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Volumn 45, Issue 2, 2018, Pages 123-139

Metabolic evolution and a comparative omics analysis of Corynebacterium glutamicum for putrescine production

Author keywords

Corynebacterium glutamicum; CRISPRi; Metabolic evolution; Proteome; Putrescine; Whole genome resequencing

Indexed keywords

BIOSYNTHETIC HUMAN PROINSULIN; BRANCHED CHAIN AMINO ACID; ORNITHINE DECARBOXYLASE; PENTOSE PHOSPHATE; PUTRESCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ORNITHINE;

EID: 85040669584     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-018-2003-y     Document Type: Article
Times cited : (42)

References (43)
  • 1
    • 33847207787 scopus 로고    scopus 로고
    • Altered metabolic flux due to deletion of odhA causes l-glutamate overproduction in Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BD2sXitlyqtLo%3D
    • Asakura Y, Kimura E, Usuda Y, Kawahara Y, Matsui K, Osumi T, Nakamatsu T (2007) Altered metabolic flux due to deletion of odhA causes l-glutamate overproduction in Corynebacterium glutamicum. Appl Environ Microb 73:1308–1319
    • (2007) Appl Environ Microb , vol.73 , pp. 1308-1319
    • Asakura, Y.1    Kimura, E.2    Usuda, Y.3    Kawahara, Y.4    Matsui, K.5    Osumi, T.6    Nakamatsu, T.7
  • 2
    • 84938858176 scopus 로고    scopus 로고
    • Effect of Tween 40 and DtsR1 on l-arginine overproduction in Corynebacterium crenatum
    • COI: 1:CAS:528:DC%2BC2MXhslOlt7bE, PID: 26264811
    • Chen ML, Chen XL, Wan F, Zhang B, Chen JC, Xiong YH (2015) Effect of Tween 40 and DtsR1 on l-arginine overproduction in Corynebacterium crenatum. Microb Cell Fact 14:119
    • (2015) Microb Cell Fact , vol.14 , pp. 119
    • Chen, M.L.1    Chen, X.L.2    Wan, F.3    Zhang, B.4    Chen, J.C.5    Xiong, Y.H.6
  • 3
    • 84973136613 scopus 로고    scopus 로고
    • Corynebacterium glutamicum metabolic engineering with CRISPR interference (CRISPRi)
    • COI: 1:CAS:528:DC%2BC28XhslyrurY%3D, PID: 26829286
    • Cleto S, Jensen JVK, Wendisch VF, Lu TK (2016) Corynebacterium glutamicum metabolic engineering with CRISPR interference (CRISPRi). ACS Synth Biol 5:375–385
    • (2016) ACS Synth Biol , vol.5 , pp. 375-385
    • Cleto, S.1    Jensen, J.V.K.2    Wendisch, V.F.3    Lu, T.K.4
  • 4
    • 57449099865 scopus 로고    scopus 로고
    • MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
    • COI: 1:CAS:528:DC%2BD1cXhsVWjtLzJ, PID: 19029910
    • Cox J, Mann M (2008) MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 26:1367–1372
    • (2008) Nat Biotechnol , vol.26 , pp. 1367-1372
    • Cox, J.1    Mann, M.2
  • 5
    • 84930971149 scopus 로고    scopus 로고
    • CRISPathBrick: modular combinatorial assembly of type II-A CRISPR arrays for dCas9-mediated multiplex transcriptional repression in E. coli
    • COI: 1:CAS:528:DC%2BC2MXlsVyqu70%3D, PID: 25822415
    • Cress BF, Toparlak OD, Guleria S, Lebovich M, Stieglitz JT, Englaender JA, Jones JA, Linhardt RJ, Koffas MAG (2015) CRISPathBrick: modular combinatorial assembly of type II-A CRISPR arrays for dCas9-mediated multiplex transcriptional repression in E. coli. ACS Synth Biol 4:987–1000
    • (2015) ACS Synth Biol , vol.4 , pp. 987-1000
    • Cress, B.F.1    Toparlak, O.D.2    Guleria, S.3    Lebovich, M.4    Stieglitz, J.T.5    Englaender, J.A.6    Jones, J.A.7    Linhardt, R.J.8    Koffas, M.A.G.9
  • 6
    • 0029018327 scopus 로고
    • Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    • COI: 1:CAS:528:DyaK2MXmvV2gtL8%3D, PID: 7608087
