Effect of exercise on inflammatory profile of older persons: Systematic review and meta-analyses

Journal of Physical Activity and Health

Volumn 15, Issue 1, 2018, Pages 64-71

  Monteiro Junior, Renato Sobral ^a,b,c,g   De Tarso Maciel Pinheiro, Paulo ^b,c   Da Matta Mello Portugal, Eduardo ^b,d   Da Silva Figueiredo, Luiz Felipe ^b   Terra, Rodrigo ^e   Carneiro, Lara S F ^f   Rodrigues, Vinícius Dias ^a,g   Nascimento, Osvaldo J M ^c   Deslandes, Andrea Camaz ^b   Laks, Jerson ^b,d  

^a STATE UNIVERSITY OF MONTES CLAROS   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^d Inst Ciencias Exatas e da Natureza   (Brazil)

^e STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^f RESEARCH CENTER IN SPORTS SCIENCES   (Portugal)

^g State University OfMontes Claros   (Brazil)

Author keywords

Aging; Gerontology; Physical activity

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; IL6 PROTEIN, HUMAN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

AGED; BLOOD; EXERCISE; FEMALE; HUMAN; INFLAMMATION; META ANALYSIS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; BIOMARKERS; C-REACTIVE PROTEIN; EXERCISE; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-6; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85039058262     PISSN: 15433080     EISSN: 15435474     Source Type: Journal    
DOI: 10.1123/jpah.2016-0735     Document Type: Review

References (54)

