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Volumn 13, Issue , 2013, Pages

Metabolic evolution of Corynebacterium glutamicum for increased production of L-ornithine

Author keywords

Adaptive evolution; Corynebacterium glutamicum; L Ornithine; Metabolic engineering; Transcriptional level analysis

Indexed keywords

ADAPTIVE EVOLUTION; BIOTECHNOLOGICAL PRODUCTION; CELLULAR PROPERTIES; COMMERCIAL APPLICATIONS; CORYNEBACTERIUM GLUTAMICUM; EVOLUTION STRATEGIES; L-ORNITHINE; TRANSCRIPTIONAL LEVELS;

EID: 84878367693     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-13-47     Document Type: Article
Times cited : (57)

References (42)
  • 1
    • 0000575772 scopus 로고
    • Mechanism of the protection by L-ornithine-L-aspartate mixture and by L-arginine in ammonia intoxication
    • 10.1016/0003-9861(64)90307-8, 14234500
    • Cimino F, Maria C, Cittadini D. Mechanism of the protection by L-ornithine-L-aspartate mixture and by L-arginine in ammonia intoxication. Arch Biochem Biophys 1964, 107:499-503. 10.1016/0003-9861(64)90307-8, 14234500.
    • (1964) Arch Biochem Biophys , vol.107 , pp. 499-503
    • Cimino, F.1    Maria, C.2    Cittadini, D.3
  • 3
    • 77950670926 scopus 로고    scopus 로고
    • Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes
    • 10.1519/JSC.0b013e3181d321ff, 20300016
    • Zajac A, Poprzecki S, Zebrowska A, Chalimoniuk M, Langfort J. Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes. J Strength Cond Res 2010, 24:1082-1090. 10.1519/JSC.0b013e3181d321ff, 20300016.
    • (2010) J Strength Cond Res , vol.24 , pp. 1082-1090
    • Zajac, A.1    Poprzecki, S.2    Zebrowska, A.3    Chalimoniuk, M.4    Langfort, J.5
  • 4
    • 9244238641 scopus 로고    scopus 로고
    • Production of L-ornithine by arginine auxotrophic mutants of Brevibacterium ketoglutamicum in dual substrate limited continuous culture
    • Choi DK, Ryu WS, Choi CY, Park YH. Production of L-ornithine by arginine auxotrophic mutants of Brevibacterium ketoglutamicum in dual substrate limited continuous culture. J Ferment Bioeng 1996, 81:216-219.
    • (1996) J Ferment Bioeng , vol.81 , pp. 216-219
    • Choi, D.K.1    Ryu, W.S.2    Choi, C.Y.3    Park, Y.H.4
  • 7
    • 84865717401 scopus 로고    scopus 로고
    • Breeding of high-yield L-ornithine-producing strain by protoplast fusion
    • Zhang JF, Wang JB, Huang JM, Zhang J. Breeding of high-yield L-ornithine-producing strain by protoplast fusion. Amino Acids Biotic Resour 2009, 31:53-57.
    • (2009) Amino Acids Biotic Resour , vol.31 , pp. 53-57
    • Zhang, J.F.1    Wang, J.B.2    Huang, J.M.3    Zhang, J.4
  • 8
    • 33749589445 scopus 로고    scopus 로고
    • Genetic manipulation of a primary metabolic pathway for L-ornithine production in Escherichia coli
    • 10.1007/s10529-006-9163-y, 16933036
    • Lee YJ, Cho JY. Genetic manipulation of a primary metabolic pathway for L-ornithine production in Escherichia coli. Biotechnol Lett 2006, 28:1849-1856. 10.1007/s10529-006-9163-y, 16933036.
    • (2006) Biotechnol Lett , vol.28 , pp. 1849-1856
    • Lee, Y.J.1    Cho, J.Y.2
  • 9
    • 48649098350 scopus 로고    scopus 로고
    • Effect of increased glutamate availability on L-ornithine production in Corynebacterium glutamicum
    • Hwang JH, Hwang GH, Cho JY. Effect of increased glutamate availability on L-ornithine production in Corynebacterium glutamicum. J Microbiol Biotechnol 2008, 18:704-710.
