, Poston L. Mechanism of butyrate-induced vasorelaxation of rat mesenteric resistance artery. Br J Pharmacol. 1996; 117(2): 365-371, doi: 10.1111/j.1476-5381. 1996.tb15200.x, indexed in Pubmed: 8789392.
37. Bauer W, Richards DW. A vasodilator action of acetates. J Physiol. 1928; 66(4): 371-378, doi: 10.1113/jphysiol.1928.sp002534, indexed in Pubmed: 16993999.
38. Wang L, Zhu Q, Lu A, et al. Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system. J Hypertens. 2017; 35(9): 1899-1908, doi: 10.1097/HJH.0000000000001378, indexed in Pubmed: 28509726.
39. Senthong V, Wang Z, Li XS, et al. Intestinal Microbiota-Generated Metabolite Trimethylamine-N-Oxide and 5-Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE-Like Patient Cohort. J Am Heart Assoc. 2016; 5(6), doi: 10.1161/JAHA.115.002816, indexed in Pubmed: 27287696.
40. Senthong V, Wang Z, Fan Y, et al. Trimethylamine N-Oxide and Mortality Risk in Patients With Peripheral Artery Disease. J Am Heart Assoc. 2016; 5(10), doi: 10.1161/JAHA.116.004237, indexed in Pubmed: 27792653.
41. Heianza Y, Ma W, Manson JE, et al. Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies. J Am Heart Assoc. 2017; 6(7), doi: 10.1161/JAHA.116.004947, indexed in Pubmed: 28663251.
42. Li XS, Obeid S, Klingenberg R, et al. Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. Eur Heart J. 2017; 38(11): 814-824, doi: 10.1093/eurheartj/ehw582, indexed in Pubmed: 28077467.
43. Suzuki T, Heaney LM, Jones DJL, et al. Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction. Clin Chem. 2017; 63(1): 420-428, doi: 10.1373/clinchem.2016.264853, indexed in Pubmed: 28062632.
44. Stubbs JR, House JA, Ocque AJ, et al. Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden. J Am Soc Nephrol. 2016; 27(1): 305-313, doi: 10.1681/ASN.2014111063, indexed in Pubmed: 26229137.
45. Kim RB, Morse BL, Djurdjev O, et al. CanPREDDICT Investigators. Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events. Kidney Int. 2016; 89(5): 1144-1152, doi: 10.1016/j.kint.2016.01.014, indexed in Pubmed: 27083288.
46. Randrianarisoa E, Lehn-Stefan A, Wang X, et al. Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans. Sci Rep. 2016; 6: 26745, doi: 10.1038/srep26745, indexed in Pubmed: 27228955.
47. Drapala A, Koszelewski D, Tomasova L, et al. Parenteral Na2S, a fast-releasing H2S donor, but not GYY4137, a slow-releasing H2S donor, lowers blood pressure in rats. Acta Biochim Pol. 2017; 64(3): 561-566, doi: 10.18388/abp.2017-1569, indexed in Pubmed: 28753683.
48. Koning AM, Meijers WC, Minović I, et al. The fate of sulfate in chronic heart failure. Am J Physiol Heart Circ Physiol. 2017; 312(3): H415-H421, doi: 10.1152/ajpheart.00645.2016, indexed in Pubmed: 27923792.
49. Dou L, Sallée M, Cerini C, et al. The cardiovascular effect of the uremic solute indole-3 acetic acid. J Am Soc Nephrol. 2015; 26(4): 876-887, doi: 10.1681/ASN.2013121283, indexed in Pubmed: 25145928.
50. Tang WH, Wang Z, Li XS, et al. Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus. Clin Chem. 2017; 63(1): 297-306, doi: 10.1373/clinchem.2016.263640, in-dexed in Pubmed: 27864387.