Fermentative production of the diamine Putrescine: System metabolic engineering of corynebacterium glutamicum

Metabolites

Volumn 5, Issue 2, 2015, Pages 211-231

  Nguyen, Anh Q D ^a   Schneider, Jens ^a,b   Reddy, Gajendar Komati ^a   Wendisch, Volker F ^a  

^a BIELEFELD UNIVERSITY   (Germany)

^b EVONIK INDUSTRIES AG   (Germany)

Author keywords

2 oxoglutatarate dehydrogenase; CgmR; Corynebacterium glutamicum; Diamine production; Flux balance analysis; Gamma glutamate kinase; Genome scale metabolic model; Glyceraldehyde 3 phosphate dehydrogenase; N acetylglutamate kinase; OdhI; Putrescine; Pyruvate carboxylase; Spermidine N acetyltransferase

Indexed keywords

ACETYLPUTRESCINE; ARGININE; DIAMINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ORNITHINE CARBAMOYLTRANSFERASE; OXOGLUTARATE DEHYDROGENASE; PUTRESCINE DERIVATIVE; PYRUVATE CARBOXYLASE; UNCLASSIFIED DRUG;

ANAPLEROSIS; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BIOSYNTHESIS; CHEMICAL ANALYSIS; COMPUTER MODEL; CORYNEBACTERIUM GLUTAMICUM; ENZYME ACTIVITY; ENZYME ASSAY; ESCHERICHIA COLI; FEEDBACK SYSTEM; FERMENTATION; FLUX BALANCE ANALYSIS; GENE OVEREXPRESSION; GENETIC ANALYSIS; GLYCOLYSIS; METABOLIC ENGINEERING; METABOLISM; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PLASMID; POLYMERASE CHAIN REACTION; QUALITY CONTROL; STATISTICAL ANALYSIS; TRANSLATION INITIATION;

CORYNEBACTERIUM GLUTAMICUM;

EID: 85016910499     PISSN: None     EISSN: 22181989     Source Type: Journal    
DOI: 10.3390/metabo5020211     Document Type: Article

References (52)