    • Guzman LM, Belin D, Carson MJ, Beckwith J (1995) Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol 177:4121–4130
    • (1995) J Bacteriol , vol.177 , pp. 4121-4130
    • Guzman, L.M.1    Belin, D.2    Carson, M.J.3    Beckwith, J.4
  • 7
    • 39449104902 scopus 로고    scopus 로고
    • Changes in enzyme activities at the pyruvate node in glutamate-overproducing Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BD1cXjvFeqsLY%3D, PID: 18295714
    • Hasegawa T, Hashimoto KI, Kawasaki H, Nakamatsu T (2008) Changes in enzyme activities at the pyruvate node in glutamate-overproducing Corynebacterium glutamicum. J Biosci Bioeng 105:12–19
    • (2008) J Biosci Bioeng , vol.105 , pp. 12-19
    • Hasegawa, T.1    Hashimoto, K.I.2    Kawasaki, H.3    Nakamatsu, T.4
  • 8
    • 85015410803 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of 2′-fucosyllactose and 3-fucosyllactose through modular pathway enhancement
    • COI: 1:CAS:528:DC%2BC2sXksFSitLY%3D, PID: 28286292
    • Huang D, Yang KX, Liu J, Xu YY, Wang YY, Wang R, Liu B, Feng L (2017) Metabolic engineering of Escherichia coli for the production of 2′-fucosyllactose and 3-fucosyllactose through modular pathway enhancement. Metab Eng 41:23–38
    • (2017) Metab Eng , vol.41 , pp. 23-38
    • Huang, D.1    Yang, K.X.2    Liu, J.3    Xu, Y.Y.4    Wang, Y.Y.5    Wang, R.6    Liu, B.7    Feng, L.8
  • 9
    • 84894441846 scopus 로고    scopus 로고
    • Enhancement of l-ornithine production by disruption of three genes encoding putative oxidoreductases in Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BC2cXksFejsg%3D%3D, PID: 24402505
    • Hwang GH, Cho JY (2014) Enhancement of l-ornithine production by disruption of three genes encoding putative oxidoreductases in Corynebacterium glutamicum. J Ind Microbiol Biotechnol 41:573–578
    • (2014) J Ind Microbiol Biotechnol , vol.41 , pp. 573-578
    • Hwang, G.H.1    Cho, J.Y.2
  • 10
    • 84878367693 scopus 로고    scopus 로고
    • Metabolic evolution of Corynebacterium glutamicum for increased production of l-ornithine
    • COI: 1:CAS:528:DC%2BC3sXhtVyhtLvP, PID: 23725060
    • Jiang LY, Chen SG, Zhang YY, Liu JZ (2013) Metabolic evolution of Corynebacterium glutamicum for increased production of l-ornithine. BMC Biotechnol 13:47
    • (2013) BMC Biotechnol , vol.13 , pp. 47
    • Jiang, L.Y.1    Chen, S.G.2    Zhang, Y.Y.3    Liu, J.Z.4
  • 11
    • 84884351925 scopus 로고    scopus 로고
    • Metabolic engineering of Corynebacterium glutamicum for increasing the production of l-ornithine by increasing NADPH availability
    • COI: 1:CAS:528:DC%2BC3sXhtVOjtrjO, PID: 23836141
    • Jiang LY, Zhang YY, Li Z, Liu JZ (2013) Metabolic engineering of Corynebacterium glutamicum for increasing the production of l-ornithine by increasing NADPH availability. J Ind Microbiol Biotechnol 40:1143–1151
    • (2013) J Ind Microbiol Biotechnol , vol.40 , pp. 1143-1151
    • Jiang, L.Y.1    Zhang, Y.Y.2    Li, Z.3    Liu, J.Z.4
  • 12
    • 84925355124 scopus 로고    scopus 로고
    • Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system
    • COI: 1:CAS:528:DC%2BC2MXkvV2hsbY%3D
    • Jiang Y, Chen B, Duan CL, Sun BB, Yang JJ, Yang S (2015) Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system. Appl Environ Microb 81:2506–2514
    • (2015) Appl Environ Microb , vol.81 , pp. 2506-2514
    • Jiang, Y.1    Chen, B.2    Duan, C.L.3    Sun, B.B.4    Yang, J.J.5    Yang, S.6
  • 13
    • 84998577581 scopus 로고    scopus 로고
