Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity

Immunity

Volumn 48, Issue 2, 2018, Pages 299-312.e5

  Smith, Logan K ^a   Boukhaled, Giselle M ^b   Condotta, Stephanie A ^a   Mazouz, Sabrina ^c,d   Guthmiller, Jenna J ^e   Vijay, Rahul ^f   Butler, Noah S ^e,f   Bruneau, Julie ^c,d   Shoukry, Naglaa H ^c,d   Krawczyk, Connie M ^a,b   Richer, Martin J ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

antigen sensitivity; CD8+ T cells; chronic infection; galectin 3; glycosylation; immune regulation; interleukin 10; Mgat5

Indexed keywords

GALECTIN; GALECTIN 3; GLYCAN; GLYCOPROTEIN; GLYCOSYLTRANSFERASE; INTERLEUKIN 10; MGAT5 PROTEIN; N GLYCAN; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ALPHA-1,6-MANNOSYLGLYCOPROTEIN BETA 1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE; LYMPHOCYTE ANTIGEN RECEPTOR; N ACETYLGLUCOSAMINYLTRANSFERASE; VIRUS ANTIGEN;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARENAVIRUS INFECTION; ARTICLE; CD8+ T LYMPHOCYTE; CELL SURFACE; CHRONIC DISEASE; EMBRYO; FEMALE; GENE EXPRESSION; GLYCOSYLATION; HEPATITIS C; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PARASITOSIS; PLASMODIUM; PLASMODIUM INFECTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; IMMUNOLOGY; MALE; PHYSIOLOGY;

ANIMALS; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GALECTINS; GLYCOSYLATION; INTERLEUKIN-10; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; MICE, INBRED C57BL; N-ACETYLGLUCOSAMINYLTRANSFERASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 85040790507     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.01.006     Document Type: Article

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