Improved fermentative production of gamma-aminobutyric acid via the putrescine route: Systems metabolic engineering for production from glucose, amino sugars, and xylose

Biotechnology and Bioengineering

Volumn 114, Issue 4, 2017, Pages 862-873

  Jorge, João M P ^a   Nguyen, Anh Q D ^a,b   Pérez García, Fernando ^a   Kind, Stefanie ^b   Wendisch, Volker F ^a  

^a BIELEFELD UNIVERSITY   (Germany)

^b Evocatal GmbH   (Germany)

Author keywords

alternative carbon sources; Corynebacterium glutamicum; GABA production; metabolic engineering; putrescine route; transport engineering

Indexed keywords

AMINO ACIDS; AMINO SUGARS; BIODEGRADABLE POLYMERS; CARBOXYLATION; GENES; GLUCOSAMINE; GLUCOSE; METABOLISM; PRODUCTIVITY; PROTEINS;

CARBON SOURCE; CORYNEBACTERIUM GLUTAMICUM; FERMENTATIVE PRODUCTION; GAMMA-AMINOBUTYRIC ACIDS; PUTRESCINE ROUTE; SYSTEMS METABOLIC ENGINEERINGS; TRANSPORT ENGINEERING; VOLUMETRIC PRODUCTIVITY;

METABOLIC ENGINEERING;

2 OXOGLUTARATE DEHYDROGENASE SUBUNIT E1O; 4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; ALANINE; BACTERIAL ENZYME; BACTERIAL PROTEIN; CARBON; DIHYDROLIPOAMIDE ACETYLTRANSFERASE; DIHYDROLIPOAMIDE DEHYDROGENASE; GABA SPECIFIC IMPORTER; GAMMA AMINOBUTYRALDEHYDE DEHYDROGENASE; GLUCOSAMINE; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; INHIBITOR PROTEIN; MESSENGER RNA; N ACETYL PUTRESCINE; N ACETYLGLUCOSAMINE; ODHA INHIBITOR; ORNITHINE CARBAMOYLTRANSFERASE; ORNITHINE DECARBOXYLASE; OXOGLUTARATE DEHYDROGENASE; PUTRESCINE; PUTRESCINE DERIVATIVE; PUTRESCINE TRANSAMINASE; SPERMIDINE N ACETYLTRANSFERASE A; SUCCINATE SEMIALDEHYDE DEHYDROGENASE; THREONINE; UNCLASSIFIED DRUG; XYLOSE; AMINOSUGAR;

ARGB GENE; ARTICLE; BACTERIAL GENE; CARBON SOURCE; CGMA GENE; CGMR GENE; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; ENZYME ACTIVITY; ESCHERICHIA COLI; FED BATCH FERMENTATION; FTN GENE; HETEROLOGOUS EXPRESSION; METABOLIC ENGINEERING; NONHUMAN; PRECURSOR; PYC GENE; REPRODUCIBILITY; START CODON; TRANSCRIPTOMICS; YGGB GENE; BATCH CELL CULTURE; BIOMASS; FERMENTATION; METABOLISM; PROCEDURES; SYSTEMS BIOLOGY;

AMINO SUGARS; BATCH CELL CULTURE TECHNIQUES; BIOMASS; CORYNEBACTERIUM GLUTAMICUM; FERMENTATION; GAMMA-AMINOBUTYRIC ACID; GLUCOSE; METABOLIC ENGINEERING; PUTRESCINE; SYSTEMS BIOLOGY; XYLOSE;

EID: 84998577581     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.26211     Document Type: Article

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