Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor

Journal of Experimental Medicine

Volumn 187, Issue 11, 1998, Pages 1779-1788

  Ishii, Satoshi ^a,b   Kuwaki, Tomoyuki ^a   Nagase, Takahide ^a   Maki, Kazushige ^a   Tashiro, Fumi ^a   Sunaga, Shinji ^a   Cao, Wei Hua ^a   Kume, Kazuhiko ^a   Fukuchi, Yoshinosuke ^a   Ikuta, Koichi ^a   Miyazaki, Jun Ichi ^a   Kumada, Mamoru ^a   Shimizu, Takao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN TOBACCO INC   (Japan)

Author keywords

Anaphylaxis; Endotoxic shock; Gene targeting; Platelet activating factor; Platelet activating factor receptor

Indexed keywords

ENDOTOXIN; THROMBOCYTE ACTIVATING FACTOR RECEPTOR;

ALLERGIC REACTION; ANAPHYLAXIS; ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CELL MIGRATION; IMMUNE RESPONSE; LONG TERM POTENTIATION; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

ANAPHYLAXIS; ANIMALS; GENE TARGETING; HEART; HOMEOSTASIS; LIPOPOLYSACCHARIDES; MALE; MICE; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; REPRODUCTION; SHOCK, SEPTIC;

EID: 17644431708     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.11.1779     Document Type: Article

References (57)