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 704-710
    • Hwang, J.H.1    Hwang, G.H.2    Cho, J.Y.3
  • 10
    • 75849133373 scopus 로고    scopus 로고
    • Enhancement of ornithine production in proline-supplemented Corynebacterium glutamicum by ornithine cyclodeaminase
    • Lee SY, Cho JY, Lee HJ, Kim YH, Min J. Enhancement of ornithine production in proline-supplemented Corynebacterium glutamicum by ornithine cyclodeaminase. J Microbiol Biotechnol 2010, 20:127-131.
    • (2010) J Microbiol Biotechnol , vol.20 , pp. 127-131
    • Lee, S.Y.1    Cho, J.Y.2    Lee, H.J.3    Kim, Y.H.4    Min, J.5
  • 11
    • 78149412362 scopus 로고    scopus 로고
    • Identification of a suppressor gene for the arginine-auxotrophic argJ mutation in Corynebacterium glutamicum
    • 10.1007/s10295-010-0760-3, 20544254
    • Hwang GH, Cho JY. Identification of a suppressor gene for the arginine-auxotrophic argJ mutation in Corynebacterium glutamicum. J Ind Microbiol Biotechnol 2010, 37:1131-1136. 10.1007/s10295-010-0760-3, 20544254.
    • (2010) J Ind Microbiol Biotechnol , vol.37 , pp. 1131-1136
    • Hwang, G.H.1    Cho, J.Y.2
  • 12
    • 84872135918 scopus 로고    scopus 로고
    • Implication of gluconate kinase activity in L-ornithine biosynthesis in Corynebacterium glutamicum
    • Hwang GH, Cho JY. Implication of gluconate kinase activity in L-ornithine biosynthesis in Corynebacterium glutamicum. J Ind Mcrobiol Biotechnol 2012, 39:1869-1874.
    • (2012) J Ind Mcrobiol Biotechnol , vol.39 , pp. 1869-1874
    • Hwang, G.H.1    Cho, J.Y.2
  • 13
    • 79958698899 scopus 로고    scopus 로고
    • Production of the amino acids L-glutamate, L-lysine, L-ornithine and L-arginine from arabinose by recombinant Corynebacterium glutamicum
    • 10.1016/j.jbiotec.2010.07.009, 20638422
    • Schneider J, Niermann K, Wendisch VF. Production of the amino acids L-glutamate, L-lysine, L-ornithine and L-arginine from arabinose by recombinant Corynebacterium glutamicum. J Biotechnol 2011, 154:191-198. 10.1016/j.jbiotec.2010.07.009, 20638422.
    • (2011) J Biotechnol , vol.154 , pp. 191-198
    • Schneider, J.1    Niermann, K.2    Wendisch, V.F.3
  • 14
    • 84873979633 scopus 로고    scopus 로고
    • Accelerated pentose utilization by Corynebacterium glutamicum for accelerated production lysine, glutamate, ornithine and putrescine
    • 10.1111/1751-7915.12001, 23164409
    • Meiswinkel TM, Gopinath V, Lindner SN, Nampoothiri M, Wendisch VF. Accelerated pentose utilization by Corynebacterium glutamicum for accelerated production lysine, glutamate, ornithine and putrescine. Microb Biotechnol 2013, 6:131-140. 10.1111/1751-7915.12001, 23164409.
    • (2013) Microb Biotechnol , vol.6 , pp. 131-140
    • Meiswinkel, T.M.1    Gopinath, V.2    Lindner, S.N.3    Nampoothiri, M.4    Wendisch, V.F.5
  • 15
    • 84865772759 scopus 로고    scopus 로고
    • Engineering of Corynebacterium glutamicum to enhance L-ornithine production by gene knockout and comparative proteomic analysis
    • Lu DM, Liu JZ, Mao ZW. Engineering of Corynebacterium glutamicum to enhance L-ornithine production by gene knockout and comparative proteomic analysis. Chinese J Chem Eng 2012, 20:731-739.