1. Schaffer, S.; Haas, T. Biocatalytic and fermentative production of alpha,omega-bifunctional polymer precursors. Org. Process. Res. Dev. 2014, 18, 752-766. Available online: http://dx.doi.org/ 10.1021/op5000418 (accessed on 11 February 2015).
2. Rydz, J.; Sikorska, W.; Kyulavska, M.; Christova, D. Polyester-based (bio)degradable polymers as environmentally friendly materials for sustainable development. Int. J. Mol. Sci. 2014, 16, 564-596.
3. Kroschwitz, J.I.; Seidel, A. Kirk-Othmer Encyclopedia of Chemical Technology, 5th ed.; Wiley-Interscienc: Hoboken, NJ, USA, 2004.
4. Schneider, J.; Eberhardt, D.; Wendisch, V.F. Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system. Appl. Microbiol. Biotechnol. 2012, 95, 169-178.
5. Schneider, J.; Wendisch, V.F. Putrescine production by engineered Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 2010, 88, 859-868.
6. Qian, Z.G.; Xia, X.X.; Lee, S.Y. Metabolic engineering of Escherichia coli for the production of putrescine: A four carbon diamine. Biotechnol. Bioeng. 2009, 104, 651-662.
7. Meiswinkel, T.M.; Rittmann, D.; Lindner, S.N.; Wendisch, V.F. Crude glycerol-based production of amino acids and putrescine by Corynebacterium glutamicum. Bioresour. Technol. 2013, 145, 254-258.
8. Meiswinkel, T.M.; Gopinath, V.; Lindner, S.N.; Nampoothiri, K.M.; Wendisch, V.F. Accelerated pentose utilization by Corynebacterium glutamicum for accelerated production of lysine, glutamate, ornithine and putrescine. Microb. Biotechnol. 2013, 6, 131-140.
9. Uhde, A.; Youn, J.W.; Maeda, T.; Clermont, L.; Matano, C.; Kramer, R.; Wendisch, V.F.; Seibold, G.M.; Marin, K. Glucosamine as carbon source for amino acid-producing Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 2013, 97, 1679-1687.
10. Meiswinkel, T.M.; Lindner, S.N.; Wendisch, V.F. Thick juice-based production of amino acids and putrescine by Corynebacterium glutamicum. J. Biotechnol. Biomater. 2014, doi:10.4172/ 2155-952X.1000167.
11. Peters-Wendisch, P.; Gotker, S.; Heider, S.A.; Komati Reddy, G.; Nguyen, A.Q.; Stansen, K.C.; Wendisch, V.F. Engineering biotin prototrophic Corynebacterium glutamicum strains for amino acid, diamine and carotenoid production. J. Biotechnol. 2014, 192, 346-354.
12. Shinfuku, Y.; Sorpitiporn, N.; Sono, M.; Furusawa, C.; Hirasawa, T.; Shimizu, H. Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum. Microb. Cell. Fact. 2009, doi:10.1186/1475-2859-8-43.
13. Blombach, B.; Riester, T.; Wieschalka, S.; Ziert, C.; Youn, J.W.; Wendisch, V.F.; Eikmanns, B.J. Corynebacterium glutamicum tailored for efficient isobutanol production. Appl. Environ. Microbiol. 2011, 77, 3300-3310.
14. Rittmann, D.; Lindner, S.N.; Wendisch, V.F. Engineering of a glycerol utilization pathway for amino acid production by Corynebacterium glutamicum. Appl. Environ. Microbiol. 2008, 74, 6216-6222.
15. Hadiati, A.; Krahn, I.; Lindner, S.N.; Wendisch, V.F. Engineering of Corynebacterium glutamicum for growth and production of L-ornithine, L-lysine, and lycopene from hexuronic acids. Bioresour. Bioprocess. 2014, doi:10.1186/s40643-014-0025-5.
16. Usuda, Y.; Tujimoto, N.; Abe, C.; Asakura, Y.; Kimura, E.; Kawahara, Y.; Kurahashi, O.; Matsui, H. Molecular cloning of the Corynebacterium glutamicum ("Brevibacterium lactofermentum" AJ12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase. Microbiology 1996, 142, 3347-3354.
17. Schwinde, J.W.; Hertz, P.F.; Sahm, H.; Eikmanns, B.J.; Guyonvarch, A. Lipoamide dehydrogenase from Corynebacterium glutamicum: Molecular and physiological analysis of the lpd gene and characterization of the enzyme. Microbiology 2001, 147, 2223-2231.
18. Niebisch, A.; Kabus, A.; Schultz, C.; Weil, B.; Bott, M. Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein. J. Biol. Chem. 2006, 281, 12300-12307.