1. Hanahan, D.J. 1986. Platelet activating factor: a biologically active phosphoglyceride. Annu. Rev. Biochem. 55:483-509.
2. Prescott, S.M., G.A. Zimmerman, and T.M. McIntyre. 1990. Platelet-activating factor. J. Biol. Chem. 265:17381-17384.
3. Barnes, P.J. 1991. Platelet activating factor and asthma. Ann. NY Acad. Sci. 629:193-204.
4. Imaizumi, T.-a., D.M. Stafforini, Y. Yamada, T.M. McIntyre, S.M. Prescott, and G.A. Zimmerman. 1995. Platelet-activating factor: a mediator for clinicians. J. Intern. Med. 238:5-20.
5. Izumi, T., and T. Shimizu. 1995. Platelet-activating factor receptor: gene expression and signal transduction. Biochim. Biophys. Acta. 1259:317-333.
6. Prpic, V., R.J. Uhing, J.E. Weiel, L. Jakoi, G. Gawdi, B. Herman, and D.O. Adams. 1988. Biochemical and functional responses stimulated by platelet-activating factor in murine peritoneal macrophages. J. Cell Biol. 107:363-372 (see published erratum 107:1260).
7. Stephens, L., T. Jackson, and P.T. Hawkins. 1993. Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. J. Biol. Chem. 268:17162-17172.
8. Liu, B., S. Nakashima, T. Takano, T. Shimizu, and Y. Nozawa. 1995. Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. Biochem. Biophys. Res. Commun. 214:418-423.
9. Honda, Z.-i., T. Takano, Y. Gotoh, E. Nishida, K. Ito, and T. Shimizu. 1994. Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. J. Biol. Chem. 269:2307-2315.
10. Honda, Z.-i., M. Nakamura, I. Miki, M. Minami, T. Watanabe, Y. Seyama, H. Okado, H. Toh, K. Ito, T. Miyamoto, and T. Shimizu. 1991. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature. 349:342-346.
11. Nakamura, M., Z.-i. Honda, T. Izumi, C. Sakanaka, H. Mutoh, M. Minami, H. Bito, Y. Seyama, T. Matsumoto, M. Noma, and T. Shimizu. 1991. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J. Biol. Chem. 266:20400-20405.
12. Ye, R.D., E.R. Prossnitz, A.H. Zou, and C.G. Cochrane. 1991. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Biochem. Biophys. Res. Commun. 180:105-111.
13. Kunz, D., N.P. Gerard, and C. Gerard. 1992. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. J. Biol. Chem. 267:9101-9106.
14. Sugimoto, T., H. Tsuchimochi, C.G. McGregor, H. Mutoh, T. Shimizu, and Y. Kurachi. 1992. Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. Biochem. Biophys. Res. Commun. 189:617-624.
15. Bito, H., Z.-i. Honda, M. Nakamura, and T. Shimizu. 1994. Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. Eur. J. Biochem. 221:211-218.
16. Ishii, S., Y. Matsuda, M. Nakamura, I. Waga, K. Kume, T. Izumi, and T. Shimizu. 1996. A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem. J. 314:671-678.
17. Hwang, S.B. 1991. High affinity receptor binding of platelet-activating factor in rat peritoneal polymorphonuclear leukocytes. Eur. J. Pharmacol. 196:169-175.
18. Kato, K., G.D. Clark, N.G. Bazan, and C.F. Zorumski. 1994. Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation. Nature. 367:175-179.
19. O'Neill, C. 1992. Embryo-derived platelet activating factor. Reprod. Fertil. Dev. 4:283-288.
20. Hoffman, D.R., C.T. Truong, and J.M. Johnston. 1986. Metabolism and function ot platelet-activating factor in fetal rabbit lung development. Biochim. Biophys. Acta. 879:88-96 (see published erratum 919:311).
21. Blank, M.L., F. Snyder, L.W. Byers, B. Brooks, and E.E. Muirhead. 1979. Antihypertensive activity of an alkyl ether analog of phosphatidylcholine. Biocliem. Biophys. Res. Commun. 90:1194-1200.
22. Kunievsky, B., and E. Yavin. 1994. Production and metabolism ot platelet-activating factor in the normal and ischemic fetal rat brain. J. Neurochem. 63:2144-2151.
23. Toyoshima, K., H. Narahara, M. Furukawa, R.A. Frenkel, and J.M. Johnston. 1995. Platelet-activating factor. Role in fetal lung development and relationship to normal and premature labor. Clin. Perinatol. 22:263-280.
24. Masugi, F., T. Ogihara, S. Saeki, A. Otsuka, and Y. Kumahara. 1985. Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. Hypertension (Dallas). 7:742-746.
25. Hattori, M., H. Adachi, M. Tsujimoto, H. Arai, and K. Inoue. 1994. Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase. Nature. 370:216-218.
26. Oettgen, H.C., T.R. Martin, A. Wynshaw-Boris, C. Deng, J.M. Drazen, and P. Leder. 1994. Active anaphylaxis in IgE-deficient mice. Nature. 370:367-370.
27. Miyajima, I., D. Dombrowicz, T.R. Martin, J.V. Ravetch, J.P. Kinet, and S.J. Galli. 1997. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE-or IgG1-dependent passive anaphylaxis. J. Clin. Invest. 99:901-914.
28. Mencia-Huerta, J.-M., R.A. Lewis, E. Razin, and K.F. Austen. 1983. Antigen-initiated release of platelet-activating factor (PAF-acether) from mouse bone marrow-derived mast cells sensitized with monoclonal IgE. J. Immunol. 131:2958-2964.
29. Hanahan, D.J., C.A. Demopoulos, J. Liehr, and R.N. Pinckard. 1980. Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphocholine. J. Biol. Chem. 255:5514-5516.
