Dopamine D2 receptor blocker thioridazine induces cell death in human uterine cervical carcinoma cell line SiHa

Journal of Obstetrics and Gynaecology Research

Volumn 41, Issue 8, 2015, Pages 1240-1245

  Mao, Min ^a   Yu, Tinghe ^a   Hu, Jianguo ^a   Hu, Lina ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

cell death; cervical cancer; dopamine D2 receptor; SiHa cell; thioridazine

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; HIGH MOBILITY GROUP B1 PROTEIN; THIORIDAZINE;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CARCINOMA CELL LINE; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EXPLORATORY RESEARCH; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR DOWN REGULATION; SIHA CELL LINE; TISSUE LEVEL; UTERINE CERVIX CARCINOMA; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; FEMALE; NECROSIS; PATHOLOGY; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOPAMINE D2 RECEPTOR ANTAGONISTS; FEMALE; HUMANS; NECROSIS; RECEPTORS, DOPAMINE D2; THIORIDAZINE; UTERINE CERVICAL NEOPLASMS;

EID: 84938212938     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/jog.12691     Document Type: Article

References (19)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D,. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
2. Dalton SO, Mellemkjaer L, Thomassen L, Mortensen PB, Johansen C,. Risk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969-1993. Schizophr Res 2005; 75: 315-324.
3. Mortensen PB,. The incidence of cancer in schizophrenic patients. J Epidemiol Community Health 1989; 43: 43-47.
4. Driver JA, Logroscino G, Buring JE, Gaziano JM, Kurth T,. A prospective cohort study of cancer incidence following the diagnosis of Parkinson's disease. Cancer Epidemiol Biomarkers Prev 2007; 16: 1260-1265.
5. Kilts CD, Knight DL, Mailman RB, Widerlöv E, Breese GR,. Effects of thioridazine and its metabolites on dopaminergic function: Drug metabolism as a determinant of the antidopaminergic actions of thioridazine. J Pharmacol Exp Ther 1984; 231: 334-342.
6. Akiyama S, Shiraishi N, Kuratomi Y, Nakagawa M, Kuwano M,. Circumvention of multiple-drug resistance in human cancer cells by thioridazine, trifluoperazine, and chlorpromazine. J Natl Cancer Inst 1986; 76: 839-844.
7. Gil-Ad I, Shtaif B, Levkovitz Y, et al,. Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth. Oncol Rep 2006; 15: 107-112.
8. Murase H, Shimazawa M, Kakino M, Ichihara K, Tsuruma K, Hara H,. The effects of Brazilian green propolis against excessive light-induced cell damage in retina and fibroblast cells. Evid Based Complement Alternat Med 2013; 2013: 238279.
9. Olive PL, Banath JP,. The comet assay: a method to measure DNA damage in individual cells. Nat Protoc 2006; 1: 23-29.
10. He H, Huang H, Yu T,. Detection of DNA damage in sonochemotherapy against cisplatin-resistant human ovarian cancer cells using the modified comet assay. Int J Radiat Biol 2014; 90: 897-902.
11. Nahata MC, Ford C, Ruymann FB,. Pharmacokinetics and safety of prochlorperazine in paediatric patients receiving cancer chemotherapy. J Clin Pharm Ther 1992; 17: 121-123.
12. Morgan RJ Jr, Synold T, Carr BI, et al,. Continuous infusion prochlorperazine: pharmacokinetics, antiemetic efficacy, and feasibility of high-dose therapy. Cancer Chemother Pharmacol 2001; 47: 327-332.
13. Rodrigues T, Santos AC, Pigoso AA, Mingatto FE, Uyemura SA, Curti C,. Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis - potentially implicated mechanisms. Br J Pharmacol 2002; 136: 136-142.
14. Kamiwatari M, Nagata Y, Kikuchi H, et al,. Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photolabeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line. Cancer Res 1989; 49: 3190-3195.
15. Pantazaki AA, Lialiaris TS,. A combined biochemical and cytogenetic study of thioridazine-induced damage to nucleic acids. Mutagenesis 1999; 14: 243-248.
16. Lagerstrom MC, Schioth HB,. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 2008; 7: 339-357.
17. Lappano R, Maggiolini M,. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov 2011; 10: 47-60.
18. Datta SR, Dudek H, Tao X, et al,. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-241.
19. Jagannathan K, Calhoun VD, Gelernter J, et al,. Genetic associations of brain structural networks in schizophrenia: a preliminary study. Biol Psychiatry 2010; 68: 657-666.