    • (2012) Chinese J Chem Eng , vol.20 , pp. 731-739
    • Lu, D.M.1    Liu, J.Z.2    Mao, Z.W.3
  • 16
    • 84879169704 scopus 로고    scopus 로고
    • Optimization of fermentation conditions of the engineered Corynebacterium glutamicum to enhance L-ornithine production by response surface methodology.
    • Lu DM, Jiang LY, Chen LA, Liu JZ, Mao ZW. Optimization of fermentation conditions of the engineered Corynebacterium glutamicum to enhance L-ornithine production by response surface methodology. J Biotechnol Biomater 2011, 1:116.
    • (2011) J Biotechnol Biomater , vol.1 , pp. 116
    • Lu, D.M.1    Jiang, L.Y.2    Chen, L.A.3    Liu, J.Z.4    Mao, Z.W.5
  • 17
    • 6944224154 scopus 로고    scopus 로고
    • Metabolic gene-deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes
    • 10.1038/ng1432, 15448692
    • Fong SS, Palsson BO. Metabolic gene-deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes. Nat Genet 2004, 36:1056-1058. 10.1038/ng1432, 15448692.
    • (2004) Nat Genet , vol.36 , pp. 1056-1058
    • Fong, S.S.1    Palsson, B.O.2
  • 18
    • 79960958091 scopus 로고    scopus 로고
    • Adaptive laboratory evolution -harnessing the power of biology for metabolic engineering
    • 10.1016/j.copbio.2011.03.007, 21497080
    • Portnoy VA, Bezdan D, Zengler K. Adaptive laboratory evolution -harnessing the power of biology for metabolic engineering. Curr Opin Biotechnol 2011, 22:590-594. 10.1016/j.copbio.2011.03.007, 21497080.
    • (2011) Curr Opin Biotechnol , vol.22 , pp. 590-594
    • Portnoy, V.A.1    Bezdan, D.2    Zengler, K.3
  • 19
    • 80052514714 scopus 로고    scopus 로고
    • Adaptive evolution of nontransgenic Escherichia coli KC01 for improved ethanol tolerance and homoethanol fermentation from xylose
    • 10.1007/s10295-010-0920-5, 21188614
    • Wang Y, Manow R, Finan C, Wang J, Garza E, Zhou S. Adaptive evolution of nontransgenic Escherichia coli KC01 for improved ethanol tolerance and homoethanol fermentation from xylose. J Ind Microbiol Biotechnol 2011, 38:1371-1377. 10.1007/s10295-010-0920-5, 21188614.
    • (2011) J Ind Microbiol Biotechnol , vol.38 , pp. 1371-1377
    • Wang, Y.1    Manow, R.2    Finan, C.3    Wang, J.4    Garza, E.5    Zhou, S.6
  • 20
    • 84863109657 scopus 로고    scopus 로고
    • Production of pyruvate in Saccharomyces cerevisiae through adaptive evolution and rational cofactor metabolic engineering
    • Wang Z, Gao C, Wang Q, Liang Q, Qi Q. Production of pyruvate in Saccharomyces cerevisiae through adaptive evolution and rational cofactor metabolic engineering. Biochem Eng J 2012, 67:126-131.
