Kinetic modelling of [ 11 C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis

Journal of Cerebral Blood Flow and Metabolism

Volumn 38, Issue 7, 2018, Pages 1227-1242

  Veronese, Mattia ^a   Reis Marques, Tiago ^a,b   Bloomfield, Peter S ^b   Rizzo, Gaia ^c   Singh, Nisha ^a   Jones, Deborah ^d   Agushi, Erjon ^e   Mosses, Dominic ^e   Bertoldo, Alessandra ^c,f   Howes, Oliver ^a,b   Roncaroli, Federico ^e   Turkheimer, Federico E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF PADOVA   (Italy)

^d SALFORD ROYAL NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

3D modelling; endothelium; immunohistochemistry; kinetic modelling; TSPO; XBD173; 11 C PBR28

Indexed keywords

CARRIER PROTEIN; EMAPUNIL; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PEROXIDASE; PLATELET ENDOTHELIAL CELL ADHESION MOLECULE 1; TRACER; UNCLASSIFIED DRUG; [11C]PBR 28; 4 AMINOBUTYRIC ACID RECEPTOR; ACETAMIDE DERIVATIVE; N-(2-METHOXYBENZYL)-N-(4-PHENOXYPYRIDIN-3-YL)ACETAMIDE; N-BENZYL-N-ETHYL-2-(7,8-DIHYDRO-7-METHYL-8-OXO-2-PHENYL-9H-PURIN-9-YL)ACETAMIDE; PURINE DERIVATIVE; PYRIDINE DERIVATIVE; TSPO PROTEIN, HUMAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BRAIN BLOOD FLOW; CEREBELLUM; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRUG UPTAKE; GENETIC POLYMORPHISM; HEAD MOVEMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; HUMAN; IMAGE ANALYSIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KINETIC MODELLING; KINETICS; MALE; MIDDLE AGED; NERVOUS SYSTEM INFLAMMATION; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN-BOUND FRACTION; SCHIZOPHRENIA; VALIDATION STUDY; BIOLOGICAL MODEL; CLINICAL TRIAL; DIAGNOSTIC IMAGING; FRONTAL LOBE; METABOLISM; ORAL DRUG ADMINISTRATION;

ACETAMIDES; ADMINISTRATION, ORAL; ADULT; CEREBELLUM; FRONTAL LOBE; HUMANS; KINETICS; MALE; MIDDLE AGED; MODELS, NEUROLOGICAL; POSITRON-EMISSION TOMOGRAPHY; PURINES; PYRIDINES; RADIOACTIVE TRACERS; RECEPTORS, GABA;

EID: 85039431190     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1177/0271678X17712388     Document Type: Article

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