Epigenetic regulation of the kappa opioid receptor gene by an insertion–deletion in the promoter region

European Neuropsychopharmacology

Volumn 28, Issue 2, 2018, Pages 334-340

  Lutz, Pierre Eric ^a,b   Almeida, Daniel ^a   Belzeaux, Raoul ^a   Yalcin, Ipek ^a,b   Turecki, Gustavo ^a  

^a MCGILL UNIVERSITY   (Canada)

^b CNRS   (France)

Author keywords

Depression; DNA methylation; Gene expression; Genotype; Insertion deletion; Kappa opioid receptor

Indexed keywords

KAPPA OPIATE RECEPTOR;

ADULT; ANTERIOR CINGULATE; ANTERIOR INSULA; ARTICLE; CONTROLLED STUDY; DEPRESSION; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE SEQUENCE; HUMAN; INDEL MUTATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROMOTER REGION; SUICIDE; THALAMUS DORSOMEDIAL NUCLEUS; BRAIN; BRAIN CORTEX; COHORT ANALYSIS; CPG ISLAND; GENETIC EPIGENESIS; GENETICS; METABOLISM; PATHOLOGY; THALAMUS;

BRAIN; CEREBRAL CORTEX; COHORT STUDIES; CPG ISLANDS; DEPRESSIVE DISORDER; EPIGENESIS, GENETIC; FEMALE; HUMANS; INDEL MUTATION; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RECEPTORS, OPIOID, KAPPA; SUICIDE; THALAMUS;

EID: 85040360618     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2017.12.013     Document Type: Article

References (28)