    • (2012) Biochem Eng J , vol.67 , pp. 126-131
    • Wang, Z.1    Gao, C.2    Wang, Q.3    Liang, Q.4    Qi, Q.5
  • 22
    • 41249084917 scopus 로고    scopus 로고
    • Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate
    • 10.1002/bit.21694, 17972330
    • Jantama K, Haupt MJ, Svoronos SA, Zhang X, Moore JC, Shanmugam KT, Ingram LO. Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate. Biotechnol Bioeng 2008, 99:1140-1153. 10.1002/bit.21694, 17972330.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 1140-1153
    • Jantama, K.1    Haupt, M.J.2    Svoronos, S.A.3    Zhang, X.4    Moore, J.C.5    Shanmugam, K.T.6    Ingram, L.O.7
  • 23
    • 35649021818 scopus 로고    scopus 로고
    • Production of L-alanine by metabolically engineered Escherichia coli
    • 10.1007/s00253-007-1170-y, 17874321
    • Zhang X, Jantama K, Moore JC, Shanmugam KT, Ingram LO. Production of L-alanine by metabolically engineered Escherichia coli. Appl Microbiol Biotechnol 2007, 77:355-366. 10.1007/s00253-007-1170-y, 17874321.
    • (2007) Appl Microbiol Biotechnol , vol.77 , pp. 355-366
    • Zhang, X.1    Jantama, K.2    Moore, J.C.3    Shanmugam, K.T.4    Ingram, L.O.5
  • 24
    • 84861125127 scopus 로고    scopus 로고
    • Combining metabolic engineering and adaptive evolution to enhance the production of dihydroxyacetone from glycerol by Gluconobacter oxydans in a low-cost way
    • Lu L, Wei L, Zhu K, Wei D, Hua Q. Combining metabolic engineering and adaptive evolution to enhance the production of dihydroxyacetone from glycerol by Gluconobacter oxydans in a low-cost way. Bioresource Technol 2012, 117:317-324.
    • (2012) Bioresource Technol , vol.117 , pp. 317-324
    • Lu, L.1    Wei, L.2    Zhu, K.3    Wei, D.4    Hua, Q.5
  • 25
    • 69949148362 scopus 로고    scopus 로고
    • The effect of ArgR-DNA binding affinity on ornithine production in Corynebacterium glutamicum
    • 10.1007/s00284-009-9467-y, 19688381
    • Lee SY, Kim YH, Min J. The effect of ArgR-DNA binding affinity on ornithine production in Corynebacterium glutamicum. Curr Microbiol 2009, 59:483-488. 10.1007/s00284-009-9467-y, 19688381.
    • (2009) Curr Microbiol , vol.59 , pp. 483-488
    • Lee, S.Y.1    Kim, Y.H.2    Min, J.3
  • 26
    • 0342940781 scopus 로고    scopus 로고
    • Polyamine distribution in actinomycetes with group B peptidoglycan and species of the genera Brevibacterium, Corynebacterium, and Tsukamurella.
    • Altenburger P, Kämpfer P, Akimov VN, Lubitz W, Busse HJ. Polyamine distribution in actinomycetes with group B peptidoglycan and species of the genera Brevibacterium, Corynebacterium, and Tsukamurella. Int J Syst Bacteriol 1997, 47:270-277.
    • (1997) Int J Syst Bacteriol , vol.47 , pp. 270-277
    • Altenburger, P.1    Kämpfer, P.2    Akimov, V.N.3    Lubitz, W.4    Busse, H.J.5
  • 27
    • 84856367465 scopus 로고    scopus 로고
    • Adaptive evolution of Saccharomyces cerevisiae to generate strains with enhanced glycerol production
    • 10.1007/s00253-011-3622-7, 21989563
    • Kutyna DR, Varela C, Stanley GA, Borneman AR, Henschke PA, Chambers PJ. Adaptive evolution of Saccharomyces cerevisiae to generate strains with enhanced glycerol production. Appl Microbiol Biotechnol 2012, 93:1175-1184. 10.1007/s00253-011-3622-7, 21989563.