    • Improved fermentative production of gamma-aminobutyric acid via the putrescine route: systems metabolic engineering for production from glucose, amino sugars, and xylose
    • COI: 1:CAS:528:DC%2BC28Xhslyksb3O, PID: 27800627
    • Jorge JMP, Nguyen AQD, Perez-Garcia F, Kind S, Wendisch VF (2017) Improved fermentative production of gamma-aminobutyric acid via the putrescine route: systems metabolic engineering for production from glucose, amino sugars, and xylose. Biotechnol Bioeng 114:862–873
    • (2017) Biotechnol Bioeng , vol.114 , pp. 862-873
    • Jorge, J.M.P.1    Nguyen, A.Q.D.2    Perez-Garcia, F.3    Kind, S.4    Wendisch, V.F.5
  • 14
    • 58149165063 scopus 로고    scopus 로고
    • Effect of odhA overexpression and odhA antisense RNA expression on Tween-40-triggered glutamate production by Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BD1cXhsFarsr3E, PID: 18923827
    • Kim J, Hirasawa T, Sato Y, Nagahisa K, Furusawa C, Shimizu H (2009) Effect of odhA overexpression and odhA antisense RNA expression on Tween-40-triggered glutamate production by Corynebacterium glutamicum. Appl Microbiol Biotechnol 81:1097–1106
    • (2009) Appl Microbiol Biotechnol , vol.81 , pp. 1097-1106
    • Kim, J.1    Hirasawa, T.2    Sato, Y.3    Nagahisa, K.4    Furusawa, C.5    Shimizu, H.6
  • 15
    • 84920074788 scopus 로고    scopus 로고
    • Metabolic engineering of Corynebacterium glutamicum for the production of l-ornithine
    • COI: 1:CAS:528:DC%2BC2cXitFygtL%2FM, PID: 25163446
    • Kim SY, Lee J, Lee SY (2015) Metabolic engineering of Corynebacterium glutamicum for the production of l-ornithine. Biotechnol Bioeng 112:416–421
    • (2015) Biotechnol Bioeng , vol.112 , pp. 416-421
    • Kim, S.Y.1    Lee, J.2    Lee, S.Y.3
  • 16
    • 0001239046 scopus 로고    scopus 로고
    • Glutamate overproduction in Corynebacterium glutamicum triggered by a decrease in the level of a complex comprising DtsR and a biotin-containing subunit
    • COI: 1:CAS:528:DyaK1MXlsFCnu74%3D
    • Kimura E, Yagoshi C, Kawahara Y, Ohsumi T, Nakamatsu T, Tokuda H (1999) Glutamate overproduction in Corynebacterium glutamicum triggered by a decrease in the level of a complex comprising DtsR and a biotin-containing subunit. Biosci Biotech Biochem 63:1274–1278
    • (1999) Biosci Biotech Biochem , vol.63 , pp. 1274-1278
    • Kimura, E.1    Yagoshi, C.2    Kawahara, Y.3    Ohsumi, T.4    Nakamatsu, T.5    Tokuda, H.6
  • 17
    • 0041429497 scopus 로고    scopus 로고
    • Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BD3sXmslensLY%3D, PID: 12948646
    • Kirchner O, Tauch A (2003) Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum. J Biotechnol 104:287–299
    • (2003) J Biotechnol , vol.104 , pp. 287-299
    • Kirchner, O.1    Tauch, A.2
  • 18
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows–Wheeler transform
    • COI: 1:CAS:528:DC%2BD1MXot1Cjtbo%3D, PID: 19451168
    • Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows–Wheeler transform. Bioinformatics 25:1754–1760
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 19
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(−Delta Delta C) method
    • COI: 1:CAS:528:DC%2BD38XhtFelt7s%3D, PID: 11846609
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(−Delta Delta C) method. Methods 25:402–408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 20
    • 84755161523 scopus 로고    scopus 로고