1. Ostan R, Bucci L, Capri M, et al. Immunosenescence and immuno-genetics of human longevity. Neuroimmunomodulation. 2008;15(4-6):224-240. PubMed doi:10.1159/000156466
2. Wohleb ES, Godbout JP. Basic aspects of the immunology of neuroinflammation. Mod Trends Pharmacopsychiatry. 2013; 28:1-19.
3. Franceschi C, Bonafe M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci. 2000;908(1):244-254. PubMed doi:10.1111/j.1749-6632.2000.tb06651.x
4. Woods JA, Wilund KR, Martin SA, et al. Exercise, inflammation and aging. Aging Dis. 2012;3:130-140. PubMed
5. Franceschi C, Capri M, Monti D, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007;128 (1):92-105. PubMed doi:10.1016/j.mad.2006.11.016
6. Goto M. Inflammaging (inflammation + aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? Biosci Trends. 2008;2:218-230. PubMed
7. Campos C, Pera A, Lopez-Fernandez I, et al. Proinflammatory status influences NK cells subsets in the elderly. Immunol Lett. 2014;162 (1):298-302. PubMed doi:10.1016/j.imlet.2014.06.015
8. Shaw AC, Joshi S, Greenwood H, et al. Aging of the innate immune system. Curr Opin Immunol. 2010;22(4):507-513. PubMed doi:10.1016/j.coi.2010.05.003
9. Solana R, Tarazona R, Gayoso I, et al. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol. 2012;24(5):331-341. PubMed doi:10.1016/j.smim.2012.04.008
10. Cohen S, Janicki-Deverts D, Doyle WJ, et al. Chronic stress, gluco-corticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012;109(16):5995-5999. PubMed doi:10.1073/pnas.1118355109
11. Sartori AC, Vance DE, Slater LZ, et al. The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research. J Neurosci Nurs. 2012;44(4):206-217. PubMed doi:10.1097/JNN.0b013e3182527690
12. Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev. 2016;31:1-8. PubMed doi:10.1016/j.arr.2016.08.006
13. Walsh NP, Gleeson M, Pyne DB, et al. Position statement. Part two: maintaining immune health. Exer Immunol Rev. 2011;17:64-103.
14. Rynders CA, Weltman A. High-intensity exercise training for the prevention of type 2 diabetes mellitus. Phys Sportsmed. 2014;42 (1):7-14. PubMed doi:10.3810/psm.2014.02.2042
15. Suchy C, Massen L, Rognmo O, et al. Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial. EurJPrev Cardiol. 2014;21(2 suppl):18-25. PubMed doi:10.1177/2047487314552764
16. Lackland DT, Voeks JH. Metabolic syndrome and hypertension: regular exercise as part of lifestyle management. Curr Hypertens Rep. 2014;16(11):492. PubMed doi:10.1007/s11906-014-0492-2
17. Ertek S, Cicero A. Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions. Arch Med Sci. 2012;8:794-804.
18. Charansonney OL, Vanhees L, Cohen-Solal A. Physical activity: from epidemiological evidence to individualized patient management. Int J Cardiol. 2013;170(3):350-357. PubMed doi:10.1016/j.ijcard.2013.11.012
19. Tanaka Y, Kawanishi N, Shiva D, et al. Exhaustive exercise reduces tumor necrosis factor-a production in response to lipopolysaccharide in mice. Neuroimmunomodulation. 2010;17(4):279-286. PubMed doi:10.1159/000290044
20. Dantzer R, O'Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9(1):46-56. PubMed doi:10.1038/nrn2297
21. Lai H-Y, Chang H-T, Lee YL, et al. Association between inflammatory markers and frailty in institutionalized older men. Maturitas. 2014;79(3):329-333. PubMed doi:10.1016/j.maturitas.2014.07.014
22. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Brit Med J. 2009;339:b2700. PubMed doi:10.1136/bmj.b2700
23. Akobeng AK. Principles of evidence based medicine. Arch Dis Child. 2005;90(8):837-840. PubMed doi:10.1136/adc.2005.071761
24. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality ofreports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1-12. PubMed doi:10.1016/0197-2456(95)00134-4
25. Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Vol 8. Chichester, UK: Wiley; 2008:649.
26. Nicklas BJ, Hsu FC, Brinkley TJ, et al. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc. 2008;56(11):2045-2052. PubMed doi:10.1111/j.1532-5415.2008.01994.x
27. Beavers KM, Hsu FC, Isom S, et al. Long-term physical activity and inflammatory biomarkers in older adults. Med Sci Sports Exerc. 2010;42(12):2189-2196. doi:10.1249/MSS.0b013e3181e3ac80
28. Tartibian B, Hajizadeh Maleki B, Kanaley J, et al. Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study. Nutr Metab. 2011;8(1):71. doi:10.1186/1743-7075-8-71
29. Starkweather AR. The effects of exercise on perceived stress and IL-6 levels among older adults. Biol Res Nurs. 2007;8(3):186-194. PubMed doi:10.1177/1099800406295990
30. Martins RA, Verissimo MT, Coelho e Silva MJ, et al. Effects of aerobic and strength-based training on metabolic health indicators in older adults. Lipids Health Dis. 2010;9:76.
31. Martins RA, Neves AP, Coelho-Silva MJ, Verissimo MT, Teixeira AM. The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults. Eur J Appl Physiol. 2010;110(1):161-169. PubMed doi:10.1007/s00421-010-1488-5
32. Rodriguez-Miguelez P, Fernandez-Gonzalo R, Almar M, et al. Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects. Age. 2014;36 (6):9734. PubMed doi:10.1007/s11357-014-9734-0
33. Rodriguez-Miguelez P, Fernandez-Gonzalo R, Collado PS, et al. Whole-body vibration improves the anti-inflammatory status in elderly subjects through toll-like receptor 2 and 4 signaling pathways. Mech Ageing Dev. 2015;150:12-19. PubMed doi:10.1016/j.mad. 2015.08.002
34. Kishimoto T. IL-6: from its discovery to clinical applications. Int Immunol. 2010;22(5):347-352. PubMed doi:10.1093/intimm/dxq030
35. Woodrick RS, Ruderman EM. IL-6 inhibition for the treatment of rheumatoid arthritis and other conditions. Bull NYU Hosp Jt Dis. 2012;70:195-199. PubMed
36. Kojima H, Inoue T, Kunimoto H, et al. IL-6-STAT3 signaling and premature senescence. JAKSTAT. 2013;2:e25763. PubMed
37. Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci. 2012;8(9):1237-1247. PubMed doi:10.7150/ijbs.4989
38. Pedersen BK. The diseasome of physical inactivity-and the role of myokines in muscle-fat cross talk. J Physiol. 2009;587(23):5559-5568. PubMed doi:10.1113/jphysiol.2009.179515
39. Mangino M. Genomics of ageing in twins. Proc Nutr Soc. 2014;640:1-6.
40. Walsh NP, Gleeson M, Shephard RJ, et al. Position statement. Part one: immune function and exercise. Exerc Immunol Rev. 2011;17: 6-63.
41. Gleeson M, Bishop NC, Stensel DJ, et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11(9):607-615. PubMed doi:10.1038/nri3041
42. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98(4):1154-1162. PubMed doi:10.1152/japplphysiol.00164.2004
43. Maynard CL, WeaverCT. Diversity in the contribution ofinterleukin-10 to T-cell-mediated immune regulation. Immunol Rev. 2008;226 (1):219-233. PubMed doi:10.1111/j.1600-065X.2008.00711.x
44. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8(12):958-969. PubMed doi:10.1038/nri2448
45. Yang H, Li T, Wei J, et al. Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors. Mediators Inflamm. 2013;2013:165453. PubMed
46. Lacy P, Stow JL. Cytokine release from innate immune cells: association with diverse membrane trafficking pathways. Blood. 2011;118(1):9-18. PubMed doi:10.1182/blood-2010-08-265892
47. Xu F, Zhang C, Graves DT. Abnormal cell responses and role of TNF-a in impaired diabetic wound healing. BioMed Res Int. 2013;2013:754802 PubMed
48. Wu Y, Zhou BP. TNF-a/NF-KB/Snail pathway in cancer cell migration and invasion. Brit J Cancer. 2010;102(4):639-644. PubMed doi:10.1038/sj.bjc.6605530
49. Karampetsou MP, Liossis SN, Sfikakis PP. TNF-a antagonists beyond approved indications: stories of success and prospects for the future. QJM. 2010;103(12):917-928. PubMed doi:10.1093/qjmed/hcq152
50. Kirwan JP, Krishnan RK, Weaver JA, et al. Human aging is associated with altered TNF-a production during hyperglycemia and hyperinsulinemia. Am J Physiol Endocrinol Metab. 2001;281: E1137-E1143. PubMed
51. Busquets N, Carmona L, Suris X. Revision sistematica: eficacia y seguridad del tratamiento anti-TNF en pacientes ancianos. Reumatol Clin. 2011;7(2):104-112. doi:10.1016/j.reuma.2010.02.001
52. SzostakJ, LaurantP. The forgotten face ofregularphysical exercise: a 'natural' anti-atherogenic activity. Clin Sci. 2011;121(3):91-106. PubMed doi:10.1042/CS20100520
53. Zhang H, Park Y, Wu J, et al. Role of TNF-a in vascular dysfunction. Clin Sci. 2009;116(3):219-230. PubMed doi:10.1042/CS20080196
54. Bremer AA, Jialal I. Adipose tissue dysfunction in nascent metabolic syndrome. J Obes. 2013;2013:393192. PubMed doi:10.1155/2013/393192