Dissecting the genetic and metabolic mechanisms of adaptation to the knockout of a major metabolic enzyme in Escherichia coli

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 1, 2018, Pages 222-227

  Long, Christopher P ^a   Gonzalez, Jacqueline E ^a   Feist, Adam M ^b,c   Palsson, Bernhard O ^b,c   Antoniewicz, Maciek R ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c Chalmers University of Technology   (Denmark)

Author keywords

Adaptive evolution; Escherichia coli; Gene knockout; Metabolism; Transhydrogenase

Indexed keywords

BACTERIAL ENZYME; CARBON 13; GLUCOSE 6 PHOSPHATE ISOMERASE; GLYOXYLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; PHOSPHOENOLPYRUVATE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ESCHERICHIA COLI PROTEIN; PGI PROTEIN, E COLI; PNTA PROTEIN, E COLI; PNTB PROTEIN, E COLI; STHA PROTEIN, E COLI;

ADAPTATION; ARTICLE; BACTERIAL GENETICS; BACTERIAL METABOLISM; CARBON METABOLISM; CATABOLISM; CATALYSIS; CONTROLLED STUDY; ENERGY METABOLISM; ENVIRONMENTAL FACTOR; ESCHERICHIA COLI; GENE INACTIVATION; GENE MUTATION; GENOMICS; GLYCOLYSIS; GROWTH RATE; HEREDITY; METABOLIC FLUX ANALYSIS; NONHUMAN; PRIORITY JOURNAL; STRESS; TRANSCRIPTION REGULATION; WHOLE GENOME SEQUENCING; DIRECTED MOLECULAR EVOLUTION; GENE KNOCKDOWN; GENETICS; METABOLISM;

ADAPTATION, PHYSIOLOGICAL; DIRECTED MOLECULAR EVOLUTION; ENERGY METABOLISM; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE KNOCKDOWN TECHNIQUES; GLUCOSE-6-PHOSPHATE ISOMERASE; NADP TRANSHYDROGENASE, B-SPECIFIC; NADP TRANSHYDROGENASES;

EID: 85040197882     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1716056115     Document Type: Article

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