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Volumn 1, Issue 3, 2016, Pages

The intersection of radiotherapy and immunotherapy: Mechanisms and clinical implications

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[No Author keywords available]

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EID: 85041734576     PISSN: None     EISSN: 24709468     Source Type: Journal    
DOI: 10.1126/sciimmunol.aag1266     Document Type: Article
Times cited : (153)

References (107)
  • 1
    • 0018569985 scopus 로고
    • Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma
    • H. B. Stone, L. J. Peters, L. Milas, Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma. J. Natl. Cancer Inst. 63, 1229–1235 (1979).
    • (1979) J. Natl. Cancer Inst. , vol.63 , pp. 1229-1235
    • Stone, H.B.1    Peters, L.J.2    Milas, L.3
  • 2
    • 0025058972 scopus 로고
    • Synergistic antitumor activity of tumor-infiltrating lymphocytes, interleukin 2, and local tumor irradiation. Studies on the mechanism of action
    • R. B. Cameron, P. J. Spiess, S. A. Rosenberg, Synergistic antitumor activity of tumor-infiltrating lymphocytes, interleukin 2, and local tumor irradiation. Studies on the mechanism of action. J. Exp. Med. 171, 249–263 (1990).
    • (1990) J. Exp. Med. , vol.171 , pp. 249-263
    • Cameron, R.B.1    Spiess, P.J.2    Rosenberg, S.A.3
  • 4
    • 79953295544 scopus 로고    scopus 로고
    • The efficacy of radiotherapy relies upon induction of type I interferon–dependent innate and adaptive immunity
    • B. C. Burnette, H. Liang, Y. Lee, L. Chlewicki, N. N. Khodarev, R. R. Weichselbaum, Y.-X. Fu, S. L. Auh, The efficacy of radiotherapy relies upon induction of type I interferon–dependent innate and adaptive immunity. Cancer Res. 71, 2488–2496 (2011).
    • (2011) Cancer Res , vol.71 , pp. 2488-2496
    • Burnette, B.C.1    Liang, H.2    Lee, Y.3    Chlewicki, L.4    Khodarev, N.N.5    Weichselbaum, R.R.6    Fu, Y.-X.7    Auh, S.L.8
  • 5
    • 45449090985 scopus 로고    scopus 로고
    • Radiation-induced IFN-g production within the tumor microenvironment influences antitumor immunity
    • A. A. Lugade, E. W. Sorensen, S. A. Gerber, J. P. Moran, J. G. Frelinger, E. M. Lord, Radiation-induced IFN-g production within the tumor microenvironment influences antitumor immunity. J. Immunol. 180, 3132–3139 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 3132-3139
    • Lugade, A.A.1    Sorensen, E.W.2    Gerber, S.A.3    Moran, J.P.4    Frelinger, J.G.5    Lord, E.M.6
  • 6
    • 0033118909 scopus 로고    scopus 로고
    • The ATM protein is required for sustained activation of NF-kB following DNA damage
    • B. Piret, S. Schoonbroodt, J. Piette, The ATM protein is required for sustained activation of NF-kB following DNA damage. Oncogene 18, 2261–2271 (1999).
    • (1999) Oncogene , vol.18 , pp. 2261-2271
    • Piret, B.1    Schoonbroodt, S.2    Piette, J.3
  • 7
    • 0025879694 scopus 로고
    • Ionizing radiation induces expression and binding activity of the nuclear factor kappa B
    • M. A. Brach, R. Hass, M. L. Sherman, H. Gunji, R. Weichselbaum, D. Kufe, Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J. Clin. Invest. 88, 691–695 (1991).
    • (1991) J. Clin. Invest. , vol.88 , pp. 691-695
    • Brach, M.A.1    Hass, R.2    Sherman, M.L.3    Gunji, H.4    Weichselbaum, R.5    Kufe, D.6
  • 8
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-kB in preventing TNF-a-induced cell death
    • A. A. Beg, D. Baltimore, An essential role for NF-kB in preventing TNF-a-induced cell death. Science 274, 782–784 (1996).
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 10
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • H. Ishikawa, Z. Ma, G. N. Barber, STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461, 788–792 (2009).