    • Production of biogenic amines “in vitro” in relation to the growth phase by Enterobacteriaceae species isolated from traditional sausages
    • COI: 1:CAS:528:DC%2BC3cXhtFCrur3N, PID: 20673614
    • Lorenzo JM, Cachaldora A, Fonseca S, Gomez M, Franco I, Carballo J (2010) Production of biogenic amines “in vitro” in relation to the growth phase by Enterobacteriaceae species isolated from traditional sausages. Meat Sci 86:684–691
    • (2010) Meat Sci , vol.86 , pp. 684-691
    • Lorenzo, J.M.1    Cachaldora, A.2    Fonseca, S.3    Gomez, M.4    Franco, I.5    Carballo, J.6
  • 21
    • 84861125127 scopus 로고    scopus 로고
    • Combining metabolic engineering and adaptive evolution to enhance the production of dihydroxyacetone from glycerol by Gluconobacter oxydans in a low-cost way
    • COI: 1:CAS:528:DC%2BC38XosVais7g%3D, PID: 22617040
    • Lu LF, Wei LJ, Zhu K, Wei DZ, Hua Q (2012) Combining metabolic engineering and adaptive evolution to enhance the production of dihydroxyacetone from glycerol by Gluconobacter oxydans in a low-cost way. Bioresour Technol 117:317–324
    • (2012) Bioresour Technol , vol.117 , pp. 317-324
    • Lu, L.F.1    Wei, L.J.2    Zhu, K.3    Wei, D.Z.4    Hua, Q.5
  • 22
    • 84975783234 scopus 로고    scopus 로고
    • Systems pathway engineering of Corynebacterium crenatum for improved l-arginine production
    • COI: 1:CAS:528:DC%2BC28XhtVKitbnI
    • Man ZW, Xu MJ, Rao ZM, Guo J, Yang TW, Zhang X, Xu ZH (2016) Systems pathway engineering of Corynebacterium crenatum for improved l-arginine production. Sci Rep UK 6:28629
    • (2016) Sci Rep UK , vol.6 , pp. 28629
    • Man, Z.W.1    Xu, M.J.2    Rao, Z.M.3    Guo, J.4    Yang, T.W.5    Zhang, X.6    Xu, Z.H.7
  • 23
    • 0033841986 scopus 로고    scopus 로고
    • The capacity of Enterobacteriaceae species to produce biogenic amines in cheese
    • COI: 1:CAS:528:DC%2BD3cXms1ensr0%3D, PID: 10972722
    • Marino M, Maifreni M, Moret S, Rondinini G (2000) The capacity of Enterobacteriaceae species to produce biogenic amines in cheese. Lett Appl Microbiol 31:169–173
    • (2000) Lett Appl Microbiol , vol.31 , pp. 169-173
    • Marino, M.1    Maifreni, M.2    Moret, S.3    Rondinini, G.4
  • 25
    • 84873979633 scopus 로고    scopus 로고
    • Accelerated pentose utilization by Corynebacterium glutamicum for accelerated production of lysine, glutamate, ornithine and putrescine
    • PID: 23164409
    • Meiswinkel TM, Gopinath V, Lindner SN, Nampoothiri KM, Wendisch VF (2013) Accelerated pentose utilization by Corynebacterium glutamicum for accelerated production of lysine, glutamate, ornithine and putrescine. Microb Biotechnol 6:131–140
    • (2013) Microb Biotechnol , vol.6 , pp. 131-140
    • Meiswinkel, T.M.1    Gopinath, V.2    Lindner, S.N.3    Nampoothiri, K.M.4    Wendisch, V.F.5
  • 26
    • 84883455148 scopus 로고    scopus 로고
    • Crude glycerol-based production of amino acids and putrescine by Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BC3sXlsVGgs70%3D, PID: 23562176
    • Meiswinkel TM, Rittmann D, Lindner SN, Wendisch VF (2013) Crude glycerol-based production of amino acids and putrescine by Corynebacterium glutamicum. Bioresour Technol 145:254–258
    • (2013) Bioresour Technol , vol.145 , pp. 254-258
    • Meiswinkel, T.M.1    Rittmann, D.2    Lindner, S.N.3    Wendisch, V.F.4
  • 27
    • 85016910499 scopus 로고    scopus 로고
    • Fermentative production of the diamine putrescine: system metabolic engineering of Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BC2MXns1SqsL8%3D, PID: 25919117
