Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

Biochemical and Biophysical Research Communications

Volumn 481, Issue 1-2, 2016, Pages 63-70

  Sun, Xiaolei ^a,b   Jiao, Xuefei ^c   Ma, Yarong ^a   Liu, Yong ^a   Zhang, Lei ^a   He, Yanzheng ^a   Chen, Yunhui ^d  

^a THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIVERSITY   (China)

^b China Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute   (Macao)

^c QINGDAO UNIVERSITY   (China)

^d QINGDAO MUNICIPAL HOSPITAL   (China)

Author keywords

Atherosclerosis; Endothelial dysfunction; NLRP3 inflammasome; Oxidative stress; Trimethylamine N oxide

Indexed keywords

BETA ACTIN; CRYOPYRIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIUM DERIVED RELAXING FACTOR; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; THIOREDOXIN INTERACTING PROTEIN; TOLL LIKE RECEPTOR 4; TRIMETHYLAMINE OXIDE; CARRIER PROTEIN; INFLAMMASOME; METHYLAMINE; NLRP3 PROTEIN, HUMAN; TRIMETHYLOXAMINE; TXNIP PROTEIN, HUMAN;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; UMBILICAL VEIN ENDOTHELIAL CELL; CELL CULTURE; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; VASCULAR ENDOTHELIUM;

CARRIER PROTEINS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMASOMES; INFLAMMATION; METHYLAMINES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; REACTIVE OXYGEN SPECIES;

EID: 85000933248     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.11.017     Document Type: Article

References (31)