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 20
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • B. Sauter, M. L. Albert, L. Francisco, M. Larsson, S. Somersan, N. Bhardwaj, Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191, 423–434 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 423-434
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 21
    • 0036911269 scopus 로고    scopus 로고
    • Increasing tumor antigen expression overcomes “ignorance” to solid tumors via crosspresentation by bone marrow-derived stromal cells
    • M. T. Spiotto, P. Yu, D. A. Rowley, M. I. Nishimura, S. C. Meredith, T. F. Gajewski, Y.-X. Fu, H. Schreiber, Increasing tumor antigen expression overcomes “ignorance” to solid tumors via crosspresentation by bone marrow-derived stromal cells. Immunity 17, 737–747 (2002).
    • (2002) Immunity , vol.17 , pp. 737-747
    • Spiotto, M.T.1    Yu, P.2    Rowley, D.A.3    Nishimura, M.I.4    Meredith, S.C.5    Gajewski, T.F.6    Fu, Y.-X.7    Schreiber, H.8
  • 23
    • 20444406500 scopus 로고    scopus 로고
    • Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor
    • A. A. Lugade, J. P. Moran, S. A. Gerber, R. C. Rose, J. G. Frelinger, E. M. Lord, Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J. Immunol. 174, 7516–7523 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 7516-7523
    • Lugade, A.A.1    Moran, J.P.2    Gerber, S.A.3    Rose, R.C.4    Frelinger, J.G.5    Lord, E.M.6
  • 26
    • 84983353116 scopus 로고    scopus 로고
    • Stereotactic radiation therapy augments antigen-specific PD-1–mediated antitumor immune responses via cross-presentation of tumor antigen
    • A. B. Sharabi, C. J. Nirschl, C. M. Kochel, T. R. Nirschl, B. J. Francica, E. Velarde, T. L. Deweese, C. G. Drake, Stereotactic radiation therapy augments antigen-specific PD-1–mediated antitumor immune responses via cross-presentation of tumor antigen. Cancer Immunol. Res. 3, 345–355 (2015).
    • (2015) Cancer Immunol. Res. , vol.3 , pp. 345-355
    • Sharabi, A.B.1    Nirschl, C.J.2    Kochel, C.M.3    Nirschl, T.R.4    Francica, B.J.5    Velarde, E.6    Deweese, T.L.7    Drake, C.G.8
  • 28
    • 82255195940 scopus 로고    scopus 로고
    • G-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo
    • A. Sharma, B. Bode, R. H. Wenger, K. Lehmann, A. A. Sartori, H. Moch, A. Knuth, L. von Boehmer, M. van den Broek, g-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo. PLOS One 6, e28217 (2011).
    • (2011) PLOS One , vol.6
    • Sharma, A.1    Bode, B.2    Wenger, R.H.3    Lehmann, K.4    Sartori, A.A.5    Moch, H.6    Knuth, A.7    Von Boehmer, L.8    Van Den Broek, M.9
  • 32
    • 79955629731 scopus 로고    scopus 로고
    • Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro
    • J. Huang, Q. J. Wang, S. Yang, Y. F. Li, M. El-Gamil, S. A. Rosenberg, P. F. Robbins, Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro. J. Immunother. 34, 327–335 (2011).
    • (2011) J. Immunother. , vol.34 , pp. 327-335
    • Huang, J.1    Wang, Q.J.2    Yang, S.3    Li, Y.F.4    El-Gamil, M.5    Rosenberg, S.A.6    Robbins, P.F.7
  • 36
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • R. K. Shrimali, Z. Yu, M. R. Theoret, D. Chinnasamy, N. P. Restifo, S. A. Rosenberg, Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res. 70, 6171–6180 (2010).
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 37
    • 0036494443 scopus 로고    scopus 로고
    • Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
    • R. Ganss, E. Ryschich, E. Klar, B. Arnold, G. J. Hämmerling, Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 62, 1462–1470 (2002).
    • (2002) Cancer Res , vol.62 , pp. 1462-1470
    • Ganss, R.1    Ryschich, E.2    Klar, E.3    Arnold, B.4    Hämmerling, G.J.5
  • 38
    • 84940372582 scopus 로고    scopus 로고
    • The next hurdle in cancer immunotherapy: Overcoming the non–T-cell–inflamed tumor microenvironment
    • T. F. Gajewski, The next hurdle in cancer immunotherapy: Overcoming the non–T-cell–inflamed tumor microenvironment. Semin. Oncol. 42, 663–671 (2015).
    • (2015) Semin. Oncol. , vol.42 , pp. 663-671
    • Gajewski, T.F.1
  • 39
    • 84962921798 scopus 로고    scopus 로고
    • Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade
    • H. Tang, Y. Wang, L. K. Chlewicki, Y. Zhang, J. Guo, W. Liang, J. Wang, X. Wang, Y.-X. Fu, Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade. Cancer Cell 29, 285–296 (2016).