    • Nguyen AQD, Schneider J, Reddy GK, Wendisch VF (2015) Fermentative production of the diamine putrescine: system metabolic engineering of Corynebacterium glutamicum. Metabolites 5:211–231
    • (2015) Metabolites , vol.5 , pp. 211-231
    • Nguyen, A.Q.D.1    Schneider, J.2    Reddy, G.K.3    Wendisch, V.F.4
  • 28
    • 84964267383 scopus 로고    scopus 로고
    • Elimination of polyamine N-acetylation and regulatory engineering improved putrescine production by Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BC2cXhvFSmsLfL, PID: 25449016
    • Nguyen AQD, Schneider J, Wendisch VF (2015) Elimination of polyamine N-acetylation and regulatory engineering improved putrescine production by Corynebacterium glutamicum. J Biotechnol 201:75–85
    • (2015) J Biotechnol , vol.201 , pp. 75-85
    • Nguyen, A.Q.D.1    Schneider, J.2    Wendisch, V.F.3
  • 29
    • 85030148668 scopus 로고    scopus 로고
    • Gene expression knockdown by modulating synthetic small RNA expression in Escherichia coli
    • COI: 1:CAS:528:DC%2BC2sXhslansLfF, PID: 28964700
    • Noh M, Yoo SM, Kim WJ, Lee SY (2017) Gene expression knockdown by modulating synthetic small RNA expression in Escherichia coli. Cell Syst 5:418–426
    • (2017) Cell Syst , vol.5 , pp. 418-426
    • Noh, M.1    Yoo, S.M.2    Kim, W.J.3    Lee, S.Y.4
  • 30
    • 0036161274 scopus 로고    scopus 로고
    • A novel methodology employing Corynebacterium glutamicum genome information to generate a new l-lysine-producing mutant
    • COI: 1:STN:280:DC%2BD387ksVegtA%3D%3D, PID: 11876415
    • Ohnishi J, Mitsuhashi S, Hayashi M, Ando S, Yokoi H, Ochiai K, Ikeda M (2002) A novel methodology employing Corynebacterium glutamicum genome information to generate a new l-lysine-producing mutant. Appl Microbiol Biotechnol 58:217–223
    • (2002) Appl Microbiol Biotechnol , vol.58 , pp. 217-223
    • Ohnishi, J.1    Mitsuhashi, S.2    Hayashi, M.3    Ando, S.4    Yokoi, H.5    Ochiai, K.6    Ikeda, M.7
  • 31
    • 84907362164 scopus 로고    scopus 로고
    • Metabolic engineering of Corynebacterium glutamicum for l-arginine production
    • COI: 1:CAS:528:DC%2BC2cXitVWgs7fL, PID: 25091334
    • Park SH, Kim HU, Kim TY, Park JS, Kim SS, Lee SY (2014) Metabolic engineering of Corynebacterium glutamicum for l-arginine production. Nat Commun 5:4618
    • (2014) Nat Commun , vol.5 , pp. 4618
    • Park, S.H.1    Kim, H.U.2    Kim, T.Y.3    Park, J.S.4    Kim, S.S.5    Lee, S.Y.6
  • 33
    • 84874687019 scopus 로고    scopus 로고
    • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    • COI: 1:CAS:528:DC%2BC3sXjsFChs7s%3D, PID: 23452860
    • Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA (2013) Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152:1173–1183
    • (2013) Cell , vol.152 , pp. 1173-1183
    • Qi, L.S.1    Larson, M.H.2    Gilbert, L.A.3    Doudna, J.A.4    Weissman, J.S.5    Arkin, A.P.6    Lim, W.A.7
  • 34
    • 70350508288 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of putrescine: a four carbon diamine
    • COI: 1:CAS:528:DC%2BD1MXhtFOrsbvI, PID: 19714672
    • Qian ZG, Xia XX, Lee SY (2009) Metabolic engineering of Escherichia coli for the production of putrescine: a four carbon diamine. Biotechnol Bioeng 104:651–662
    • (2009) Biotechnol Bioeng , vol.104 , pp. 651-662
    • Qian, Z.G.1    Xia, X.X.2    Lee, S.Y.3
  • 35
    • 84861451922 scopus 로고    scopus 로고
    • Bio-samtools: ruby bindings for SAMtools, a library for accessing BAM files containing high-throughput sequence alignments