    • (2012) Appl Microbiol Biotechnol , vol.93 , pp. 1175-1184
    • Kutyna, D.R.1    Varela, C.2    Stanley, G.A.3    Borneman, A.R.4    Henschke, P.A.5    Chambers, P.J.6
  • 29
    • 34447620670 scopus 로고    scopus 로고
    • Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis
    • 10.1186/1475-2859-6-19, 1919393, 17587457
    • Shirai T, Fujimura K, Furusawa C, Nagahisa K, Shioya S, Shimizu H. Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis. Microb Cell Fact 2007, 6:19. 10.1186/1475-2859-6-19, 1919393, 17587457.
    • (2007) Microb Cell Fact , vol.6 , pp. 19
    • Shirai, T.1    Fujimura, K.2    Furusawa, C.3    Nagahisa, K.4    Shioya, S.5    Shimizu, H.6
  • 30
    • 77953083412 scopus 로고    scopus 로고
    • Polyphosphate/ATP-dependent NAD kinase of Corynebacterium glutamicum: biochemical properties and impact of ppnK overexpression on lysine production
    • 10.1007/s00253-010-2481-y, 20180116
    • Lindner SN, Niederholtmeyer H, Schmitz K, Schoberth SM, Wendisch VF. Polyphosphate/ATP-dependent NAD kinase of Corynebacterium glutamicum: biochemical properties and impact of ppnK overexpression on lysine production. Appl Microbiol Biotechnol 2010, 87:583-593. 10.1007/s00253-010-2481-y, 20180116.
    • (2010) Appl Microbiol Biotechnol , vol.87 , pp. 583-593
    • Lindner, S.N.1    Niederholtmeyer, H.2    Schmitz, K.3    Schoberth, S.M.4    Wendisch, V.F.5
  • 31
    • 77955429093 scopus 로고    scopus 로고
    • High NADPH/NADP ratio improves thymidine production by a metabolically engineered Escherichia coli strain
    • 10.1016/j.jbiotec.2010.06.011, 20600382
    • Lee HC, Kim JS, Jang W, Kim SY. High NADPH/NADP ratio improves thymidine production by a metabolically engineered Escherichia coli strain. J Biotechnol 2010, 149:24-32. 10.1016/j.jbiotec.2010.06.011, 20600382.
    • (2010) J Biotechnol , vol.149 , pp. 24-32
    • Lee, H.C.1    Kim, J.S.2    Jang, W.3    Kim, S.Y.4
  • 32
    • 34247584154 scopus 로고    scopus 로고
    • Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation
    • 10.1007/s00253-006-0804-9, 17216441
    • Kabus A, Georgi T, Wendisch VF, Michael B. Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation. Appl Microbiol Biotechnol 2007, 75:47-53. 10.1007/s00253-006-0804-9, 17216441.
    • (2007) Appl Microbiol Biotechnol , vol.75 , pp. 47-53
    • Kabus, A.1    Georgi, T.2    Wendisch, V.F.3    Michael, B.4
  • 33
    • 84872131864 scopus 로고    scopus 로고
    • Activating transhydrogenase and NAD kinase in combination for improving isobutanol production
    • Shi A, Zhu X, Lu J, Zhang X, Ma Y. Activating transhydrogenase and NAD kinase in combination for improving isobutanol production. Metab Eng 2013, 16:1-10.
    • (2013) Metab Eng , vol.16 , pp. 1-10
    • Shi, A.1    Zhu, X.2    Lu, J.3    Zhang, X.4    Ma, Y.5
  • 34
    • 78149443330 scopus 로고    scopus 로고
    • Engineering of Corynebacterium glutamicum with an NADPH-generating glycolytic pathway for L-lysine production
    • 10.1128/AEM.01464-10, 2976228, 20851994
    • Takeno S, Murata R, Kobayashi R, Mitsuhashi S, Ikeda M. Engineering of Corynebacterium glutamicum with an NADPH-generating glycolytic pathway for L-lysine production. Appl Environ Microbiol 2010, 76:7154-7160. 10.1128/AEM.01464-10, 2976228, 20851994.