    • (2016) Cancer Cell , vol.29 , pp. 285-296
    • Tang, H.1    Wang, Y.2    Chlewicki, L.K.3    Zhang, Y.4    Guo, J.5    Liang, W.6    Wang, J.7    Wang, X.8    Fu, Y.-X.9
  • 40
    • 84863291227 scopus 로고    scopus 로고
    • Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells
    • S. Wan, S. Pestka, R. G. Jubin, Y. L. Lyu, Y.-C. Tsai, L. F. Liu, Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells. PLOS One 7, e32542 (2012).
    • (2012) PLOS One , vol.7
    • Wan, S.1    Pestka, S.2    Jubin, R.G.3    Lyu, Y.L.4    Tsai, Y.-C.5    Liu, L.F.6
  • 41
    • 3042569675 scopus 로고    scopus 로고
    • External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing
    • M. Chakraborty, S. I. Abrams, C. N. Coleman, K. Camphausen, J. Schlom, J. W. Hodge, External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing. Cancer Res. 64, 4328–4337 (2004).
    • (2004) Cancer Res , vol.64 , pp. 4328-4337
    • Chakraborty, M.1    Abrams, S.I.2    Coleman, C.N.3    Camphausen, K.4    Schlom, J.5    Hodge, J.W.6
  • 42
    • 7444258053 scopus 로고    scopus 로고
    • Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes
    • C. T. Garnett, C. Palena, M. Chakraborty, K.-Y. Tsang, J. Schlom, J. W. Hodge, Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes. Cancer Res. 64, 7985–7994 (2004).
    • (2004) Cancer Res , vol.64 , pp. 7985-7994
    • Garnett, C.T.1    Palena, C.2    Chakraborty, M.3    Tsang, K.-Y.4    Schlom, J.5    Hodge, J.W.6
  • 43
    • 2342485077 scopus 로고    scopus 로고
    • Bystander elimination of antigen loss variants in established tumors
    • M. T. Spiotto, D. A. Rowley, H. Schreiber, Bystander elimination of antigen loss variants in established tumors. Nat. Med. 10, 294–298 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 294-298
    • Spiotto, M.T.1    Rowley, D.A.2    Schreiber, H.3
  • 45
    • 0022616253 scopus 로고
    • Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
    • K. Kärre, H. G. Ljunggren, G. Piontek, R. Kiessling, Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319, 675–678 (1986).
    • (1986) Nature , vol.319 , pp. 675-678
    • Kärre, K.1    Ljunggren, H.G.2    Piontek, G.3    Kiessling, R.4
  • 46
    • 0035949563 scopus 로고    scopus 로고
    • Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
    • A. Cerwenka, J. L. Baron, L. L. Lanier, Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. U.S.A. 98, 11521–11526 (2001).
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 11521-11526
    • Cerwenka, A.1    Baron, J.L.2    Lanier, L.L.3
  • 47
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • S. Gasser, S. Orsulic, E. J. Brown, D. H. Raulet, The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436, 1186–1190 (2005).
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 48
    • 65349131915 scopus 로고    scopus 로고
    • ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
    • A. Soriani, A. Zingoni, C. Cerboni, M. L. Iannitto, M. R. Ricciardi, V. Di Gialleonardo, M. Cippitelli, C. Fionda, M. T. Petrucci, A. Guarini, R. Foà, A. Santoni, ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood 113, 3503–3511 (2009).
    • (2009) Blood , vol.113 , pp. 3503-3511
    • Soriani, A.1    Zingoni, A.2    Cerboni, C.3    Iannitto, M.L.4    Ricciardi, M.R.5    Di Gialleonardo, V.6    Cippitelli, M.7    Fionda, C.8    Petrucci, M.T.9    Guarini, A.10    Foà, R.11    Santoni, A.12
  • 49
    • 77956911325 scopus 로고    scopus 로고
    • Chemotherapy-induced genotoxic stress promotes sensitivity to natural killer cell cytotoxicity by enabling missing-self recognition
    • J. H. Fine, P. Chen, A. Mesci, D. S. J. Allan, S. Gasser, D. H. Raulet, J. R. Carlyle, Chemotherapy-induced genotoxic stress promotes sensitivity to natural killer cell cytotoxicity by enabling missing-self recognition. Cancer Res. 70, 7102–7113 (2010).