19. Kawahara, Y.; Takahashi-Fuke, K.; Shimizu, E.; Nakamatsu, T.; Nakamori, S. Relationship between the glutamate production and the activity of 2-oxoglutarate dehydrogenase in Brevibacterium lactofermentum. Biosci. Biotechnol. Biochem. 1997, 61, 1109-1112. Available online: http://dx.doi.org/10.1271/bbb.61.1109 (accessed on 24 July 2014).
20. Asakura, Y.; Kimura, E.; Usuda, Y.; Kawahara, Y.; Matsui, K.; Osumi, T.; Nakamatsu, T. Altered metabolic flux due to deletion of odhA causes L-glutamate overproduction in Corynebacterium glutamicum. Appl. Environ. Microbiol. 2006, 73, 1308-1319.
21. Raasch, K.; Bocola, M.; Labahn, J.; Leitner, A.; Eggeling, L.; Bott, M. Interaction of 2-oxoglutarate dehydrogenase OdhA with its inhibitor OdhI in Corynebacterium glutamicum: Mutants and a model. J. Biotechnol. 2014, 191, 99-105.
22. Krawczyk, S.; Raasch, K.; Schultz, C.; Hoffelder, M.; Eggeling, L.; Bott, M. The FHA domain of OdhI interacts with the carboxyterminal 2-oxoglutarate dehydrogenase domain of OdhA in Corynebacterium glutamicum. FEBS Lett. 2010, 584, 1463-1468.
23. Schultz, C.; Niebisch, A.; Schwaiger, A.; Viets, U.; Metzger, S.; Bramkamp, M.; Bott, M. Genetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL of Corynebacterium glutamicum: Evidence for non-essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases. Mol. Microbiol. 2009, 74, 724-741.
24. Schultz, C.; Niebisch, A.; Gebel, L.; Bott, M. Glutamate production by Corynebacterium glutamicum: Dependence on the oxoglutarate dehydrogenase inhibitor protein OdhI and protein kinase PknG. Appl. Microbiol. Biotechnol. 2007, 76, 691-700.
25. Yukawa, H.; Inui, M.; Vertes, A.A. Genomes and genome-level engineering of amino acid-producing bacteria. In Amino Acid Biosynthesis-Pathways, Regulation and Metabolic Engineering; Wendisch, V.F., Ed.; Springer: Heidelberg, Germany, 2007; Volume 5, pp. 349-401, doi:10.1007/ 7171_2006_066.
26. Peters-Wendisch, P.G.; Wendisch, V.F.; Paul, S.; Eikmanns, B.J.; Sahm, H. Pyruvate carboxylase as an anaplerotic enzyme in Corynebacterium glutamicum. Microbiology 1997, 143, 1095-1103.
27. Peters-Wendisch, P.G.; Schiel, B.; Wendisch, V.F.; Katsoulidis, E.; Mockel, B.; Sahm, H.; Eikmanns, B.J. Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum. J. Mol. Microbiol. Biotechnol. 2001, 3, 295-300.
28. Jojima, T.; Fujii, M.; Mori, E.; Inui, M.; Yukawa, H. Engineering of sugar metabolism of Corynebacterium glutamicum for production of amino acid L-alanine under oxygen deprivation. Appl. Microbiol. Biotechnol. 2010, 87, 159-165.
29. Shirai, T.; Fujimura, K.; Furusawa, C.; Nagahisa, K.; Shioya, S.; Shimizu, H. Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis. Microb. Cell. Fact. 2007, doi:10.1186/1475-2859-6-19.
30. Siedler, S.; Lindner, S.N.; Bringer, S.; Wendisch, V.F.; Bott, M. Reductive whole-cell biotransformation with Corynebacterium glutamicum: Improvement of NADPH generation from glucose by a cyclized pentose phosphate pathway using pfkA and gapA deletion mutants. Appl. Microbiol. Biotechnol. 2013, 97, 143-152.
31. Jiang, L.Y.; Chen, S.G.; Zhang, Y.Y.; Liu, J.Z. Metabolic evolution of Corynebacterium glutamicum for increased production of L-ornithine. BMC Biotechnol. 2013, doi:10.1186/1472-6750-13-47.
32. Kim, S.Y.; Lee, J.; Lee, S.Y. Metabolic engineering of Corynebacterium glutamicum for the production of L-ornithine. Biotechnol. Bioeng. 2015, 112, 416-421.
33. Lee, S.Y.; Shin, H.S.; Park, J.S.; Kim, Y.H.; Min, J. Proline reduces the binding of transcriptional regulator ArgR to upstream of argB in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 2010, 86, 235-242.