1. [1] Wilson, A., McLean, C., Kim, R.B., Trimethylamine-N-oxide: a link between the gut microbiome, bile acid metabolism, andatherosclerosis. Curr. Opin. Lipidol. 27 (2016), 148–154.
2. [2] Spector, R., New insight into the dietary cause of atherosclerosis: implications for pharmacology. J. Pharmacol. Exp. Ther. 358 (2016), 103–108.
3. [3] Yin, J., Liao, S.X., He, Y., et al. Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack. J. Am. Heart Assoc., 4, 2015, e002699.
4. [4] Gao, X., Liu, X., Xu, J., Xue, C., Xue, Y., Wang, Y., Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J. Biosci. Bioeng. 118 (2014), 476–481.
5. [5] Xu, R., Wang, Q., Li, L., A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat. BMC Genomics(Suppl 7), 2015, S4.
6. [6] Randrianarisoa, E., Lehn-Stefan, A., Wang, X., et al. Relationship of serum trimethylamine N-Oxide (TMAO) levels with early atherosclerosis in humans. Sci. Rep., 6, 2016, 26745.
7. [7] Paramel Varghese, G., Folkersen, L., Strawbridge, R.J., et al. NLRP3 inflammasome expression and activation in human atherosclerosis. J. Am. Heart Assoc., 5, 2016.
8. [8] Janoudi, A., Shamoun, F.E., Kalavakunta, J.K., Abela, G.S., Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque. Eur. Heart J. 37 (2016), 1959–1967.
9. [9] Ding, C., Zhao, Y., Shi, X., Zhang, N., et al. New insights into salvianolic acid A action: regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats. Sci. Rep., 6, 2016, 28734.
10. [10] Lee, M.S., Role of innate immunity in diabetes and metabolism: recent progress in the study of inflammasomes. Immune Netw. 11 (2011), 95–99.
11. [11] Feng, H., Gu, J., Gou, F., Huang, W., et al. High glucose and lipopolysaccharide prime NLRP3 inflammasome via ROS/TXNIP pathway in mesangial cells. J. Diabetes Res., 2016, 2016, 6973175.
12. [12] Sharma, A., Chhibber-Goel, J., Singhal, V., Parakh, N., Bhargava, B., The metabolite trimethylamine-N-oxide is an emergent biomarker of human health. Curr. Med. Chem., 23, 2016 (Epub ahead of print) PMID: 27573063.
13. [13] Gao, X., Xu, J., Jiang, C., Zhang, Y., Xue, Y., Li, Z., Wang, J., Xue, C., Wang, Y., Fish oil ameliorates trimethylamine N-oxide-exacerbated glucose intolerance in high-fat diet-fed mice. Food Funct. 6 (2015), 1117–1125.
14. [14] Ufnal, M., Zadlo, A., Ostaszewski, R., TMAO: A small molecule of great expectations. Nutrition 31 (2015), 1317–1323.
15. [15] Suska, A., Ibanez, A.B., Lundstrom, I., Berghard, A., G protein-coupled receptor mediated trimethylamine sensing. Biosens. Bioelectron. 25 (2009), 715–720.
16. [16] Wallrabenstein, I., Kuklan, J., Weber, L., et al. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. PLoS One, 8, 2013, e54950.
17. [17] Kong, F., Ye, B., Lin, L., Cai, X., Huang, W., Huang, Z., Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes. Biomed. Pharmacother. 82 (2016), 167–172.
18. [18] Seldin, M.M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S.L., Lusis, A.J., Shih, D.M., Trimethylamine N-Oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-κB. J. Am. Heart Assoc., 5, 2016, e002767.
19. [19] Abderrazak, A., Couchie, D., Mahmood, D.F., et al. Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet. Circulation 131 (2015), 1061–1070.
20. [20] Grau, A., Tabib, A., Grau, I., Reiner, I., Mevorach, D., Apoptotic cells induce NF-κB and inflammasome negative signaling. PLoS One, 10, 2015, e0122440.
21. [21] Abderrazak, A., Syrovets, T., Couchie, D., El Hadri, K., Friguet, B., Simmet, T., Rouis, M., NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol. 4 (2015), 296–307.
22. [22] Jung, H., Choi, I., Thioredoxin-interacting protein, hematopoietic stem cells, and hematopoiesis. Curr. Opin. Hematol. 21( (2014), 265–270.
23. [23] Davis, B.K., Ting, J.P., NLRP3 has a sweet tooth. Nat. Immunol. 11 (2010), 105–106.
24. [24] Kuppan, G., Balasubramanyam, J., Monickaraj, F., Srinivasan, G., Mohan, V., Balasubramanyam, M., Transcriptional regulation of cytokines and oxidative stress by gallic acid in human THP-1 monocytes. Cytokine 49 (2010), 229–234.
25. [25] Singh, L.P., Thioredoxin interacting protein (TXNIP) and pathogenesis of diabetic retinopathy. J. Clin. Exp. Ophthalmol., 4, 2013.
26. [26] Devi, T.S., Hosoya, K., Terasaki, T., Singh, L.P., Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. Exp. Cell Res. 319 (2013), 1001–1012.
27. [27] Chu, P., Han, G., Ahsan, A., Sun, Z., Liu, S., Zhang, Z., Sun, B., Song, Y., Lin, Y., Peng, J., Tang, Z., Phosphocreatine protects endothelial cells from methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-қB pathway. Vasc. Pharmacol. S1537–1891 (2016), 30106–30109.
28. [28] Li, H., Horke, S., Förstermann, U., Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 237 (2014), 208–219.
29. [29] Liu, P., Xie, Q., Wei, T., Chen, Y., Chen, H., Shen, W., Activation of the NLRP3 inflammasome induces vascular dysfunction in obese OLETF rats. Biochem. Biophys. Res. Commun. 468 (2015), 319–325.
30. [30] Yang, W.L., Sharma, A., Wang, Z., Li, Z., Fan, J., Wang, P., Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of NLRP3 inflammasome. Sci. Rep., 6, 2016, 26571.
31. [31] Lee, J., Bae, E.H., Ma, S.K., Kim, S.W., Altered nitric oxide system in cardiovascular and renal diseases. Chonnam Med. J. 52 (2016), 81–90.