    • (2010) Cancer Res , vol.70 , pp. 7102-7113
    • Fine, J.H.1    Chen, P.2    Mesci, A.3    Allan, D.S.J.4    Gasser, S.5    Raulet, D.H.6    Carlyle, J.R.7
  • 50
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • R. Noy, J. W. Pollard, Tumor-associated macrophages: From mechanisms to therapy. Immunity 41, 49–61 (2014).
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 53
    • 84864828790 scopus 로고    scopus 로고
    • The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
    • C. Medrek, F. Pontén, K. Jirström, K. Leandersson, The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer 12, 306 (2012).
    • (2012) BMC Cancer , vol.12 , pp. 306
    • Medrek, C.1    Pontén, F.2    Jirström, K.3    Leandersson, K.4
  • 54
    • 0023119113 scopus 로고
    • Macrophage content of murine sarcomas and carcinomas: Associations with tumor growth parameters and tumor radiocurability
    • L. Milas, J. Wike, N. Hunter, J. Volpe, I. Basic, Macrophage content of murine sarcomas and carcinomas: Associations with tumor growth parameters and tumor radiocurability. Cancer Res. 47, 1069–1075 (1987).
    • (1987) Cancer Res , vol.47 , pp. 1069-1075
    • Milas, L.1    Wike, J.2    Hunter, N.3    Volpe, J.4    Basic, I.5
  • 57
    • 77949697909 scopus 로고    scopus 로고
    • Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
    • M. Kioi, H. Vogel, G. Schultz, R. M. Hoffman, G. R. Harsh, J. M. Brown, Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J. Clin. Invest. 120, 694–705 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 694-705
    • Kioi, M.1    Vogel, H.2    Schultz, G.3    Hoffman, R.M.4    Harsh, G.R.5    Brown, J.M.6
  • 58
    • 84881087399 scopus 로고    scopus 로고
    • Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis
    • S.-C. Wang, C.-F. Yu, J.-H. Hong, C.-S. Tsai, C.-S. Chiang, Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis. PLOS One 8, e69182 (2013).
    • (2013) PLOS One , vol.8
    • Wang, S.-C.1    Yu, C.-F.2    Hong, J.-H.3    Tsai, C.-S.4    Chiang, C.-S.5
  • 59
    • 84877738839 scopus 로고    scopus 로고
    • CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer
    • J. Xu, J. Escamilla, S. Mok, J. David, S. Priceman, B. West, G. Bollag, W. McBride, L. Wu, CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. Cancer Res. 73, 2782–2794 (2013).
    • (2013) Cancer Res , vol.73 , pp. 2782-2794
    • Xu, J.1    Escamilla, J.2    Mok, S.3    David, J.4    Priceman, S.5    West, B.6    Bollag, G.7    McBride, W.8    Wu, L.9
  • 60
    • 77952389941 scopus 로고    scopus 로고
    • Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment
    • G.-O. Ahn, D. Tseng, C.-H. Liao, M. J. Dorie, A. Czechowicz, J. M. Brown, Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment. Proc. Natl. Acad. Sci. U.S.A. 107, 8363–8368 (2010).
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 8363-8368
    • Ahn, G.-O.1    Tseng, D.2    Liao, C.-H.3    Dorie, M.J.4    Czechowicz, A.5    Brown, J.M.6
  • 61
    • 39849100541 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells
    • G.-O. Ahn, J. M. Brown, Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells. Cancer Cell 13, 193–205 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 193-205
    • Ahn, G.-O.1    Brown, J.M.2
  • 63
    • 39049141295 scopus 로고    scopus 로고
    • Indirect macrophage responses to ionizing radiation: Implications for genotype-dependent bystander signaling
    • P. J. Coates, J. K. Rundle, S. A. Lorimore, E. G. Wright, Indirect macrophage responses to ionizing radiation: Implications for genotype-dependent bystander signaling. Cancer Res. 68, 450–456 (2008).
    • (2008) Cancer Res , vol.68 , pp. 450-456
    • Coates, P.J.1    Rundle, J.K.2    Lorimore, S.A.3    Wright, E.G.4
  • 64
    • 0022972367 scopus 로고
    • Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells
    • R. J. North, Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells. J. Exp. Med. 164, 1652–1666 (1986).