    • (2010) Appl Environ Microbiol , vol.76 , pp. 7154-7160
    • Takeno, S.1    Murata, R.2    Kobayashi, R.3    Mitsuhashi, S.4    Ikeda, M.5
  • 35
    • 0029097533 scopus 로고
    • Effect of dilution rate in continuous production of L-ornithine by an arginine auxotrophic mutant
    • Choi DK, Ryu WS, Chung BH, Hwang SO, Park YH. Effect of dilution rate in continuous production of L-ornithine by an arginine auxotrophic mutant. J Ferment Bioeng 1995, 80:97-100.
    • (1995) J Ferment Bioeng , vol.80 , pp. 97-100
    • Choi, D.K.1    Ryu, W.S.2    Chung, B.H.3    Hwang, S.O.4    Park, Y.H.5
  • 36
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt Method
    • 10.1006/meth.2001.1262, 11846609
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt Method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 37
    • 0028031441 scopus 로고
    • Nucleotide sequence, expression, and transcription analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase
    • Eikmanns BJ, Thum-Schmitz N, Eggeling L, Ludtke KU, Sahm H. Nucleotide sequence, expression, and transcription analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase. Microbiol 1994, 140:1817-1828.
    • (1994) Microbiol , vol.140 , pp. 1817-1828
    • Eikmanns, B.J.1    Thum-Schmitz, N.2    Eggeling, L.3    Ludtke, K.U.4    Sahm, H.5
  • 38
    • 0032741016 scopus 로고    scopus 로고
    • A heat shock following electroporation induces highly efficient transformation of Corynebacterium glutamicum with xenogeneic plasmid DNA
    • 10.1007/s002530051557, 10570802
    • Van der Rest ME, Lange C, Molenaar D. A heat shock following electroporation induces highly efficient transformation of Corynebacterium glutamicum with xenogeneic plasmid DNA. Appl Microbiol Biotechnol 1999, 52:541-545. 10.1007/s002530051557, 10570802.
    • (1999) Appl Microbiol Biotechnol , vol.52 , pp. 541-545
    • Van der Rest, M.E.1    Lange, C.2    Molenaar, D.3
  • 39
    • 0028289983 scopus 로고
    • Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum.
    • 10.1016/0378-1119(94)90324-7, 8045426
    • Schäfer A, Tauch A, Jäger W, Kalinowski J, Thierbach G, Pühler A. Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 1994, 145:69-73. 10.1016/0378-1119(94)90324-7, 8045426.
    • (1994) Gene , vol.145 , pp. 69-73
    • Schäfer, A.1    Tauch, A.2    Jäger, W.3    Kalinowski, J.4    Thierbach, G.5    Pühler, A.6
  • 40
    • 77954143208 scopus 로고    scopus 로고
    • An improved shuttle vector constructed for metabolic engineering research in Corynebacterium glutamicum
    • 10.1016/j.plasmid.2010.05.004, 20580910
    • Xu D, Tan Y, Shi F, Wang X. An improved shuttle vector constructed for metabolic engineering research in Corynebacterium glutamicum. Plasmid 2010, 64:85-91. 10.1016/j.plasmid.2010.05.004, 20580910.
    • (2010) Plasmid , vol.64 , pp. 85-91
    • Xu, D.1    Tan, Y.2    Shi, F.3    Wang, X.4
  • 41
    • 0041429497 scopus 로고    scopus 로고
    • Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum
    • 10.1016/S0168-1656(03)00148-2, 12948646
    • Kirchner O, Tauch A. Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum. J Biotechnol 2003, 104:287-299. 10.1016/S0168-1656(03)00148-2, 12948646.
    • (2003) J Biotechnol , vol.104 , pp. 287-299
    • Kirchner, O.1    Tauch, A.2
  • 42
    • 33749787148 scopus 로고
    • Photometric estimation of proline and ornithine
    • Chinard FP. Photometric estimation of proline and ornithine. J Biol Chem 1952, 199:91-95.
    • (1952) J Biol Chem , vol.199 , pp. 91-95
    • Chinard, F.P.1


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