Glutamate overproduction in corynebacterium glutamicum triggered by a decrease in the level of a complex comprising dtsR and a biotin-containing subunit

Bioscience, Biotechnology and Biochemistry

Volumn 63, Issue 7, 1999, Pages 1274-1278

  Kimura, Eiichiro ^a   Yagoshi, Chizu ^a   Kawahara, Yoshio ^a   Ohsumi, Tsuyoshi ^a   Nakamatsu, Tsuyoshi ^a   Tokuda, Hajime ^b  

^a AJINOMOTO CO INC   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Biotin; DtsR; Glutamate overproduction; Tween 40

Indexed keywords

EID: 0001239046     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.63.1274     Document Type: Article

References (27)

1. Kinoshita, S., Udaka, S., and Shimono, M., Studies on the ami-no acid fermentation: Part I. Production of L-glutamic acid by various microorganisms. J. Gen. Appl. Microbiol., 3, 193-205 (1957).
2. Udaka, S., Screening method for microorganisms accumulating metabolites and its use in the isolation of Micrococcus glutami-cus. J. Bacteriol., 79, 754-755 (1960).
3. T to Corynebacterium glutamicum and their distinction by rRNA gene restriction patterns. Int. J. Syst. Bacteriol, 41, 255-260 (1991).
4. Kinoshita, S., Glutamic acid bacteria. In “Biology of industrial microorganisms”, eds. Demain, A. L., and Solomon, N. A., The Benjamin/Cummings Publishing Company, Inc., California, pp. 115-142 (1985).
5. Yoshinaga, F., and Nakamori, S., Amino acids biosynthesis and genetic regulation. In “Production of amino acids”, eds. Herrmann, K. M., and Somerville, R. L., Addison-Wesley Publishing Company, London, pp. 405-430 (1983).
6. Shiio, I., Otsuka, S., and Takahashi, M., Effect of biotin on the bacterial formation of glutamic acid: I. Glutamate formation and cellular permeability of amino acids. J. Biochem., 51, 56-62 (1962).
7. Takinami, K., Yoshii, H., Tsuri, H., and Okada, H., Biochemical effects of fatty acid and its derivatives on L-glutamic acid fermentation: Part III. Biotin-Tween 60 relationship in the accumulation of L-glutamic acid and the growth of Brevibacterium lactofermentum. Agr. Biol. Chem., 29, 351-359 (1965).
8. Nunheimer, T. D., Birnbaum, J., Ihnen, E. D., and Demain A. L., Product inhibition of the fermentative formation of glutamic acid. Appl. Microbiol., 20, 215-217 (1970).
9. Kimura, E., Abe, C., Kawahara, Y., and Nakamatsu, T., Molecular cloning of a novel gene, dtsR, which rescues the detergent sensitivity of a mutant derived from Brevibacterium lactofermentum. Biosci. Biotechnol. Biochem., 60, 1565-1570 (1996).
10. Kimura, E., Abe, C., Kawahara, Y., Nakamatsu, T., and Tokuda, H., A dtsR gene-disrupted mutant of Brevibacterium lactofermetum requires fatty acids for growth and efficiently produces L-glutamate in the presence of an excess of biotin. Biochem. Biophys. Res. Commun., 234, 157-161 (1997).
11. Wolfgang, J., Peters-Wendisch, P. G., Kalinowski, J., and Piihler, A., A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-car-boxyl-carrier proteins. Arch. Microbiol., 166, 76-82 (1996).
12. Norman, E., de Smet, K. A. L., Stoker, N. G., Ratledge, C., Wheeler, P. R., and Dale, J. W., Lipid synthesis in Mycobacteria: Characterization of the biotin carboxyl carrier protein genes from Mycobacterium leprae and M. tuberculosis. J. Bacteriol., 176, 2525-2531 (1994).
13. Shiio, I., and Ujigawα-Takeda, K., Presence and regulation of α-ketoglutarate dehydrogenase complex in a glutamate-producing bacterium, Brevibacterium flavum. Agric. Biol. Chem., 44, 1897-1904 (1980).
14. Davis, B. D., Kornberg, H. L., Nagler, A., Miller, P., and Mingioli, E., Formation and functions of succinate in Escherichia coli. Federation Proceedings, 18, 211 (1959).
15. Shiio, I., Otsuka, S., and Takahashi, M., Significance of α-ketoglutaric dehydrogenase on the glutamic acid formation in Brevibacterium flavum. J. Biochem., 50, 164-165 (1961).
16. Shingu, H., and Terui, G., Studies on the process of glutamic acid fermentation at the enzyme level: I. On the changes of α-ketoglutaric acid dehydrogenase in the course of culture. J. Ferment. Technol., 49, 400-405 (1971).
17. Kawahara, Y., Takahashi-Fuke, K., Shimizu, E., Nakamatsu, T., and Nakamori, S., Relationship between the glutamate production and the activity of 2-oxoglutarate dehydrogenase in Brevibacterium lactofermentum. Biosci. Biotechnol. Biochem., 61, 1109-1112 (1997).
18. Tanaka, T., Chiba, M., Takinami, K., and Yoshii, H., Japan Kokai Tokkyo Koho, 52-126877 (July 1, 1997).
19. Sugimoto, M., Kojima, H., Tanaka, A., Matsui, H., Satoh, K., and Nakamatsu, T., Japan Kokai Tokkyo Koho, 7405-7491 (Jan. 19, 1993).
20. Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685 (1970).
21. Kaziro, Y., Ochoa, S., Warner, R. C., and Chen, J.-Y., Metabolism of propionic acid in animal tissues: VIII. Crystalline propionyl carboxylase. J. Biol. Chem., 236, 1917-1923 (1961).
22. Haase, F. C., Henrikson, K. P., Treble, D. H., and Allen, S. H. G., The subunit structure and formation of the propionyl coenzyme A carboxylase of Mycobacterium smegmatis. J. Biol. Chem., 257, 11994-11999 (1982).
23. Demain, A. L., and Birnbaum, J., Alteration of permeability for the release of metabolites from microbial cell. Curr. Top. Microbiol. Immunol., 46, 1-25 (1968).
24. Bunch, A. W., and Harris, R. E., The manipulation of micro-organisms for the production of secondary metabolites. Biotechnol. Genet. Engineer. Rev., 4, 117-144 (1986).
25. Karaus, J. P., Girgaira, F., Novotny, J., Kalousek, F., Williams, K. R., Williamson, C., Ohura, T., and Rosenberg, L. E., Coding sequence of the precursor of the P subunit of rat propionyl-CoA carboxylase. Proc. Natl. Acad. Sci. USA, 83, 8049-8053 (1986).
26. Lamhonwah, A.-M., Barankiewicz, T. J., Willard, H. F., Mahuran, D. J., Quan, F., and Gravel, R. A., Isolation of cDNA clones coding for the a and p chains of human propionyl-CoA carboxylase: Chromosomal assignments and DNA polymorphisms associated with PCCA and PCCB genes. Proc. Natl. Acad. Sci. USA, 83, 4864-4868 (1986).
27. Li, S.-J., and Cronan, Jr. J. E., The genes encoding the two car-boxyltransferase subunits of Escherichia coli acetyl-CoA carboxylase J. Biol. Chem., 267, 16841-16847 (1992).