    • (1986) J. Exp. Med. , vol.164 , pp. 1652-1666
    • North, R.J.1
  • 69
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • S. Demaria, N. Kawashima, A. M. Yang, M. L. Devitt, J. S. Babb, J. P. Allison, S. C. Formenti, Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin. Cancer Res. 11 (2 Pt. 1), 728–734 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.2 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3    Devitt, M.L.4    Babb, J.S.5    Allison, J.P.6    Formenti, S.C.7
  • 70
    • 59449094876 scopus 로고    scopus 로고
    • Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade
    • K. A. Pilones, N. Kawashima, A. M. Yang, J. S. Babb, S. C. Formenti, S. Demaria, Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade. Clin. Cancer Res. 15, 597–606 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 597-606
    • Pilones, K.A.1    Kawashima, N.2    Yang, A.M.3    Babb, J.S.4    Formenti, S.C.5    Demaria, S.6
  • 81
    • 84954348557 scopus 로고    scopus 로고
    • Splenectomy inhibits non-small cell lung cancer growth by modulating anti-tumor adaptive and innate immune response
    • L. Levy, I. Mishalian, R. Bayuch, L. Zolotarov, J. Michaeli, Z. G. Fridlender, Splenectomy inhibits non-small cell lung cancer growth by modulating anti-tumor adaptive and innate immune response. Oncoimmunology 4, e998469 (2015).
    • (2015) Oncoimmunology , vol.4 , pp. e998469
    • Levy, L.1    Mishalian, I.2    Bayuch, R.3    Zolotarov, L.4    Michaeli, J.5    Fridlender, Z.G.6
  • 83
    • 84962033778 scopus 로고    scopus 로고
    • The beneficial local and abscopal effect of splenic irradiation in frail patients with chronic lymphocytic leukaemia
    • A. M. Aalbers, M. J. Aarts, A. D. G. Krol, C. A. M. Marijnen, E. F. M. Posthuma, The beneficial local and abscopal effect of splenic irradiation in frail patients with chronic lymphocytic leukaemia. Neth. J. Med. 74, 122–129 (2016).
    • (2016) Neth. J. Med. , vol.74 , pp. 122-129
    • Aalbers, A.M.1    Aarts, M.J.2    Krol, A.D.G.3    Marijnen, C.A.M.4    Posthuma, E.F.M.5
  • 85
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • M. S. Rooney, S. A. Shukla, C. J. Wu, G. Getz, N. Hacohen, Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48–61 (2015).
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 90
    • 84912558665 scopus 로고    scopus 로고
    • Abscopal effects of radiation therapy: A clinical review for the radiobiologist
    • S. Siva, M. P. MacManus, R. F. Martin, O. A. Martin, Abscopal effects of radiation therapy: A clinical review for the radiobiologist. Cancer Lett. 356, 82–90 (2015).
    • (2015) Cancer Lett , vol.356 , pp. 82-90
    • Siva, S.1    MacManus, M.P.2    Martin, R.F.3    Martin, O.A.4
  • 98
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non–small cell lung cancer
    • E. B. Golden, S. Demaria, P. B. Schiff, A. Chachoua, S. C. Formenti, An abscopal response to radiation and ipilimumab in a patient with metastatic non–small cell lung cancer. Cancer Immunol. Res. 1, 365–372 (2013).
    • (2013) Cancer Immunol. Res. , vol.1 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3    Chachoua, A.4    Formenti, S.C.5
  • 101
    • 84927150740 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer therapy
    • M. A. Postow, M. K. Callahan, J. D. Wolchok, Immune checkpoint blockade in cancer therapy. J. Clin. Oncol. 33, 1974–1982 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1974-1982
    • Postow, M.A.1    Callahan, M.K.2    Wolchok, J.D.3
  • 102
    • 84904216679 scopus 로고    scopus 로고
    • Ipilimumab and radiation therapy for melanoma brain metastases
    • A. W. Silk, M. F. Bassetti, B. T. West, C. I. Tsien, C. D. Lao, Ipilimumab and radiation therapy for melanoma brain metastases. Cancer Med. 2, 899–906 (2013).
    • (2013) Cancer Med , vol.2 , pp. 899-906
    • Silk, A.W.1    Bassetti, M.F.2    West, B.T.3    Tsien, C.I.4    Lao, C.D.5
  • 103
    • 0034698825 scopus 로고    scopus 로고
    • Homeostatic T cell proliferation: How far can T cells be activated to self-ligands?
    • C. D. Surh, J. Sprent, Homeostatic T cell proliferation: How far can T cells be activated to self-ligands? J. Exp. Med. 192, F9–F14 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. F9-F14
    • Surh, C.D.1    Sprent, J.2


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