30. Nagaoka, J., K. Harada, A. Kimura, S. Kobayashi, M. Murakami, T. Yoshimura, K. Yamada, O. Asano, K. Katayama, and I. Yamatsu. 1991. Inhibitory effects of the novel platelet activating factor receptor antagonist, 1-ethyl-2-[N-(2-methoxy) benzoyl-N-[(2R)-2-methoxy-3-(4-octadecylcarbamoyloxy) piperidinocarbonyloxypropyloxy]carbonyl] aminomethyl-pyridinium chloride, in several experimentally induced shock models. Arzneim.-Forsch./Drug Res. 41:719-724.
31. Casals-Stenzel, J. 1987. Effects of WEB 2086, a novel antagonist of platelet activating factor, in active and passive anaphylaxis. Immunopharmacology. 13:117-124.
32. Terashita, Z., M. Kawamura, M. Takatani, S. Tsushima, Y. Imura, and K. Nishikawa. 1992. Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents. J. Pharmacol. Exp. Ther. 260:748-755.
33. Morrison, D.C., and J.L. Ryan. 1987. Endotoxins and disease mechanisms. Annu. Rev. Med. 38:417-432.
34. Bone, R.C. 1991. The pathogenesis of sepsis. Ann. Intern. Med. 115:457-469.
35. Chang, T.W., M.H. Wu, and Y.J. Yang. 1992. Blood levels of platelet-activating factor in endotoxin-sensitive and endotoxin-resistant mice during endotoxemia. J. Formosan Med. Assoc. 91:1133-1137.
36. Graham, R.M., C.J. Stephens, W. Silvester, L.L. Leong, M.J. Sturm, and R.R. Taylor. 1994. Plasma degradation of platelet-activating factor in severely ill patients with clinical sepsis. Crit. Care Med. 22:204-212.
37. Casals-Stenzel, J. 1987. Protective effect of WEB 2086, a novel antagonist of platelet activating factor, in endotoxin shock. Eur. Pharmacol. 135:117-122.
38. Guinot, P., and P. Braquet. 1994. Effects of the PAF antagonists, ginkgolides (BN-52063, BN-52021), in various clinical indications. J. Lipid Medial. Cell Signal. 10:144-146.
39. Giral, M., D. Balsa, R. Ferrando, M. Merlos, R.J. Garcia, and J. Forn. 1996. Effects of UR-12633, a new antagonist of platelet-activating factor, in rodent models of endotoxic shock. Br. J. Pharmacol. 118:1223-1231.
40. Merlos, M., M. Giral, D. Balsa, R. Ferrando, M. Queralt, A. Puigdemont, R.J. Garcia, and J. Forn. 1997. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J. Pharmacol. Exp. Ther. 280: 114-121.
41. Ishii, S., T. Nagase, F. Tashiro, K. Ikuta, S. Sato, I. Waga, K. Kume, J.-i. Miyazaki, and T. Shimizu. 1997. Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO (Eur. Mol. Biol. Organ.) J. 16: 133-142.
42. Svetlov, S.I., K.M. Howard, M. Miwa, B.D. Flickinger, and M.S. Olson. 1996. Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein ryrosine phosphorylation. Arch. Biochem. Biophys. 327:113-122.
43. Adachi, T., J. Aoki, H. Manya, H. Asou, H. Arai, and K. Inoue. 1997. PAF analogues capable ot inhibiting PAF acetylhydrolase activity suppress migration ot isolated rat cerebellar granule cells. Neurosci. Lett. 235:133-136.
44. Carceller, E., M. Merlos, M. Giral, D. Balsa, C. Almansa, J. Bartroli, R.J. Garcia, and J. Forn. 1994. [(3-Pyridylalkyl)pipendylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine. J. Med. Chem. 37:2697-2703.
45. 2+ signaling via platelet-activating factor receptor. FEBS Lett. 314:125-129.
46. Nagase, T., E. Ohga, E. Sudo, H. Katayama, Y. Uejima, T. Matsuse, and Y. Fukuchi. 1996. Intercellular adhesion molecule-1 mediates acid aspiration-induced lung injury. Am. J. Rapir. Crit. Care Med. 154:504-510.
47. 2 in allergic response and parturition. Nature. 390:618-622.
48. Casals-Stenzel, J., G. Muacevic, and K. Weber. 1987. Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor. J. Pharmacol. Exp. Ther. 241:974-981.
49. Ferby, I.M., I. Waga, C. Sakanaka, K. Kume, and T. Shimizu. 1994. Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils. J. Biol. Chem. 269:30485-30488.
50. Chen, X.-S., J.R. Sheller, E.N. Johnson, and C.D. Funk. 1994. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature. 372:179-182.
51. Sapir, T., M. Elbaum, and O. Reiner. 1997. Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. EMBO (Eur. Mol. Biol. Organ.) J. 16:6977-6984.
52. Maki, N., D.R. Hoffman, and J.M. Johnston. 1988. Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation. Proc. Natl. Acad. Sci. USA. 85:728-732.
53. O'Neill, C., J.P. Ryan, M. Collier, D.M. Saunders, A.J. Ammit, and I.L. Pike. 1989. Supplementation of in-vitro fertilisation culture medium with platelet activating factor. Lancet. 2:769-772.
54. Ryan, J.P., N.R. Spinks, C. O'Neill, and R.G. Wales. 1990. Implantation potential and fetal viability of mouse embryos cultured in media supplemented with platelet-activating factor. J. Reprod. Fertil. 89:309-315.
55. Serhan, C.N., J.Z. Haeggstrom, and C.C. Leslie. 1996. Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J. 10:1147-1158.
56. Martin, T.R., N.P. Gerard, S.J. Galli, and J.M. Drazen. 1988. Pulmonary responses to bronchoconstrictor agonists in the mouse. J. Appl. Physiol. 64:2318-2323.
57. Szabo, C., C.C. Wu, J.A. Mitchell, S.S. Gross, C. Thiemermann, and J.R. Vane. 1993. Platelet-activating factor contributes to the induction ot nitric oxide synthase by bacterial lipopolysaccharide. Circ. Res. 73:991-999.