    • PID: 22640879
    • Ramirez-Gonzalez RH, Bonnal R, Caccamo M, Maclean D (2012) Bio-samtools: ruby bindings for SAMtools, a library for accessing BAM files containing high-throughput sequence alignments. Source Code Biol Med 7:6
    • (2012) Source Code Biol Med , vol.7 , pp. 6
    • Ramirez-Gonzalez, R.H.1    Bonnal, R.2    Caccamo, M.3    Maclean, D.4
  • 36
    • 84862002824 scopus 로고    scopus 로고
    • Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system
    • COI: 1:CAS:528:DC%2BC38XotVShsbc%3D
    • Schneider J, Eberhardt D, Wendisch VF (2012) Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system. Appl Microbiol Biotehnol 95:169–178
    • (2012) Appl Microbiol Biotehnol , vol.95 , pp. 169-178
    • Schneider, J.1    Eberhardt, D.2    Wendisch, V.F.3
  • 37
    • 79952108763 scopus 로고    scopus 로고
    • Putrescine production by engineered Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BC3cXhtFyqt7jE, PID: 20661733
    • Schneider J, Wendisch VF (2010) Putrescine production by engineered Corynebacterium glutamicum. Appl Microbiol Biotechnol 88:859–868
    • (2010) Appl Microbiol Biotechnol , vol.88 , pp. 859-868
    • Schneider, J.1    Wendisch, V.F.2
  • 38
    • 34547421751 scopus 로고    scopus 로고
    • Biomass in the manufacture of industrial products—the use of proteins and amino acids
    • COI: 1:CAS:528:DC%2BD2sXlslCltbw%3D, PID: 17387469
    • Scott E, Peter F, Sanders J (2007) Biomass in the manufacture of industrial products—the use of proteins and amino acids. Appl Microbiol Biotechnol 75:751–762
    • (2007) Appl Microbiol Biotechnol , vol.75 , pp. 751-762
    • Scott, E.1    Peter, F.2    Sanders, J.3
  • 39
    • 34447620670 scopus 로고    scopus 로고
    • Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis
    • PID: 17587457
    • Shirai T, Fujimura K, Furusawa C, Nagahisa K, Shioya S, Shimizu H (2007) Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis. Microb Cell Fact 6:19
    • (2007) Microb Cell Fact , vol.6 , pp. 19
    • Shirai, T.1    Fujimura, K.2    Furusawa, C.3    Nagahisa, K.4    Shioya, S.5    Shimizu, H.6
  • 40
    • 84952943845 scopus 로고    scopus 로고
    • Rationally engineered Cas9 nucleases with improved specificity
    • COI: 1:CAS:528:DC%2BC2MXitV2nt7nE, PID: 26628643
    • Slaymaker IM, Gao LY, Zetsche B, Scott DA, Yan WX, Zhang F (2016) Rationally engineered Cas9 nucleases with improved specificity. Science 351:84–88
    • (2016) Science , vol.351 , pp. 84-88
    • Slaymaker, I.M.1    Gao, L.Y.2    Zetsche, B.3    Scott, D.A.4    Yan, W.X.5    Zhang, F.6
  • 42
    • 77956534324 scopus 로고    scopus 로고
    • ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
    • PID: 20601685
    • Wang K, Li MY, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 38:e164
    • (2010) Nucleic Acids Res , vol.38
    • Wang, K.1    Li, M.Y.2    Hakonarson, H.3
  • 43
    • 84884532775 scopus 로고    scopus 로고
    • Isolation of fully synthetic promoters for high-level gene expression in Corynebacterium glutamicum
    • COI: 1:CAS:528:DC%2BC3sXosFCisr4%3D, PID: 23633298
    • Yim SS, An SJ, Kang M, Lee J, Jeong KJ (2013) Isolation of fully synthetic promoters for high-level gene expression in Corynebacterium glutamicum. Biotechnol Bioeng 110:2959–2969
    • (2013) Biotechnol Bioeng , vol.110 , pp. 2959-2969
    • Yim, S.S.1    An, S.J.2    Kang, M.3    Lee, J.4    Jeong, K.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.