1. Anderson, S.A., Michaelides, M., Zarnegar, P., Ren, Y., Fagergren, P., Thanos, P.K., Wang, G.J., Bannon, M., Neumaier, J.F., Keller, E., Volkow, N.D., Hurd, Y.L., Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. J. Clin. Investig. 123 (2013), 5334–5341.
2. Baker-Andresen, D., Ratnu, V.S., Bredy, T.W., Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation. Trends Neurosci. 36 (2013), 3–13.
3. Bruchas, M.R., Land, B.B., Chavkin, C., The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res. 1314 (2010), 44–55.
4. Butelman, E.R., Yuferov, V., Kreek, M.J., kappa-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends Neurosci. 35 (2012), 587–596.
5. Carlezon, W.A. Jr., Krystal, A.D., Kappa-Opioid antagonists for psychiatric disorders: from bench to clinical trials. Depress Anxiety 33 (2016), 895–906.
6. Chen, G.G., Gross, J.A., Lutz, P.E., Vaillancourt, K., Maussion, G., Bramoulle, A., Theroux, J.F., Gardini, E.S., Ehlert, U., Bourret, G., Masurel, A., Lepage, P., Mechawar, N., Turecki, G., Ernst, C., Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine. BMC Genom., 18, 2017, 96.
7. Chen, J., Evans, A.N., Liu, Y., Honda, M., Saavedra, J.M., Aguilera, G., Maternal deprivation in rats is associated with corticotrophin-releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood. J. Neuroendocrinol. 24 (2012), 1055–1064.
8. Edenberg, H.J., Wang, J., Tian, H., Pochareddy, S., Xuei, X., Wetherill, L., Goate, A., Hinrichs, T., Kuperman, S., Nurnberger, J.I. Jr., Schuckit, M., Tischfield, J.A., Foroud, T., A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. Hum. Mol. Genet. 17 (2008), 1783–1789.
9. Falcon, E., Browne, C.A., Leon, R.M., Fleites, V.C., Sweeney, R., Kirby, L.G., Lucki, I., Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors. Neuropsychopharmacology 41 (2016), 2344–2351.
10. Horvath, S., DNA methylation age of human tissues and cell types. Genome Biol., 14, 2013, R115.
11. Hurd, Y.L., Subjects with major depression or bipolar disorder show reduction of prodynorphin mRNA expression in discrete nuclei of the amygdaloid complex. Mol. Psychiatry 7 (2002), 75–81.
12. Hurd, Y.L., Herman, M.M., Hyde, T.M., Bigelow, L.B., Weinberger, D.R., Kleinman, J.E., Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects. Mol. Psychiatry 2 (1997), 495–500.
13. Ji, H., Wang, Y., Liu, G., Xu, X., Dai, D., Chen, Z., Zhou, D., Zhou, X., Han, L., Li, Y., Zhuo, R., Hong, Q., Jiang, L., Zhang, X., Liu, Y., Xu, L., Chang, L., Li, J., An, P., Duan, S., Wang, Q., OPRK1 promoter hypermethylation increases the risk of Alzheimer's disease. Neurosci. Lett. 606 (2015), 24–29.
14. Jones, M.J., Goodman, S.J., Kobor, M.S., DNA methylation and healthy human aging. Aging Cell 14 (2015), 924–932.
15. Lalanne, L., Ayranci, G., Filliol, D., Gaveriaux-Ruff, C., Befort, K., Kieffer, B.L., Lutz, P.E., Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence. Addict. Biol. 22 (2017), 1010–1021.
16. Lalanne, L., Ayranci, G., Kieffer, B.L., Lutz, P.E., The kappa opioid receptor: from addiction to depression, and back. Front. Psychiatry, 5, 2014, 170.
17. Lutz, P.E., Almeida, D., Fiori, L.M., Turecki, G., Childhood maltreatment and stress-related psychopathology: the epigenetic memory hypothesis. Curr. Pharm. Des. 21 (2015), 1413–1417.
18. Lutz, P.E., Kieffer, B.L., Opioid receptors: distinct roles in mood disorders. Trends Neurosci. 36 (2013), 195–206.
19. Lutz, P.E., Mechawar, N., Turecki, G., Neuropathology of suicide: recent findings and future directions. Mol. Psychiatry 22 (2017), 1395–1412.
20. Lutz, P.E., Tanti, A., Gasecka, A., Barnett-Burns, S., Kim, J.J., Zhou, Y., Chen, G.G., Wakid, M., Shaw, M., Almeida, D., Chay, M.A., Yang, J., Lariviere, V., M'Boutchou, M.N., van Kempen, L.C., Yerko, V., Prud'homme, J., Davoli, M.A., Vaillancourt, K., Theroux, J.F., Bramoulle, A., Zhang, T.Y., Meaney, M.J., Ernst, C., Cote, D., Mechawar, N., Turecki, G., Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: convergent epigenetic, transcriptional, and morphological evidence. Am. J. Psychiatry, 2017 (appiajp201716111286).
21. Lutz, P.E., Zhou, Y., Labbe, A., Mechawar, N., Turecki, G., Decreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicides. Eur. Neuropsychopharmacol. 25 (2015), 2008–2014.
22. Masser, D.R., Berg, A.S., Freeman, W.M., Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing. Epigenetics Chromatin, 6, 2013, 33.
23. Peckys, D., Hurd, Y.L., Prodynorphin and kappa opioid receptor mRNA expression in the cingulate and prefrontal cortices of subjects diagnosed with schizophrenia or affective disorders. Brain Res. Bull. 55 (2001), 619–624.
24. Pietrzak, R.H., Naganawa, M., Huang, Y., Corsi-Travali, S., Zheng, M.Q., Stein, M.B., Henry, S., Lim, K., Ropchan, J., Lin, S.F., Carson, R.E., Neumeister, A., Association of in vivo kappa-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology. JAMA Psychiatry 71 (2014), 1262–1270.
25. Vire, E., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L., Van Eynde, A., Bernard, D., Vanderwinden, J.M., Bollen, M., Esteller, M., Di Croce, L., de Launoit, Y., Fuks, F., The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439 (2006), 871–874.
26. Weber, M., Hellmann, I., Stadler, M.B., Ramos, L., Paabo, S., Rebhan, M., Schubeler, D., Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat. Genet. 39 (2007), 457–466.
27. Wee, S., Koob, G.F., The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology 210 (2010), 121–135.
28. Xu, K., Seo, D., Hodgkinson, C., Hu, Y., Goldman, D., Sinha, R., A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk. Transl. Psychiatry, 3, 2013, e292.