34. Ronsch, H.; Kramer, R.; Morbach, S. Impact of osmotic stress on volume regulation, cytoplasmic solute composition and lysine production in Corynebacterium glutamicum MH20-22B. J. Biotechnol. 2003, 104, 87-97.
35. Weinand, M.; Kramer, R.; Morbach, S. Characterization of compatible solute transporter multiplicity in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 2007, 76, 701-708.
36. Schneider, J.; Niermann, K.; Wendisch, V.F. Production of the amino acids L-glutamate, L-lysine, L-ornithine and L-arginine from arabinose by recombinant Corynebacterium glutamicum. J. Biotechnol. 2011, 154, 191-198.
37. Xu, M.; Rao, Z.; Dou, W.; Jin, J.; Xu, Z. Site-directed mutagenesis studies on the L-arginine-binding sites of feedback inhibition in N-acetyl-L-glutamate kinase (NAGK) from Corynebacterium glutamicum. Curr. Microbiol. 2012, 64, 164-172.
38. Schendzielorz, G.; Dippong, M.; Grunberger, A.; Kohlheyer, D.; Yoshida, A.; Binder, S.; Nishiyama, C.; Nishiyama, M.; Bott, M.; Eggeling, L. Taking control over control: Use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways. ACS Synth. Biol. 2014, 3, 21-29.
39. Nguyen, A.Q.; Schneider, J.; Wendisch, V.F. Elimination of polyamine N-acetylation and regulatory engineering improved putrescine production by Corynebacterium glutamicum. J. Biotechnol. 2015, 201, 75-85.
40. Itou, H.; Watanabe, N.; Yao, M.; Shirakihara, Y.; Tanaka, I. Crystal structures of the multidrug binding repressor Corynebacterium glutamicum CgmR in complex with inducers and with an operator. J. Mol. Biol. 2010, 403, 174-184.
41. Kind, S.; Kreye, S.; Wittmann, C. Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum. Metab. Eng. 2011, 13, 617-627.
42. Kind, S.; Jeong, W.K.; Schroder, H.; Zelder, O.; Wittmann, C. Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum. Appl. Environ. Microbiol. 2010, 76, 5175-5180.
43. Eggeling, L.; Bott, M. Handbook of Corynebacterium Glutamicum; CRC Press: Boca Raton, FL, USA, 2005.
44. Stansen, C.; Uy, D.; Delaunay, S.; Eggeling, L.; Goergen, J.L.; Wendisch, V.F. Characterization of a Corynebacterium glutamicum lactate utilization operon induced during temperature-triggered glutamate production. Appl. Environ. Microbiol. 2005, 71, 5920-5928.
45. Schäfer, A.; Tauch, A.; Jäger, W.; Kalinowski, J.; Thierbach, G.; Puhler, A. Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 1994, 145, 69-73.
46. Hanahan, D. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 1983, 166, 557-580.
47. Gibson, D.G.; Young, L.; Chuang, R.Y.; Venter, J.C.; Hutchison, C.A., 3rd; Smith, H.O. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 2009, 6, 343-345.
48. Schellenberger, J.; Que, R.; Fleming, R.M.; Thiele, I.; Orth, J.D.; Feist, A.M.; Zielinski, D.C.; Bordbar, A.; Lewis, N.E.; Rahmanian, S., et al. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0. Nat. Protoc. 2011, 6, 1290-1307.
49. Shen, L.; Haufe, J.; Patel, M.K. Product overview and market projection of emerging bio-based plastics (Utrecht University). 2009. Available online: http://en.european-bioplastics.org (accessed on 9 February 2015).
50. Hoffelder, M.; Raasch, K.; van Ooyen, J.; Eggeling, L. The E2 domain of OdhA of Corynebacterium glutamicum has succinyltransferase activity dependent on lipoyl residues of the acetyltransferase AceF. J. Bacteriol. 2010, 192, 5203-5211.
51. Omumasaba, C.A.; Okai, N.; Inui, M.; Yukawa, H. Corynebacterium glutamicum glyceraldehyde-3-phosphate dehydrogenase isoforms with opposite, ATP-dependent regulation. J. Mol. Microbiol. Biotechnol. 2004, 8, 91-103.
52. Haas, D.; Leisinger, T. N-acetylglutamate 5-phosphotransferase of Pseudomonas aeruginosa. Purification and ligand-directed association-dissociation. Eur. J. Biochem. 1975, 52, 365-375.